Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury by Dongwoo Yu, Seul Ah Mun, Sang Woo Kim, Dae-Chul Cho, Chi Heon Kim, Inbo Han, Subum Lee, Sang-Woo Lee, Kyoung-Tae Kim

Subjects: “…serine…”
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Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway by Ewa Wilcz‐Villega, Edward Carter, Alastair Ironside, Ruoyan Xu, Isabella Mataloni, Julie Holdsworth, William Jones, Rocío Moreno Béjar, Lukas Uhlik, Robert B Bentham, Susana A Godinho, Jesmond Dalli, Richard Grose, Gyorgy Szabadkai, Louise Jones, Kairbaan Hodivala‐Dilke, Katiuscia Bianchi

“…These effects were mediated by the breast cancer oncogene IKKε and its downstream target—the serine biosynthesis pathway as demonstrated by genetic or pharmacological tools. …”
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Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity by Hiroki Furuie, Yuka Kimura, Tatsuhiro Akaishi, Misa Yamada, Yoshiki Miyasaka, Akiyoshi Saitoh, Norihiro Shibuya, Akiko Watanabe, Naoki Kusunose, Tomoji Mashimo, Takeo Yoshikawa, Mitsuhiko Yamada, Kazuho Abe, Hideo Kimura

“…Here, we showed that H2S/H2S2 applied to the rat hippocampus by in vivo microdialysis induces the release of GABA, glutamate, and d-serine, a co-agonist of NMDA receptors. Animals with genetically knocked-out 3MST and the target of H2S2, transient receptor potential ankyrin 1 (TRPA1) channels, revealed that H2S/H2S2, 3MST, and TRPA1 activation play a critical role in LTP induction, and the lack of 3MST causes behavioral hypersensitivity to NMDA receptor antagonism, as in schizophrenia. …”
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Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2 by Shanshan Qin, Shanshan Qin, Zidi Wang, Congcong Huang, Congcong Huang, Pan Huang, Pan Huang, Dandan Li, Dandan Li

Subjects: “…serine protease PRSS23…”
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Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner by Sliusar Myroslava Y., Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhij V., Ratushna Oksana O., Minchenko Oleksandr H.

“…Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma. …”
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The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases by Marcin Gradowski, Krzysztof Pawłowski

“…Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. …”
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Improved NMDA Receptor Activation by the Secreted Amyloid-Protein Precursor-α in Healthy Aging: A Role for D-Serine? by Jean-Marie Billard, Thomas Freret

“…Significant NMDAR improvement occurred in adult mice when sAPPα was raised to 1 nM, and this effect was drastically reduced in transgenic mice deprived of D-serine through genetic deletion of the synthesizing enzyme serine racemase. …”
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New insights in the targets of action of dimethyl fumarate in endothelial cells: effects on energetic metabolism and serine synthesis in vitro and in vivo by Mª Carmen Ocaña, Manuel Bernal, Chendong Yang, Carlos Caro, Alejandro Domínguez, Hieu S. Vu, Casimiro Cárdenas, María Luisa García-Martín, Ralph J. DeBerardinis, Ana R. Quesada, Beatriz Martínez-Poveda, Miguel Ángel Medina

“…We demonstrate for the first time that dimethyl fumarate promotes glycolysis and diminishes cell respiration in endothelial cells, which could be a consequence of a down-regulation of serine and glycine synthesis through inhibition of PHGDH activity in these cells. …”
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Unraveling the Complexity of the Rhomboid Serine Protease 4 Family of <i>Babesia bovis</i> Using Bioinformatics and Experimental Studies by Romina Gallenti, Hala E. Hussein, Heba F. Alzan, Carlos E. Suarez, Massaro Ueti, Sebastián Asurmendi, Daniel Benitez, Flabio R. Araujo, Peter Rolls, Kgomotso Sibeko-Matjila, Leonhard Schnittger, Mónica Florin-Christensen

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Sustainable Synthesis of Novel Arylamide L-Cysteine Methyl Esters Peptidomimetic Derivatives: Inhibitors of Serine and Cysteine-like Proteases by Aline Silveira Serralbo, Daniel de Carvalho Santos, Marghuel Aparecida Vieira Silveira, Débora Noma Okamoto, Maria Aparecida Juliano, Suzan Pantaroto de Vasconcellos, Adriana Karla Cardoso Amorim Reis

