-
6981
Cell cycle dysregulation in pituitary oncogenesis.
Published 2004“…Very recent findings from our group have established up-regulation of the serine-threonine kinase Akt in pituitary tumours compared to normal pituitary, which may cause phosphorylation of p27 on Thr157 and cytoplasmic retention of p27. …”
Journal article -
6982
Molecular characterisation and pathogenicity of chicken astrovirus isolated from commercial broiler chickens in Malaysia
Published 2021“…The genomic organisation of the three isolates exhibited three open reading frames, ORF-1a, ORF-1b, and ORF-2, that encode for trypsin-like serine protease, RNA-dependent RNA polymerase (RdRp) and capsid protein, respectively. …”
Get full text
Thesis -
6983
Biodegradation of recalcitrant chicken feather wastes by locally isolated heavy metal tolerant Alcaligenes sp. strain AQ05-001
Published 2016“…Crude keratinase produced by strain AQ05-001 displayed relative activity over a temperature ranging from 30-60°C, pH 7-10 and was highly inhibited by serine inhibitor, Tween20, Trixton-100 and sodium dodecyl sulphate. …”
Get full text
Thesis -
6984
Structural implications of Pseudomonas fluorescence strain AMS8 cold-active lipase in organic solvent
Published 2018“…Cold-active AMS8 lipase was catalytically active at 25 – 45 °C and has two alpha-helix lids, a pentapeptide motif with nucleophilic-serine and repeat-toxin sequence motifs distribution at C-terminus. …”
Get full text
Thesis -
6985
The biosynthesis of intestinal mucoproteins
Published 1966“…This is considered to consist of a central protein core (rich in serine and threonine, together 32% of the total amino acids) carrying carbohydrate side-branches (Kent and Marsden, 1963). …”
Thesis -
6986
eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma
Published 2022-03-01“…Mechanistically, eEF2K directly bound to and inactivated glycogen synthase kinase 3 beta (GSK3β) by phosphorylating it at serine 9 (S9), leading to PD-L1 protein stabilization and upregulation, and subsequently tumor immune evasion. …”
Get full text
Article -
6987
On a Cold Night: Transcriptomics of Grapevine Flower Unveils Signal Transduction and Impacted Metabolism
Published 2019-03-01“…We also identified some mechanisms not yet known to be involved in the response to cold stress, i.e., (1) the up-regulation of genes encoding G-type lectin S-receptor-like serine threonine-protein kinase, pathogen recognition receptor (PRR5), or heat-shock factors among others; (2) the down-regulation of Myeloblastosis (MYB)-related transcription factors and the Constans-like zinc finger family; and (3) the down-regulation of some genes encoding Pathogen-Related (PR)-proteins. …”
Get full text
Article -
6988
Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas
Published 2023-12-01“…Here, we identify that stabilizing vimentin phosphorylation at serine 56 induces multinucleation, specifically in hybrid E/M cells with stemness properties but not epithelial or mesenchymal cells. …”
Get full text
Article -
6989
Integration analysis of metabolome and transcriptome reveals the effect of exogenous supplementation with mixtures of vitamins ADE, zinc, and selenium on follicular growth and gran...
Published 2022-10-01“…Combined multi-omics analysis revealed that the protein digestion and absorption, ABC transporters, biosynthesis of amino acids, aminoacyl-tRNA biosynthesis, mineral absorption, alanine, aspartate and glutamate metabolism, glycine, serine and threonine metabolism, arginine biosynthesis, and ovarian steroidogenesis were significantly enriched. …”
Get full text
Article -
6990
Assessment of Mixed <i>Plasmodium falciparum</i> <i>sera5</i> Infection in Endemic Burkitt Lymphoma: A Case-Control Study in Malawi
Published 2021-04-01“…We examined this hypothesis by measuring diversity in <i>Pf-</i>serine repeat antigen-5 (<i>Pfsera5</i>), an antigenic target of blood-stage immunity to malaria, among 200 eBL cases and 140 controls, all <i>Pf</i> polymerase chain reaction (PCR)-positive, in Malawi. …”
Get full text
Article -
6991
Transcriptome and digital gene expression analysis reveal immune responses of mantle and visceral mass pearl culturing in Hyriopsis cumingii
Published 2023-08-01“…We also screened 22 immune-related DEGs in the mantle and visceral mass during the same pearl culture period, including serine/threonine-protein kinase NLK, C-type lectin, and galectin. …”
Get full text
Article -
6992
Discovery of a small-molecule NDR1 agonist for prostate cancer therapy
Published 2024-02-01“…Nuclear Dbf2-related kinase 1 (NDR1), also known as STK38, is a serine/threonine kinase in the NDR/LATS kinase family that plays a critical role in cellular processes, including immunity, inflammation, metastasis, and tumorigenesis. …”
Get full text
Article -
6993
Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%: real-world da...
