Biological signatures and prediction of an immunosuppressive status—persistent critical illness—among orthopedic trauma patients using machine learning techniques by Mingxing Lei, Mingxing Lei, Mingxing Lei, Zhencan Han, Shengjie Wang, Chunxue Guo, Xianlong Zhang, Ya Song, Feng Lin, Feng Lin, Tianlong Huang

“…Eight variables, including albumin, serum calcium, red cell volume distributing width (RDW), blood pH, heart rate, respiratory failure, pneumonia, and the Sepsis-related Organ Failure Assessment (SOFA) score, were significantly associated with PerCI, according to the least absolute shrinkage and selection operator (LASSO) logistic regression model combined with the 10-fold cross-validation. …”
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Zerumbone Suppresses the LPS-Induced Inflammatory Response and Represses Activation of the NLRP3 Inflammasome in Macrophages by Chia-Cheng Su, Chia-Cheng Su, Chia-Cheng Su, Shu-Chi Wang, I-Chen Chen, I-Chen Chen, I-Chen Chen, Fang-Yen Chiu, Po-Len Liu, Chi-Han Huang, Kuan-Hua Huang, Shih-Hua Fang, Wei-Chung Cheng, Shu-Pin Huang, Shu-Pin Huang, Hsin-Chih Yeh, Hsin-Chih Yeh, Ching-Chih Liu, Ching-Chih Liu, Po-Yen Lee, Po-Yen Lee, Ming-Yii Huang, Chia-Yang Li, Chia-Yang Li, Chia-Yang Li

“…These results imply that zerumbone may be beneficial for treating sepsis and inflammasome-related diseases.…”
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Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration by Honorine Dushime, Stéphanie G. Moreno, Christine Linard, Annie Adrait, Yohann Couté, Juliette Peltzer, Sébastien Messiaen, Claire Torres, Lydia Bensemmane, Daniel Lewandowski, Paul-Henri Romeo, Vanessa Petit, Nathalie Gault

“…Exposition of the small intestine to high doses of irradiation (IR) delivered after radiotherapy or nuclear accident results in a lethal gastrointestinal syndrome (GIS) characterized by acute loss of intestinal stem cells, impaired epithelial regeneration and subsequent loss of the mucosal barrier resulting in sepsis and death. To date, there is no effective medical treatment for GIS. …”
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Fluid Management, Intra-Abdominal Hypertension and the Abdominal Compartment Syndrome: A Narrative Review by Rita Jacobs, Robert D. Wise, Ivan Myatchin, Domien Vanhonacker, Andrea Minini, Michael Mekeirele, Andrew W. Kirkpatrick, Bruno M. Pereira, Michael Sugrue, Bart De Keulenaer, Zsolt Bodnar, Stefan Acosta, Janeth Ejike, Salar Tayebi, Johan Stiens, Colin Cordemans, Niels Van Regenmortel, Paul W. G. Elbers, Xavier Monnet, Adrian Wong, Wojciech Dabrowski, Philippe G. Jorens, Jan J. De Waele, Derek J. Roberts, Edward Kimball, Annika Reintam Blaser, Manu L. N. G. Malbrain

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Brazilian experience using high-dose sequential therapy (HDS) followed by autologous hematopoietic stem cell transplantation (ASCT) for malignant lymphomas Experiência brasileira u... by Cármino A. de Souza, Kátia B. B. Pagnano, Irene Lorand-Metze, Eliana C. M. Miranda, Renata Baldissera, Francisco J. P. Aranha, Afonso C. Vigorito, Bruno K. L. Duarte

“…After HDCY, 9 patients died, 7 from toxicity and 2 from sepsis. Eighty patients underwent ASCT, 47% were in complete remission (CR) and 15% died, all from toxicity. …”
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Resultados do tratamento cirúrgico da coarctação de aorta em adultos Outcomes of aortic coarctation surgical treatment in adults by Marcelo Biscegli Jatene, Décio Cavalet Soares Abuchaim, José de Lima Oliveira Junior, Arlindo Riso, Carla Tanamati, Nana Miura, Antonio Augusto Lopes, Miguel L Barbero-Marcial

