Formulation Development for Transdermal Delivery of Raloxifene, a Chemoprophylactic Agent against Breast Cancer by Deepal Vora, Amruta Dandekar, Sonalika Bhattaccharjee, Onkar N. Singh, Vivek Agrahari, M. Melissa Peet, Gustavo F. Doncel, Ajay K. Banga

“…Raloxifene (RLX) is a second-generation selective estrogen receptor modulator approved for the prevention of invasive breast cancer in women. …”
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G-protein modulation of ionic currents in cardiac myocytes by Goodstadt, L, Leo Goodstadt

“…Raloxifene, a selective estrogen receptor modulator (SERM), was similarly able to potentiate the results of sympathetic stimulation but with a much slower time course.…”

Long-Term Tamoxifen Effects in the Cyclic Interaction of the Endocannabinoid and Endocrine System in the Rat Central Nervous System by Bruno M. Fonseca, Niloy Bhowmick, Sara Cunha, João Maia, Georgina Correia-da-Silva, Natércia Teixeira, Susana I. Sá

“…Here, we addressed the mechanisms involved in ECS fluctuations within the central nervous system and evaluated the effects of tamoxifen (TAM), a selective estrogen receptor modulator, in central AEA regulation. …”
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Tamoxifen or aromatase inhibitors with ovarian function suppression in pre-menopausal stage I-III lobular breast cancer by Helena Record, Elle Clelland, Harriet T. Rothschild, Mandeep Kaur, A. Jo Chien, Michelle Melisko, Hope S. Rugo, Firdows Mujir, Laura Huppert, Rita A. Mukhtar

“…Abstract While adjuvant treatment with the selective-estrogen receptor modulator (SERM) tamoxifen has been the standard of care for pre-menopausal patients with hormone receptor (HR) positive breast cancer, recent trials showed a benefit of aromatase inhibitors (AI) and ovarian function suppression (OFS) for some patients. …”
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Raloxifene Ameliorates Glucosamine-Induced Insulin Resistance in Ovariectomized Rats by Chung-Hwan Chen, Tsung-Lin Cheng, Chi-Fen Chang, Hsuan-Ti Huang, Sung-Yen Lin, Meng-Hsing Wu, Lin Kang

“…Raloxifene (RLX) is a selective estrogen receptor modulator and also an OP drug. Previously, we found that estrogen could improve GlcN-induced insulin resistance in ovariectomized (OVX) rats. …”
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Long-Term Oral Tamoxifen Administration Decreases Brain-Derived Neurotrophic Factor in the Hippocampus of Female Long-Evans Rats by Laura E. Been, Amanda R. Halliday, Sarah M. Blossom, Elena M. Bien, Anya G. Bernhard, Grayson E. Roth, Karina I. Domenech Rosario, Karlie B. Pollock, Petra E. Abramenko, Leily M. Behbehani, Gabriel J. Pascal, Mary Ellen Kelly

“…Tamoxifen, a selective estrogen receptor modulator (SERM), is commonly used as an adjuvant drug therapy for estrogen-receptor-positive breast cancers. …”
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Influence of CYP2D6, CYP2C19 and CYP3A5 polymorphisms on plasma levels of tamoxifen metabolites in Algerian women with ER+ breast cancer by Amira Boucenna, Khadidja Boudaoud, Ahmed Hireche, Mohamed Larbi Rezgoune, Noureddine Abadi, Taha Filali, Dalila Satta

“…Abstract Background Tamoxifen, a selective estrogen receptor modulator, is indicated for breast cancer developed in response to estrogen. …”
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Improvements to the Vulva, Vestibule, Urethral Meatus, and Vagina in Women Treated With Ospemifene for Moderate to Severe Dyspareunia: A Prospective Vulvoscopic Pilot Study by Sue W. Goldstein, BA, CCRC, CSE, IF, Ashley G. Winter, MD, Irwin Goldstein, MD, IF

“…Introduction: Ospemifene, an oral selective estrogen receptor modulator approved for the treatment of mild to moderate dyspareunia from menopause, has been shown to moderate sexual pain and vaginal epithelial cell characteristics. …”
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Neuroprotective Potential of Raloxifene via G-Protein-Coupled Estrogen Receptors in Aβ-Oligomer-Induced Neuronal Injury by Tetsuhito Nohara, Mayumi Tsuji, Tatsunori Oguchi, Yutaro Momma, Hideaki Ohashi, Miki Nagata, Naohito Ito, Ken Yamamoto, Hidetomo Murakami, Yuji Kiuchi

“…Raloxifene, a selective estrogen receptor modulator, exhibits protective effects by activating the transmembrane G-protein-coupled estrogen receptor (GPER). …”
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88116 Effect of conjugated estrogens and bazedoxifene on glucose, energy and lipid metabolism in obese postmenopausal women by Kara Marlatt, Dragana Lovre, Robbie Beyl, Chandra Tate, Evelyn Hayes, Charles Burant, Eric Ravussin, Franck Mauvais-Jarvis

“…OBJECTIVES/GOALS: Combining conjugated estrogens (CE) with the selective estrogen receptor modulator bazedoxifene (BZA) is a novel, orally-administered menopausal therapy. …”
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Simultaneous quantification of 4-hydroxytamoxifen and hesperidin in liposomal formulations: Development and validation of a RP-HPLC method by Cynthia Lizzie Lobo, Manohar M, Amitha Shetty, Ananya S, Pallavi K, Akhilesh Dubey

