The G protein-coupled estrogen receptor 1 (GPER/GPR30) does not predict survival in patients with ovarian cancer by Kolkova Zuzana, Casslén Vera, Henic Emir, Ahmadi Sara, Ehinger Anna, Jirström Karin, Casslén Bertil

“…Furthermore, it binds selective estrogen receptor modulators with agonistic effect, which could explain tamoxifen controversies.…”
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Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early‐stage luminal breast cancer by Petr Holý, Veronika Brynychová, Karolína Šeborová, Vojtěch Haničinec, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Pavel Souček

“…Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen receptor modulators and affect cholesterol homeostasis, drug transport, nuclear and cell receptors, and other signaling proteins. …”
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Antiresorptive Drugs and the Risk of Femoral Shaft Fracture in Men and Women With Osteoporosis: A Cohort Study Using the National Database of Health Insurance Claims of Japan by Takumi Imai, Takayuki Hosoi, Hiroshi Hagino, Takanori Yamamoto, Tatsuhiko Kuroda, Hiroshi Watanabe, Shiro Tanaka

“…Adjusted incidence rate ratios in patients taking versus not taking each type of antiresorptive drug were 1.00 (95% confidence interval [CI], 0.98–1.03) for bisphosphonates, 0.46 (95% CI, 0.44–0.48) for selective estrogen receptor modulators, 0.24 (95% CI, 0.18–0.32) for estrogens, 0.75 (95% CI, 0.71–0.79) for calcitonins, and 0.93 (95% CI, 0.84–1.03) for denosumab. …”
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Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer end... by Folasade R. Olayoku, Nicolette J. D. Verhoog, Ann Louw

“…Endocrine therapies such as, selective estrogen receptor modulators (SERMs), aromatase inhibitors (AIs), and selective estrogen receptor downregulators (SERDs) are used to treat ER+ breast cancer. …”
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The impact of different strategies to handle missing data on both precision and bias in a drug safety study: a multidatabase multinational population-based cohort study by Martin-Merino, E, Calderón-Larrañaga, A, Hawley, S, Poblador-Plou, B, Llorente, A, Petersen, I, Prieto-Alhambra, D

“…<strong>Methods:</strong> New users of AOM (alendronic acid, other bisphosphonates, strontium ranelate, selective estrogen receptor modulators, teriparatide, or denosumab) aged ≥50 years during 1998–2014 were identified in two Spanish (the Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria [BIFAP] and EpiChron cohort) and one UK (Clinical Practice Research Datalink [CPRD]) EMR. …”

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells by David J Hosfield, Sandra Weber, Nan-Sheng Li, Madline Sauvage, Carstyn F Joiner, Govinda R Hancock, Emily A Sullivan, Estelle Ndukwe, Ross Han, Sydney Cush, Muriel Lainé, Sylvie C Mader, Geoffrey L Greene, Sean W Fanning

“…Chemical manipulation of estrogen receptor alpha ligand binding domain structural mobility tunes receptor lifetime and influences breast cancer therapeutic activities. Selective estrogen receptor modulators (SERMs) extend estrogen receptor alpha (ERα) cellular lifetime/accumulation. …”
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Modulation of Estrogen Receptor Alpha (ERα) and Tumor Suppressor Gene BRCA1 in Breast Cancer Cells by Bazedoxifene Acetate (BZA) by Monica Szmyd, Aisha Zanib, Victoria Behlow, Erin Hallman, Samantha Pfiffner, Raquel Yaldo, Nina Prudhomme, Katelyn Farrar, Sumi Dinda

“…Selective estrogen receptor modulators (SERMs) are steroid analogs with dual functionality, acting as partial estrogen receptor agonists to preserve postmenopausal bone density and as estrogen receptor antagonists in breast tissue. …”
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Contemporaneous symptom networks and correlates during endocrine therapy among breast cancer patients: A network analysis by Feng Jing, Zheng Zhu, Jiajia Qiu, Lichen Tang, Lei Xu, Weijie Xing, Yan Hu

“…There were no significant differences in network structure (P = 0.088), and global strength (P = 0.330) across treatment types (selective estrogen receptor modulators vs. aromatase inhibitors). …”
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Secular trends of use of anti-osteoporosis treatments in Spain: a population-based cohort study including over 1.5 million people and more than 12 years of follow-up by Martín-Merino, E, Huerta-Álvarez, C, Prieto-Alhambra, D, Álvarez-Gutiérrez, A, Montero-Corominas, C

“…Participants entered the study when aged ≥50 years in 2001-2013 and after 1 year of data available, and were followed to an AOM prescription (including alendronate, other bisphosphonates, SERM (selective estrogen receptor modulators), strontium ranelate, teriparatide or denosumab), death, lost or the end of December 2013. …”

Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on “real-world” data: a meta-analysis of propensity-matched cohort findings from the UK... by Khalid, S, Calderon-Larrañaga, S, Hawley, S, Ali, M, Judge, A, Arden, N, Van Staa, T, Cooper, C, Javaid, M, Prieto-Alhambra, D

“…Users of alendronate (reference group) were compared to those of (1) OBP, (2) strontium ranelate (SR), and (3) selective estrogen receptor modulators (SERMs), after matching on baseline characteristics using propensity scores. …”

Manipulating Estrogenic/Anti-Estrogenic Activity of Triphenylethylenes towards Development of Novel Anti-Neoplastic SERMs by Heba E. Elnakib, Marian M. Ramsis, Nouran O. Albably, Merna A. Vector, Jan J. Weigand, Kai Schwedtmann, Jannette Wober, Oliver Zierau, Günter Vollmer, Ashraf H. Abadi, Nermin S. Ahmed

“…Selective estrogen receptor modulators (SERMs) act as estrogen receptor (ERα) agonists or antagonists depending on the target issue. …”
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Autophagy and senescence facilitate the development of antiestrogen resistance in ER positive breast cancer by Michael K. McGrath, Michael K. McGrath, Ali Abolhassani, Ali Abolhassani, Luke Guy, Luke Guy, Ahmed M. Elshazly, Ahmed M. Elshazly, Ahmed M. Elshazly, John T. Barrett, John T. Barrett, Nahid F. Mivechi, Nahid F. Mivechi, David A. Gewirtz, David A. Gewirtz, Patricia V. Schoenlein, Patricia V. Schoenlein

“…Endocrine therapy includes treatment with antiestrogens, such as selective estrogen receptor modulators (SERMs), selective estrogen receptor downregulators (SERDs), and aromatase inhibitors (AIs). …”
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Corifolitropin-Alfa plus Five Days Letrozole Versus Daily Recombinant-FSH in Expected Normo-Responder Patients: A Retrospective Comparative Study by Giuseppe D’Amato, Anna Maria Caringella, Antonio Stanziano, Clementina Cantatore, Antonio D’Amato, Ettore Cicinelli, Amerigo Vitagliano

“…<b>Background:</b> In recent times, different novel GnRH-antagonist protocols with various combinations of gonadotropins and other molecules (e.g., aromatase inhibitors, selective estrogen receptor modulators) have been proposed for expected normal ovarian responders undergoing assisted reproductive treatments. …”
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Guava Leaf Essential Oil as a Potent Antioxidant and Anticancer Agent: Validated through Experimental and Computational Study by Ashok Kumar Mandal, Samrat Paudel, Anisha Pandey, Parasmani Yadav, Prateek Pathak, Maria Grishina, Mariusz Jaremko, Abdul-Hamid Emwas, Habibullah Khalilullah, Amita Verma

“…While conducting an in silico study of all the screened compounds, the potential for hydroxycaryophyllene, caryophyllene, caryophyllene oxide, humulene, terpineol, and calamenene to inhibit tumor growth was bolstered due to a resemblance to 4-hydroxytamoxifen, thereby implying that these compounds may act as selective estrogen receptor modulators (SERMs). The ADME analysis of the compounds indicated above revealed that they exhibit excellent drug likeness properties and follow the Lipinski rule of five. …”
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Medicamentos para o tratamento da osteoporose: revisão Drugs for the management of osteoporosis: a review by Deepak Kumar Khajuria, Rema Razdan, D.Roy Mahapatra

“…Current treatment alternatives include bisphosphonates, calcitonin, selective estrogen receptor modulators and inhibitors of RANK pathway but sufficient calcium and vitamin D are a prerequisite. …”
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Expert consensus on clinical applications of ovarian function suppression for Chinese women with early breast cancer (2024 edition) by Committee of Breast Cancer Society, China Anti-Cancer Association

“…After 5 years’ endocrine therapy combined with GnRHa, if they are not menopausal and well tolerated, they may consider continuing 2 to 5 years of endocrine therapy combined with GnRHa or using selective estrogen receptor modulators (SERM) alone for 2 to 5 years. …”
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Formulation and optimization of raloxifene loaded nanotransfersomes by response surface methodology for transdermal drug delivery by Mahmood, Syed, Bakhtiar, M. Taher, Mandal, Uttam Kumar

“…Raloxifene HCl belongs to selective estrogen receptor modulators (SERM), structurally similar to estrogen with important effects on reproductive and many non-reproductive tissues. …”
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