Transmigration of melanoma cells through the blood-brain barrier: role of endothelial tight junctions and melanoma-released serine proteases. by Csilla Fazakas, Imola Wilhelm, Péter Nagyoszi, Attila E Farkas, János Haskó, Judit Molnár, Hannelore Bauer, Hans-Christian Bauer, Ferhan Ayaydin, Ngo Thi Khue Dung, László Siklós, István A Krizbai

“…During this process melanoma cells produced and released large amounts of proteolytic enzymes, mainly gelatinolytic serine proteases, including seprase. The serine protease inhibitor Pefabloc® was able to decrease to 44-55% the number of melanoma cells migrating through CECs. …”
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Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels by Yutaka Kakizoe, Terumasa Nakagawa, Yasunobu Iwata, Qinyuan Deng, Masataka Adachi, Yoshikazu Miyasato, Miyuki Nakagawa, Yu Nagayoshi, Kayo Nishiguchi, Yuki Narita, Yuichiro Izumi, Takashige Kuwabara, Kimio Tomita, Kenichiro Kitamura, Masashi Mukoyama

Subjects: “…Serine protease…”
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A putative cytotoxic serine protease from Salmonella typhimurium UcB5 recovered from undercooked burger by Essam Kotb, Baher A. El-Nogoumy, Haifa A. Alqahtani, Asmaa A. Ahmed, Hussah A. Al-shwyeh, Sakina M. Algarudi, Hanan Almahasheer

“…It was drastically inhibited by TLCK, PMSF, SBTI, and aprotinin while, DTT, β-mercaptoethanol, 2,2′-bipyridine, o-phenanthroline, EDTA, and EGTA had no effect, which suggested a serine protease-type. Also, it has shown a broad substrate specificity against a broad range of natural proteins including serum proteins. …”
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Bacillaceae serine proteases and Streptomyces epsilon-poly-l-lysine synergistically inactivate Caliciviridae by inhibiting RNA genome release by Soh Yamamoto, Noriko Ogasawara, Yuka Sudo-Yokoyama, Sachiko Sato, Nozomu Takata, Nana Yokota, Tomomi Nakano, Kyoko Hayashi, Akira Takasawa, Mayumi Endo, Masako Hinatsu, Keitaro Yoshida, Toyotaka Sato, Satoshi Takahashi, Kenichi Takano, Takashi Kojima, Jun Hiraki, Shin-ich Yokota

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SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. by Adrian Leontovyč, Lenka Ulrychová, Anthony J O'Donoghue, Jiří Vondrášek, Lucie Marešová, Martin Hubálek, Pavla Fajtová, Marta Chanová, Zhenze Jiang, Charles S Craik, Conor R Caffrey, Michael Mareš, Jan Dvořák, Martin Horn

“…BACKGROUND:Serine proteases are important virulence factors for many pathogens. …”
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Optimization of the conditions for extraction of serine protease from kesinai plant (Streblus asper) leaves using response surface methodology. by Mehrnoush, Amid, Mustafa, Shuhaimi, Sarker, Zaidul Islam, Abd. Manap, Mohd. Yazid

“…Response surface methodology (RSM) using a central composite design (CCD) was employed to optimize the conditions for extraction of serine protease from kesinai (Streblus asper) leaves. …”
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Zymography of proteases in honey bees (Apis Mellifera) infected with Nosema ceranae by Doghuzlu Mohammad Afrasiabi, Nabian Sedigheh, Paghaleh Gholam Ali Nehzati, Taheri Mohammad, Asadollahi Zahra, Akhzari Soheila

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Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients by Lei Zhao, Yasuto Yamaguchi, Xiaomei Ge, William H. Robinson, John Morser, Lawrence L. K. Leung

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Extracellular proteolytic enzymes produced by human pathogenic Vibrio species by Shin-Ichi eMiyoshi

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Signal transduction pathways in mast cell granule-mediated endothelial cell activation by Luqi Chi, Lisa Stehno-bittel, Irina Smirnova, Daniel J Stechschulte, Kottarappat N. Dileepan

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Correlation of Serum Vaspin Level with the Severity of Cardiovascular Risk in Patients with Acute Coronary Syndrome: A Cross-sectional Study by S Harshitha, P Renuka, M Vengatesh, V Sriram, RB Pavithra, VM Vinodhini

