Risks of Aromatase Inhibitor-Related Cardiotoxicity in Patients with Breast Cancer in Asia by Wei-Ting Chang, Po-Wei Chen, Hui-Wen Lin, Yu-Hsuan Kuo, Sheng-Hsiang Lin, Yi-Heng Li

“…Methods: Through the Taiwanese National Cohort, we identified breast cancer patients initiating selective estrogen receptor modulators (SERMs) or AIs from 2010 to 2016. …”
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The Current Strategy in Hormonal and Non-Hormonal Therapies in Menopause—A Comprehensive Review by Anca Lucia Pop, Bogdana Adriana Nasui, Roxana Georgiana Bors, Ovidiu Nicolae Penes, Ana Gabriela Prada, Eliza Clotea, Simona Crisan, Calin Cobelschi, Claudia Mehedintu, Monica Mihaela Carstoiu, Valentin Nicolae Varlas

“…We selected 62 RCTs, which are focused on four main topics: (a) epidemiology of menopause-related symptoms, (b) hormonal replacement therapy (HRT) selective estrogen receptor modulators, (c) emerging therapies, and (d) menopause. …”
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Evaluation of the Method of Binding Tamoxifen to DNA Experimentally and Computationally by Fatemeh Sharafi Bajgan, Reza Safari, Maryam Nejat Dehkordi

“…Background and Aim: Tamoxifen is a group of drugs of selective estrogen receptor modulators, and is one of the drugs effective in the prevention and treatment of some cancers (such as breast cancer). …”
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Osteoporosis in women in menopause/postmenopause: what to do? by E. V. Kulchavenya, L. S. Treyvish, V. V. Prokudina

“…However, the main place in the prevention and treatment of osteoporosis in postmenopausal women is occupied by medication therapy, which can reduce the risk of fractures by 70%: bisphosphonates, drugs derived from parathyroid hormone, denosumab and selective estrogen receptor modulators. It is advisable to start therapy with oral bisphosphonates in most cases. …”
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Cannabinoids and Hormone Receptor-Positive Breast Cancer Treatment by Luka Dobovišek, Fran Krstanović, Simona Borštnar, Nataša Debeljak

“…Two studies have shown that tamoxifen and several other selective estrogen receptor modulators (SERM) can act as inverse agonists on CB1 and CB2, an interaction with possible clinical consequences. …”
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New approaches to pharmacological treatment of osteoporosis by Åkesson Kristina

“…Current treatment alternatives include bisphosphonates, calcitonin, and selective estrogen receptor modulators, but sufficient calcium and vitamin D are a prerequisite. …”
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Estrogens in schizophrenia: What do we know? by L. Paulino Ferreira, M. Alves, M. Duarte, A. Gamito

“…The use of selective estrogen receptor modulators (SERMs), as raloxifene, could be a favorable and safer alternative. …”
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Transdermal delivery of raloxifene HCl via ethosomal system: Formulation, advanced characterizations and pharmacokinetic evaluation by Mahmood, Syed, Mandal, Uttam K., Chatterjee, Bappaditya

“…Raloxifene HCl belongs to a class of selective estrogen receptor modulators (SERMs) which is used for the management of breast cancer. …”
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iPSC screening for drug repurposing identifies anti‐RNA virus agents modulating host cell susceptibility by Keiko Imamura, Yasuteru Sakurai, Takako Enami, Ran Shibukawa, Yohei Nishi, Akira Ohta, Tsugumine Shu, Jitsutaro Kawaguchi, Sayaka Okada, Thomas Hoenen, Jiro Yasuda, Haruhisa Inoue

“…Selected hit compounds were evaluated for their efficacy against two important human pathogens: Ebola virus (EBOV) using Huh7 cells and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) using Vero E6 cells. Selective estrogen receptor modulators (SERMs), including raloxifene, exhibited antiviral activities against EBOV and SARS‐CoV‐2. …”
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The Effect of ormeloxifene on mastalgia: A systematic review and meta-analysis of clinical trials by Masumeh Ghazanfarpour, Zari Dolatabadi, Masumeh Saeidi, Mohammad Ali Kiani, Nasibeh Roozbeh, Farzaneh Ashrafinia

“…Therefore, this study was performed with aim to determine the effect of ormeloxifene on mastalgia in clinical trial studies.Methods: To perform this review study, the English electronic databases including ISI Web of Science, PubMed, Scopus, and Cochrane Library; also, Magiran and Scientific Information Database (SID) were searched without time limitation until January 1, 2021, by using the keywords of Mastalgia or Mastalgias or Mastodynia, or Mastodynias or Mammalgia or Mammalgias, and Breast Pain, Breast, pain, and Centchroman or Selective Estrogen Receptor Modulators (SERM), and Systematic Review, and Meta-Analysis.  …”
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Maintaining bone health by estrogen therapy in patients with advanced prostate cancer: a narrative review by Herjan J T Coelingh Bennink, Jan Krijgh, Jan F M Egberts, Maria Slootweg, Harm H E van Melick, Erik P M Roos, Diederik M Somford, Yvette Zimmerman, Iman J Schultz, Noel W Clarke, R Jeroen A van Moorselaar, Frans M J Debruyne

