Severe bacterial neonatal infections in Madagascar, Senegal, and Cambodia: A multicentric community-based cohort study. by Bich-Tram Huynh, Elsa Kermorvant-Duchemin, Rattanak Chheang, Frederique Randrianirina, Abdoulaye Seck, Elisoa Hariniaina Ratsima, Zafitsara Zo Andrianirina, Jean-Baptiste Diouf, Armya Youssouf Abdou, Sophie Goyet, Véronique Ngo, Siyin Lach, Long Pring, Touch Sok, Michael Padget, Fatoumata Diene Sarr, Laurence Borand, Benoit Garin, Jean-Marc Collard, Perlinot Herindrainy, Agathe de Lauzanne, Muriel Vray, Elisabeth Delarocque-Astagneau, Didier Guillemot, BIRDY study group

“…Almost one-third of the isolates were resistant to both first-line drugs recommended for the management of neonatal sepsis (ampicillin and gentamicin). Overall, 38 deaths occurred among neonates with SBI (possible and culture-confirmed SBI together). …”
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Randomized Cross Over Study Assessing the Efficacy of Non-invasive Stimulation of the Vagus Nerve in Patients With Axial Spondyloarthritis Resistant to Biotherapies: The ESNV-SPA S... by Eric Azabou, Eric Azabou, Guillaume Bao, Guillaume Bao, Félicie Costantino, Félicie Costantino, Félicie Costantino, Madalina Jacota, Chanez Lazizi, Lionelle Nkam, Martin Rottman, Martin Rottman, Anne-Laure Roux, Anne-Laure Roux, Sylvain Chevallier, Lamiae Grimaldi, Maxime Breban, Maxime Breban, Maxime Breban

“…Inflammatory reflex signaling, which is enhanced by electrically stimulating the vagus nerve, significantly reduces cytokine production and attenuates disease severity in animal models of endotoxemia, sepsis, colitis, and other preclinical models of inflammatory diseases. …”
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Perforated appendix! An experience of a Public teaching hospital by Naqqash Adnan, Ahmed Mujtaba Malik, Gohar Rasheed, Maryam Iftikhar, Maariah Asif, Jahangir Sarwar khan

“…Significant complications were surgical wound infection (p=0.001) and intra-abdominal sepsis and collections (p= 0.046). Two patients developed wound dehiscence both of which were in the perforated group. …”
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Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study by Iván D. Benítez, Jordi de Batlle, Gerard Torres, Jessica González, David de Gonzalo-Calvo, Adriano D.S. Targa, Clara Gort-Paniello, Anna Moncusí-Moix, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Rosario Menéndez, Anna Motos, Oscar Peñuelas, Jordi Riera, Jesús F. Bermejo-Martin, Yhivian Peñasco, Pilar Ricart, María Cruz Martin Delgado, Luciano Aguilera, Alejandro Rodríguez, Maria Victoria Boado Varela, Fernando Suarez-Sipmann, Juan Carlos Pozo-Laderas, Jordi Solé-Violan, Maite Nieto, Mariana Andrea Novo, José Barberán, Rosario Amaya Villar, José Garnacho-Montero, Jose Luis García-Garmendia, José M. Gómez, José Ángel Lorente, Aaron Blandino Ortiz, Luis Tamayo Lomas, Esther López-Ramos, Alejandro Úbeda, Mercedes Catalán-González, Angel Sánchez-Miralles, Ignacio Martínez Varela, Ruth Noemí Jorge García, Nieves Franco, Víctor D. Gumucio-Sanguino, Arturo Huerta Garcia, Elena Bustamante-Munguira, Luis Jorge Valdivia, Jesús Caballero, Elena Gallego, Amalia Martínez de la Gándara, Álvaro Castellanos-Ortega, Josep Trenado, Judith Marin-Corral, Guillermo M Albaiceta, Maria del Carmen de la Torre, Ana Loza-Vázquez, Pablo Vidal, Juan Lopez Messa, Jose M. Añón, Cristina Carbajales Pérez, Victor Sagredo, Neus Bofill, Nieves Carbonell, Lorenzo Socias, Carme Barberà, Angel Estella, Manuel Valledor Mendez, Emili Diaz, Ana López Lago, Antoni Torres, Ferran Barbé

