Evaluation of a natural S‐equol supplement in treating premenstrual symptoms and the effect of the gut microbiota: An open‐label pilot study by Takashi Takeda, Yasutaka Chiba

“…Isoflavones might cause changes in the estrogen cycle by their selective estrogen receptor modulator‐like activities. Equol, which is a metabolite of a soy isoflavone, has greater biological activity than other soy isoflavones. …”
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Aromatase inhibitor strategies in metastatic breast cancer by Heather L McArthur, Patrick G Morris

“…Historically, the selective estrogen receptor modulator tamoxifen has been the most extensively studied and widely used hormone maneuver in breast cancer. …”
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Human serum albumin-based nanoparticles alter raloxifene administration and improve bioavailability by Shu-Jyuan Yang, Chih-Hao Chang, Tai-Horng Young, Chung-Hao Wang, Tzu-Hao Tseng, Man-Ling Wang

“…Raloxifene is a selective estrogen receptor modulator used to treat postmenopausal osteoporosis. …”
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Regression of choroidal metastasis from breast carcinoma with palbociclib by Shweta Parakh, Shrutanjoy Das, Shrey Maheshwari, Vinita Gupta, Gaurav Luthra, Saurabh Luthra

“…We report a case of a patient who developed choroidal metastasis, while on endocrine therapy with selective estrogen receptor modulator (SERM), tamoxifen, for estrogen receptor (ER) positive, progesterone receptor (PR) positive and (human epidermal growth factor receptor 2) HER2 negative primary breast carcinoma, which then regressed following systemic chemotherapy with palbociclib. …”
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HUBUNGAN ANTARA PENEBALAN ENDOMETRIUM PADA PEMERIKSAAN ULTRASONOGRAFI TRANSVAGINAL DENGAN PEMBERIAN TERAPI TAMOXIFEN TERHADAP PENDERITA KANKER PAYUDARA by MARINA, TINA

“…Tamoxifen is a selective estrogen receptor modulator drug whose pharmacological profile is estrogen antagonist on some body tissue, while to some other tissue act as estrogen agonist. …”

Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents by Zaraei, S-O, Dohle, W, Anbar, HS, El-Gamal, R, Leblond, B, Foster, PA, Al-Tel, TH, Potter, BVL, El-Gamal, MI

“…All three possible sulfamate derivatives of the selective estrogen receptor modulator Raloxifene (bis-sulfamate 7 and two mono-sulfamates 8–9) were synthesized and evaluated as inhibitors of the clinical drug target steroid sulfatase (STS), both in cell-free and in cell-based assays, and also as estrogen receptor (ER) modulators. …”

The Novel Pharmacological Approaches to Coumestrol: Focusing on the Psychiatric and Neurological Benefits and the Newly Identified Receptor Interactions by Kiarash Fekri, Alireza Mohajjel Nayebi, Javad Mahmoudi, Saeed Sadigh-Eteghad

“…Pharmacologically, this phytoestrogen would act as a selective estrogen receptor modulator with several-fold more affinity to β sub-types of the receptors (ERβ); although other mechanisms of action may be involved. …”
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Insights Into the Role of Epigenetic Factors Determining the Estrogen Response in Estrogen-Positive Ovarian Cancer and Prospects of Combining Epi-Drugs With Endocrine Therapy by Sadia Sarwar, Abir Alamro, Fazlul Huq, Amani Alghamdi

“…The concept of hormonal manipulations got attention during the last half of the 20th century when tamoxifen was approved by the FDA as the first selective estrogen receptor modulator (SERM). Endocrine therapy that has been found to be effective against breast cancer can be an option for ovarian cancer. …”
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ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE by D. B. Erdyneeva, N. N. Babyshkina, T. A. Dronova, S. V. Vtorushin, E. M. Slonimskaya, V. N. Stegniy, N. V. Cherdyntseva

“…Tamoxifen, a selective estrogen receptor modulator, remains the first adjuvant treatment choice for the hormone-receptor positive BC patients. …”
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Tamoxifen Affects Aquaporin-3 Expression and Subcellular Localization in Rat and Human Renal Collecting Ducts by Stine Julie Tingskov, Mariagrazia D’Agostino, Frédéric H. Login, Grazia Tamma, Lene N. Nejsum, Rikke Nørregaard

“…Sex hormones play an important role in the regulation of water homeostasis, and we have previously shown that tamoxifen (TAM), a selective estrogen receptor modulator (SERM), affects the regulation of aquaporin (AQP)-2. …”
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Bilateral ovarian endometriomas after laparoscopic hysterectomy following adjuvant tamoxifen therapy for breast cancer: A case report by Satoshi Nishiyama, Sotaro Hayashi, Naoki Abe, Sachino Kira, Miho Oda, Lifa Lee, Yoko To, Maki Goto, Hiroshi Tsujioka

