Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. by Zhang, W, Prakash, C, Prakash, C, Sum, C, Sum, C, Gong, Y, Gong, Y, Li, Y, Li, Y, Kwok, J, Kwok, J, Thiessen, N, Thiessen, N, Pettersson, S, Pettersson, S, Jones, S, Jones, S, Knapp, S, Knapp, S, Yang, H, Yang, H, Chin, K, Chin, K

“…Our findings suggest that BRD4-driven Pol II phosphorylation at serine 2 plays an important role in regulating lineage-specific gene transcription in human CD4+ T cells.…”

An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions by Clark, A, Kugathasan, U, Baskozos, G, Priestman, D, Fugger, N, Che, K, Blesneac, I, Platt, F, Bennett, D

“…Hereditary sensory neuropathy type 1 (HSN1) is caused by mutations in the SPTLC1 or SPTLC2 sub-units of the enzyme serine palmitoyltransferase, resulting in the production of toxic 1-deoxysphingolipid bases (DSBs). …”

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression by Buss, H, Handschick, K, Jurrmann, N, Pekkonen, P, Beuerlein, K, Müller, H, Wait, R, Saklatvala, J, Ojala, P, Schmitz, M, Naumann, M, Kracht, M

“…Using an unbiased approach we identified human CDK6 as a novel kinase phosphorylating NF-κB p65 at serine 536. Purified and reconstituted CDK6/cyclin complexes phosphorylated p65 in vitro and in transfected cells. …”

Shotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium by Yap, H.Y.Y., Fung, S.Y., Ng, S.T., Tan, C.S., Tan, N.H.

“…Both bands were identified to be serine protease by LC-MS/MS analysis. Phenylmethylsulfonyl fluoride, a specific serine protease inhibitor, inhibited both the proteolytic activity and cytotoxicity of F5, suggesting that the cytotoxicity of F5 is related to its protease activity. …”

Novel Peptides Inhibit Zika NS2B-NS3 Serine Protease and Virus Replication in Human Hepatic Cell Line by Abdulrahman, Ammar Yasir, Khazali, Ahmad Suhail, Teoh, Teow Chong, Rothan, Hussin A., Yusof, Rohana

“…Herein, we targeted ZIKV NS2B-NS3 serine protease with short peptides to inhibit ZIKV replication in human hepatic cell line (WRL-68). …”

Nonsubstrate based inhibitors of dengue virus serine protease: a molecular docking approach to study binding interactions between protease and inhibitors by Lee, Y.K., Tan, S.K., Wahab, H.A., Yusof, Rohana, Abd Rahman, N.

“…The protein-ligand binding interactions studies were carried out by performing dockings of the ligands that were found to be competitively inhibiting the activities of the DEN2 NS2B/NS3 serine protease onto the catalytic triad of a model of DEN2 NS2B/NS3 protease. …”
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Sequence and expression analysis of EgSAPK, a putative member of the serine/threonine protein kinases in oil palm (Elaeis guineensis Jacq.) by Huynh, Ky, Le Vinh, Thuc, Siew-Eng, Ooi, Ishak, Z., Namasivayam, Parameswari, Napis, Suhaimi

“…The deduced protein sequence shares 89% identity with the serine/threonine protein kinase SAPK9 from rice (AB125310.1). …”
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Molecular Mechanisms on the Selectivity Enhancement of Ascorbic Acid, Dopamine, and Uric Acid by Serine Oligomers Decoration on Graphene Oxide: A Molecular Dynamics Study by Threrawee Sanglaow, Pattanan Oungkanitanon, Piyapong Asanithi, Thana Sutthibutpong

“…AA radicals received electrons from serine through hydrogen bonds that promoted oxidation reaction and caused the negative shifts and separation of the oxidation potential in experiments, as DA and UA were less affected by serine. …”
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Efficient Hydrolysis of Gluten-Derived Celiac Disease-Triggering Immunogenic Peptides by a Bacterial Serine Protease from <i>Burkholderia gladioli</i> by Yu-You Liu, Cheng-Cheng Lee, Jun-Hao Hsu, Wei-Ming Leu, Menghsiao Meng