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Metagenomic Next-Generation Sequencing Versus Traditional Laboratory Methods for the Diagnosis and Treatment of Infection in Liver Transplantation by Jun-Feng Huang, Jun-Feng Huang, Jun-Feng Huang, Qing Miao, Jian-Wen Cheng, Jian-Wen Cheng, Ao Huang, Ao Huang, De-Zhen Guo, De-Zhen Guo, Ting Wang, Liu-Xiao Yang, Du-Ming Zhu, Ya Cao, Xiao-Wu Huang, Xiao-Wu Huang, Jia Fan, Jia Fan, Jia Fan, Jian Zhou, Jian Zhou, Jian Zhou, Xin-Rong Yang, Xin-Rong Yang

“…Of the 8 patients with infections, 7 recipients recovered, and 1 patient died of severe sepsis.ConclusionsOur preliminary results show that mNGS analyses can provide rapid and precise pathogen detection compared with TMs in a variety of clinical samples from patients undergoing LT. …”
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Hearing Loss from S. Suis Meningitis In A Middle-Aged Couple by Norberto Martinez, Michiko Hosojima

“… Streptococcus suis is a bacterial pathogen causing a wide range of infections including meningitis, lung infections, arthritis, sepsis and endocarditis.1 Over the years, an increasing number of cases have been reported among humans especially in countries in Southeast Asia specifically in Vietnam and Thailand where pig-rearing is common.2 One of the prominent symptoms of S. suis infection is hearing loss that may be present during the onset or a few days after.1 We report two cases of adult S. suis meningitis presenting with bilateral hearing loss. …”
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The new timing in acute care surgery (new TACS) classification: a WSES Delphi consensus study by Belinda De Simone, Yoram Kluger, Ernest E. Moore, Massimo Sartelli, Fikri M. Abu-Zidan, Federico Coccolini, Luca Ansaloni, Giovanni D. Tebala, Salomone Di Saverio, Isidoro Di Carlo, Boris E. Sakakushev, Luigi Bonavina, Michael Sugrue, Joseph M. Galante, Rao Ivatury, Edoardo Picetti, Mircea Chirica, Imtiaz Wani, Miklosh Bala, Ibrahima Sall, Andrew W. Kirkpatrick, Vishal G. Shelat, Emmanouil Pikoulis, Ari Leppäniemi, Edward Tan, Richard P. G. ten Broek, Solomon Gurmu Beka, Andrey Litvin, Elie Chouillard, Raul Coimbra, Yunfeng Cui, Nicola De’ Angelis, Gabriele Sganga, Philip F. Stahel, Vanni Agnoletti, Alessia Rampini, WSES TACS panel of experts, Mario Testini, Francesca Bravi, Ronald V. Maier, Walter L. Biffl, Fausto Catena

“…Haemodynamic stability is the main tool to stratify patients for immediate surgery or not in the presence of sepsis/septic shock. Fifty-one surgical diseases were included in the different colour-code classes of priority. …”
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A Clinically Oriented antimicrobial Resistance surveillance Network (ACORN): pilot implementation in three countries in Southeast Asia, 2019-2020 [version 1; peer review: 2 approve... by Anousone Douangnouvong, Chansovannara Soputhy, Tamalee Roberts, Naomi Waithira, Prapass Wannapinij, H. Rogier van Doorn, Meymey Lem, Ngan Ta Thi Dieu, Bandith Soumphonphakdy, Danoy Chommanam, Khamphong Thanadabouth, Khaysy Rassavong, Vilada Chansamouth, Tien Viet Dung Vu, Manoloth Sayarath, Phu Khiem Dong, Clare Ling, Minh Dien Vu, Van Bac Tran, Paul Turner, Van Duong Dang, Thi Ngoc Ninh, Thi Kim Yen Do, Ngoc Hao Kim, Hong Long Nguyen, Dinh Trang Van, Sothea Prak, Olivier Celhay, Hong Khanh Nguyen, Susath Vongphachanh, Thyl Miliya, Chanpheaktra Ngoun, Elizabeth A. Ashley, Ngoc Thach Pham, Thi Kim Tuyen Nguyen, Manivanh Vongsouvath, Raph L. Hamers, Valy Keoluangkhot

