Significance of the d-Serine-deaminase and d-Serine metabolism of staphylococcus saprophyticus for virulence by Kline, Kimberly A., Korte-Berwanger, Miriam, Sakinc, Türkan, Nielsen, Hailyn V., Hultgren, Scott, Gatermann, Sören G.

“…Staphylococcus saprophyticus is the only species of Staphylococcus that is typically uropathogenic and possesses a gene coding for a D-serine-deaminase (DsdA). As D-serine is prevalent in urine and toxic or bacteriostatic to many bacteria, it is not surprising that the D-serine-deaminase gene is found in the genome of uropathogens. …”
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The role of serine-type serine repeat antigen in plasmodium yoelii blood stage development by Huang, Ximei, Liew, Kingsley Jiin Liang, Natalang, Onguma, Siau, Anthony, Zhang, Neng, Preiser, Peter Rainer

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The importance of serine metabolism in cancer by Mattaini, Katherine Ruth, Sullivan, Mark Robert, Vander Heiden, Matthew G.

“…In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells increase serine synthesis from glucose and require de novo serine synthesis even in the presence of abundant extracellular serine. …”
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Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting by Sullivan, Mark Robert, Mattaini, Katherine Ruth, Dennstedt, Emily A, Nguyen, Anna, Sivanand, Sharanya, Reilly, Montana F., Meeth, Katrina, Muir, Alexander, Darnell, Alicia, Bosenberg, Marcus W., Lewis, Caroline A., Vander Heiden, Matthew G.

“…However, whether increased serine synthesis promotes tumor growth and how serine synthesis benefits tumors is controversial. …”
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D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO). by Sikka, P, Walker, R, Cockayne, R, Wood, M, Harrison, P, Burnet, P

“…D-serine is an endogenous N-methyl-D-aspartate (NMDA) receptor coagonist. …”

The role of serine metabolism in B lymphocytes by Khan, A

“…I found no effect on proliferation or viability of serine and glycine deprivation on wild type B cells. …”

Serine 297 and serine 306: Two new phosphorylation sites involved in the regulation of Connexin43 during ischemia by Axelsen, L, Mohammed, S, Kjolbye, A, Nielsen, MS, Holstein-Rathlou, N, Jensen, O, Andersen, S, Hennan, J, Stahlhut, M

Functions and evolution of FAM111 serine proteases by Allison L. Welter, Allison L. Welter, Yuichi J. Machida

“…Proteolysis plays fundamental and regulatory roles in diverse cellular processes. The serine protease FAM111A (FAM111 trypsin-like peptidase A) emerged recently as a protease involved in two seemingly distinct processes: DNA replication and antiviral defense. …”
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A serine sensor for multicellularity in a bacterium by Arvind R Subramaniam, Aaron DeLoughery, Niels Bradshaw, Yun Chen, Erin O’Shea, Richard Losick, Yunrong Chai

“…As serine is one of the first amino acids to be exhausted at the end of exponential phase growth, reduced translation speed at serine codons may be exploited by other microbes in adapting to stationary phase.…”
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L-serine: Neurological Implications and Therapeutic Potential by Soe Maung Maung Phone Myint, Liou Y. Sun

Subjects: “…L-serine…”
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OMICS INSIGHTS INTO SERINE METABOLISM IN ALZHEIMER’S DISEASE by Valentina Rabattoni, Giulia Murtas, Elisa Maffioli, Beatrice Badone, Tripodi Farida, Filomena Iannuzzi, Danilo Licastro, Simona Nonnis, Anna Rinaldi, Zoraide Motta, Silvia Sacchi, Nadia Canu, Gabriella Tedeschi, Paola Cocetti, Loredano Pollegioni

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Linking Serine/Glycine Metabolism to Radiotherapy Resistance by Anaís Sánchez-Castillo, Marc Vooijs, Kim R. Kampen

Subjects: “…serine and glycine metabolism…”
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Structural analyses on intermediates in serine protease catalysis. by Liu, B, Schofield, C, Wilmouth, R

“…Although the subject of many studies, detailed structural information on aspects of the catalytic cycle of serine proteases is lacking. Crystallographic analyses were performed in which an acyl-enzyme complex, formed from elastase and a peptide, was reacted with a series of nucleophilic dipeptides. …”

Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase. by Leartsakulpanich, U, Kongkasuriyachai, D, Imwong, M, Chotivanich, K, Yuthavong, Y

“…Serine hydroxymethyltransferase (SHMT), which catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate, is one of the three enzymes in dTMP synthesis pathway that is highly active during cell division and has been proposed as a potential chemotherapeutic target in infectious diseases and cancer. …”

Structural and functional analysis of serine-ADP-ribosylation by Fontana, P

“…In the second chapter, I will show a structural and biochemical characterisation of HPF1 and the discovery of HPF1 as a specificity factor inducing a novel post-translational modification named serine-ADP-ribosylation. In the third chapter, I will show that serine-ADP-ribosylation induced by HPF1 is a reversible post-translational modification. …”

Serine ADP-Ribosylation Depends on HPF1 by Bonfiglio, J, Fontana, P, Zhang, Q, Colby, T, Gibbs-Seymour, I, Atanassov, I, Bartlett, E, Zaja, R, Ahel, I, Matic, I

“…Recently, by precision mapping on all possible amino acid residues, we identified histone serine ADPr marks in the DNA damage response. However, the biochemical basis underlying this serine modification remained unknown. …”

Interplay of histone marks with serine ADP-ribosylation by Bartlett, E, Bonfiglio, J, Prokhorova, E, Colby, T, Zobel, F, Ahel, I, Matic, I

“…Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1). …”

α-Synuclein serine129 phosphorylation – the physiology of pathology by Nagendran Ramalingam, Ulf Dettmer

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Effects of l-Serine on Macrolide Resistance in Streptococcus suis by Tong Wu, Xiaozhen Wang, Yue Dong, Chen Xing, Xueying Chen, Lu Li, Chunliu Dong, Yanhua Li

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Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function by Nathalie Dautin

“…Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) constitute a large family of proteases secreted by Escherichia coli and Shigella. …”
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