Formononetin Inhibits Progression of Endometriosis via Regulation of p27, pSTAT3, and Progesterone Receptor: In Vitro and In Vivo Studies by Yunjeong Park, Sung Pil Choo, Gee Soo Jung, Sehee Kim, Min Jung Lee, Wooseok Im, Hyemin Park, Inha Lee, Jae Hoon Lee, Sihyun Cho, Young Sik Choi

“…Objectives: Formononetin is one of the phytoestrogens that functions like a selective estrogen receptor modulator (SERM). In this study, we evaluated the effects of formononetin on endometriosis progression in vitro and in vivo. …”
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Comparison of dyslipidemia incidence in Chinese early-stage breast cancer patients following different endocrine therapies: A population-based cohort study by Junren Wang, Junren Wang, Jin Yin, Jin Yin, Jin Yin, Jiajun Qiu, Jiajun Qiu, Jingwen Jiang, Jingwen Jiang, Yao Hu, Yao Hu, Kunrui Zhu, Kunrui Zhu, Hong Zheng, Hong Zheng, Ting Luo, Ting Luo, Xiaorong Zhong, Xiaorong Zhong

“…Based on a large breast cancer cohort at West China Hospital, we aimed to compare the risk of dyslipidemia between premenopausal and postmenopausal women based on the endocrine therapy used.MethodsA total of 1,883 early-stage breast cancer (EBC) patients who received endocrine monotherapy [selective estrogen receptor modulator (SERM) and aromatase inhibitor (AI), with or without ovarian function suppression] with normal blood lipid levels at baseline were retrospectively included between October 2008 and April 2017. …”
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Selective Liver Estrogen Receptor α Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice by Maeva Guillaume, Elodie Riant, Aurélie Fabre, Isabelle Raymond‐Letron, Melissa Buscato, Morgane Davezac, Blandine Tramunt, Alexandra Montagner, Sarra Smati, Rana Zahreddine, Gaëlle Palierne, Marie‐Cécile Valera, Hervé Guillou, Françoise Lenfant, Klaus Unsicker, Raphaël Metivier, Coralie Fontaine, Jean‐François Arnal, Pierre Gourdy

“…The present study defined to what extent hepatocyte ERα could be involved in preserving metabolic homeostasis in response to a full (17β‐estradiol [E2]) or selective (selective estrogen receptor modulator [SERM]) activation. Ovariectomized mice harboring a hepatocyte‐specific ERα deletion (LERKO mice) and their wild‐type (WT) littermates were fed a high‐fat diet (HFD) and concomitantly treated with E2, tamoxifen (TAM; the most used SERM), or vehicle. …”
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Osteometabolic changes in patients under antineoplastic treatment: scoping review by Lucas Dalvi Armond Rezende, Davi de Souza Catabriga, Karielly Gasperazzo Pansini, Mateus Gonçalves Prata dos Reis, Paula de Souza Silva Freitas, Bruno Henrique Fiorin

“…Results: Many antineoplastics affect bone architecture by reducing its density, such as selective estrogen receptor modulators, aromatase inhibitors, androgen deprivation therapy, and glucocorticoids. …”
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Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness—A Concise Literature Review by Agnieszka Wiesner, Mariusz Szuta, Agnieszka Galanty, Paweł Paśko

“…Bisphosphonates and selective estrogen receptor modulators (SERMs) represent the two most important groups of medications taken orally and employed in osteoporosis treatment. …”
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Efficacy of Osteoporosis Drugs Anabolic and Antiresorptive Classes in Post Menopause Women by Ribka Carolin, Basuki Supartono, Yanto Sandy Tjang

“…The results showed that abaloparatide, teriparatide, and SERM (Selective Estrogen Receptor Modulators) were more effective than bisphosphonates. …”
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SERM Therapy for patients of breast cancer and otherwise by Eman Sikandar, Arysha Javid, Minahel Ahmed

“…This letter aims to draw attention to a newer form of treatment for breast cancer known as selective estrogen receptor modulators (SERMs). Selective estrogen receptor modulators (SERMs) are synthetic molecules that provide a non-invasive therapy for breast cancer patients. …”
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Estrogen Receptor Signaling in Breast Cancer by Paulina Miziak, Marzena Baran, Ewa Błaszczak, Alicja Przybyszewska-Podstawka, Joanna Kałafut, Jolanta Smok-Kalwat, Magdalena Dmoszyńska-Graniczka, Michał Kiełbus, Andrzej Stepulak

“…The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens’ synthesis and ER-dependent signal transmission, such as aromatase inhibitors or selective estrogen receptor modulators, is discussed. As a consequence, the challenges associated with the resistance to these therapies resulting from acquired ER mutations and potential strategies to overcome them are the critical point for the new treatment strategies’ development.…”
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Tissue Specific Effects of Loss of Estrogen During Menopause and Aging by Korinna eWend, Peter eWend, Susan A Krum