“…Methods: An ACORN pilot was implemented in three hospitals in Southeast Asia (1 paediatric, 2 general) to collect clinical and microbiological data from patients with community- or hospital-acquired pneumonia, sepsis, or meningitis. The implementation package included tools to capture site and laboratory capacity information, guidelines on diagnostic stewardship, and a web-based data visualisation and analysis platform. …”
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Cardiovascular Collapse in COVID-19 Infection: The Role of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO) by Justin Chow, MD, FRCPC, Anhar Alhussaini, MBBS, FRCPC, Oscar Calvillo-Argüelles, MD, Filio Billia, MD, PhD, FRCPC, Adriana Luk, MD, MSc, FRCPC

“…We identified potential clinical scenarios (cardiac injury, myocardial infarction with and without obstructive coronary artery disease, viral myocarditis, and decompensated heart failure) leading to CS and risk factors for poor/uncertain benefit (age, sepsis, mixed/predominantly vasodilatory shock, prothrombotic state or coagulopathy, severe acute respiratory distress syndrome, multiorgan failure, or high-risk prognostic scores) specific to using VA-ECMO as a bridge to recovery in COVID-19 infection. …”
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Konu ve Yazar İndeksi by Halis Dokgöz

“…KONU İNDEKSİ / SUBJECT INDEX Acil Servis 93 Çocuk 52,98,137 İşkence 16 Ruh Sağlığı Bozulması 159 Adli Bilimsel Yöntem ve Çocukluk Çağı 93 İşkencenin Belgelenmesi 16 Sepsis 130 Teknikler 59 Çocuk ve Ergen 193 Kannabinoid 43 Sosyal Medya 193 Adli Bilimler 39,116 Çocuk Hakları 134 Katı Faz Ekstraksiyon 1 Sosyodemografik Özellikler 86 Adli Değerlendirme 98 Çocuklar Arasında 52 Kaza 31,93 Solunum Sistem Fistülü 43 Adli Entomoloji 67 Çocuk İstismarı 167 Kemik Berelenmesi 47 Sıvı-sıvı Ekstraksiyon 1 Adli Hemşirelik 39 Çürüme 67 Kemik Kırığı 47 Sözel Şiddet 72 Adli olgu 23 Demirjian 144 Kemik Sintigrafisi 16 Suç 134 Adli Patoloji 183 Diş fokal infection 130 Komplikasyon 153 Suça Sürüklenen Çocuklar 86 Adli Rapor 159 Diş Hekimi 72 Kronolojik Yaş 144 Sr 177 Adli Tıp 8,31,52,55,167,199 Diş Yaşı 144 Kurumlararası karşılaştırma 8 Şiddet 72 Aile İçi İlişki 167 Engelli 31 Lazer 153 Tanı Metodu 16 Aile İçi Şiddet 167 Epidemyoloji 86 Lighter Fluid 55 Tazminat 31 Alkalin Piller 196 Epilasyon 153 Malpraktis 78 TCH-COOH 1 Alzheimer Hastalığı 116 Ergen 55,98,137 Manyetik Rezonans Tiyosülfat 189 Amputasyon 31 Farkındalık 78 Medicolegal Assessment 47 Trabzon 26 Aortopulmoner Fistül 43 Fiziksel şiddet 72 Mevzuat 78 Travma 23,31 Asliksi 189 Gaz Kromotgrfi Kütle Nükleer Test 177 Turkey 39 Beden Çalışma Gücü 8 Spektrometrisi 1 Olay Yeri İnceleme 