Establishing the Inhibition of the Serine Protease Plasmin as a Skin Anti-Aging Pathway by Remo Campiche, Dominik Imfeld, Chennakesava Cuddapah, Leithe Budel, Mathias Gempeler

“…Plasmin is a serine protease induced by UV-irradiation in skin that contributes to inflammation. …”
Get full text

Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function by Qingyu Wu, Shuo Li, Xianrui Zhang, Ningzheng Dong

Subjects: “…type II transmembrane serine protease…”
Get full text

The Activity of Metalloproteases and Serine Proteases in Various Organs after Leiurus macroctenus Envenomation by Valery Gunas, Oleksandr Maievskyi, Nataliia Raksha, Tetiana Vovk, Oleksiy Savchuk, Serhii Shchypanskyi, Igor Gunas

“…The present study aimed to examine the total proteolysis levels in various organs after Leiurus macroctenus envenomation and evaluate the metalloproteases and serine proteases’ contributions to the total proteolytic activity. …”
Get full text

Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets by Asrar Alam

“…This review focuses on the potential of P. falciparum serine proteases as antimalarial drug targets.…”
Get full text

Improving the catalytic activity of a detergent‐compatible serine protease by rational design by Xiao Wang, Xing Qin, Lige Tong, Jie Zheng, Tao Dong, Xiaolu Wang, Yuan Wang, Huoqing Huang, Bin Yao, Honglian Zhang, Huiying Luo

“…Abstract Serine proteases are among the most important biological additives in various industries such as detergents, leather, animal feed and food. …”
Get full text

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate. by Wilmouth, R, Edman, K, Neutze, R, Wright, P, Clifton, I, Schneider, T, Schofield, C, Hajdu, J

“…Studies on the catalytic mechanism and inhibition of serine proteases are widely used as paradigms for teaching enzyme catalysis. …”

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition. by Migaud, M, Wilmouth, R, Mills, G, Wayne, G, Risley, C, Chambers, C, Macdonald, S, Schofield, C

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition. by Migaud, M, Wilmouth, R, Mills, G, Wayne, G, Risley, C, Chambers, C, Macdonald, S, Schofield, C

Activation of Drosophila Toll during fungal infection by a blood serine protease. by Ligoxygakis, P, Pelte, N, Hoffmann, J, Reichhart, J

“…We show that ethylmethane sulfonate-induced mutations in the persephone gene, which encodes a previously unknown serine protease, block induction of the Toll pathway by fungi and resistance to this type of infection.…”

New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria. by McDonough, M, Schofield, C

“…Together with structures for a related inhibitor bound to trypsin, the work may assist in the design of reversible serine protease inhibitors.…”

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. by Urban, S, Lee, JR, Freeman, M

“…Until now, the mechanism of this key signaling regulator has been obscure, but our analysis suggests that Rhomboid-1 is a novel intramembrane serine protease that directly cleaves Spitz. In accordance with the putative Rhomboid active site being in the membrane bilayer, Spitz is cleaved within its transmembrane domain, and thus is, to our knowledge, the first example of a growth factor activated by regulated intramembrane proteolysis. …”

Characterization of serine protease from mango (Mangifera indica cv. Chokanan) peel by Amid, Mehrnoush, Abdul Manap, Mohd Yazid

“…This study aimed at characterizing serine protease which was previously purified from mango peel by alcohol salt aqueous two-phase system (ATPS). …”
Get full text

Molecular verification and bioinformatic analysis of a serine protease gene from Bacillus Pumilus / by Musab Hassan Abdelmagid Elzamzami, 1984-, author 639705, Haryati Jamaluddin, supervisor 601462, Fakulti Sains 8004

Molecular verification and bioinformatic analysis of a serine protease gene from Bacillus Pumilus / by Musab Hassan Abdelmagid Elzamzami, 1984-, author 639705

Serine proteases in the extracellular preparations of Phytophthora infestans: does their presence relate to the aggressiveness of the pathogen? by J. Hamill, C. Selby, L.R. Cooke

Subjects: Get full text

Intramolecular Modulation of Serine Protease Inhibitor Activity in a Marine Cyanobacterium with Antifeedant Properties by Susan Matthew, Ranjala Ratnayake, Mikel A. Becerro, Raphael Ritson-Williams, Valerie J. Paul, Hendrik Luesch

Subjects: Get full text

Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth by Yong Zuo, Jiawei Bai, Huiyuan Bai, Siyu Tian, Hongtao Sun, Zhenhua Shi, Peng Yu, Guofen Gao, Yuan Li, Yan-Zhong Chang

“…Abstract Transmembrane serine protease 6 (Tmprss6) has been correlated with the occurrence and progression of tumors, but any specific molecular mechanism linking the enzyme to oncogenesis has remained elusive thus far. …”
Get full text

HATL5: a cell surface serine protease differentially expressed in epithelial cancers. by Gregory S Miller, Gina L Zoratti, Andrew S Murray, Christopher Bergum, Lauren M Tanabe, Karin List

“…Here we demonstrate that HATL5 is a catalytically active serine protease that is inhibited by the two Kunitz type serine protease inhibitors, hepatocyte growth factor activator inhibitor (HAI)-1 and 2, as well as by serpinA1. …”
Get full text

Serine protease activities in Oxysarcodexia thornax (Walker) (Diptera: Sarcophagidae) first instar larva by Patrícia Cuervo, Camila Mesquita-Rodrigues, Claudia Masini d'Avila Levy, Constança Britto, Fabiano Araújo Pires, Rodrigo Gredilha, Carlos Roberto Alves, Jose Batista de Jesus

Subjects: “…chymotrypsin-like serine proteases…”
Get full text

SPINK6 inhibits human airway serine proteases and restricts influenza virus activation by Dong Wang, Cun Li, Man Chun Chiu, Yifei Yu, Xiaojuan Liu, Xiaoyu Zhao, Jingjing Huang, Zhongshan Cheng, Shuofeng Yuan, Vincent Poon, Jian‐Piao Cai, Hin Chu, Jasper Fuk‐Woo Chan, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou

“…Abstract SPINK6 was identified in human skin as a cellular inhibitor of serine proteases of the KLK family. Airway serine proteases are required to cleave hemagglutinin (HA) of influenza A viruses (IAVs) to initiate an infection in the human airway. …”
Get full text