“…Peptidases that can digest the toxic peptides may formulate an oral enzyme therapy to improve the patients’ health condition. Bga1903 is a serine endopeptidase secreted by <i>Burkholderia gladioli</i>. …”
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In Silico Structural Analysis of Serine Carboxypeptidase <i>Nf</i>314, a Potential Drug Target in <i>Naegleria fowleri</i> Infections by Pablo A. Madero-Ayala, Rosa E. Mares-Alejandre, Marco A. Ramos-Ibarra

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A Serine Protease Inhibitor, Camostat Mesilate, Suppresses Urinary Plasmin Activity and Alleviates Hypertension and Podocyte Injury in Dahl Salt-Sensitive Rats by Yasunobu Iwata, Qinyuan Deng, Yutaka Kakizoe, Terumasa Nakagawa, Yoshikazu Miyasato, Miyuki Nakagawa, Kayo Nishiguchi, Yu Nagayoshi, Yuki Narita, Yuichiro Izumi, Takashige Kuwabara, Masataka Adachi, Masashi Mukoyama

“…In proteinuric renal diseases, the serine protease (SP) plasmin activates the epithelial sodium channel (ENaC) by cleaving its γ subunit. …”
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Cloning, expression, and structural modeling of two alkaline serine protease genes from extremophilic Bacillaceae -related species: Application in valorization of invasive crustaceans by Sondes MECHRI, Khelifa BOUACEM, Fawzi ALLALA, Marwa KHALED, Amel BOUANANE-DARENFED, Hocine HACENE, Bassem JAOUADI

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Identification of an interaction between calcium-dependent protein kinase 4 (EtCDPK4) and serine protease inhibitor (EtSerpin) in Eimeria tenella by Ling Lv, Bing Huang, Qiping Zhao, Zongping Zhao, Hui Dong, Shunhai Zhu, Ting Chen, Ming Yan, Hongyu Han

“…One of the proteins, E. tenella serine protease inhibitor 1 (EtSerpin), was further confirmed. …”
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Cloning, expression, and structural modeling of two alkaline serine protease genes from extremophilic Bacillaceae -related species: Application in valorization of invasive crustaceans by Sondes MECHRI, Khelifa BOUACEM, Fawzi ALLALA, Marwa KHALED, Amel BOUANANE-DARENFED, Hocine HACENE, Bassem JAOUADI

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Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition by Brian C Del Rosario, Andrea J Kriz, Amanda M Del Rosario, Anthony Anselmo, Christopher J Fry, Forest M White, Ruslan I Sadreyev, Jeannie T Lee

“…Here, we performed CTCF mass spectrometry, identified a novel phosphorylation site at Serine 224 (Ser224-P), and demonstrate that phosphorylation is carried out by Polo-like kinase 1 (PLK1). …”
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Blockade of D-serine signaling and adult hippocampal neurogenesis attenuates remote contextual fear memory following multiple memory retrievals in male mice by Ran Inoue, Ran Inoue, Xiance Ni, Xiance Ni, Hisashi Mori, Hisashi Mori

Subjects: “…D-serine…”
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Efficient secretory production of proline/alanine/serine (PAS) biopolymers in Corynebacterium glutamicum yielding a monodisperse biological alternative to polyethylene glycol (PEG) by L. Friedrich, Y. Kikuchi, Y. Matsuda, U. Binder, A. Skerra

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Cloning, expression, and structural modeling of two alkaline serine protease genes from extremophilic Bacillaceae -related species: Application in valorization of invasive crustaceans by Sondes MECHRI, Khelifa BOUACEM, Fawzi ALLALA, Marwa KHALED, Amel BOUANANE-DARENFED, Hocine HACENE, Bassem JAOUADI

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The Putative Secreted Serine Protease Chp-7 Is Required for Full Virulence and Induction of a Nonhost Hypersensitive Response by Clavibacter michiganensis subsp. sepedonicus by Riitta Nissinen, Yunjian Xia, Laura Mattinen, Carol A. Ishimaru, Dennis L. Knudson, Susan E. Knudson, Mary Metzler, Minna Pirhonen

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Attenuation of Avian Flavivirus by Rewiring the Leucine and Serine Codons of Its E-NS1 Protein toward Stop Mutation To Redirect Virus Evolution by Jiaqi Guo, Yu He, Xiaoli Wang, Andres Merits, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Bin Tian, Anchun Cheng, Shun Chen

“…Using avian flavivirus as a model, the 69 serine and 53 leucine codons on the E-NS1 genes were modified to change evolutionary direction of the viral sequence space. …”
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