“…Breast cancer treatment options are diverse, with tamoxifen commonly used as a selective estrogen receptor modulator (SERM) for hormone receptor-positive breast cancer. …”
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Prediction of Drug–Drug–Gene Interaction Scenarios of (<i>E</i>)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling by Christina Kovar, Lukas Kovar, Simeon Rüdesheim, Dominik Selzer, Boian Ganchev, Patrick Kröner, Svitlana Igel, Reinhold Kerb, Elke Schaeffeler, Thomas E. Mürdter, Matthias Schwab, Thorsten Lehr

“…Clomiphene, a selective estrogen receptor modulator (SERM), has been used for the treatment of anovulation for more than 50 years. …”
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Pharmacokinetic Interactions Between Bazedoxifene and Cholecalciferol: An Open-Label, Randomized, Crossover Study in Healthy Male Volunteers by Lee MH, Yoon SK, Kim H, Cho YS, Han S, Lee SH, Bae KS, Jung J, Hong SH, Lim HS

“…Ltd., Seoul, Republic of KoreaCorrespondence: Hyeong-Seok Lim, Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea, Tel +82-2-3010-4613, Fax +82-2-3010-4623, Email mdlhs@amc.seoul.krPurpose: The combined administration of bazedoxifene, a tissue-selective estrogen receptor modulator, and cholecalciferol can be a promising therapeutic option for postmenopausal osteoporosis patients. …”
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The Effects of Tamoxifen on Tolerogenic Cells in Cancer by Ros Akmal Mohd Idris, Ali Mussa, Suhana Ahmad, Mohammad A. I. Al-Hatamleh, Rosline Hassan, Tengku Ahmad Damitri Al Astani Tengku Din, Wan Faiziah Wan Abdul Rahman, Norhafiza Mat Lazim, Jennifer C. Boer, Magdalena Plebanski, Rohimah Mohamud

“…Tamoxifen (TAM) is the most prescribed selective estrogen receptor modulator (SERM) to treat hormone-receptor-positive breast cancer patients and has been used for more than 20 years. …”
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Targeting Interleukin-6/Glycoprotein-130 Signaling by Raloxifene or SC144 Enhances Paclitaxel Efficacy in Pancreatic Cancer by Nina A. Hering, Emily Günzler, Marco Arndt, Miriam Zibell, Johannes C. Lauscher, Martin E. Kreis, Katharina Beyer, Hendrik Seeliger, Ioannis Pozios

“…The present study aimed to clarify if targeting the interleukin-6/glycoprotein-130 signaling cascade using the small-molecule gp130 inhibitor SC144 or raloxifene, a non-steroidal selective estrogen receptor modulator, enhances paclitaxel efficacy. …”
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Tamoxifen triggers the in vitro release of neutrophil extracellular traps in healthy horses by Constanza Salinas, Kassandra Barriga, Alejandro Albornoz, Pablo Alarcon, John Quiroga, Benjamín Uberti, José Sarmiento, Claudio Henriquez, Pamela Ehrenfeld, Rafael A. Burgos, Gabriel Moran

“…Tamoxifen (TX) is a selective estrogen receptor modulator which belongs to the triphenylethyllenes group of molecules, and which is used as a treatment in all stages of estrogen-positive human breast cancer. …”
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Circulating 27-hydroxycholesterol, lipids, and steroid hormones in breast cancer risk: a nested case–control study of the Multiethnic Cohort Study by Mindy C. DeRouen, Juan Yang, Yuqing Li, Adrian A. Franke, Anne N. Tome, Kami K. White, Brenda Y. Hernandez, Yurii Shvetsov, Veronica Setiawan, Anna H. Wu, Lynne R. Wilkens, Loïc Le Marchand, Lenora W. M. Loo, Iona Cheng

“…Abstract Background Laboratory studies have indicated that a cholesterol metabolite and selective estrogen receptor modulator, 27-hydroxycholesterol (27HC), may be important in breast cancer etiology and explain associations between obesity and postmenopausal breast cancer risk. …”
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Expert consensus on clinical applications of ovarian function suppression for Chinese women with early breast cancer 2021 CACA-CBCS by Chinese Anti-Cancer Association, Committee of Breast Cancer Society

“…Medium- and high-risk premenopausal HR positive breast cancer patients are recommended for endocrine therapy including OFS; low-risk patients are recommended for selective estrogen receptor modulator (SERM) monotherapy; premenopausal patients who use aromatase inhibitor (AI) instead of SERM need to receive OFS at the same time. …”
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Impact of clinicopathological factors on extended endocrine therapy decision making in estrogen receptor–positive breast cancer by Weilin Chen, Jiayi Wu, Yifei Zhu, Jiahui Huang, Xiaosong Chen, Ou Huang, Jianrong He, Yafen Li, Weiguo Chen, Kunwei Shen, Li Zhu

“…In the previously selective estrogen receptor modulator (SERM)–treated subgroup, pN and receipt of chemotherapy were independent predictors for the recommendation of EET. …”
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Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aerug... by Maytham Hussein, Mei-Ling Han, Yan Zhu, Elena K. Schneider-Futschik, Xiaohan Hu, Qi Tony Zhou, Yu-Wei Lin, Dovile Anderson, Darren J. Creek, Daniel Hoyer, Jian Li, Tony Velkov

“…Herein we used untargeted metabolomics to investigate the mechanism(s) of synergy between polymyxin B and the selective estrogen receptor modulator (SERM) tamoxifen against a polymyxin-resistant MDR cystic fibrosis (CF) Pseudomonas aeruginosa FADDI-PA006 isolate (polymyxin B MIC=8 mg/L , it is an MDR polymyxin resistant P. aeruginosa isolated from the lungs of a CF patient). …”
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