Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation by Nicole Albrecht, Nicole Tegtmeyer, Heinrich Sticht, Joanna Skórko-Glonek, Steffen Backert

“…The HtrA family of serine proteases is found in most bacteria, and plays an essential role in the virulence of the gastric pathogen Helicobacter pylori. …”
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Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants. by Mallinath Chakraborty, Eamon P McGreal, Andrew Williams, Philip L Davies, Wendy Powell, Salima Abdulla, Nikolai N Voitenok, John Hogwood, Elaine Gray, Brad Spiller, Rachel C Chambers, Sailesh Kotecha

“…Purified neutrophil serine proteases efficiently converted interleukin-877 to shorter isoforms in a time- and dose-dependent fashion; shorter interleukin-8 isoforms were primarily responsible for neutrophil chemotaxis (p<0.001). …”
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Human primary endothelial label-free biochip assay reveals unpredicted functions of plasma serine proteases by Márta Lídia Debreczeni, Inna Szekacs, Boglarka Kovacs, Andras Saftics, Sándor Kurunczi, Péter Gál, József Dobó, László Cervenak, Robert Horvath

“…Using our EnLaB platform, we screened a set of plasma serine proteases as possible endothelial cell activators, and first identified the endothelial cell activating function of three important serine proteases – namely kallikrein, C1r and mannan-binding lectin-associated serine-protease 2 (MASP-2) – and verified these results in well-established functional assays. …”
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Correction: A Novel Serine Protease Secreted by Medicinal Maggots Enhances Plasminogen Activator-Induced Fibrinolysis

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Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network. by Joakim E Swedberg, Simon J de Veer, Kei C Sit, Cyril F Reboul, Ashley M Buckle, Jonathan M Harris

“…BACKGROUND: Canonical serine protease inhibitors commonly bind to their targets through a rigid loop stabilised by an internal hydrogen bond network and disulfide bond(s). …”
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Molecular characterization of a putative serine protease from Trichinella spiralis and its elicited immune protection by Ge Ge Sun, Hua Nan Ren, Ruo Dan Liu, Yan Yan Song, Xin Qi, Chen Xi Hu, Fan Yang, Peng Jiang, Xi Zhang, Zhong Quan Wang, Jing Cui

“…Abstract In our previous work, a Trichinella spiralis putative serine protease (TsSP) was identified from ES products of T. spiralis intestinal infective larvae (IIL) and adult worms (AW) by immunoproteomics: it was highly expressed in IIL compared with muscle larvae (ML). …”
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Spontaneous binding of potential COVID-19 drugs (Camostat and Nafamostat) to human serine protease TMPRSS2 by Haixia Zhu, Wenhao Du, Menghua Song, Qing Liu, Andreas Herrmann, Qiang Huang

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In order to lower the antinutritional activity of serine protease inhibitors, we need to understand their role in seed development by Juan Vorster, Willem van der Westhuizen, Gedion du Plessis, Diana Marais, Francesca Sparvoli, Eleonora Cominelli, Emanuela Camilli, Marika Ferrari, Cinzia Le Donne, Stefania Marconi, Silvia Lisciani, Alessia Losa, Tea Sala, Karl Kunert

Subjects: “…serine proteases…”
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CRISPR/Cas9-mediated Serine protease 2 disruption induces male sterility in Spodoptera litura by Honglun Bi, Xia Xu, Xiaowei Li, Yaohui Wang, Shutang Zhou, Yongping Huang

“…Here, we focus on the Serine protease 2 (Ser2) gene in the lepidopteran pest Spodoptera litura. …”
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Pharmacokinetics of Nafamostat, a Potent Serine Protease Inhibitor, by a Novel LC-MS/MS Analysis by Hyeon Seok Oh, Taehyung Kim, Dong-Hyeon Gu, Tae Suk Lee, Tae Hwan Kim, Soyoung Shin, Beom Soo Shin

“…Nafamostat, a synthetic serine protease inhibitor, has been used for the treatment of inflammatory diseases such as pancreatitis. …”
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Trypsin-like serine proteases in Lutzomyia longipalpis--expression, activity and possible modulation by Leishmania infantum chagasi. by Erich Loza Telleria, Adriana Pereira Oliveira de Araújo, Nágila Francinete Secundino, Claudia Masini d'Avila-Levy, Yara Maria Traub-Csekö

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Systematic functional analysis and potential application of a serine protease from cold-adapted Planococcus bacterium by Weijun Leng, Xiaoyun Wu, Xianghui Qi, Hongying Liu, Li Yuan, Ruichang Gao

“…In this study, a gene encoding serine protease (PmSpr288) from cold-adapted bacterium, namely Planococcus maritimus XJ11, was cloned and overexpressed in Escherichia coli BL21 (DE3). …”
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The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol by Flores Rhonda, Chen Ding, Gong Siqi, Lei Lei, Wu Xiang, Zhong Guangming

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Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment by Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati

“…A single-crystal X-ray analysis of the complex of the human mitochondrial caseinolytic serine protease type C (<i>h</i>ClpP) and ONC201 (PDB ID: 6DL7) allowed <i>h</i>ClpP to be identified as its main target. …”
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Impacts of transmembrane serine protease 4 expression on susceptibility to severe acute respiratory syndrome coronavirus 2 by Qi Tan, Jiewen Fu, Zhiying Liu, Haoyue Deng, Lianmei Zhang, Jiayue He, Xiaotao Li, Junjiang Fu, Xiangxiang Pan, Peifang Wei

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Involvement of the serine protease inhibitor, SERPINE2, and the urokinase plasminogen activator in cumulus expansion and oocyte maturation. by Chung-Hao Lu, Robert Kuo-Kuang Lee, Yuh-Ming Hwu, Ming-Huei Lin, Ling-Yu Yeh, Ying-Jie Chen, Shau-Ping Lin, Sheng-Hsiang Li

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Serine protease CrKP43 interacts with MAPK and regulates fungal development and mycoparasitism in Clonostachys chloroleuca by Binna Lv, Xue Zhao, Yan Guo, Shidong Li, Manhong Sun

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Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros. by Sakthivel Vaiyapuri, Robert A Harrison, Andrew B Bicknell, Jonathan M Gibbins, Gail Hutchinson

“…Serine proteases are a major component of viper venoms and are thought to disrupt several distinct elements of the blood coagulation system of envenomed victims. …”
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Purification and partial characterization of a coagulant serine protease from the venom of the Iranian snake Agkistrodon halys by M Ghorbanpur, A Zare Mirakabadi, F Zokaee, H Zolfagarrian, H Rabiei

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N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding by Hao Wang, Shuo Li, Juejin Wang, Shenghan Chen, Xue-Long Sun, Qingyu Wu

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