59 Uçucu Madde 55 Belge inceleme 26 Genç 172 Otopsi 43,55,126,130,189 Üniversite 172 Böcek Süksesyonu 67 Geriatri 23 Ölüm 126 Vasküler Fistül 43 Bronşiyal Fistül 43 Görüntüleme 199 Ölüm Zamanı 67,177 Yara Yaşı 183 Bütan 55 Hemoptizi 43 Önleme 93 Yaralanma 23 Canlılık 183 Hemşire 39,78 Pb 177 Yanık 153 Ceset 67 Hidrojen Sülfür 126,189 Pebtic Ülser Perforasyonu 130 Yara İyileşmesi 199 Ceza Sorumluluğu 193 Hukuki Sorumluluk 78 Peritonit 130 Yaş Özellikleri 199 Cinsel İstismar İdrar 1 Pnömani 196 Yazı 26,116 98,134,137,159,167 İstanbul Protocol 16 Radyoizotop Analizi 177 Zehirlenme 93 Cinsel Saldırı 159 İletişim 98 Retropharyngeal Apse 130   Cinsellik 52 İmza 26,116 Risk Faktörleri 86   CSI Etkisi 59 İntihar 126,189 Riskli Davranışlar 172   YAZAR İNDEKSİ / AUTHOR INDEX Afşin H 72 DağlıoğluN 172 Katkıcı U 134 Şenol E 159 Akan O 23 Demir M 8,126 Kaya A 72,199 Şişmanlar ŞG 193 Akgür SA 1 Dinç C 52 Kaya Tİ 153 Şimşek NE 193 Aksu H 134 Dirlik M 134 Kazındır G 55 Tekindal MA 144 AlbayrakB 153 Dokgöz H 153 Ketenci HÇ 55 Toros F 98 Alkan HA 43 Dokudan EY 16 Kırcı GS 26 Turla A 93 Alkan N 116 Durak D 23 Koçak U 189 Turna Ö 55 Alpaslan AH 189 Duran S 130 Korkmaz B 134 Ural MN 23 Altınok M 72 ElbekT 134 Kökdener M 67 UytunMÇ 137 Altıparmak AE 159 Erdoğan M 31 Kömür İ 126 Uzun M 116 Anolay N 31 Erel Ö 134 Kutlu L 16 Ünal EÖ 8,31 Argın M 199 Eryılmaz A 167 Kurtaş Ö 116 Ünal S 39 Aydın B 93 Fedakar R 23 Kütük MÖ 98 Ünal V 8,31 Aydoğdu Hİ 26 Fırat S 39,86,172 Meral O 159,199 Ünlütürk Ö 177 Baklacıoğlu F 8,31 Fincancı ŞK 16 Okumuş H 26 Ünüvar Ü 16 Balcı Y 52 Geleş ÇY39 Olgun NN 193 Ünver H 193 BaşpınarB 126 Girgin S 1 Özarslan A 72 Yarlık E 72 Biçer Ü 193 Gökmen A 43,130 Özdemir Ç 137 Vuruk S 1 Bilgin NG 153 Güler G 98 Özdemir MH 47 Yağan M 189 Birincioğlu İ 26,55,116 Güler H 159,199 Özdemirei RÖ 126 YakupoğluA59 Bostancı Hİ 1 Güler Ü 1 Özer E 26,189 Yaşar ZF 144 Boz H 55 Gülmen MK 86,172 Özkalıpçı Ö 16 YayayürükAE 1 Büken E 144 Güngör M 1 Özkan DS 47 Yazıcı S 196 Can M 116,197 Gürbeden B 47 Özkök S 134 Yıldırım V 98 Coşkun A 193 Gürses MS 23 Özsoy S 43,130 YoldaşcanE 172 Coşkunol H 159 İltaş Y 86 Öztop DB 137 Yöndem M 130 Çağdır AS 8 İnanır NT 23 Pakiş I 183 Yılmaz D 16 Çağlayan S 93 Javan GT 130 Pehlivan S 43 Yılmaz R 137 Çakı İE 72 KallemFÇ 134 Polat E 67 Yılmaz RZ 116,167 Çalıcı C 59 Kar H 153 Polat ST 93 Yılmaz S 126 Çetin G 78 Karabakır B 78 Sertöz ÖÖ 159 Yurtseven A 31 Çetin S 23 Karadayı B 72 Sücüllü İ 130 Ziyalar N 59 Çetinkaya Z 8 Karadeniz H 55 Şahin A 193   Çot DA 172 Karbeyaz K 52 Şarkış C 196…”
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Importancia de la valoración clínica preoperatoria en cirugía de catarata by Diley Estrada Ramos

