Assessment of intracranial aneurysm rupture risk using a point cloud-based deep learning model by Heshan Cao, Hui Zeng, Lei Lv, Qi Wang, Hua Ouyang, Long Gui, Ping Hua, Songran Yang, Songran Yang

“…However, as the original dataset authors stated, we observed potential generalizability concerns when applying trained models to datasets with different selection biases. Nevertheless, our method outperformed the LASSO regression model in terms of generalizability, with an AUC of 0.71 versus 0.67.Conclusion: The point cloud, as a 3D visualization technique for intracranial aneurysms, can effectively capture the spatial contour and morphological aspects of aneurysms. …”
Get full text

Effectiveness of pharmacological treatments for severe agitation in real-world emergency settings: protocol of individual-participant-data network meta-analysis by Spyridon Siafis, Hui Wu, Nobuyuki Nomura, Johannes Schneider-Thoma, Irene Bighelli, Carolin Lorenz, Joseph E. Dib, Prathap Tharyan, Leonie A. Calver, Geoffrey K. Isbister, Esther W. Y. Chan, Jonathan C. Knott, Celene Y. L. Yap, Célia Mantovani, Marc L. Martel, David Barbic, William G. Honer, Wulf-Peter Hansen, Gisele Huf, Jacob Alexander, Nirmal S. Raveendran, Evandro S. F. Coutinho, Josef Priller, Clive E. Adams, Georgia Salanti, Stefan Leucht

“…We will exclude studies before 2002, those focusing on specific reasons for agitation and placebo-controlled trials to avoid concerns related to the transitivity assumption and potential selection biases. We will search for eligible studies in BIOSIS, CENTRAL, CINAHL Plus, Embase, LILACS, MEDLINE via Ovid, PubMed, ProQuest, PsycINFO, ClinicalTrials.gov, and WHO-ICTRP. …”
Get full text

The Stellar Mass–Black Hole Mass Relation at z ∼ 2 down to Determined by HETDEX by Yechi Zhang, Masami Ouchi, Karl Gebhardt, Chenxu Liu, Yuichi Harikane, Erin Mentuch Cooper, Dustin Davis, Daniel J. Farrow, Eric Gawiser, Gary J. Hill, Wolfram Kollatschny, Yoshiaki Ono, Donald P. Schneider, Steven L. Finkelstein, Caryl Gronwall, Shardha Jogee, Mirko Krumpe

“…We obtain the ${{ \mathcal M }}_{* }\mbox{--}{{ \mathcal M }}_{\mathrm{BH}}$ relation covering the unexplored low-mass ranges of ${{ \mathcal M }}_{\mathrm{BH}}\,\sim \,{10}^{7}\mbox{--}{10}^{8}\,{M}_{\odot }$ , and conduct forward modeling to fully account for the selection biases and observational uncertainties. The intrinsic ${{ \mathcal M }}_{* }\mbox{--}{{ \mathcal M }}_{\mathrm{BH}}$ relation at z ∼ 2 has a moderate positive offset of 0.52 ± 0.14 dex from the local relation, suggestive of more efficient black hole growth at higher redshift even in the low-mass regime of ${{ \mathcal M }}_{\mathrm{BH}}\,\sim \,{10}^{7}\mbox{--}{10}^{8}\,{M}_{\odot }$ . …”
Get full text

Body mass index modified the effectiveness of low dose aspirin treatment on frozen-thawed embryo transfer outcome: a propensity score-matched study by Kaijie Chen, Jiali Cai, Jiali Cai, Jie Tong, Lanlan Liu, Lanlan Liu, Zhenfang Liu, Jinhua Chen, Xiaolian Yang, Chao Yang, Jie Geng, Caihui Ma, Jianzhi Ren, Xiaoming Jiang, Xiaoming Jiang

“…Propensity score matching was performed to avoid selection biases and potential confounders.ResultsThe clinical pregnancy rate and live birth rate were similar before matching (54.4% versus 55.4%, RR: 1.02, 95%CI: 0.95-1.09, and 46.3 versus 47.8, RR: 1.03, 95%CI: 0.95-1.12 respectively). …”
Get full text

Quantifying Lumbar Foraminal Volumetric Dimensions: Normative Data and Implications for Stenosis—Part 2 of a Comprehensive Series by Renat Nurmukhametov, Manuel De Jesus Encarnacion Ramirez, Medet Dosanov, Abakirov Medetbek, Stepan Kudryakov, Laith Wisam Alsaed, Gennady Chmutin, Gervith Reyes Soto, Jeff Ntalaja Mukengeshay, Tshiunza Mpoyi Chérubin, Vladimir Nikolenko, Artem Gushcha, Sabino Luzzi, Andreina Rosario Rosario, Carlos Salvador Ovalle, Katherine Valenzuela Mateo, Jesus Lafuente Baraza, Juan Carlos Roa Montes de Oca, Carlos Castillo Rangel, Salman Sharif

