Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells by Maria Carmen Rodenas, Julia Peñas-Martínez, Irene Pardo-Sánchez, David Zaragoza-Huesca, Carmen Ortega-Sabater, Jorge Peña-García, Salvador Espín, Guillermo Ricote, Sofía Montenegro, Francisco Ayala-De La Peña, Ginés Luengo-Gil, Andrés Nieto, Francisco García-Molina, Vicente Vicente, Francesco Bernardi, María Luisa Lozano, Victoriano Mulero, Horacio Pérez-Sánchez, Alberto Carmona-Bayonas, Irene Martínez-Martínez

“…Introduction: Hepsin is a type II transmembrane serine protease and its expression has been linked to greater tumorigenicity and worse prognosis in different tumors. …”
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The Genome of <em>Rhyzopertha dominica</em> (Fab.) (Coleoptera: Bostrichidae): Adaptation for Success by Brenda Oppert, Anna Muszewska, Kamil Steczkiewicz, Eva Šatović-Vukšić, Miroslav Plohl, Jeffrey A. Fabrick, Konstantin S. Vinokurov, Igor Koloniuk, J. Spencer Johnston, Timothy P. L. Smith, Raul Narciso C. Guedes, Walter R. Terra, Clélia Ferreira, Renata O. Dias, Konstantin A. Chaply, Elena N. Elpidina, Valeriia F. Tereshchenkova, Robert F. Mitchell, Audra J. Jenson, Rachel McKay, Tisheng Shan, Xiaolong Cao, Zelong Miao, Chao Xiong, Haobo Jiang, William R. Morrison, Sergey Koren, David Schlipalius, Marcé D. Lorenzen, Raman Bansal, Yu-Hui Wang, Lindsey Perkin, Monica Poelchau, Kenlee Friesen, Morgan L. Olmstead, Erin Scully, James F. Campbell

“…The expansion of carbohydrase and serine peptidase genes suggest that they combine to enable efficient digestion of cereal proteins. …”
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Dietary supplementation with 2-hydroxy-4-methyl(thio) butanoic acid and DL-methionine improves productive performance, egg quality and redox status of commercial laying ducks by Yanan Zhang, Zhiwei Zhuang, Tahir Mahmood, Yves Mercier, Yongyan Jin, Xuebing Huang, Kaichao Li, Shuang Wang, Weiguang Xia, Shenglin Wang, Miao Yu, Wei Chen, Chuntian Zheng

“…Dietary DL-Met or HMTBa supplementation increased taurine, methionine, leucine, tryptophan and arginine content, and decreased serine and lysine content in plasma (P < 0.05). The redox status of laying ducks was improved by enhancing the glutathione peroxidase and catalase activities, glutathione content and its ratio relative to glutathione (oxidized) content and decreasing malondialdehyde content and increasing mRNA expression of superoxide dismutase-1, glutathione peroxidase-1, hemeoxygenase-1 and nuclear factor-like 2 in liver and ileum with the supplementation of DL-Met or HMTBa (P < 0.05). …”
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Increased sinusoidal pressure impairs liver endothelial mechanosensing, uncovering novel biomarkers of portal hypertension by Martí Ortega-Ribera, Albert Gibert-Ramos, Laia Abad-Jordà, Marta Magaz, Luis Téllez, Lorena Paule, Elisa Castillo, Raül Pastó, Bruno de Souza Basso, Pol Olivas, Lara Orts, Juan José Lozano, Rosa Villa, Jaime Bosch, Agustín Albillos, Joan Carles García-Pagán, Jordi Gracia-Sancho