Published 2021-01-01“…In the real-world setting, no statistically significant differences in long-term outcomes with P vs PCT were observed; a prospective randomized trial addressing the comparative efficacy of P and PCT in different patient subgroups is highly anticipated.List of abbreviations: AE - adverse events; ALK - anaplastic lymphoma kinase gene; ALT - alanine aminotransferase; (a)NSCLC - (advanced) non-small cell lung cancer; AST - aspartate aminotransferase; BRAF - v-Raf murine sarcoma viral oncogene homolog B; BRCA2 - BReast CAncer gene 2; c-Met - tyrosine-protein kinase Met; CTCAE, v. 4.03 - Common Terminology Criteria for Adverse Events, version 4.03; CTLA-4 - cytotoxic T-lymphocyte-associated protein 4; ECOG PS - Eastern Cooperative Oncology Group performance status; EGFR - epidermal growth factor receptor gene; FISH - fluorescent in situ hybridization; HER2 - human epidermal growth factor receptor 2; IC - tumor-infiltrating immune cells; ICI - immune check-point inhibitors; IHC - immunohistochemistry; IQR - interquartile range; irAE - immune related adverse events; ISCORT - Israeli Society for Clinical Oncology and Radiotherapy; KRAS - Kirsten rat sarcoma viral oncogene homolog; (m)TTD -(median) time-to-treatment discontinuation; mo - months; (m)OS - (median) overall survival; (m)PFS - (median) progression-free survival; muts/Mb - mutations per megabase; NA - not specified/not available; NOS - not otherwise specified; NR - not reported/not reached; ORR - objective response rate; P - pembrolizumab; PCR - polymerase chain reaction; PCT - combination of pembrolizumab with platinum-based chemotherapy; PD – progression of disease; PD-1 - programmed cell death-1; PD-L1 - programmed cell death ligand-1; pts - patients; RET - proto-oncogene RET; ROS1 - proto-oncogene tyrosine-protein kinase ROS1; SD - standard deviation; STK11 - serine/threonine kinase 11; TC - tumor cells; TMB - Tumor mutation burden; TPS - tumor proportion score.…”
Get full text
Article -
6994
Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?
Published 2020-07-01“…The novel coronavirus canonically utilizes the angiotensin-converting enzyme 2 (ACE2) receptor and the serine protease TMPRSS2 for cell entry. Herein, building upon our previous single-cell study (Pique-Regi et al., 2019), another study, and new single-cell/nuclei RNA-sequencing data, we investigated the expression of ACE2 and TMPRSS2 throughout pregnancy in the placenta as well as in third-trimester chorioamniotic membranes. …”
Get full text
Article -
6995
Blood gene expression biomarkers of response to anti-TNF drugs in pediatric inflammatory bowel diseases before initiation of treatment
Published 2024-04-01“…Genes participating in defense response to Gram-negative bacterium, serine-type endopeptidase activity, and transcriptional misregulation in cancer are good candidates for anticipating the response to anti-TNF drugs in children with IBDs.…”
Get full text
Article -
6996
Selective Targeting of Protein Kinase C (PKC)-θ Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8<sup>+</sup> T Cells in Immunotherapy-R...
