Prospects for the use of selective estrogen receptor modulator tamoxifen

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Role of cholesterol metabolism in the anticancer pharmacology of selective estrogen receptor modulators by Gómez-Coronado, D, Lasunción, MA, Martínez-Botas, J, Fernandez-Suarez, ME

“…Selective estrogen receptor modulators (SERMs) are a class of compounds that bind to estrogen receptors (ERs) and possess estrogen agonist or antagonist actions in different tissues. …”

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth by Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand

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Peri-implant osteonecrosis of the jaw in a patient prescribed selective estrogen receptor modulators by Tona Yoshino, Keisuke Seki, Maki Nagasaki, Atsushi Kamimoto

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Tamoxifen and Endometrial Cancer: A Janus-Headed Drug by Günter Emons, Alexander Mustea, Clemens Tempfer

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Selective estrogen receptor modulators and deep venous thrombosis after an emergent operation in senior women by Keiko Kishida, Masanobu Furukawa, Masayuki Nakashima, Idumi Kubota, Yukio Hayashi

Subjects: “…Drugs: Selective estrogen receptor modulators…”
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Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs) by Lephart ED, Naftolin F

“…Edwin D Lephart,1 Frederick Naftolin2 1Department of Cell Biology, Physiology and The Neuroscience Center, Brigham Young University, Provo, UT, USA; 2Department of Research and Development, e-Bio Corporation, Woodbridge, CT, USACorrespondence: Edwin D Lephart, Department of Cell Biology, Physiology and The Neuroscience Center, LS 4005, College of Life Sciences, Brigham Young University, Provo, UT, 84602, USA, Tel +801 422-2006 ; +801 319 8173, Fax +1 801 422 0700, Email Edwin_Lephart@byu.eduAbstract: The narrative for this overview focuses on updating the factors that influence skin aging and the important role estrogens and selective estrogen receptor modulators (SERMs) play in this process (mainly utilizing journal reports and reviews from the last four years). …”
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Incident Type 2 Diabetes Risk of Selective Estrogen Receptor Modulators in Female Patients with Breast Cancer by Yeo-Jin Choi, Keunhyeong Bak, Yoon Yeo, Yongwon Choi, Sooyoung Shin

“…Accumulating evidence indicates a link between diabetes and cancer. Selective estrogen receptor modulators (SERMs) may increase diabetes risk via antiestrogen effects. …”
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Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR by Fernandez-Suarez, ME, Daimiel, L, Villa-Turégano, G, Pavón, MV, Busto, R, Escolà-Gil, JC, Platt, FM, Lasunción, MA, Martínez-Botas, J, Gómez-Coronado, D

“…Selective estrogen receptor modulators (SERMs) are nonsteroidal drugs that display an estrogen‐agonist or estrogen‐antagonist effect depending on the tissue targeted. …”

Selective estrogen receptor modulator inhibits osteocyte apoptosis during estrogen loss. Implications for bone quality maintenance by Huber, C, Collishaw, S, Mosley, JR, Taylor, C, Reeve, J, Noble, B

Clinically used selective estrogen receptor modulators affect different steps of macrophage-specific reverse cholesterol transport. by Fernández-Suárez, ME, Escolà-Gil, JC, Pastor, O, Dávalos, A, Blanco-Vaca, F, Lasunción, MA, Martínez-Botas, J, Gómez-Coronado, D

“…Selective estrogen receptor modulators (SERMs) are widely prescribed drugs that alter cellular and whole-body cholesterol homeostasis. …”

Bazedoxifene, a Selective Estrogen Receptor Modulator, Promotes Functional Recovery in a Spinal Cord Injury Rat Model by Yiyoung Kim, Eun Ji Roh, Hari Prasad Joshi, Hae Eun Shin, Hyemin Choi, Su Yeon Kwon, Seil Sohn, Inbo Han

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Selective estrogen receptor modulator inhibits osteocyte apoptosis during abrupt estrogen withdrawal: implications for bone quality maintenance. by Huber, C, Collishaw, S, Mosley, JR, Reeve, J, Noble, B

“…Ideally, selective estrogen receptor modulators (SERMs) confer all of the positive bone-associated effects of estrogens without any adverse effects. …”

The immune activity of selective estrogen receptor modulators is gene and macrophage subtype-specific yet converges on Il1b downregulation by Chiara Sfogliarini, Giovanna Pepe, Candida Maria Cesta, Marcello Allegretti, Massimo Locati, Elisabetta Vegeto

“…Raloxifene belongs to the family of Selective Estrogen Receptor Modulators (SERMs), which are drugs widely prescribed for Estrogen Receptor alpha (ERα)-related pathologies. …”
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A selective estrogen receptor modulator (SERM) inhibits osteocyte apoptosis during estrogen loss. Implications for bone quality maintenance. by Collishaw, S, Mosley, J, Taylor, C, Reeve, J, Noble, B

A selective estrogen receptor modulator (SERM) inhibits osteocyte apoptosis during estrogen loss. Implications for bone quality maintenance by Collishaw, S, Mosley, J, Taylor, C, Reeve, J, Noble, B

Osteoporosis Associated with Breast Cancer Treatments Based on Types of Hormonal Therapy: A Cross-Sectional Study Using Korean National Sample Data by Yen Min Wang, Yu-Cheol Lim, Deok-Sang Hwang, Yoon Jae Lee, In-Hyuk Ha, Ye-Seul Lee

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Temporal Changes of Clomiphene on Testosterone Levels and Semen Parameters in Subfertile Men by Tommy Jiang, John T. Sigalos, Vadim Osadchiy, Alvaro Santamaria, Michael H. Zheng, Neilufar Modiri, Keith V. Regets, Jesse N. Mills, Sriram V. Eleswarapu

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Regioselective One-Pot Synthesis of Hydroxy-(S)-Equols Using Isoflavonoid Reductases and Monooxygenases and Evaluation of the Hydroxyequol Derivatives as Selective Estrogen Receptor Modulators and Antioxidants by Hanbit Song, Hanbit Song, Pyung-Gang Lee, Pyung-Gang Lee, Pyung-Gang Lee, Junyeob Kim, Junyeob Kim, Joonwon Kim, Joonwon Kim, Sang-Hyuk Lee, Sang-Hyuk Lee, Hyun Kim, Hyun Kim, Uk-Jae Lee, Uk-Jae Lee, Jin Young Kim, Jin Young Kim, Eun-Jung Kim, Byung-Gee Kim, Byung-Gee Kim, Byung-Gee Kim, Byung-Gee Kim

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Comparative differential cytotoxicity of clinically used SERMs in human cancer lines of different origin and its predictive molecular docking studies of key target genes involved i... by Lakshmi S, Shanitha A, Shiny Dv, Rahul Bs, Saikant R, Shehna Sharaf, Abi Sa, Rajmohan G

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