The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis. by Nao Itai, Tsukasa Shimazu, Takayuki Kimura, Issei Ibe, Ryo Yamashita, Yasushi Kaburagi, Taeko Dohi, Takashi Tonozuka, Toshifumi Takao, Atsushi Nishikawa

“…Using ESI-LCMS/MS analysis, we confirmed that SNX5 serine 226 is phosphorylated. Since SNX5 forms heterodimers with SNX1 or SNX2, we examined the effect of phosphorylation at S226 on the heterodimer formations. …”
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Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver by Hong Chen, Chong Liu, Qian Wang, Mingrui Xiong, Xia Zeng, Dong Yang, Yunhao Xie, Hua Su, Yu Zhang, Yixue Huang, Yuchen Chen, Junqiu Yue, Chengyu Liu, Shun Wang, Kun Huang, Ling Zheng

“…Chen et al. report on a renal UTX-phosphoglycerate dehydrogenase axis that regulates serine secretion to affect lipid metabolism in the kidney and liver upon over-nutrition, suggesting potential treatment targets for obesity-related diseases.…”
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Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization by Francesco Marchesani, Annalisa Michielon, Elisabetta Viale, Annalisa Bianchera, Davide Cavazzini, Loredano Pollegioni, Giulia Murtas, Andrea Mozzarelli, Stefano Bettati, Alessio Peracchi, Barbara Campanini, Stefano Bruno

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Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway by Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra, Gerta Hoxhaj

“…Here, the authors show that purine depletion induces serine synthesis to promote cancer cell migration and metastasis.…”
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Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling by Jugal Mohapatra, Kyuto Tashiro, Ryan L Beckner, Jorge Sierra, Jessica A Kilgore, Noelle S Williams, Glen Liszczak

“…Serine ADP-ribosylation (ADPr) is a DNA damage-induced post-translational modification catalyzed by the PARP1/2:HPF1 complex. …”
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Improving the catalytic activity of a detergent‐compatible serine protease by rational design by Xiao Wang, Xing Qin, Lige Tong, Jie Zheng, Tao Dong, Xiaolu Wang, Yuan Wang, Huoqing Huang, Bin Yao, Honglian Zhang, Huiying Luo

“…Abstract Serine proteases are among the most important biological additives in various industries such as detergents, leather, animal feed and food. …”
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SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism by Kory, Nora, Wyant, Gregory A., Prakash, Gyan, De Bos, Jelmi uit, Pacold, Michael E., Chan, Sze Ham, Lewis, Caroline A., Wang, Tim, Keys, Heather R., Sabatini, David M.

“…Purified SFXN1 transports serine in vitro. Thus, SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism.…”
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Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy by Pikman, Yana, Ocasio-Martinez, Nicole, Alexe, Gabriela, Dimitrov, Boris, Kitara, Samuel, Diehl, Frances F, Robichaud, Amanda L, Conway, Amy Saur, Ross, Linda, Su, Angela, Ling, Frank, Qi, Jun, Roti, Giovanni, Lewis, Caroline A, Puissant, Alexandre, Vander Heiden, Matthew G, Stegmaier, Kimberly

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Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy by Pikman, Yana, Ocasio-Martinez, Nicole, Alexe, Gabriela, Dimitrov, Boris, Kitara, Samuel, Diehl, Frances F., Robichaud, Amanda L, Conway, Amy Saur, Ross, Linda, Su, Angela, Ling, Frank, Qi, Jun, Roti, Giovanni, Lewis, Caroline, Puissant, Alexandre, Vander Heiden, Matthew G., Stegmaier, Kimberly

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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

“…Metabolic constraints imposed by the serine and glycine–limited brain environment restrict metastatic tumor growth. …”
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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition by Luengo, Alba, Ahmed, Ali, Sabatini, David, Vander Heiden, Matthew G.

“…Metabolic constraints imposed by the serine and glycine–limited brain environment restrict metastatic tumor growth. …”
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Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer by Possemato, Richard, Marks, Kevin M., Kim, Dohoon, Birsoy, Kivanc, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G., Jha, Abhishek K., Chen, Walter W., Barrett, Francesca G., Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S., Barretina, Jordi, Kalaany, Nada Y., Hsu, Peggy P., Ottina, Kathleen, Chan, Albert M., Yuan, Bingbing B., Garraway, Levi A., Root, David E., Mino-Kenudson, Mari, Brachtel, Elena F., Driggers, Edward M., Shaul, Yoav, Pacold, Michael Edward, Sabatini, David

“…PHGDH catalyses the first step in the serine biosynthesis pathway, and breast cancer cells with high PHGDH expression have increased serine synthesis flux. …”
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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy by Vander Heiden, Matthew G.

“…PKM2 activation resulted in a metabolic rewiring of cancer cells manifested by a profound dependency on the nonessential amino acid serine for continued cell proliferation. Induction of serine auxotrophy by PKM2 activation was accompanied by reduced carbon flow into the serine biosynthetic pathway and increased expression of high affinity serine transporters. …”
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X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate. by Wilmouth, R, Edman, K, Neutze, R, Wright, P, Clifton, I, Schneider, T, Schofield, C, Hajdu, J

“…Studies on the catalytic mechanism and inhibition of serine proteases are widely used as paradigms for teaching enzyme catalysis. …”

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition. by Migaud, M, Wilmouth, R, Mills, G, Wayne, G, Risley, C, Chambers, C, Macdonald, S, Schofield, C

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. by Brault, L, Gasser, C, Bracher, F, Huber, K, Knapp, S, Schwaller, J

“…The identification as cooperating targets of Proviral Integrations of Moloney virus in murine lymphomas suggested early on that PIM serine/threonine kinases play an important role in cancer biology. …”

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition. by Migaud, M, Wilmouth, R, Mills, G, Wayne, G, Risley, C, Chambers, C, Macdonald, S, Schofield, C

Reaction of clavams with elastase reveals a general method for inhibiting 'serine' enzymes by Wilmouth, R, Li, Y, Wright, P, Claridge, T, Aplin, RT, Schofield, C

“…Formation of such derivatives maybe a general way of inhibiting 'serine' enzymes. (C) 2000 Elsevier Science Ltd.…”

Syntheses of (S)-beta-pyrazolylalanine and (S)-quisqualic acid from a serine-derived aziridine by Farthing, C, Baldwin, J, Russell, A, Schofield, C, Spivey, A

Serine-linked PARP1 auto-modification controls PARP inhibitor response. by Prokhorova, E, Zobel, F, Smith, R, Zentout, S, Gibbs-Seymour, I, Schützenhofer, K, Peters, A, Groslambert, J, Zorzini, V, Agnew, T, Brognard, J, Nielsen, ML, Ahel, D, Huet, S, Suskiewicz, MJ, Ahel, I

“…Following recent findings that PARP1- or PARP2-mediated modification is predominantly serine-linked, we demonstrate here that serine ADPr plays a vital role in cellular responses to PARP1/PARP2 inhibitors. …”