“…This work aimed to synthesize new peptidomimetics arylamides, endeavoring to provide these compounds with the capacity to inhibit mainly cysteine and serine-like proteases.  The effectiveness of COMU as coupling reagent, under classical and sustainable approaches, were evaluated. …”
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A phenylalanine to serine substitution within an O-protein mannosyltransferase led to strong resistance to PMT-inhibitors in Pichia pastoris. by Rebecca Argyros, Stephanie Nelson, Angela Kull, Ming-Tang Chen, Terrance A Stadheim, Bo Jiang

“…Protein O-mannosyltransferases (PMTs) catalyze the initial reaction of protein O-mannosylation by transferring the first mannose unit onto serine and threonine residues of a nascent polypeptide being synthesized in the endoplasmic reticulum (ER). …”
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A Comprehensive Identification and Function Analysis of Serine/Arginine-Rich (SR) Proteins in Cotton (<i>Gossypium</i> spp.) by Fei Wei, Pengyun Chen, Hongliang Jian, Lu Sun, Xiaoyan Lv, Hengling Wei, Hantao Wang, Tingli Hu, Liang Ma, Xiaokang Fu, Jianhua Lu, Shiyun Li, Shuxun Yu

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Isolation, Molecular Cloning, and Expression of yyxA Serine Protease Gene Extracted from Bacillus licheniformis in Escherichia coli by Zahra Aghaei Jeshvaghani, Ramin Hoseini

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Interactions of the Lysosomotropic Detergent O-Methyl-Serine Dodecylamide Hydrochloride (MSDH) with Lipid Bilayer Membranes—Implications for Cell Toxicity by Ana-Maria Villamil Giraldo, Ida Eriksson, Stefan Wennmalm, Timmy Fyrner, Thomas Ederth, Karin Öllinger

“…O-methyl-serine dodecylamine hydrochloride (MSDH) is a detergent that accumulates selectively in lysosomes, a so-called lysosomotropic detergent, with unexpected chemical properties. …”
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The ΦBT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia by Marion Herisse, Jessica L. Porter, Romain Guerillot, Takehiro Tomita, Anders Goncalves Da Silva, Torsten Seemann, Benjamin P. Howden, Timothy P. Stinear, Sacha J. Pidot

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Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming by Zhangnan Liu, Mengzhen Fan, Junqing Hou, Sijing Pan, Yanxin Xu, Hailong Zhang, Chen Liu, Xiangjun Hao, Xia Li, Huijuan Wang

“…Abstract Serine hydroxymethyltransferase 2 (SHMT2) plays an important role in converting serine to glycine and supplying carbon to one-carbon metabolism to sustain cancer cell proliferation. …”
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Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells by Yulemi Gonzalez Quesada, Florence Bonnet-Magnaval, Luc DesGroseillers

“…Interestingly, a mutation that mimics the phosphorylation of STAU1 serine 20 is sufficient to cause these phenotypes, indicating that serine 20 is at the heart of the molecular mechanism leading to apoptosis. …”
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Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS) by Nazanin R. Kondori, Nazanin R. Kondori, Praveen Paul, Jacqueline P. Robbins, Ke Liu, John C. W. Hildyard, Dominic J. Wells, Jacqueline S. de Belleroche

“…We have investigated a pathogenic mutation in D-amino acid oxidase (DAO), DAOR199W, associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine metabolism and causes protein aggregation, autophagy and cell death in motor neuron cell lines. …”
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Application of the RBBP9 Serine Hydrolase Inhibitor, ML114, Decouples Human Pluripotent Stem Cell Proliferation and Differentiation by Seakcheng Lim, Rachel A. Shparberg, Jens R. Coorssen, Michael D. O’Connor

“…In non-pluripotent cells, RBBP9 is also known to have serine hydrolase (SH) activity, acting on currently undefined target proteins. …”
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FK506-binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast by Mayuki Sasaki, Shinichi Nishimura, Yoko Yashiroda, Akihisa Matsuyama, Hideaki Kakeya, Minoru Yoshida

“…In screening for small molecules that inhibit serine assimilation, we found that the growth of fission yeast cells in medium supplemented with serine as the sole nitrogen source, but not in glutamate-supplemented medium, was suppressed by FKBP12 inhibitors. …”
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