“…Two downstream targets inhibited by CBX7, namely, E-cadherin (ECAD) and serine protease inhibitor Kazal-type 1 (SPINK1), were found increased in the bloodstream of patients with PH and were highly predictive of PH and clinically significant PH. …”
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Impact of a TAK-1 inhibitor as a single or as an add-on therapy to riociguat on the metabolic reprograming and pulmonary hypertension in the SUGEN5416/hypoxia rat model by Daniel Morales-Cano, Daniel Morales-Cano, Daniel Morales-Cano, Daniel Morales-Cano, Daniel Morales-Cano, Jose Luis Izquierdo-García, Jose Luis Izquierdo-García, Jose Luis Izquierdo-García, Bianca Barreira, Bianca Barreira, Bianca Barreira, Sergio Esquivel-Ruiz, Sergio Esquivel-Ruiz, Sergio Esquivel-Ruiz, Maria Callejo, Maria Callejo, Maria Callejo, Rachele Pandolfi, Rachele Pandolfi, Rachele Pandolfi, Palmira Villa-Valverde, Palmira Villa-Valverde, Ignacio Rodríguez, Ignacio Rodríguez, Angel Cogolludo, Angel Cogolludo, Angel Cogolludo, Jesus Ruiz-Cabello, Jesus Ruiz-Cabello, Jesus Ruiz-Cabello, Francisco Perez-Vizcaino, Francisco Perez-Vizcaino, Francisco Perez-Vizcaino, Laura Moreno, Laura Moreno, Laura Moreno

“…Importantly, combined therapy had an additive effect on pulmonary vascular remodeling and induced a significant metabolic effect over taurine, amino acids, glycolysis, and TCA cycle metabolism via glycine-serine-threonine metabolism. However, it did not improve the effects induced by riociguat alone on pulmonary pressure or RV remodeling. …”
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Metabolomics and biochemical assays reveal the metabolic responses to hypo-salinity stress and osmoregulatory role of cAMP-PKA pathway in Mercenaria mercenaria by Cong Zhou, Hao Song, Jie Feng, Zhi Hu, Mei-jie Yang, Pu Shi, Yong-ren Li, Yong-jun Guo, Hai-zhou Li, Tao Zhang

“…Antioxidant metabolites, such as serine and Tyr-containing dipeptides, were significantly up-regulated to resist oxidative stress. …”
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RIPK1 mutations causing infantile-onset IBD with inflammatory and fistulizing features by Mutaz Sultan, Mohammad Adawi, Nitzan Kol, Nitzan Kol, Nitzan Kol, Blake McCourt, Blake McCourt, Ihda Adawi, Liran Baram, Liran Baram, Noa Tal, Noa Tal, Lael Werner, Lael Werner, Atar Lev, Atar Lev, Atar Lev, Atar Lev, Scott B. Snapper, Scott B. Snapper, Ortal Barel, Ortal Barel, Ortal Barel, Liza Konnikova, Liza Konnikova, Raz Somech, Raz Somech, Raz Somech, Raz Somech, Dror S. Shouval, Dror S. Shouval

“…PurposeReceptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an important regulator of necroptosis and inflammatory responses. …”
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Stigma/Style Cell-Cycle Inhibitor 1, a Regulator of Cell Proliferation, Interacts With a Specific 14-3-3 Protein and Is Degraded During Cell Division by Edward J. Strini, Edward J. Strini, Lígia T. Bertolino, Lígia T. Bertolino, Juca A. B. San Martin, Hebréia A. O. Souza, Francine Pessotti, Francine Pessotti, Vitor F. Pinoti, Vitor F. Pinoti, Pedro B. Ferreira, Pedro B. Ferreira, Henrique C. De Paoli, Henrique C. De Paoli, Greice Lubini, Greice Lubini, Luiz-Eduardo Del-Bem, Andréa C. Quiapim, Mateus Mondin, Ana Paula U. Araujo, Nubia B. Eloy, Matteo Barberis, Matteo Barberis, Matteo Barberis, Maria Helena S. Goldman, Maria Helena S. Goldman

“…Site-directed mutagenesis of seven serines into alanines in the predicted 14-3-3 binding sites on the SCI1 sequence prevented its degradation during mitosis. …”
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Association of HLA-class II alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population by Aya Kawasaki, Aya Kawasaki, Ken-ei Sada, Ken-ei Sada, Premita Ari Kusumawati, Premita Ari Kusumawati, Fumio Hirano, Fumio Hirano, Shigeto Kobayashi, Kenji Nagasaka, Takahiko Sugihara, Takahiko Sugihara, Nobuyuki Ono, Takashi Fujimoto, Makio Kusaoi, Naoto Tamura, Yasuyoshi Kusanagi, Kenji Itoh, Takayuki Sumida, Kunihiro Yamagata, Hiroshi Hashimoto, Hirofumi Makino, Yoshihiro Arimura, Yoshihiro Arimura, Masayoshi Harigai, Naoyuki Tsuchiya, Naoyuki Tsuchiya