“…We also describe the tissue-specific effects of selective estrogen receptor modulators (SERMs) used for the treatment of breast cancers and post-menopausal symptoms.…”
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Phytoestrogens, novel dietary supplements for breast cancer by Shuo Huang, Baowen Qi, Ling Yang, Xue Wang, Jing Huang, Ya Zhao, Yonghe Hu, Wenjing Xiao

“…It was also shown that not only endogenous estrogens can activate GPERs, but many phytoestrogens can also function as selective estrogen receptor modulators (SERMs) to interact GPERs. …”
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Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions by Szidónia Farkas, Adrienn Szabó, Anita Emőke Hegyi, Bibiána Török, Csilla Lea Fazekas, Dávid Ernszt, Tamás Kovács, Dóra Zelena

“…Here, we review the current knowledge about estrogen effects in a broader sense, and the possibility of using selective estrogen-receptor modulators (SERMs), selective estrogen-receptor downregulators (SERDs), phytoestrogens, and activators of non-genomic estrogen-like signaling (ANGELS) molecules as treatment.…”
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An emerging generation of endocrine therapies in breast cancer: a clinical perspective by Rima Patel, Paula Klein, Amy Tiersten, Joseph A. Sparano

“…The new generation of drugs includes selective estrogen receptor modulators (SERMs), orally administered selective estrogen receptor degraders (SERDs), as well as more unique agents such as complete estrogen receptor antagonists (CERANs), proteolysis targeting chimeric (PROTACs), and selective estrogen receptor covalent antagonists (SERCAs). …”
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Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review by Matúš Čoma, Veronika Lachová, Petra Mitrengová, Peter Gál

“…Therefore, selective estrogen receptor modulators (SERMs) have been developed to overcome the detrimental side effects of ERT on breast and/or uterine tissues. …”
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Oral Agents for Ovulation Induction by Raziye Narin

“…Oral agents used in ovulation induction can be divided into two groups, selective estrogen receptor modulators and aromatase inhibitors as first-line agents, and metformin and inositols as second-line agents. …”
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Distinct Approaches of Raloxifene: Its Far-Reaching Beneficial Effects Implicating the HO-System by Denise Börzsei, Renáta Szabó, Alexandra Hoffmann, Médea Veszelka, Imre Pávó, Zsolt Turcsán, Csaba Viczián, Krisztina Kupai, Csaba Varga, Anikó Pósa

“…Selective estrogen receptor modulators (SERMs) were discovered in the mid-1900s in connection with estrogen-related pathological conditions. …”
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The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases by Coralie Fontaine, Florent Morfoisse, Florence Tatin, Audrey Zamora, Rana Zahreddine, Daniel Henrion, Jean-François Arnal, Françoise Lenfant, Barbara Garmy-Susini

“…In this review, we will summarize the complex vascular effects of estrogens and selective estrogen receptor modulators (SERMs) that have been described using different transgenic mouse models with selective loss of ERα function and numerous animal models of vascular and lymphatic diseases.…”
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Estrogen Receptors Alpha and Beta in Acute Myeloid Leukemia by Alessia Roma, Paul A. Spagnuolo

“…Furthermore, we assess how these signaling pathways can be targeted by various selective estrogen receptor modulators to induce AML cell death. We also provide insight into ER targeting in AML and discuss pending questions that require further study.…”
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Estrogen Receptors in Polycystic Ovary Syndrome by Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu

“…Over the years, some selective estrogen receptor modulators (SERMs) have made substantial strides in clinical applications for subfertility with PCOS, such as tamoxifen and clomiphene, however the role of ER in PCOS still needs to be understood. …”
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Depresion y estrógenos: ¿son los estrógenos una opción terapéutica? by ALEJANDRO CORREA P

“…Los moduladores selectivos de receptores de estrógeno (selective estrogen receptor modulators, SERM) no han demostrado beneficio en el tratamiento de los trastornos depresivos. …”
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Investigation of the potential effects of estrogen receptor modulators on immune checkpoint molecules by Nikita Abramenko, Fréderic Vellieux, Kateřina Veselá, Zdeněk Kejík, Jan Hajduch, Michal Masařík, Petr Babula, David Hoskovec, Karel Pacák, Pavel Martásek, Karel Smetana, Milan Jakubek

“…We explored the potential of estrogens and 17 Selective Estrogen Receptor Modulators (SERMs) as inhibiting ligands for immune checkpoint proteins (CTLA-4, PD-L1, PD-1, and CD80). …”
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