“…There was one related death due to sepsis secondary to endocarditis. CONCLUSION: Surgical treatment of aortic coarctation, even in adult patients, is an efficient therapeutic choice, regardless of the applied surgical technique, with low morbidity and mortality. …”
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Necrotising enterocolitis: Case series, of General Hospital of Mexico Dr. Eduardo Liceaga by L. Sansón-Riofrío, V.R. Chávez-Gómez, M.P. Peralta-Álvarez, M.A. Durán-Padilla

“…Keywords: Necrotising enterocolitis, Prematurity, Neonate, Necrosis, Sepsis, Palabras clave: Enterocolitis necrotizante, Prematurez, Neonato, Necrosis, Sepsis…”
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Classic galactosemia: features of diagnosis and treatment by N.O. Pichkur, N.V. Olkhovych, Ya.I. Doronina

“…CG is a life-threatening disease characterized by severe hepatocellular lesions, dyspeptic syndrome, sepsis, and high mortality in the neonatal period. …”
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Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity by Ko Chang, Nan-Yao Lee, Wen-Chien Ko, Wei-Ru Lin, Yen-Hsu Chen, Jih-Jin Tsai, Tun-Chieh Chen, Chun-Yu Lin, Ya-Ting Chang, Po-Liang Lu

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Veno‐Arterial Extracorporeal Life Support in Heart Transplant and Ventricle Assist Device Centres. Meta‐analysis by Mariusz Kowalewski, Kamil Zieliński, Mirosław Gozdek, Giuseppe Maria Raffa, Michele Pilato, Musab Alanazi, Martijn Gilbers, Sam Heuts, Ehsan Natour, Elham Bidar, Rick Schreurs, Thijs Delnoij, Rob Driessen, Jan Willem Sels, Marcel van dePoll, Paul Roekaerts, Michał Pasierski, Paolo Meani, Jos Maessen, Piotr Suwalski, Roberto Lorusso

“…No differences were seen with respect to ECLS duration, limb complications, and reoperations for bleeding, kidney injury, and sepsis. Yet, weaning rates were higher in HTx/VAD vs. non‐HTx/VAD centres: 58.7% (56.2–61.1%) vs. 48.9% (42.0–55.9%), P = 0.010. …”
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Embelin attenuates lipopolysaccharide-induced acute kidney injury through the inhibition of M1 macrophage activation and NF-κB signaling in mice by Qiao Tang, Yun Tang, Qun Yang, Rong Chen, Hong Zhang, Haojun Luo, Qiong Xiao, Kaixiang Liu, Liming Huang, Jie Chen, Lin Wang, Xinrou Song, Sipei Chen, Guisen Li, Li Wang, Yi Li

“…We found that embelin attenuated renal dysfunction and pathological renal damage in the LPS-induced sepsis mouse model. Molecular docking predicted that embelin could bind to phosphorylated NF-κB p65 at the ser536 site. …”
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EARLY POSTOPERATIVE PERIOD AFTER ORTHOTOPIC HEART TRANSPLANTATION IN RECIPIENTS OF 60 YEARS AND OLDER by V. N. Poptsov, E. A. Spirina, S. G. Ukhrenkov, S. Yu. Ustin, E. Z. Aliev, S. A. Masyutin, V. Yu. Voronkov, N. S. Chibisov, D. M. Bondarenko, N. Z. Mebonija, N. P. Mozheyko, A. O. Shevchenko

“…Hospital lethality (n = 6; 9.5%) was due to multiple organ failure syndrome and sepsis.Conclusion. Our own experience demonstrates satisfactory short-term and long-term survival after heart transplantation in recipients of 60 years and older.…”
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Designed antimicrobial peptides : structure-activity correlations and mode of action by Harini Mohanram

“…Such circulating LPS when accumulated in higher amounts were recognized to stimulate inflammatory pathway provoking septic shock syndrome. Sepsis is identified as one of the major mortality causing condition in hospital Intensive care units (ICU). …”
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Barriers to the implementation of effective maternal health care in the developing world: views from the frontline by Knight, H

“…Participants were randomised to one of five condition-specific surveys on the five major causes of maternal mortality: postpartum haemorrhage; sepsis; pre-eclampsia/eclampsia; obstructed/prolonged labour and complications of termination of pregnancy. …”

Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study by Katherine Plewes, Hugh W.F. Kingston, Aniruddha Ghose, Richard J. Maude, M. Trent Herdman, Stije J. Leopold, Haruhiko Ishioka, Md. Mahtab Uddin Hasan, Md. Shafiul Haider, Shamsul Alam, Kim A. Piera, Prakaykaew Charunwatthana, Kamolrat Silamut, Tsin W. Yeo, Md. Abul Faiz, Sue J Lee, Mavuto Mukaka, Gareth D.H. Turner, Nicholas M. Anstey, L. Jackson Roberts, Nicholas J. White, Nicholas P.J. Day, Md. Amir Hossain, Arjen M. Dondorp

“…Methods As part of a prospective observational study, enrolment plasma cell-free hemoglobin (CFH), lipid peroxidation markers (F2-isoprostanes (F2-IsoPs) and isofurans (IsoFs)), red cell deformability, and serum creatinine were quantified in Bangladeshi patients with severe falciparum malaria (n = 107), uncomplicated malaria (n = 80) and sepsis (n = 28). The relationships between these indices and kidney function and clinical outcomes were examined. …”
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Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital... by Uduak Okomo, PhD, Madikay Senghore, PhD, Saffiatou Darboe, MSc, Ebrima Bojang, MRes, Syed M A Zaman, PhD, Mohammad Jahangir Hossain, MBBS, Davis Nwakanma, PhD, Kirsty Le Doare, PhD, Kathryn E Holt, ProfPhD, Nina Judith Hos, MD, Joy E Lawn, ProfFMedSCi, Stephen D Bentley, PhD, Beate Kampmann, ProfPhD

“…We also sequenced historical B cepacia isolates associated with neonatal sepsis in the same ward. Results: Between March 1 and Dec 31, 2016, 321 blood cultures were done, of which 178 (55%) were positive with a clinically significant isolate. 49 episodes of neonatal B cepacia bacteraemia and 45 episodes of bacteraemia due to ESBL-producing K pneumoniae were reported. …”
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CD8+ T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunctionResearch in context by Fanny Lebossé, Cathrin Gudd, Enes Tunc, Arjuna Singanayagam, Rooshi Nathwani, Evangelos Triantafyllou, Oltin Pop, Naveenta Kumar, Sujit Mukherjee, Tie Zheng Hou, Alberto Quaglia, Fabien Zoulim, Julia Wendon, Ameet Dhar, Mark Thursz, Charalambos G. Antoniades, Wafa Khamri

“…ABSTRACT: Background: Cirrhosis-associated immune dysfunction (CAID) contributes to high sepsis risk in patients with chronic liver disease. …”
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Role of cytarabine in paediatric acute promyelocytic leukemia treated with the combination of all-trans retinoic acid and arsenic trioxide: a randomized controlled trial by Li Zhang, Yao Zou, Yumei Chen, Ye Guo, Wenyu Yang, Xiaojuan Chen, Shuchun Wang, Xiaoming Liu, Min Ruan, Jiayuan Zhang, Tianfeng Liu, Fang Liu, Benquan Qi, Wenbin An, Yuanyuan Ren, Lixian Chang, Xiaofan Zhu

“…Greater myelosuppression and sepsis were observed in the Ara-C group during the consolidation courses. …”
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Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon by Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke A. J. O’Neill

“…Abstract Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one of the leading causes of mortality worldwide. …”
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Prognostic and risk factor analysis of cancer patients after unplanned ICU admission: a real-world multicenter study by Miao Wei, Mingguang Huang, Yan Duan, Donghao Wang, Xuezhong Xing, Rongxi Quan, Guoxing Zhang, Kaizhong Liu, Biao Zhu, Yong Ye, Dongmin Zhou, Jianghong Zhao, Gang Ma, Zhengying Jiang, Bing Huang, Shanling Xu, Yun Xiao, Linlin Zhang, Hongzhi Wang, Ruiyun Lin, Shuliang Ma, Yu’an Qiu, Changsong Wang, Zhen Zheng, Ni Sun, Lewu Xian, Ji Li, Ming Zhang, Zhijun Guo, Yong Tao, Li Zhang, Xiangzhe Zhou, Wei Chen, Daoxie Wang, Jiyan Chi

“…The most common reason for ICU admission was sepsis (n = 940, 63.2%). During their ICU stay, 29.7% of patients required vasoactive drug support (n = 442), 39.8% needed invasive mechanical ventilation support (n = 592), and 82 patients (5.5%) received renal replacement therapy. …”
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