Toxoplasma gondii Suppresses Th2-Induced by Trichinella spiralis Infection and Downregulates Serine Protease Genes Expression: A Critical Role in Vaccine Development by Enas Fakhry Abdel Hamed, Nahed ElSayed Mostafa, Eman Magdy Fawzy, Mohamed Nabil Ibrahim, Basma Hamed Ibrahim, Mona Radwan, Marwa Ahmed Salama

“…Methods: The parasite burden, the expression of T. gondii rhoptry kinase ROP18 and T. spiralis putative serine protease (TsSP), the IgG1 and IgG2a responses, besides histopathological and immunohistochemical staining with iNOS and arginase were used to evaluate the dynamics of coinfection. …”
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Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease. by Martin Zühlsdorf, Sebastiaan Werten, Barbara G Klupp, Gottfried J Palm, Thomas C Mettenleiter, Winfried Hinrichs

“…Herpesviruses encode a characteristic serine protease with a unique fold and an active site that comprises the unusual triad Ser-His-His. …”
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Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury by Domenico Mercurio, Francesca Pischiutta, Serena Seminara, Francesca Tribuzio, Ilaria Lisi, Laura Pasetto, Valentina Bonetto, Maria-Grazia De Simoni, Wilhelm Schwaeble, Sadam Yaseen, Thomas Dudler, Elisa R. Zanier, Stefano Fumagalli

Subjects: “…Mannan-binding lectin-associated serine proteases…”
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Cloning, Expression, and Structural Elucidation of a Biotechnologically Potential Alkaline Serine Protease From a Newly Isolated Haloalkaliphilic Bacillus lehensis JO-26 by Hitarth B. Bhatt, Satya P. Singh

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Study on active capacity and detergent application potential of low-temperature alkaline serine protease produced by new strain Exiguobacterium indicum 1.2.3 by Ahmet Kati, Gamze Balci

“…This strain produced alkaline serine protease, which works in lower temperatures (20–40 °C) with casein as a specific substrate. …”
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Nasopharyngeal Expression of Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 in Children within SARS-CoV-2-Infected Family Clusters by Mohammad Rubayet Hasan, Muneera Naseer Ahmad, Soha Roger Dargham, Hatem Zayed, Alaa Al Hashemi, Nonhlanhla Ngwabi, Andres Perez Lopez, Simon Dobson, Laith Jamal Abu Raddad, Patrick Tang

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A rare CTSC mutation in Papillon-Lefèvre Syndrome results in abolished serine protease activity and reduced NET formation but otherwise normal neutrophil function. by Felix P Sanchez Klose, Halla Björnsdottir, Agnes Dahlstrand Rudin, Tishana Persson, Arsham Khamzeh, Martina Sundqvist, Sara Thorbert-Mros, Régis Dieckmann, Karin Christenson, Johan Bylund

“…CTSC is responsible for the activation of the pro-forms of the neutrophil serine proteases (NSPs; Elastase, Proteinase 3 and Cathepsin G), suggesting its involvement in a variety of neutrophil functions. …”
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Oral vaccination of mice with attenuated Salmonella encoding Trichinella spiralis calreticulin and serine protease 1.1 confers protective immunity in BALB/c mice. by Sheng Jie Bai, Lu Lu Han, Ruo Dan Liu, Shao Rong Long, Xi Zhang, Jing Cui, Zhong Quan Wang

“…In this study, two novel T. spiralis genes (calreticulin and serine protease 1.1) in combination were used to construct oral DNA vaccines, and their induced protective immunity was evaluated in a murine model.…”
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Nafamostat Mesilate, a Potent Serine Protease Inhibitor, Inhibits Airway Eosinophilic Inflammation and Airway Epithelial Remodeling in a Murine Model of Allergic Asthma by Masayuki Ishizaki, Hiroyuki Tanaka, Daisuke Kajiwara, Tatsuyuki Toyohara, Keiko Wakahara, Naoki Inagaki, Hiroichi Nagai

“…To clarify the involvement of serine proteases in the development of allergic airway inflammation, we investigated the effect of nafamostat mesilate, a serine protease inhibitor, in a murine model of allergic asthma. …”
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Excreted/Secreted 15-kDa Proteins and Serine Protease Peptides from <i>Haemonchus contortus</i> Act as Immune-Response Enhancers in Lambs by René Camas-Pereyra, Génesis Andrea Bautista-García, Gustavo Pérez-Anzúrez, Zaira Carolina Duran-Cortes, David Emanuel Reyes-Guerrero, Jocelyn Maza-Lopez, Agustín Olmedo-Juárez, María Eugenia López-Arellano

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Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2. by Vorup-Jensen, T, Petersen, S, Hansen, A, Poulsen, K, Schwaeble, W, Sim, R, Reid, K, Davis, S, Thiel, S, Jensenius, J

“…Structural similarities shared by MBL and C1 complexes and by the MBL- and C1q-associated serine proteases, MBL-associated serine protease (MASP)-1 and MASP-2, and C1r and C1s, respectively, have led to the expectation that the pathways of complement activation by MBL and C1 complexes are likely to be very similar. …”

Purification of serine proteases from mango (Mangifera indica cv. Chokanan) peel using expanded bed adsorption: optimisation using response surface methodology by Amid, Mehrnoush, Abd Manap, Mohd Yazid

“…It was demonstrated that the serine protease could be recovered with a yield of 82% and a purification factor of 11.3 after a single step elution with 1.0 M NaCl. …”
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Safety and efficacy of live attenuated serine protease Vibrio harveyi (MVh_vhs) vaccine against vibriosis in Asian seabass [Lates calcarifer (Bloch, 1790)] by Chin, Yong Kit

“…Vibrio species is bacteria that cause natural outbreak of Vibriosis in marine aquaculture and cause the serious economic loss indirectly particularly in the early development of farmed fishes’ species. Live attenuated serine protease V. harveyi (MVh_vhs) was developed previously as vaccine candidate for farmed fishes against V. harveyi. …”
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Genome resequencing and genome-wide polymorphisms in mosquito vectors Aedes aegypti and Aedes albopictus from south India by Preeti Acharya, Upasana Shyamsunder Singh, Veeramanoharan Rajamannar, Mayilsamy Muniaraj, Binata Nayak, Aparup Das

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Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis by Steven P. Grover, Nigel Mackman

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Mast Cell and Basophil Granule Proteases - In Vivo Targets and Function by Lars Hellman, Srinivas Akula, Zhirong Fu, Sara Wernersson

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TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice by Jingjing Zhang, Jingjing Zhang, Xinli Zhou, Danyang Wan, Li Yu, Xu Chen, Tong Yan, Zhu Wu, Meimei Zheng, Meimei Zheng, Feng Zhu, Feng Zhu, Hui Zhu

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Bio-Mechanism of Catechin as Pheromone Signal Inhibitor: Prediction of Antibacterial Agent Action Mode by In Vitro and In Silico Study by Dikdik Kurnia, Zenika Febian Ramadhanty, Aprilina Mora Ardani, Achmad Zainuddin, Hendra Dian Adhita Dharsono, Mieke Hemiawati Satari

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Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2) by Noor Rahman, Zarrin Basharat, Muhammad Yousuf, Giuseppe Castaldo, Luca Rastrelli, Haroon Khan

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Serpin functions in host-pathogen interactions by Jialing Bao, Guoqing Pan, Mortimer Poncz, Junhong Wei, Maoshuang Ran, Zeyang Zhou

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