“…Además, la diabetes mellitus descompensada, la sepsis oral y cualquier proceso respiratorio agudo alto o bajo contraindican esta cirugía. …”
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Effectiveness of nationwide programmatic testing and treatment for latent tuberculosis infection in migrants in England: a retrospective, population-based cohort study by Luis C Berrocal-Almanza, PhD, Ross J Harris, PhD, Simon M Collin, PhD, Morris C Muzyamba, PhD, Olivia D Conroy, MSc, Adil Mirza, MSc, Anne-Marie O'Connell, MSc, Lynn Altass, MSc, Sarah R Anderson, MD (Res), H Lucy Thomas, MD, Colin Campbell, MD, Dominik Zenner, MD, Nick Phin, MD, Onn Min Kon, ProfMD, E Grace Smith, FRCPath, Ajit Lalvani, ProfFMedSci

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Selected Abstracts of the 12th International Congress of UENPS; Krakow (Poland); September 2nd-4th, 2022 by --- Various Authors

“…OUTBREAK OF NOSOCOMIAL SEPSIS IN NICU BY MULTIDRUG-RESISTANT KLEBSIELLA PNEUMONIAE – DIAGNOSTIC CHALLENGES • P. …”
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Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya,... by Proma Paul, Simon R. Procter, Ziyaad Dangor, Quique Bassat, Amina Abubakar, Sridhar Santhanam, Romina Libster, Bronner P. Gonçalves, Shabir A. Madhi, Azucena Bardají, Eva Mwangome, Adam Mabrouk, Hima B. John, Clara Sánchez Yanotti, Jaya Chandna, Pamela Sithole, Humberto Mucasse, Patrick V. Katana, Artemis Koukounari, Lois M. Harden, Celine Aerts, Azra Ghoor, Shannon Leahy, Sibongile Mbatha, Sarah Lowick, Sanjay G. Lala, Justina Bramugy, Charles Newton, A. K. M. Tanvir Hossain, Qazi Sadeq-ur Rahman, Philipp Lambach, Mark Jit, Joy E. Lawn

“…Sepsis and meningitis due to invasive group B Streptococcus (iGBS) disease during early infancy is a leading cause of child mortality. …”
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TRPC1 contributes to endotoxemia-induced myocardial dysfunction via mediating myocardial apoptosis and autophagy by Wen Tian, Shao-Yuan Liu, Meng Zhang, Jing-Ru Meng, Na Tang, Ying-Da Feng, Yang Sun, Yuan-Yuan Gao, Lei Zhou, Wei Cao, Xiao-Qiang Li

“…Importantly, cecal ligation and puncture-stimulated cardiac dysfunction and mortality were significantly alleviated in Trpc1-/- and cavtratin-treated mice, which further validated the contribution of TRPC1-caveolin-1 signaling axis in sepsis-induced pathological process. Overall, this study indicated that TRPC1 could promote LPS-triggered intracellular Ca2+ release, mediate caveolin-1 reduction, and in turn activates calpain to regulate myocardial apoptosis and autophagy, contributing to ETM-induced cardiac dysfunction of mice.…”
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Prophylactic Administration of Vasopressors Prior to Emergency Intubation in Critically Ill Patients: A Secondary Analysis of Two Multicenter Clinical Trials by Mikita Fuchita, MD, Jack Pattee, PhD, Derek W. Russell, MD, Brian E. Driver, MD, Matthew E. Prekker, MD, MPH, Christopher R. Barnes, MD, Joseph M. Brewer, DO, Kevin C. Doerschug, MD, John P. Gaillard, MD, Sheetal Gandotra, MD, Shekhar Ghamande, MD, Kevin W. Gibbs, MD, Christopher G. Hughes, MD, MS, David R. Janz, MD, MSc, Akram Khan, MD, Steven H. Mitchell, MD, David B. Page, MD, Todd W. Rice, MD, MSc, Wesley H. Self, MD, MPH, Lane M. Smith, MD, PhD, Susan B. Stempek, PA-C, MBA, MMSc, Stacy A. Trent, MD, MPH, Derek J. Vonderhaar, MD, Jason R. West, MD, Micah R. Whitson, MD, Kayla Williamson, MS, Matthew W. Semler, MD, MSc, Jonathan D. Casey, MD, MSc, Adit A. Ginde, MD, MPH, for the Pragmatic Critical Care Research Group