“…Tamoxifen, a selective estrogen receptor modulator, is widely used as adjunctive therapy for women with breast cancer. …”
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Baseline FSH Predicts Semen Parameter Response in Infertile Men on Clomiphene Citrate by Ryan Smith, Jake Fantus, Ella J. Doerge, Larry Lipshultz, Jason R. Kovac, Robert Coward

“…Background: Clomiphene citrate (CC) is a selective estrogen receptor modulator that increases gonadotropin production and may improve spermatogenesis. …”
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The Divergent Effects of Ovarian Steroid Hormones in the MCF-7 Model for Luminal A Breast Cancer: Mechanistic Leads for Therapy by Nitin T. Telang

“…The long-term exposure to the selective estrogen-receptor modulator tamoxifen selects a drug-resistant phenotype, exhibiting increased expressions of stem cell markers. …”
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Gynecomastia: A systematic review of pharmacological treatments by Ori Berger, Zohar Landau, Zohar Landau, Ran Talisman

“…We conducted this systematic literature review to assess the efficacy, safety, side effects, and complications of pharmacological treatments published.MethodsMEDLINE, Embase, and Cochrane CENTRAL were searched for the terms “gynecomastia”, “pubertal”, and “adolescent” in conjunction with medications from the Selective Estrogen Receptor Modulator (SERM), aromatase inhibitors (AI), and androgens groups in different combinations to optimize the search results. …”
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Tamoxifen is better than low-dose clomiphene or gonadotropins in women with thin endometrium (<7 mm) after clomiphene in intrauterine insemination cycles: A prospective study by Sunita Sharma, Geetha Rani, Gunja Bose, Indranil Saha, Sikha Bathwal, B N Chakravarty

“…Tamoxifen (TMX), a selective estrogen receptor modulator, acts as an agonist on the endometrium. …”
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A randomized open label trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis by Ngan, N, Mai, N, Tung, N, Lan, N, Tai, L, Phu, N, Chau, N, Binh, T, Hung, L, Beardsley, J, White, N, Lalloo, D, Krysan, D, Hope, W, Geskus, R, Wolbers, M, Nhat, L, Thwaites, G, Kestelyn, E, Day, J

“…Tamoxifen, a selective estrogen receptor modulator used to treat breast cancer, has anti-cryptococcal activity, appearing synergistic when combined in vitro with amphotericin, and fungicidal when combined with fluconazole. …”

Assessment of 28-day oral exposure to Pueraria candollei var. mirifica (Fabaceae) roots on pituitary-ovarian axis function and selected metabolic parameters in ovary-intact rats by Mallika Srasri, Prayook Srivilai, Panida Loutchanwoot

“…Pueraria candollei var. mirifica (Fabaceae) root (PMR) has recently been developed as a potential selective estrogen receptor modulator (SERM) in menopausal women. …”
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Asoprisnil, a Selective Progesterone Receptor Modulator (SPRM), Inhibits Melanosome Export in B16F10 Cells and HEMn-DP Melanocytes by Shilpi Goenka, Sanford R. Simon

“…Previous studies have reported that estrogen hormone promotes melanogenesis while progesterone inhibits it. A selective estrogen receptor modulator (SERM), tamoxifen, has been shown to promote melanogenesis; however, to date, there have been no reports on the effects of a selective progesterone receptor modulator (SPRM) on melanogenesis. …”
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<i>Rheum rhaponticum</i> Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model by Mickey Wilson, Veera Konda, Kathryn Heidt, Thirumurugan Rathinasabapathy, Anuradha Desai, Slavko Komarnytsky

“…Unlike hormone therapy, ERr 731 (a standardized botanical extract of Siberian rhubarb <i>Rheum rhaponticum</i> L. high in rhaponticin) acts like a selective estrogen receptor modulator for ERβ receptors and may offer a higher degree of safety while maintaining the desired efficacy profile. …”
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Tamoxifen Derivatives Alter Retromer-Dependent Endosomal Tubulation and Sorting to Block Retrograde Trafficking of Shiga Toxins by Andrey S. Selyunin, Karinel Nieves-Merced, Danyang Li, Stanton F. McHardy, Somshuvra Mukhopadhyay

“…We further reported that the activity of tamoxifen against STx1/STx2 is independent of its selective estrogen receptor modulator (SERM) property and instead depends on its weakly basic chemical nature, which allows tamoxifen to increase endolysosomal pH and alter the recruitment of retromer to endosomes. …”
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