Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease by Yasunori Iwata, Yusuke Nakade, Masashi Kinoshita, Hemragul Sabit, Riho Nakajima, Kengo Furuichi, Masashi Mita, Maiko Nakane, Norihiko Sakai, Shinji Kitajima, Tadashi Toyama, Taro Miyagawa, Akinori Hara, Miho Shimizu, Kouichi Sato, Megumi Oshima, Shiori Nakagawa, Yuta Yamamura, Hisayuki Ogura, Yoshitaka Koshino, Mitsutoshi Nakada, Takashi Wada

Subjects: “…l-serine…”
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p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair by Keane K. Y. Lai, Xiaohui Hu, Keisuke Chosa, Cu Nguyen, David P. Lin, Keith K. Lai, Nobuo Kato, Yusuke Higuchi, Sarah K. Highlander, Elizabeth Melendez, Yoshihiro Eriguchi, Patrick T. Fueger, Andre J. Ouellette, Nyam-Osor Chimge, Masaya Ono, Michael Kahn

“…Based upon our earlier pharmacologic studies, p300 serine 89 (S89) is critical for controlling differential coactivator usage by β-catenin via post-translational phosphorylation in stem/progenitor populations, and appears to be a target for a number of kinase cascades. …”
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Blocking serine protease (TMPRSS2) by Bromhexine; looking at potential treatment to prevent COVID-19 infection by Ramin Tolouian, Audrey Tolouian, Mohammadreza Ardalan

Subjects: “…serine protease…”
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Putative Serine Protease Effectors of Clavibacter michiganensis Induce a Hypersensitive Response in the Apoplast of Nicotiana Species by You Lu, Noriyuki Hatsugai, Fumiaki Katagiri, Carol A. Ishimaru, Jane Glazebrook

“…The genomes of both subspecies encode members of the pat-1 family of putative serine proteases known to function in virulence on host plants and induction of hypersensitive responses (HR) on nonhosts. …”
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Phosphorylation of β-catenin at Serine552 correlates with invasion and recurrence of non-functioning pituitary neuroendocrine tumours by Ashutosh Rai, Soujanya D. Yelamanchi, Bishan D. Radotra, Sunil K. Gupta, Kanchan K. Mukherjee, Manjul Tripathi, Rajesh Chhabra, Chirag K. Ahuja, Narendra Kumar, Akhilesh Pandey, Márta Korbonits, Pinaki Dutta, Carles Gaston-Massuet

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In Silico and In Vitro Potential of FDA-Approved Drugs for Antimalarial Drug Repurposing against Plasmodium Serine Hydroxymethyltransferases by Pitchayathida Mee-udorn, Kochakorn Phiwkaow, Ruchanok Tinikul, Kamonpan Sanachai, Somchart Maenpuen, Thanyada Rungrotmongkol

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Modification of Serine 1040 of SIBRI1 Increases Fruit Yield by Enhancing Tolerance to Heat Stress in Tomato by Shufen Wang, Tixu Hu, Aijuan Tian, Bote Luo, Chenxi Du, Siwei Zhang, Shuhua Huang, Fei Zhang, Xiaofeng Wang

“…In this study, we investigated the biological functions of the phosphorylation site serine 1040 (Ser-1040) of SlBRI1 in tomato. Phenotype analysis indicated that transgenic tomato harbouring SlBRI1 dephosphorylated at Ser-1040 showed increased tolerance to heat stress, exhibiting better plant growth and plant yield under high temperature than transgenic lines expressing SlBRI1 or SlBRI1 phosphorylated at Ser-1040. …”
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Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography by Victoria N. Drago, Claudia Campos, Mattea Hooper, Aliyah Collins, Oksana Gerlits, Kevin L. Weiss, Matthew P. Blakeley, Robert S. Phillips, Andrey Kovalevsky

“…By analyzing the observed protonation states, Glu53, but not His residues, is proposed as the general base catalyst, orchestrating the retro-aldol transformation of L-serine into glycine.…”
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Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats by Nikita Hanning, Michelle De bruyn, Hannah Ceuleers, Tim Boogaerts, Maya Berg, Annemieke Smet, Heiko U. De Schepper, Jurgen Joossens, Alexander L. N. van Nuijs, Joris G. De Man, Koen Augustyns, Ingrid De Meester, Benedicte Y. De Winter

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Regulation of a serine protease homolog by the JNK pathway during thoracic development ofDrosophila melanogaster by Ajay Srivastava, Qian Dong

