Pharmacokinetics of Nafamostat, a Potent Serine Protease Inhibitor, by a Novel LC-MS/MS Analysis by Hyeon Seok Oh, Taehyung Kim, Dong-Hyeon Gu, Tae Suk Lee, Tae Hwan Kim, Soyoung Shin, Beom Soo Shin

“…Nafamostat, a synthetic serine protease inhibitor, has been used for the treatment of inflammatory diseases such as pancreatitis. …”
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Systematic functional analysis and potential application of a serine protease from cold-adapted Planococcus bacterium by Weijun Leng, Xiaoyun Wu, Xianghui Qi, Hongying Liu, Li Yuan, Ruichang Gao

“…In this study, a gene encoding serine protease (PmSpr288) from cold-adapted bacterium, namely Planococcus maritimus XJ11, was cloned and overexpressed in Escherichia coli BL21 (DE3). …”
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The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol by Flores Rhonda, Chen Ding, Gong Siqi, Lei Lei, Wu Xiang, Zhong Guangming

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Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment by Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati

“…A single-crystal X-ray analysis of the complex of the human mitochondrial caseinolytic serine protease type C (<i>h</i>ClpP) and ONC201 (PDB ID: 6DL7) allowed <i>h</i>ClpP to be identified as its main target. …”
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Impacts of transmembrane serine protease 4 expression on susceptibility to severe acute respiratory syndrome coronavirus 2 by Qi Tan, Jiewen Fu, Zhiying Liu, Haoyue Deng, Lianmei Zhang, Jiayue He, Xiaotao Li, Junjiang Fu, Xiangxiang Pan, Peifang Wei

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Serine protease CrKP43 interacts with MAPK and regulates fungal development and mycoparasitism in Clonostachys chloroleuca by Binna Lv, Xue Zhao, Yan Guo, Shidong Li, Manhong Sun

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Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros. by Sakthivel Vaiyapuri, Robert A Harrison, Andrew B Bicknell, Jonathan M Gibbins, Gail Hutchinson

“…Serine proteases are a major component of viper venoms and are thought to disrupt several distinct elements of the blood coagulation system of envenomed victims. …”
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Purification and partial characterization of a coagulant serine protease from the venom of the Iranian snake Agkistrodon halys by M Ghorbanpur, A Zare Mirakabadi, F Zokaee, H Zolfagarrian, H Rabiei

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N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding by Hao Wang, Shuo Li, Juejin Wang, Shenghan Chen, Xue-Long Sun, Qingyu Wu

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Blocking serine protease (TMPRSS2) by Bromhexine; looking at potential treatment to prevent COVID-19 infection by Ramin Tolouian, Audrey Tolouian, Mohammadreza Ardalan

Subjects: “…serine protease…”
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Putative Serine Protease Effectors of Clavibacter michiganensis Induce a Hypersensitive Response in the Apoplast of Nicotiana Species by You Lu, Noriyuki Hatsugai, Fumiaki Katagiri, Carol A. Ishimaru, Jane Glazebrook

“…The genomes of both subspecies encode members of the pat-1 family of putative serine proteases known to function in virulence on host plants and induction of hypersensitive responses (HR) on nonhosts. …”
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Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats by Nikita Hanning, Michelle De bruyn, Hannah Ceuleers, Tim Boogaerts, Maya Berg, Annemieke Smet, Heiko U. De Schepper, Jurgen Joossens, Alexander L. N. van Nuijs, Joris G. De Man, Koen Augustyns, Ingrid De Meester, Benedicte Y. De Winter

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Regulation of a serine protease homolog by the JNK pathway during thoracic development ofDrosophila melanogaster by Ajay Srivastava, Qian Dong

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Characterization of a novel cold-adapted intracellular serine protease from the extremophile Planococcus halocryophilus Or1 by Casper Bøjer Rasmussen, Carsten Scavenius, Ida B. Thøgersen, Seandean Lykke Harwood, Øivind Larsen, Gro Elin Kjaereng Bjerga, Peter Stougaard, Jan J. Enghild, Mariane Schmidt Thøgersen

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The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels by Rossana García-Fernández, Steve Peigneur, Tirso Pons, Carlos Alvarez, Lidice González, María A. Chávez, Jan Tytgat

“…Using enzyme kinetics, we now investigated its activity against other serine proteases. Considering previous reports of bifunctional Kunitz-type proteins from anemones, we also studied the effect of rShPI-1A on voltage-gated potassium (Kv) channels. rShPI-1A binds Kv1.1, Kv1.2, and Kv1.6 channels with IC50 values in the nM range. …”
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Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. by Shotaro Nakano, Soshiro Kashio, Kei Nishimura, Asuka Takeishi, Hina Kosakamoto, Fumiaki Obata, Erina Kuranaga, Takahiro Chihara, Yoshio Yamauchi, Toshiaki Isobe, Masayuki Miura

“…In Drosophila, various types of tissue damage, including epidermal injury, tumor formation, cell competition, and apoptosis deficiency, induce sterile activation of the Toll pathway, a process that requires the use of extracellular serine protease (SP) cascades. Upon infection, the SP Spätzle (Spz)-processing enzyme (SPE) cleaves and activates the Toll ligand Spz downstream of two paralogous SPs, Hayan and Persephone (Psh). …”
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Characterization of a Trichinella spiralis putative serine protease. Study of its potential as sero-diagnostic tool. by Ge Ge Sun, Yan Yan Song, Peng Jiang, Hua Na Ren, Shu Wei Yan, Yue Han, Ruo Dan Liu, Xi Zhang, Zhong Quan Wang, Jing Cui

“…The aim of this study was to characterize the T. spiralis putative serine protease (TsSP) and to investigate its potential use for diagnosis of trichinellosis.The full-length TsSP sequence was cloned and expressed, and recombinant TsSP (rTsSP) was purified by Ni-NTA-Sefinose Column. …”
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The Versatility of Serine Proteases from Brazilian <i>Bothrops</i> Venom: Their Roles in Snakebites and Drug Discovery by Marcela Romanazzi, Eloise T. M. Filardi, Geovanna M. M. Pires, Marcos F. Cerveja, Guilherme Melo-dos-Santos, Isadora S. Oliveira, Isabela G. Ferreira, Felipe A. Cerni, Norival Alves Santos-Filho, Wuelton M. Monteiro, José R. Almeida, Sakthivel Vaiyapuri, Manuela B. Pucca

Subjects: “…serine protease…”
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X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution. by Katona, G, Wilmouth, R, Wright, P, Berglund, G, Hajdu, J, Neutze, R, Schofield, C

“…The accuracy of the crystallographic coordinates allows structural issues concerning the mechanism of serine proteases to be addressed. Significantly, the ester bond of the acyl-enzyme showed a high level of planarity, suggesting geometric strain of the ester link is not important during catalysis. …”

Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules by Ab Aziz, Nurohaida

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