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Crystal Structure of Bovine Alpha-Chymotrypsin in Space Group P6₅ by Andrew C. Marshall, Benjamin G. Keiller, Jordan L. Pederick, Andrew D. Abell, John B. Bruning

Subjects: “…trypsin-like serine protease…”
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Serine protease Rv2569c facilitates transmission of Mycobacterium tuberculosis via disrupting the epithelial barrier by cleaving E-cadherin. by Xinxin Zang, Jiajun Zhang, Yanyan Jiang, Tingting Feng, Yingying Cui, Hui Wang, Ziyin Cui, Guanghui Dang, Siguo Liu

“…Collectively, these results strongly suggest that M.tb employs the serine protease Rv2569c to disrupt epithelial defenses and facilitate its systemic dissemination by crossing the epithelial barrier.…”
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Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries. by Olivier Barré, Antoine Dufour, Ulrich Eckhard, Reinhild Kappelhoff, François Béliveau, Richard Leduc, Christopher M Overall

“…BACKGROUND:Type II transmembrane serine proteases (TTSPs) are a family of cell membrane tethered serine proteases with unclear roles as their cleavage site specificities and substrate degradomes have not been fully elucidated. …”
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Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes by Sowmiya Palani, Yuka Machida, Julia R. Alvey, Vandana Mishra, Allison L. Welter, Gaofeng Cui, Benoît Bragantini , Maria Victoria Botuyan, Anh T. Q. Cong, Georges Mer, Matthew J. Schellenberg, Yuichi J. Machida

“…Abstract FAM111A, a serine protease, plays roles in DNA replication and antiviral defense. …”
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The Procoagulant Snake Venom Serine Protease Potentially Having a Dual, Blood Coagulation Factor V and X-Activating Activity by Zorica Latinović, Adrijana Leonardi, Cho Yeow Koh, R. Manjunatha Kini, Alenka Trampuš Bakija, Jože Pungerčar, Igor Križaj

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The spleen as a possible source of serine protease inhibitors and migrating monocytes required for liver regeneration after 70% resection in mice by Andrey Elchaninov, Andrey Elchaninov, Polina Vishnyakova, Polina Vishnyakova, Maria Kuznetsova, Elena Gantsova, Elena Gantsova, Viktoria Kiseleva, Anastasiya Lokhonina, Anastasiya Lokhonina, Maria Antonova, Aiaz Mamedov, Anna Soboleva, Dmitry Trofimov, Timur Fatkhudinov, Timur Fatkhudinov, Gennady Sukhikh

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Serine Protease-Mediated Cutaneous Inflammation: Characterization of an Ex Vivo Skin Model for the Assessment of Dexamethasone-Loaded Core Multishell-Nanocarriers by Janna Frombach, Fiorenza Rancan, Katharina Kübrich, Fabian Schumacher, Michael Unbehauen, Ulrike Blume-Peytavi, Rainer Haag, Burkhard Kleuser, Robert Sabat, Kerstin Wolk, Annika Vogt

“…Among the various pathological alterations in inflamed skin, aberrant serine protease (SP) activity directly affects the biochemical environment in the superficial compartments, which interact with topically applied formulations. …”
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Isolation and Characterization of Poecistasin, an Anti-Thrombotic Antistasin-Type Serine Protease Inhibitor from Leech <i>Poecilobdella manillensis</i> by Xiaopeng Tang, Mengrou Chen, Zilei Duan, James Mwangi, Pengpeng Li, Ren Lai

“…Antistasin, first identified as a potent inhibitor of the blood coagulation factor Xa, is a novel family of serine protease inhibitors. In this study, we purified a novel antistasin-type inhibitor from leech <i>Poecilobdella manillensis</i> called poecistasin. …”
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The extracellular serine protease from Staphylococcus epidermidis elicits a type 2-biased immune response in atopic dermatitis patients by Goran Abdurrahman, Rebecca Pospich, Leif Steil, Manuela Gesell Salazar, Juan José Izquierdo González, Nicole Normann, Daniel Mrochen, Christian Scharf, Uwe Völker, Thomas Werfel, Thomas Werfel, Barbara M. Bröker, Lennart M. Roesner, Lennart M. Roesner, Lidia Gómez-Gascón

“…Mature Esp cleaved and activated the alarmin IL-33.ConclusionThe extracellular serine protease Esp of S. epidermidis can activate IL-33. …”
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