“…Relapse-free survival was shorter with nominal significance in carriers of DRB1*09:01 (Puncorr=0.049, Q=0.42, hazard ratio [HR]:1.87), DQA1*03:02 (Puncorr=0.020, Q=0.22, HR:2.11) and DQB1*03:03 (Puncorr=0.043, Q=0.48, HR:1.91) than in non-carriers in the log-rank test. Conversely, serine carriers at position 13 of HLA-DRβ1 (HLA-DRβ1_13S), including DRB1*13:02 carriers, showed longer relapse-free survival with nominal significance (Puncorr=0.010, Q=0.42, HR:0.31). …”
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Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function by K. M. Hudock, K. M. Hudock, K. M. Hudock, M. S. Collins, M. A. Imbrogno, E. L. Kramer, E. L. Kramer, J. J. Brewington, J. J. Brewington, A. Ziady, A. Ziady, N. Zhang, N. Zhang, J. Snowball, Y. Xu, Y. Xu, Y. Xu, B. C. Carey, B. C. Carey, Y. Horio, Y. Horio, S. M. O’Grady, S. M. O’Grady, E. J. Kopras, J. Meeker, H. Morgan, A. J. Ostmann, E. Skala, M. E. Siefert, C. L. Na, C. R. Davidson, K. Gollomp, K. Gollomp, N. Mangalmurti, N. Mangalmurti, B. C. Trapnell, B. C. Trapnell, B. C. Trapnell, J. P. Clancy

“…Pretreatment of NETs with alpha-1 antitrypsin (A1AT) inhibits NET serine protease activity, limits E-cadherin cleavage, decreases bronchial cell apoptosis and preserves epithelial integrity. …”
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Macrophage RIPK3 triggers inflammation and cell death via the XBP1–Foxo1 axis in liver ischaemia–reperfusion injury by Xiaoye Qu, Tao Yang, Xiao Wang, Dongwei Xu, Yeping Yu, Jun Li, Longfeng Jiang, Qiang Xia, Douglas G. Farmer, Bibo Ke

“…Background &amp; Aims: Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) is a central player in triggering necroptotic cell death. …”
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Expression, characterization and organic solvent stability of protease from Bacillus pumilus 115b by Nazarirad, Peiman

“…As PMSF completely deactivated the recombinant protease activity, this protease was grouped as serine protease. The casein, a major protein component in milk was the most susceptible to hydrolysis compared to other substrates (albumin, haemoglobin, azocasien and azocoll). …”
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Genome sequencing and pathogenicity of recent infectious bursal disease viruses in Malaysia by Bako, Aliyu Hayatuddeen

“…Deduced aa sequences of HVR revealed the characteristic motifs that showed seven isolates belong to very virulent strains (genogroup 3), two isolates belong to variant strains (genogroup 2), and two have an identity to vaccine strain (genogroup 1) of IBD viruses. The serine rich-heptapeptide sequence “SWSASGS” was conserved in all 11 isolates. …”
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Deciphering the pharmacological effects of andrographolide on erythrocytes and Plasmodium falciparum 3D7 via metabolic changes by the ¹H NMR-based metabolomics approach by Alapid, Ashraf Ahmad Issa

“…Whereas in the iRBCs-AG, the disturbed metabolic pathways identified include glyoxylate and dicarboxylate metabolism, glycine, serine and threonine metabolism, and histidine metabolism. …”
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Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer by Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang

“…Protein cell division cycle 7 (CDC7) is a conserved serine/threonine kinase that plays important roles in the initiation of DNA replication and is associated with chemotherapy resistance in ovarian cancer. …”
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CK2β-regulated signaling controls B cell differentiation and function by Laura Quotti Tubi, Laura Quotti Tubi, Elisa Mandato, Elisa Mandato, Elisa Mandato, Sara Canovas Nunes, Sara Canovas Nunes, Sara Canovas Nunes, Arash Arjomand, Arash Arjomand, Fortunato Zaffino, Fortunato Zaffino, Sabrina Manni, Sabrina Manni, Alessandro Casellato, Alessandro Casellato, Paolo Macaccaro, Paolo Macaccaro, Nicola Vitulo, Sara Zumerle, Odile Filhol, Brigitte Boldyreff, Christian W. Siebel, Antonella Viola, Giorgio Valle, Federica Mainoldi, Stefano Casola, Valeria Cancila, Alessandro Gulino, Claudio Tripodo, Claudio Tripodo, Marco Pizzi, Angelo Paolo Dei Tos, Livio Trentin, Livio Trentin, Gianpietro Semenzato, Gianpietro Semenzato, Francesco Piazza, Francesco Piazza

“…Serine-Threonine kinase CK2 supports malignant B-lymphocyte growth but its role in B-cell development and activation is largely unknown. …”
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Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology by Lorraine N. Clark, Yizhe Gao, Gao T. Wang, Nora Hernandez, Allison Ashley-Koch, Joseph Jankovic, Ruth Ottman, Suzanne M. Leal, Sandra M. Barral Rodriguez, Elan D. Louis

“…Interpretation: Linkage and association analyses of WGS identified several novel ET candidate genes, which are implicated in four major pathways that include 1) the epidermal growth factor receptor-phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha-AKT serine/threonine kinase 1 (EGFR-PI3K-AKT) and Mitogen-activated protein Kinase 1 (ERK) pathways, 2) Reactive oxygen species (ROS) and DNA repair, 3) gamma-aminobutyric acid-ergic (GABAergic) system and 4) RNA binding and regulation of RNA processes. …”
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CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress by Fan Wu, Rui Hu, Xueping Huang, Jintao Lou, Ziyi Cai, Guisheng Chen, Wenji Zhao, Hao Xiong, Su-Hua Sha, Yiqing Zheng

“…We found that noise exposure increases phosphorylation of CFTR at serine 737 (p-CFTR, S737), which reduces wildtype CFTR function, resulting in oxidative stress in cochlear sensory hair cells. …”
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<i>Haslea silbo</i>, A Novel Cosmopolitan Species of Blue Diatoms by Romain Gastineau, Gert Hansen, Michel Poulin, Claude Lemieux, Monique Turmel, Jean-François Bardeau, Vincent Leignel, Yann Hardivillier, Michèle Morançais, Joël Fleurence, Pierre Gaudin, Vona Méléder, Eileen J. Cox, Nikolaï A. Davidovich, Olga I. Davidovich, Andrzej Witkowski, Irena Kaczmarska, James M. Ehrman, Emilio Soler Onís, Antera Martel Quintana, Maja Mucko, Solenn Mordret, Diana Sarno, Boris Jacquette, Charlotte Falaise, Julie Séveno, Niels L. Lindquist, Philip S. Kemp, Elif Eker-Develi, Merve Konucu, Jean-Luc Mouget

“…The two sequenced strains hosts three plasmids coding for putative serine recombinase protein whose sequences are compared, and four out of six of these plasmids were highly conserved.…”
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Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4 by Samantha Cooray, Fiona Price-Kuehne, Ying Hong, Ebun Omoyinmi, Alice Burleigh, Alice Burleigh, Kimberly C. Gilmour, Bilal Ahmad, Sangdun Choi, Mohammad W. Bahar, Paul Torpiano, Andrey Gagunashvili, Barbara Jensen, Evangelos Bellos, Evangelos Bellos, Vanessa Sancho-Shimizu, Vanessa Sancho-Shimizu, Jethro A. Herberg, Jethro A. Herberg, Kshitij Mankad, Atul Kumar, Marios Kaliakatsos, Austen J. J. Worth, Despina Eleftheriou, Elizabeth Whittaker, Elizabeth Whittaker, Paul A. Brogan

“…We describe a novel, severe autoinflammatory syndrome characterized by neuroinflammation, systemic autoinflammation, splenomegaly, and anemia (NASA) caused by bi-allelic mutations in IRAK4. IRAK-4 is a serine/threonine kinase with a pivotal role in innate immune signaling from toll-like receptors and production of pro-inflammatory cytokines. …”
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