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Characterization of a novel cold-adapted intracellular serine protease from the extremophile Planococcus halocryophilus Or1 by Casper Bøjer Rasmussen, Carsten Scavenius, Ida B. Thøgersen, Seandean Lykke Harwood, Øivind Larsen, Gro Elin Kjaereng Bjerga, Peter Stougaard, Jan J. Enghild, Mariane Schmidt Thøgersen

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Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. by Shotaro Nakano, Soshiro Kashio, Kei Nishimura, Asuka Takeishi, Hina Kosakamoto, Fumiaki Obata, Erina Kuranaga, Takahiro Chihara, Yoshio Yamauchi, Toshiaki Isobe, Masayuki Miura

“…In Drosophila, various types of tissue damage, including epidermal injury, tumor formation, cell competition, and apoptosis deficiency, induce sterile activation of the Toll pathway, a process that requires the use of extracellular serine protease (SP) cascades. Upon infection, the SP Spätzle (Spz)-processing enzyme (SPE) cleaves and activates the Toll ligand Spz downstream of two paralogous SPs, Hayan and Persephone (Psh). …”
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Serine/threonine kinase 36 induced epithelial-mesenchymal transition promotes docetaxel resistance in prostate cancer by Tao He, Nan-Xing Li, Zhao-Jun Pan, Zi-Hao Zou, Jie-Chuan Chen, Si-Zhe Yu, Fa Lv, Quan-Cheng Xie, Jun Zou

“…Abstract To investigate the role and potential mechanism of serine/threonine kinase 36 (STK36) in docetaxel resistance-prostate cancer (PCa). …”
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Receptor-Interacting Serine/Threonine-Protein Kinase-2 as a Potential Prognostic Factor in Colorectal Cancer by Rola F. Jaafar, Zeid Ibrahim, Karim Ataya, Joelle Hassanieh, Natasha Ard, Walid Faraj

“…<i>Background and objectives</i>: Receptor-interacting serine/threonine-protein kinase-2 (RIPK2) is an important mediator in different pathways in the immune and inflammatory response system. …”
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Preliminary investigations on the serine and aspartic protease inhibitors from <i>Nothopegia</i> <i>beddomei</i> by M.G.K.P. Dayarathne, Sanath Rajapakse

“…However, the serine protease inhibitory activity was significantly higher. …”
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Insights Into the Known 13C Depletion of Methane—Contribution of the Kinetic Isotope Effects on the Serine Hydroxymethyltransferase Reaction by Gerd Gleixner

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Genome-wide identification and expression analysis of serine hydroxymethyltransferase (SHMT) gene family in tomato (Solanum lycopersicum) by Zesheng Liu, Xuejuan Pan, Chunlei Wang, Fahong Yun, Dengjing Huang, Yandong Yao, Rong Gao, Fujin Ye, Xingjuan Liu, Weibiao Liao

“…Serine hydroxymethyltransferase (SHMT) is one of the most important enzyme families in one-carbon metabolic pathway and photorespiration within plant cells. …”
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TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC by Huimin Sun, Jianzhong Zheng, Juanjuan Xiao, Juntao Yue, Zhiyuan Shi, Zuodong Xuan, Chen Chen, Yue Zhao, Wenbin Tang, Shaopei Ye, Jinxin Li, Qiumin Deng, Lei Zhang, Feng Zhu, Chen Shao

“…Abstract TOPK/PBK (T-LAK Cell-Originated Protein Kinase) is a serine/threonine kinase that is highly expressed in a variety of human tumors and is associated with poor prognosis in many types of human malignancies. …”
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Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis by Andrew Kuo, Antonio Checa, Colin Niaudet, Bongnam Jung, Zhongjie Fu, Craig E Wheelock, Sasha A Singh, Masanori Aikawa, Lois E Smith, Richard L Proia, Timothy Hla

“…Serine palmitoyl transferase (SPT), the rate-limiting enzyme in the de novo synthesis of sphingolipids (SL), is needed for embryonic development, physiological homeostasis, and response to stress. …”
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Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulation by Xuejing Yan, Shen Wu, Qian Liu, Ying Cheng, Yufei Teng, Tianmin Ren, Jingxue Zhang, Ningli Wang

“…Abstract Glaucoma is a highly heritable disease, and myocilin was the first identified causal and most common pathogenic gene in glaucoma. Serine-to-proline mutation at position 341 of myocilin (MYOCS341P) is associated with severe glaucoma phenotypes in a five-generation primary open-angle glaucoma family. …”
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