Glycan-Dependent and -Independent Dual Recognition between DC-SIGN and Type II Serine Protease MSPL/TMPRSS13 in Colorectal Cancer Cells by Motohiro Nonaka, Shogo Matsumoto, Bruce Yong Ma, Hiroshi Kido, Nana Kawasaki, Nobuko Kawasaki, Toshisuke Kawasaki

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Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (<i>Lepisosteus oculatus</i>) by Paolo Valentini, Srinivas Akula, Abigail Alvarado-Vazquez, Jenny Hallgren, Zhirong Fu, Brett Racicot, Ingo Braasch, Michael Thorpe, Lars Hellman

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Matefin/SUN-1 Phosphorylation on Serine 43 Is Mediated by CDK-1 and Required for Its Localization to Centrosomes and Normal Mitosis in C. elegans Embryos by Noam Zuela, Yosef Gruenbaum

“…Taken together, these results support a role for phosphorylation of serine 43 in matefin/SUN-1 in mitosis.…”
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Increased Expression Levels of Thermophilic Serine Protease TTHA0724 through Signal Peptide Screening in <i>Bacillus subtilis</i> and Applications of the Enzyme by Yiwen Xu, Xiaoran Xuan, Renjun Gao, Guiqiu Xie

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STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness by J. Arévalo, I. Campoy, M. Durán, S. Nemours, A. Areny, M. Vall-Palomar, C. Martínez, G. Cantero-Recasens, A. Meseguer

“…Abstract The signal transducer and activator of transcription 3 (STAT3) is a transcription factor mainly activated by phosphorylation in either tyrosine 705 (Y705) or serine 727 (S727) residues that regulates essential processes such as cell differentiation, apoptosis inhibition, or cell survival. …”
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Purification and biochemical characterization of a novel thermostable serine alkaline protease from Aeribacillus pallidus C10: a potential additive for detergents by Vildan Yildirim, Mustafa Ozkan Baltaci, Ilknur Ozgencli, Melda Sisecioglu, Ahmet Adiguzel, Gulsah Adiguzel

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RAndomized Clinical Trial Of NAfamostat Mesylate, A Potent Transmembrane Protease Serine 2 (TMPRSS2) Inhibitor, in Patients with COVID-19 Pneumonia by Teresa Maria Seccia, Tungalagtamir Shagjaa, Margherita Morpurgo, Brasilina Caroccia, Viola Sanga, Sonia Faoro, Francesca Venturini, Girolama Iadicicco, Sara Lococo, Maria Mazzitelli, Filippo Farnia, Paola Fioretto, Yusuke Kobayashi, Dario Gregori, Gian Paolo Rossi

Subjects: “…transmembrane protease serine 2 TMPRSS2…”
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Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial by David Cipolla, Jimin Zhang, Brice Korkmaz, James D. Chalmers, Jessica Basso, Daniel Lasala, Carlos Fernandez, Ariel Teper, Kevin C. Mange, Walter R. Perkins, Eugene J. Sullivan

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Computational and cellular exploration of the protein-protein interaction between Vibrio fischeri STAS domain protein SypA and serine kinase SypE by Morgan E. Milton, Karen L. Visick

“…The Vibrio fischeri STAS domain protein SypA is also proposed to employ a partner-switching mechanism with its partner SypE, a serine kinase/phosphatase that controls SypA’s phosphorylation state. …”
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Stat3 Tyrosine 705 and Serine 727 Phosphorylation Associate With Clinicopathological Characteristics and Distinct Tumor Cell Phenotypes in Triple-Negative Breast Cancer by Michaela Stenckova, Michaela Stenckova, Rudolf Nenutil, Borivoj Vojtesek, Philip J. Coates

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De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell lines by Jasmin Sponagel, Siddhartha Devarakonda, Joshua B. Rubin, Jingqin Luo, Joseph E. Ippolito

