Proteomic profiling of low muscle and high fat mass: a machine learning approach in the KORA S4/FF4 study by Marie‐Theres Huemer, Alina Bauer, Agnese Petrera, Markus Scholz, Stefanie M. Hauck, Michael Drey, Annette Peters, Barbara Thorand

“…Results In the cross‐sectional analysis, we identified kallikrein‐6, C‐C motif chemokine 28 (CCL28), and tissue factor pathway inhibitor as previously unknown biomarkers for muscle mass [association with low ASMM: odds ratio (OR) per 1‐SD increase in log2 normalized protein expression values (95% confidence interval (CI)): 1.63 (1.37–1.95), 1.31 (1.14–1.51), 1.24 (1.06–1.45), respectively] and serine protease 27 for fat mass [association with high BFMI: OR (95% CI): 0.73 (0.61–0.86)]. …”
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Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study by Ming-Liang Zhang, Xu Zhao, Wei-Xia Li, Xiao-Yan Wang, Ming Niu, Hui Zhang, Yu-Long Chen, De-Xin Kong, Yuan Gao, Yu-Ming Guo, Zhao-Fang Bai, Yan-Ling Zhao, Jin-Fa Tang, Xiao-He Xiao

“…Furthermore, 4 DEGs (aldehyde dehydrogenase 1 family member B1 (Aldh1b1), solute carrier family 25 member 25 (Slc25a25), Pim-3 proto-oncogene, serine/threonine kinase (Pim3), out at first homolog (Oaf)) and 4 metabolites (phosphatidate, phosphatidylcholine, N-Acetylleucine, biliverdin) in the Yangsyn group and 1 DEG [galectin 5 (Lgals5)] and 1 metabolite (5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate) in Yinsyn group were significantly correlated to the ALT and AST levels of BGZ treated and untreated groups (receiver operating characteristic (ROC) ≥ 0.9). …”
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SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus by Qiuchen Li, Zhimin Jiang, Shuning Ren, Hui Guo, Zhimin Song, Saini Chen, Xintao Gao, Fanfeng Meng, Junda Zhu, Litao Liu, Qi Tong, Honglei Sun, Yipeng Sun, Juan Pu, Kin‐Chow Chang, Jinhua Liu

“…Here, it is demonstrated that induction of host serine and arginine‐rich splicing factor 5 (SRSF5) by IAV facilitated viral replication by enhancing viral M mRNA splicing. …”
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Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis by Darian Williams, Marwa Mahmoud, Renfa Liu, Aitor Andueza, Sandeep Kumar, Dong-Won Kang, Jiahui Zhang, Ian Tamargo, Nicolas Villa-Roel, Kyung-In Baek, Hwakyoung Lee, Yongjin An, Leran Zhang, Edward W Tate, Pritha Bagchi, Jan Pohl, Laurent O Mosnier, Eleftherios P Diamandis, Koichiro Mihara, Morley D Hollenberg, Zhifei Dai, Hanjoong Jo

“…Previously, we identified kallikrein-related peptidase 10 (Klk10, a secreted serine protease) as a flow-sensitive gene in mouse arterial ECs, but its role in endothelial biology and atherosclerosis was unknown. …”
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Systemic effects of hypophosphatasia characterization of two novel variants in the ALPL gene by Luis Martínez-Heredia, Manuel Muñoz-Torres, Manuel Muñoz-Torres, Manuel Muñoz-Torres, Manuel Muñoz-Torres, Raquel Sanabria-de la Torre, Raquel Sanabria-de la Torre, Ángela Jiménez-Ortas, Ángela Jiménez-Ortas, Francisco Andújar-Vera, Francisco Andújar-Vera, Francisco Andújar-Vera, Trinidad González-Cejudo, Trinidad González-Cejudo, Victoria Contreras-Bolívar, Sheila González-Salvatierra, Sheila González-Salvatierra, Sheila González-Salvatierra, José María Gómez-Vida, Cristina García-Fontana, Cristina García-Fontana, Cristina García-Fontana, Beatriz García-Fontana, Beatriz García-Fontana, Beatriz García-Fontana, Beatriz García-Fontana