“…Efforts to minimize bias included blinding observers to patient information and employing broad inclusion criteria to mitigate referral and selection biases. The methodology and findings aim to enhance the understanding of normal lumbar foramina anatomy and its implications for diagnosing and treating lumbar conditions. …”
Get full text

Impact of Timing of Immunotherapy and Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma: Real-World Data on Survival Outcomes from the CKCis Database by Changsu Lawrence Park, Feras Ayman Moria, Sunita Ghosh, Lori Wood, Georg A. Bjarnason, Bimal Bhindi, Daniel Yick Chin Heng, Vincent Castonguay, Frederic Pouliot, Christian K. Kollmannsberger, Dominick Bosse, Naveen S. Basappa, Antonio Finelli, Nazanin Fallah-rad, Rodney H. Breau, Aly-Khan A. Lalani, Simon Tanguay, Jeffrey Graham, Ramy R. Saleh

“…Limitations include the small number of patients in the ST-CN group and residual confounding and selection biases that may influence the outcomes in patients undergoing CN.…”
Get full text

High-Risk Hepatocellular Carcinoma: Hepatic Arterial Infusion Chemotherapy versus Transarterial Chemoembolization by Zhang B, Huang B, Yang F, Yang J, Kong M, Wang J, Xiang Y, Wang K, Peng R, Yang K, An C, Yan D

“…The study used propensity score matching (PSM) to reduce selectivity bias. Overall survival (OS) and progression-free survival (PFS) were compared using Kaplan‒Meier curves with the Log rank test. …”
Get full text

Epidemiologia do transtorno obsessivo-compulsivo: uma revisão Epidemiology of obsessive-compulsive disorder: a review by Albina Rodrigues Torres, Maria Cristina Pereira Lima

“…<br>Epidemiological surveys are important because clinical samples are subject of several selection biases. Sociodemographic factors and clinical aspects of the morbid condition itself influence help seeking behaviors. …”
Get full text

Self-Reported Data and Physician-Reported Data in Patients With Eosinophilic Granulomatosis With Polyangiitis: Comparative Analysis by Irena Doubelt, Jason M Springer, Tanaz A Kermani, Antoine G Sreih, Cristina Burroughs, David Cuthbertson, Simon Carette, Nader A Khalidi, Curry L Koening, Carol Langford, Carol A McAlear, Larry W Moreland, Paul A Monach, Dianne G Shaw, Philip Seo, Ulrich Specks, Kenneth J Warrington, Kalen Young, Peter A Merkel, Christian Pagnoux

“…However, observed differences between patient and physician reports imply the potential occurrence of selection biases. These results support the use of patient-reported data in EGPA but also the need for careful consideration of disease-specific definitions for the study of EGPA and how patient- and physician-reported data are collected. …”
Get full text

On the kinetic features of orexin receptor antagonists at orexin receptors, transduction systems and receptor binding by Daniel Hoyer, Laura H. Jacobson

“…On the other hand, selective orexin 2 receptor agonists are in clinical trials for the treatment of narcolepsy with (NT1) or without cataplexy (NT2) and other aspects of extreme day time sleepiness.Traditionally, the medium to high throughput screening procedures used to screen / characterize orexin receptor antagonists or agonists (and for that matter ligands acting on a variety of potential drug targets), frequently ignore two aspects of new drugs candidates: possible functional selectivity (biased agonism or antagonism) and intrinsic receptor-ligand kinetic properties (i.e. association and dissociation features at the target level), since most screening protocols are conducted under short incubation time conditions with usually a single functional readout. …”
Get full text

Efficacy and safety of acupuncture for cognitive impairment in Alzheimer's disease: a systematic review and meta-analysis by Ruyue Guo, Ruyue Guo, Xiaoming Shen, John Ealing, Jiao Zhou, Jiao Zhou, Jin Lu, Jin Lu, Yunfan Ning, Yunfan Ning

“…However, due to the small number of RCTS and cases evaluating the efficacy of acupuncture, and the possibility of measurement bias and selectivity bias in included studies, it is still unable to conduct high-intensity demonstration on its effectiveness. …”
Get full text

Parent control and IJV performance in China : an examination from local partner’s managerial perspective = 합작 모기업의 경영통제가 조인트벤처 경영 성과에 미치는 영향 : 중국 현지 모기업의 경영자 관점에서... by Hwang, Yong-Sik, Chen, Dong, Park, Seung Ho

“…Second, the study sample was composed of relatively big IJVs with an average age of 10, which might be subject to selection biases. It is likely that the findings are more applicable to long-standing partnerships instead of relatively new ones. …”
Get full text