“…Compared with patients who did not receive prophylactic vasopressors, those who did were older, had higher Acute Physiology and Chronic Health Evaluation II scores, were more likely to have a diagnosis of sepsis, had lower pre-induction systolic blood pressures, and were more likely to be on continuous vasopressor infusions prior to intubation. …”
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2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting by Massimo Sartelli, Dieter G. Weber, Yoram Kluger, Luca Ansaloni, Federico Coccolini, Fikri Abu-Zidan, Goran Augustin, Offir Ben-Ishay, Walter L. Biffl, Konstantinos Bouliaris, Rodolfo Catena, Marco Ceresoli, Osvaldo Chiara, Massimo Chiarugi, Raul Coimbra, Francesco Cortese, Yunfeng Cui, Dimitris Damaskos, Gian Luigi de’ Angelis, Samir Delibegovic, Zaza Demetrashvili, Belinda De Simone, Francesco Di Marzo, Salomone Di Saverio, Therese M. Duane, Mario Paulo Faro, Gustavo P. Fraga, George Gkiokas, Carlos Augusto Gomes, Timothy C. Hardcastle, Andreas Hecker, Aleksandar Karamarkovic, Jeffry Kashuk, Vladimir Khokha, Andrew W. Kirkpatrick, Kenneth Y. Y. Kok, Kenji Inaba, Arda Isik, Francesco M. Labricciosa, Rifat Latifi, Ari Leppäniemi, Andrey Litvin, John E. Mazuski, Ronald V. Maier, Sanjay Marwah, Michael McFarlane, Ernest E. Moore, Frederick A. Moore, Ionut Negoi, Leonardo Pagani, Kemal Rasa, Ines Rubio-Perez, Boris Sakakushev, Norio Sato, Gabriele Sganga, Walter Siquini, Antonio Tarasconi, Matti Tolonen, Jan Ulrych, Sannop K. Zachariah, Fausto Catena

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High-dose vitamin D versus placebo to prevent complications in COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial (CARED-TRIAL) by Javier Mariani, Carlos Tajer, Laura Antonietti, Felipe Inserra, León Ferder, Walter Manucha

“…Intervention and comparator The intervention consists in a single oral dose of 500.000 IU of commercially available cholecalciferol soft gel capsules (5 capsules of 100.000 IU) or matching placebo Main outcomes The primary outcome for the first stage is the change in the respiratory Sepsis-related Organ Failure Assessment (SOFAr) score between pre-treatment value and the worst value recorded during the first 7 seven days of hospitalization, the death or discharge, whichever occurs first. …”
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Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection by Xintong Zhao, Jing Feng, Jie Zhang, Zunsheng Han, Yuhua Hu, Hui-Hui Shao, Tianlei Li, Jie Xia, Kangfan Lei, Weiping Wang, Fangfang Lai, Yuan Lin, Bo Liu, Kun Zhang, Chi Zhang, Qingyun Yang, Xinyu Luo, Hanyilan Zhang, Chuang Li, Wenxuan Zhang, Song Wu

“…Compound 28 had better protective effects than the positive control drugs such as DS-2969 (5) and AZD5099 (6) in mouse models of sepsis induced by methicillin-resistant Staphylococcus aureus (MRSA) infection. …”
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Tratamento de Crianças com Desnutrição Grave Utilizando o Protocolo da OMS: Experiência de um Centro de Referência, São Paulo/Brasil Tratamento de crianças com desnutrição grave... by Roseli Oselka Saccardo Sarni, Fabíola Isabel Suano de Souza, Priscila Catherino, Cristiane Kochi, Fernanda Luisa Ceragioli Oliveira, Fernando José Nóbrega

“…The formulas chosen were all industrialized: lactose-free polymeric formula (PLF) for children with diarrhea, low lactose polymeric formula (PLL) for children without diarrhea and cow’s milk hydrolysate (H) for sepsis or chronic diarrhea. In the rehabilitation phase, all the children used PLL formula. …”
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