“…The dominant negative effect was analyzed by co-transfection of each variant with the wild-type gene, measuring ALP activity and analyzing cellular localization by flow cytometry.ResultsTwo previously undescribed variants were found in the ALPL gene: leucine 6 to serine missense mutation (c.17T>C, L6S) affecting the signal peptide and threonine 167 deletion (c.498_500delCAC, T167del) affecting the vicinity of the active site. …”
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Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis by Ramón Pérez-Núñez, Alejandro Chamorro, María Fernanda González, Pamela Contreras, Rocío Artigas, Alejandro H. Corvalán, Brigitte van Zundert, Christopher Reyes, Pablo R. Moya, Ana María Avalos, Pascal Schneider, Andrew F. G. Quest, Lisette Leyton

“…We evaluated the phosphorylation of Cx43 serine residue 373 (S373) by AKT and ATP release as a functional assay for HC opening. …”
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Gene coexpression analysis reveals key pathways and hub genes related to late-acting self-incompatibility in Camellia oleifera by Chang Li, Chang Li, Yi Long, Yi Long, Mengqi Lu, Mengqi Lu, Junqin Zhou, Junqin Zhou, Sen Wang, Sen Wang, Yan Xu, Yan Xu, Xiaofeng Tan, Xiaofeng Tan

“…Network establishment indicated that genes encoding G-type lectin S-receptor-like serine (lecRLK), isoflavone 3’-hydroxylase-like (CYP81Q32), cytochrome P450 87A3-like (CYP87A3), and probable calcium-binding protein (CML41) were the hub genes that positively responded to the LSI reaction. …”
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Study on the Mechanisms of Multiple Myeloma Cells Promoting M2 Macrophage Polarization through PI3K/AKT Signaling Pathway by PENG Yilun, LI Yang, WANG Xiaotao

“…Background The incidence of multiple myeloma has long been high, however, there are fewer studies on phosphatidylinositol 3-kinase (PI3K) /serine-threonine kinase (AKT) signaling pathway and M2 macrophage polarization promoting the progression of multiple myeloma. …”
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Natural Changbai mineral water reduces obesity risk through regulating metabolism and gut microbiome in a hyperuricemia male mouse model by Maichao Li, Maichao Li, Maichao Li, Kai Guo, Kai Guo, Kai Guo, Yuwei He, Yuwei He, Hailong Li, Wenyan Sun, Wenyan Sun, Wenyan Sun, Xuan Yuan, Xuan Yuan, Xuan Yuan, Zhen Liu, Zhen Liu, Xinde Li, Xinde Li, Tony R. Merriman, Tony R. Merriman, Changgui Li, Changgui Li, Changgui Li, Hui Zhang, Hui Zhang, Hui Zhang

“…Hepatic metabolite profiling revealed a shift in the pathway of glycine, serine and threonine metabolism, pantothenate and CoA biosynthesis, and biosynthesis of cofactors in KO mice fed with C-cell mineral water. …”
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Comparative Investigation of Composition, Antifungal, and Anti-Inflammatory Effects of the Essential Oil from Three Industrial Hemp Varieties from Italian Cultivation by Giustino Orlando, Sabrina Adorisio, Domenico Delfino, Annalisa Chiavaroli, Luigi Brunetti, Lucia Recinella, Sheila Leone, Marianna D’Antonio, Gokhan Zengin, Alessandra Acquaviva, Mirko Antico, Paola Angelini, Giancarlo Angeles Flores, Roberto Venanzoni, Massimo Tacchini, Simonetta Cristina Di Simone, Luigi Menghini, Claudio Ferrante