“…Therefore, the guidelines for ADT indicate to combine ADT routinely with bone-sparing agents such as bisphosphonates, denosumab or selective estrogen receptor modulators. However, these compounds may have side effects and some require inconvenient parenteral administration. …”
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Current and Perspective Approaches to the Treatment of Prolactinomas by Nadiya Barabash, Tetiana Tykhonova, Olena Kanishcheva

“…Metformin, somatostatin analogues, selective estrogen receptor modulators, tyrosine kinase inhibitors, inhibitors of the mammalian target of rapamycin, epidermal growth factor receptor antagonists are investigated nowadays as potential alternative methods of drug treatment of prolactinomas. …”
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Epigenetic and transcriptome responsiveness to ER modulation by tissue selective estrogen complexes in breast epithelial and breast cancer cells. by Terri L Messier, Joseph R Boyd, Jonathan A R Gordon, Coralee E Tye, Natalie A Page, Rabail H Toor, Sayyed K Zaidi, Barry S Komm, Seth Frietze, Janet L Stein, Jane B Lian, Gary S Stein

“…Selective estrogen receptor modulators (SERMs), including the SERM/SERD bazedoxifene (BZA), are used to treat postmenopausal osteoporosis and may reduce breast cancer (BCa) risk. …”
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Profile of bazedoxifene/conjugated estrogens for the treatment of estrogen deficiency symptoms and osteoporosis in women at risk of fracture by Rossini M, Lello S, Sblendorio I, Viapiana O, Fracassi E, Adami S, Gatti D

“…Unfortunately, estrogen therapy and hormone therapy increase the risk of endometrial and breast cancer, respectively. The selective estrogen receptor modulators (SERMs) result in positive estrogenic effects on bone, with no negative effects on the endometrium and breast but do not provide relief from postmenopausal symptoms. …”
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Inhibition of Metabolism as a Therapeutic Option for Tamoxifen-Resistant Breast Cancer Cells by Friederike Steifensand, Julia Gallwas, Gerd Bauerschmitz, Carsten Gründker

“…In the therapy of estrogen receptor α (ERα)-positive breast cancer (BC), the focus lies on hormone sensitivity targeting therapy with selective estrogen receptor modulators (SERMs) such as 4-hydroxytamoxifen (4-OHT), although this therapy is partially limited by the development of resistance. …”
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Antiresorptive Versus Anabolic Therapy in Managing Osteoporosis in People with Type 1 and Type 2 Diabetes by Tatiane Vilaca, Richard Eastell

“…Observational studies and post hoc analyses of previous trials have indicated that antiresorptive drugs, such as bisphosphonates and selective estrogen receptor modulators, are equally effective in reducing fracture risk and increasing bone mineral density (BMD) in individuals with and without T2D. …”
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Exploring the Anti-Osteoporotic Potential of Daucosterol: Impact on Osteoclast and Osteoblast Activities by Sumin Lee, Jae-Hyun Kim, Minsun Kim, Sooyeon Hong, Hoyeon Park, Eom Ji Kim, Eun-Young Kim, Chungho Lee, Youngjoo Sohn, Hyuk Sang Jung

“…While conventional treatments, such as bisphosphonates and selective estrogen receptor modulators (SERMs), have been employed to mitigate bone loss, their effectiveness is often compromised by a spectrum of adverse side effects, ranging from gastrointestinal discomfort and musculoskeletal pain to more severe concerns like atypical fractures and hormonal imbalances. …”
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A summary of the Malaysian Clinical Practice Guidelines on the management of postmenopausal osteoporosis, 2022 by Terence Ing Wei Ong, Lee Ling Lim, Siew Pheng Chan, Winnie Siew Swee Chee, Alan Swee Hock Ch’ng, Elizabeth Gar Mit Chong, Premitha Damodaran, Fen Lee Hew, Luqman bin Ibrahim, Hui Min Khor, Pauline Siew Mei Lai, Joon Kiong Lee, Ai Lee Lim, Boon Ping Lim, Sharmila Sunita Paramasivam, Jeyakantha Ratnasingam, Yew Siong Siow, Alexander Tong Boon Tan, Nagammai Thiagarajan, Swan Sim Yeap

“…In low-risk individuals, menopausal hormone replacement or selective estrogen receptor modulators can be used, if indicated. …”
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Excellent outcomes with adjuvant toremifene or tamoxifen in early stage breast cancer by Jaime D. Lewis, Anees B. Chagpar, Elizabeth A. Shaughnessy, Jacob Nurko, Kelly McMasters, Michael J. Edwards

“…Fareston (toremifene) and tamoxifen, both selective estrogen receptor modulators, are therapeutically equivalent treatments for metastatic breast cancer. …”
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The impact of adjuvant antihormonal therapy versus observation on recurrence of borderline ovarian tumors: A retrospective cohort study by Kelsey C. Goon, Jeanelle Sheeder, Miriam D. Post, Jill Alldredge

“…Methods: This is a retrospective review of BOT at one academic institution over thirteen years comparing management with antihormonal therapy, including aromatase inhibitors, progestins, and selective estrogen receptor modulators, to surveillance alone. Patients with concurrent malignancy were excluded. …”
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