Published 2022-03-01“…Protein kinase C (PKC)-θ is a serine/threonine kinase with both cytoplasmic and nuclear functions. …”
Get full text
Article -
6997
Hyperforin-mediated anticancer mechanisms in MDA-MB-231 cell line: insights into apoptotic mediator modulation and caspase activation
Published 2023-12-01“…The results suggest that hyperforin may act as a good cell death-inducing agent.ABBREVIATIONS: TNBC: Triple negative breast cancer; DNA: Deoxyribonucleic acid; RNA: Ribonucleic acid; ROS: Reactive oxygen species; 5-FU: Fluorouracil; TRAIL: TNF-related apoptosis-inducing ligand; AKT: Protein kinase B; COX-2: Cyclooxygenase-2; PCR: Polymerase chain reaction; Bax: Bcl-2-associated X protein; BCL-2: B-cell lymphoma 2; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; mRNA: Messenger ribonucleic acid; MCL1: Myeloid-cell leukemia 1; LDH: Lactate dehydrogenase; ELISA: Enzyme-linked immunosorbent assay; MMP: Mitochondrial membrane potential; MCP-1: Monocyte chemoattractant protein-1; ATCC: American Type Culture Collection; RPMI: Roswell Park Memorial Institute; XIAP: X-linked inhibitor of apoptosis protein; FBS: Fetal bovine serum; MCL-1: Myeloid-cell leukemia 1; DMEM: Dulbecco’s Modified Eagle Medium; DMSO: Dimethyl sulfoxide; CASP3: Caspase 3; RPMI: Roswell Park Memorial Institute; DMEM: Dulbecco’s Modified Eagle Medium; FBS: Fetal bovine serum; h: Hour; TNF-α: Tumour necrosis factor alpha; P53: Tumor protein P53; min: Minutes; cps: Count presecond; OD: Optical density; rpm: Revolutions per minute; PI: Propidium iodide; SD: Standard deviation; DDR: Death Domoin Receptor; TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain; HRK: Harakiri, BCL2 Interacting Protein; RIPK2: Receptor-interacting serine/threonine-protein kinase 2; BIK: BCL2 interacting killer; DCF: 2’, 7’ –dichlorofluorescein; DCF-DA: Dichlorofluorescin Diacetate; FADD: Fas Associated Via Death Domain; TNFRSF: Tumor necrosis factor receptor superfamily; FITC: Fluorescein isothiocyanate; DMSO: Dimethyl sulfoxide; CFLAR: CASP8 And FADD Like Apoptosis Regulator; BID: BH3-interacting domain death agonist; BIRC: Baculoviral IAP repeat-containing protein; CIDEA: Cell death activator CIDE-A; CIDEB: Cell Death Inducing DFFA Like Effector B; BrdU: Bromodeoxyuridine; RFU: Relative fluorescence unit; NF-kB: Nuclear Factor kappa-light-chain-enhancer of activated B cells; %: Percentage; µL: microliter; µM: Micromolar; °C: degree Celcius; ng/mL: Nanograms per millimeter; mg/mL: Milligrams per milliliter; µg/mL: Micrograms per milliliter; ΔΨm: Mitochondrial membrane potential; TNFα: Tumour necrosis factor α; Bcl-xL: B-cell lymphoma-extra large; MDR1: Multidrug Resistance Mutation; AIB1: Amplified in breast cancer 1; LTBR: Lymphotoxin Beta Receptor HighlightsUtilization of hyperforin as anticancer agent against triple negative breast cancer.Hyperforin exhibited a lower IC50 compared to taxol in inhibiting growth of MDA-MB-231 cells.Hyperforin shows similar potential anticancer activity as taxol.Hyperforin uses mitochondrial death pathway to induce cell death in MDA-MB-231 cells.…”
Get full text
Article -
6998
Expression of Selected Genes and Circulating microRNAs in Patients with Celiac Disease
Published 2022-01-01“…The aim of the study is to describe the expression of selected genes (Wnt family member 3, <i>WNT3</i>; Wnt family member 11, <i>WNT11</i>; tumor necrosis factor alpha, <i>TNFα</i>; mitogen-activated protein kinase 1, <i>MAPK1</i>; AKT serine/threonine kinase 3, <i>AKT3</i>; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, <i>PIK3CA</i>; and cyclin <i>D1, CCND1</i>) and miRNAs (miR-192-5p, miR-194-5p, miR-449a and miR-638) in adult patients with CD. …”
Get full text
Article -
6999
Effective-component compatibility of Bufei Yishen formula alleviates chronic obstructive pulmonary disease inflammation by regulating GSK3β-mediated NLRP3 inflammasome activation
Published 2023-12-01“…Moreover, ECC-BYF suppressed the activation of the NLRP3 inflammasome by increasing the phosphorylation at serine 9 and decreasing the phosphorylation at tyrosine 216 of GSK3β, followed by the inhibition of IL-1β secretion in macrophages. …”
Get full text
Article -
7000
In silico study of novel niclosamide derivatives, SARS-CoV-2 nonstructural proteins catalytic residue-targeting small molecules drug candidates
Published 2023-05-01“…In the present study, we reported eight (SCOV-L-02, SCOV-L-09, SCOV-L-10, SCOV-L-11, SCOV-L-15, SCOV-L-18, SCOV-L-22, and SCOV-L-23) novel structurally related small-molecule derivatives of niclosamide (SCOV-L series) for their targeting potential against angiotensin-converting enzyme-2 (ACE2), type II transmembrane serine protease (TMPRSS2), and SARS-COV-2 nonstructural proteins (NSPs) including NSP5 (3CLpro), NSP3 (PLpro), and RdRp. …”
Get full text
Article