“…In human H1299 lung adenocarcinoma cells, we also evaluated the influence of the EOs on the gene expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2), which are involved in SARS-CoV-2 entry in human host. …”
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Cornelian Cherry (<i>Cornus mas</i> L.) Fruit Extract Lowers SREBP-1c and C/EBPα in Liver and Alters Various PPAR-α, PPAR-γ, LXR-α Target Genes in Cholesterol-Rich Diet Rabbit Mode... by Maciej Danielewski, Andrzej Rapak, Angelika Kruszyńska, Małgorzata Małodobra-Mazur, Paweł Oleszkiewicz, Stanisław Dzimira, Alicja Z. Kucharska, Wojciech Słupski, Agnieszka Matuszewska, Beata Nowak, Adam Szeląg, Narcyz Piórecki, Urszula Zaleska-Dorobisz, Tomasz Sozański

“…Also, the levels of lipoprotein lipase (LPL), visceral adipose tissue-derived serine protease inhibitor (Vaspin), and retinol-binding protein 4 (RBP4) in visceral adipose tissue were measured. …”
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Medication rule and mechanism of traditional Chinese medicine in treating metabolism-associated fatty liver disease based on bioinformatics technology by Zhang Yunkun, Yao Rong, Li Lin, Li Wenli, Li Changqing, Pan Yu, Li Shunxiang

“…Network pharmacological showed that the main components of the core formula “Shanzha (Crataegi Fructus) - Danshen (Salviae Miltiorrhizae Radix et Rhizoma) - Zexie (Alismatis Rhizoma) - Chaihu (Bupleuri Radix) - Fuling (Poria)” in the treatment of MAFLD were quercetin, apigenin, puerarin, luteolin, ursolic acid, kaempferol, tanshinone IIA, emodin, paeonol, etc., which involved RAC-alpha serine/threonine-protein kinase 1 (AKT1), cellular tumor antigen p53 (TP53), interleukin (IL)-6, IL-1β, signal transducer and activator of transcription 3 (STAT3), epidermal growth factor receptor (EGFR), peroxisome proliferative activated receptor gamma (PPARG), and other key targets. …”
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CircSMARCA5 Regulates VEGFA mRNA Splicing and Angiogenesis in Glioblastoma Multiforme Through the Binding of SRSF1 by Davide Barbagallo, Angela Caponnetto, Duilia Brex, Federica Mirabella, Cristina Barbagallo, Giovanni Lauretta, Antonio Morrone, Francesco Certo, Giuseppe Broggi, Rosario Caltabiano, Giuseppe M. Barbagallo, Vittoria Spina-Purrello, Marco Ragusa, Cinzia Di Pietro, Thomas B. Hansen, Michele Purrello

“…We recently proposed that circSMARCA5 acts as sponge for the splicing factor Serine and Arginine Rich Splicing Factor 1 (SRSF1) in glioblastoma multiforme (GBM). …”
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SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes by Zine‐Eddine Kherraf, Marie Christou‐Kent, Thomas Karaouzene, Amir Amiri‐Yekta, Guillaume Martinez, Alexandra S Vargas, Emeline Lambert, Christelle Borel, Béatrice Dorphin, Isabelle Aknin‐Seifer, Michael J Mitchell, Catherine Metzler‐Guillemain, Jessica Escoffier, Serge Nef, Mariane Grepillat, Nicolas Thierry‐Mieg, Véronique Satre, Marc Bailly, Florence Boitrelle, Karin Pernet‐Gallay, Sylviane Hennebicq, Julien Fauré, Serge P Bottari, Charles Coutton, Pierre F Ray, Christophe Arnoult

“…Exome sequencing analysis of two azoospermic brothers allowed the identification of a homozygous splice mutation in SPINK2, encoding a serine protease inhibitor believed to target acrosin, the main sperm acrosomal protease. …”
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Lost genome segments associate with trait diversity during rice domestication by Xiaoming Zheng, Limei Zhong, Hongbo Pang, Siyu Wen, Fei Li, Danjing Lou, Jinyue Ge, Weiya Fan, Tianyi Wang, Zhenyun Han, Weihua Qiao, Xiaowu Pan, Yebao Zhu, Jilin Wang, Cuifeng Tang, Xinhua Wang, Jing Zhang, Zhijian Xu, Sung Ryul Kim, Ajay Kohli, Guoyou Ye, Kenneth M. Olsen, Wei Fang, Qingwen Yang