“…Using [13C6] glucose tracing in NSCLC cell lines, we found that a subset of male cells generated significantly more serine from glucose than female cells. Higher serine biosynthesis was further correlated with increased sensitivity to pemetrexed in male cells only. …”
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L-Serine-Modified Poly-L-Lysine as a Biodegradable Kidney-Targeted Drug Carrier for the Efficient Radionuclide Therapy of Renal Cell Carcinoma by Hidemasa Katsumi, Sho Kitada, Shintaro Yasuoka, Rie Takashima, Tomoki Imanishi, Rina Tanaka, Satoru Matsuura, Hiroyuki Kimura, Hidekazu Kawashima, Masaki Morishita, Akira Yamamoto

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Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells by Monica Dominguez, Verena Truemper, Ana Carolina Mota, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Dmitry Namgaladze

“…It has been demonstrated that ACLY activity can be positively regulated via phosphorylation at serine 455 by Akt and protein kinase A. Nonetheless, the impact of phosphorylation on ACLY function in human myeloid cells is poorly understood. …”
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The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis. by Toru Tateno, Sylvia L Asa, Lei Zheng, Thomas Mayr, Axel Ullrich, Shereen Ezzat

“…Growth promoting effects of FGFR4-R388 as evidenced by enhanced colony formation was ascribed to Src activation and mitochondrial serine phosphorylation of STAT3 (pS-STAT3). In contrast, diminished pY-STAT3 mediated by FGFR4-R388 relieved GH inhibition leading to hormone excess. …”
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Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells by Wonhee Hur, Byung Yoon Kang, Sung Min Kim, Gil Won Lee, Jung-Hee Kim, Min-Kyung Nam, Hyangshuk Rhim, and Seung Kew Yoon

“…High-temperature requirement protein A2 (HtrA2/Omi), a mitochondrial serine protease with various functions, is responsible for quality control in mitochondrial homeostasis. …”
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Low-molecular-weight heparin reduces hyperoxia-augmented ventilator-induced lung injury via serine/threonine kinase-protein kinase B by Huang Chung-Chi, Yang Cheng-Ta, Li Li-Fu, Liu Yung-Yang, Kao Kuo-Chin, Lin Horng-Chyuan

“…We hypothesized that subcutaneous injections of enoxaparin would decrease the effects of hyperoxia on high-tidal-volume ventilation-induced HMGB1 production and neutrophil infiltration via the serine/threonine kinase/protein kinase B (Akt) pathway.…”
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Role of the Subtilisin-like Serine Protease CJPRB from <i>Cordyceps javanica</i> in Eliciting an Immune Response in <i>Hyphantria cunea</i> by Wenxiu Wang, Fengmao Chen

Subjects: “…subtilisin-like serine protease CJPRB…”
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Knockout of <i>ovary serine protease</i> Leads to Ovary Deformation and Female Sterility in the Asian Corn Borer, <i>Ostrinia furnacalis</i> by Porui Zhang, Zuerdong Jialaliding, Junwen Gu, Austin Merchant, Qi Zhang, Xuguo Zhou

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Cloning, expression, and structural modeling of two alkaline serine protease genes from extremophilic Bacillaceae -related species: Application in valorization of invasive crustaceans by Sondes MECHRI, Khelifa BOUACEM, Fawzi ALLALA, Marwa KHALED, Amel BOUANANE-DARENFED, Hocine HACENE, Bassem JAOUADI

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Serum Serine and the Risk of All-Cause Mortality: A Nested Case-Control Study From the China Stroke Primary Prevention Trial (CSPPT) by Qiangqiang He, Qiangqiang He, Nan Zhang, Qiongyue Liang, Zhuo Wang, Ping Chen, Yun Song, Yun Song, Ziyi Zhou, Ziyi Zhou, Yaping Wei, Yong Duan, Yong Duan, Binyan Wang, Binyan Wang, Peiwu Qin, Xianhui Qin, Xiping Xu, Xiping Xu

Subjects: “…serum serine…”
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