Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition by Sandra Hoefgen, Alexander U. Bissell, Ying Huang, Fabio Gherlone, Luka Raguž, Christine Beemelmanns, Vito Valiante

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Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers by Amiram Sananes, Itay Cohen, Irit Allon, Oshrit Ben‐David, Raghda Abu Shareb, Ksenia M. Yegodayev, David Stepensky, Moshe Elkabets, Niv Papo

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YB-1 Phosphorylation at Serine 209 Inhibits Its Nuclear Translocation by Ekaterina M. Sogorina, Ekaterina R. Kim, Alexey V. Sorokin, Dmitry N. Lyabin, Lev P. Ovchinnikov, Daria A. Mordovkina, Irina A. Eliseeva

“…In particular, well-studied phosphorylation at serine 102 (S102) activates YB-1 nuclear import. Here, we report that Akt kinase phosphorylates YB-1 in vitro at serine 209 (S209), which is located in the vicinity of the YB-1 nuclear localization signal. …”
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Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. by Sumaira Z Hasnain, Michael A McGuckin, Richard K Grencis, David J Thornton

“…Specifically, the serine protease(s) acted on the N-terminal polymerising domain of the major intestinal mucin Muc2, resulting in depolymerisation of Muc2 polymers. …”
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Evolutionary divergence in the conformational landscapes of tyrosine vs serine/threonine kinases by Joan Gizzio, Abhishek Thakur, Allan Haldane, Ronald M Levy

“…Tyrosine kinases (TKs) typically show strong binding affinity with a wide spectrum of type-II inhibitors while serine/threonine kinases (STKs) usually bind more weakly which we suggest here is due to differences in the folded to extended conformational equilibrium of the activation loop between TKs vs. …”
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Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota by Xiaoyan Cui, Jingqing Chen, Jingqing Chen, Yuexi Yang

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Mutations in the Serine/Threonine Kinase BRAF: Oncogenic Drivers in Solid Tumors by Paola Roa, Nicole Virginia Bremer, Valentina Foglizzo, Emiliano Cocco

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D-SERINE CAN AMELIORATE ALTERATIONS IN MOTIVATION AND MOOD ASSOCIATED WITH AGING by Alejandro Meda-Hernández, Monica López-Hidalgo, Alejandra Calero-Vargas, Laura Nava-Gómez

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Proton Bridging in Catalysis by and Inhibition of Serine Proteases of the Blood Cascade System by Ildiko M Kovach

“…The principal conclusion of this review is that proton sharing at distances below the sum of van der Waals radii of the hydrogen and both donor and acceptor atoms contribute to the remarkable catalytic prowess of serine proteases of the blood clotting system and other enzymes that employ acid-base catalysis. …”
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Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. by Martin Horn, Pavla Fajtová, Liliana Rojo Arreola, Lenka Ulrychová, Pavla Bartošová-Sojková, Zdeněk Franta, Anna V Protasio, David Opavský, Jiří Vondrášek, James H McKerrow, Michael Mareš, Conor R Caffrey, Jan Dvořák

“…Most attention has focused on the 'cercarial elastase' serine proteases that facilitate skin invasion by infective schistosome larvae, and the cysteine and aspartic proteases that worms use to digest the blood meal. …”
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Plant Serpins: Potential Inhibitors of Serine and Cysteine Proteases with Multiple Functions by Monaliza Macêdo Ferreira, Ariana Silva Santos, Adriadna Souza Santos, Maria Zugaib, Carlos Priminho Pirovani

“…According to the eligible studies, serpins inhibit different serine and non-serine proteases from plants, animals, and pathogens, and their expression is affected by biotic and abiotic stresses. …”
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The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment by Xijia Zhou, Chang Tian, Yingshu Cao, Min Zhao, Ke Wang

Subjects: “…serine metabolism…”
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Genetic Variation of the Serine Acetyltransferase Gene Family for Sulfur Assimilation in Maize by Zhixuan Zhao, Shuai Li, Chen Ji, Yong Zhou, Changsheng Li, Wenqin Wang

“…Improving sulfur assimilation in maize kernels is essential due to humans and animals’ inability to synthesize methionine. Serine acetyltransferase (SAT) is a critical enzyme that controls cystine biosynthesis in plants. …”
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Serine Metabolism in Health and Disease and as a Conditionally Essential Amino Acid by Milan Holeček

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Serine is a new target residue for endogenous ADP-ribosylation on histones by Leidecker, O, Bonfiglio, J, Colby, T, Zhang, Q, Atanassov, I, Zaja, R, Palazzo, L, Stockum, A, Ahel, I, Matic, I

“…We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.…”

Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP. by Kaschani, F, Nickel, S, Pandey, B, Cravatt, B, Kaiser, M, van der Hoorn, R

“…Here, we use competitive activity-based protein profiling (ABPP) of serine hydrolases (SHs) to detect targets of these agrochemicals and other compounds in Arabidopsis thaliana. …”

Faropenem reacts with serine and metallo-β-lactamases to give multiple products by Lucic, A, Hinchliffe, P, Malla, T, Tooke, C, Brem, J, Calvopina, K, Lohans, C, Rabe, P, McDonough, M, Armistead, T, Orville, A, Spencer, J, Schofield, C

“…We report studies on the reactions of faropenem with carbapenem-hydrolysing β-lactamases, focusing on the class A serine βlactamase KPC-2 and the metallo β-lactamases (MBLs) VIM-2 (a subclass B1 MBL) and L1 (a B3 MBL). …”

Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana. by Kaschani, F, Gu, C, Niessen, S, Hoover, H, Cravatt, B, van der Hoorn, R

“…Except for some well characterized Ser hydrolases like subtilases TPP2 and ARA12, prolyl oligopeptidase acylamino acid-releasing enzyme, serine carboxypeptidase-like SNG1 and BRS1, carboxylesterase-like CXE12, methylesterases MES2 and MES3, and S-formylglutathione hydrolase, the majority of these serine hydrolases have not been described before. …”

Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia. by Burnet, P, Hutchinson, L, von Hesling, M, Gilbert, E, Brandon, N, Rutter, A, Hutson, P, Harrison, P

“…The NMDA receptor co-agonists D-serine and glycine are thought to contribute to glutamatergic dysfunction in schizophrenia. …”

Sugar promotes feeding in flies via the serine protease homologue scarface by Prasad, N, Hens, K

“…Here, we used Drosophila to understand how the brain responds to carbohydrate deprivation. We found that serine protease homologs (SPHs) are enriched among genes that are transcriptionally regulated in flies deprived of carbohydrates. …”