“…An 824-bp deletion in japonica rice, which encodes a serine carboxypeptidase family protein, is shown to be associated with grain length. …”
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Genomic Features and Phylogenetic Analysis of Antimicrobial-Resistant <i>Salmonella</i> Mbandaka ST413 Strains by Valdinete P. Benevides, Mauro M. S. Saraiva, Camila F. Nascimento, Enrique J. Delgado-Suárez, Celso J. B. Oliveira, Saura R. Silva, Vitor F. O. Miranda, Henrik Christensen, John E. Olsen, Angelo Berchieri Junior

“…A point mutation in ParC at the 57th position (threonine → serine) associated with quinolone resistance was present in all investigated genomes. …”
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Metabolomics profile and 10-year atherosclerotic cardiovascular disease (ASCVD) risk score by Hojat Dehghanbanadaki, Salimeh Dodangeh, Peyvand Parhizkar Roudsari, Shaghayegh Hosseinkhani, Pouria Khashayar, Mohammad Noorchenarboo, Negar Rezaei, Arezou Dilmaghani-Marand, Moein Yoosefi, Babak Arjmand, Kazem Khalagi, Kazem Khalagi, Niloufar Najjar, Ardeshir Kakaei, Fatemeh Bandarian, Hamid Aghaei Meybodi, Bagher Larijani, Farideh Razi

“…The high-risk group had higher odds of factor 1 (12 long-chain acylcarnitines, OR = 1.103), factor 2 (5 medium-chain acylcarnitines, OR = 1.063), factor 3 (methionine, leucine, valine, tryptophan, tyrosine, phenylalanine, OR = 1.074), factor 5 (6 short-chain acylcarnitines, OR = 1.205), factor 6 (5 short-chain acylcarnitines, OR = 1.229), factor 7 (alanine, proline, OR = 1.343), factor 8 (C18:2OH, glutamic acid, aspartic acid, OR = 1.188), and factor 10 (ornithine, citrulline, OR = 1.570) compared to the low-risk ones; the odds of factor 9 (glycine, serine, threonine, OR = 0.741), however, were lower in the high-risk group. …”
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A Metabolomic Severity Score for Airflow Obstruction and Emphysema by Suneeta Godbole, Wassim W. Labaki, Katherine A. Pratte, Andrew Hill, Matthew Moll, Annette T. Hastie, Stephen P. Peters, Andrew Gregory, Victor E. Ortega, Dawn DeMeo, Michael H. Cho, Surya P. Bhatt, J. Michael Wells, Igor Barjaktarevic, Kathleen A. Stringer, Alejandro Comellas, Wanda O’Neal, Katerina Kechris, Russell P. Bowler

“…The metabolomic pathways for arginine biosynthesis; aminoacyl-tRNA biosynthesis; and glycine, serine, and threonine pathway were enriched by adaLASSO metabolites for FEV₁. …”
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Exploring the impact of fungal spores from agricultural environments on the mice lung microbiome and metabolic profile by Bing Wu, Jinyou Li, Yuting Wang, Jin Yang, Yongli Ye, Jiadi Sun, Lina Sheng, Mengying Wu, Yinzhi Zhang, Yajun Gong, Jianzhong Zhou, Jian Ji, Xiulan Sun

“…Cysteine and methionine metabolism, along with glycine, serine and threonine metabolism, emerged as particularly crucial pathways. …”
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Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation studyResearch in context by Jian Zhao, Isobel D. Stewart, Denis Baird, Dan Mason, John Wright, Jie Zheng, Tom R. Gaunt, David M. Evans, Rachel M. Freathy, Claudia Langenberg, Nicole M. Warrington, Deborah A. Lawlor, Maria Carolina Borges

“…Findings: Our results provide evidence that maternal circulating glutamine (59 g offspring birthweight increase per standard deviation increase in maternal amino acid level, 95% CI: 7, 110) and serine (27 g, 95% CI: 9, 46) raise, while leucine (−59 g, 95% CI: −106, −11) and phenylalanine (−25 g, 95% CI: −47, −4) lower offspring birthweight. …”
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