Clinical Cost-Effectiveness as a Novel Metric for Steering Emerging Medical Technology by Richards, Daniel Herndon

“…Results: The most sensitive driver of incremental effectiveness of LDD over surgery was, per the model, the potential of LDD to reduce systemic side effects. The potential clinical benefit of LDD over surgery was estimated, probabilistically, as between P10 and P90 values of 0.081 and 0.339 QALYs, respectively. …”
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Complex coacervates loaded with nano enzymes as microreactor by Ng, Si Yi

“…These nanoparticles are able to penetrate tissues and target specific cells due to their small size in nature and reduce potential side effects, improving the overall treatment efficacy. …”
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Diffuse Correlation Spectroscopy (DCS) and Diffuse Optical Spectroscopy (DOS) for photodynamic therapy monitoring. by Siti Raudhah Matyasir.

“…PDT is an emerging modality that has many advantages such as non-invasive, low side effects, low scarring, low risk of resistance, cost effective and shorter treatment time. …”
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Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study by Patone, M, Snelling, AJ, Tibble, H, Coupland, C, Sheikh, A, Hippisley-Cox, J

“…Trials have shown it to have mild to moderate side effects, however, evidence regarding its safety in real-world settings remains insufficient. …”

Low-dose spironolactone and cardiovascular outcomes in moderate stage chronic kidney disease: a randomized controlled trial by Hobbs, FDR, McManus, RJ, Taylor, CJ, Jones, NR, Rahman, JK, Wolstenholme, J, Kim, S, Kwon, J, Jones, L, Hirst, JA, Yu, L-M, Mort, S

“…The most common reason for stopping spironolactone was a decrease in the estimated glomerular filtration rate that met prespecified stop criteria (n = 239, 35.4%), followed by participants being withdrawn due to treatment side effects (n = 128, 18.9%) and hyperkalemia (n = 54, 8.0%). …”

First-in-man study of the PSMA Minibody IR800-IAB2M for molecularly targeted intraoperative fluorescence guidance during radical prostatectomy by Hamdy, FC, Lamb, AD, Tullis, IDC, Verrill, C, Rombach, I, Rao, SR, Colling, R, Barber, PR, Volpi, D, Barbera-Martin, L, Lopez, JF, Omer, A, Hewitt, A, Lovell, S, Niederer, J, Lambert, A, Snoeck, J, Thomson, C, Leslie, T, Bryant, RJ, Mascioni, A, Jia, F, Torgov, M, Wilson, I, Gudas, J, Wu, AM, Olafsen, T, Vojnovic, B

“…Overall sensitivity and specificity in detecting non-lymph-node extra-prostatic cancer tissue were 100% and 65%, and 64% and 64% respectively for lymph node positivity. There were no side-effects associated with administration of the reagent. …”

Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopause-associated mood disorder in ovariectomized mice by Liang, Gengfan, Kow, Audrey Siew Foong, Lee, Yu-Zhao, Yusof, Rohana, Tham, Chau Ling, Ho, Yu-Chung, Lee, Ming Tatt

“…The current treatment for menopause-associated mood disorder provides only symptomatic relief and is associated with many side effects. Supplementation with vitamin E has been shown to be effective in ameliorating anxiety and depression. …”
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In vitro and in silico studies of Lawsone on inflammation-induced skin cells for development of skin anti-inflammatory treatment by Abdullah, Shazleen Sofea, Mohammad Latif, Muhammad Alif, Md Tohid, Siti Farah

“…Lawsone, an active phytoconstituent of Lawsonia inermis sp., is proposed as a safer alternative for the current skin anti-inflammatory treatments that are mainly steroidal with unwanted side effects which does not conform to the concept of halalan toyyiban in medicine. …”
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Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…Its favorable biocompatibility, pH sensitivity, and sustained release properties facilitated reduced toxic side effects of 5-FU on NIH3T3 normal cells and enhanced inhibitory effects on CT26 colon cancer cells. …”
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Tinospora crispa ethanolic extract downregulates Protein Kinase genes expression and activity during Toxoplasma gondii infection: a prospective drug target for lytic cycle inhibiti... by Abdullahi, Sharif Alhassan, Nordin, Norshariza, Unyah, Ngah Zasmy, Basir, Rusliza, Daneji, Isa Muhammad, Nasiru, Wana Mohammed, Majid, Roslaini Abd

“…The infection is poorly controlled due to lack of a potent vaccine against the parasite, and the current medication presents severe side effects on the host, less efficacy on the parasite and is accompanied by the potential development of resistance by the parasite. …”
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Camel Milk and Oxidative stress: Therapeutic potential against metabolic syndrome diseases by Musa, Khalid Hamid, Hamad, Essam M., Elnour, Ahmed Adam Hassan Mohammed

“…Standardization of production and processing is essential for quality and safety, and research into potential risks and side effects is needed, especially for those with specific health conditions. …”
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Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii by Yang, Yuchen

“…Compared to traditional synthetic small-molecule drugs, recombinant therapeutic proteins offer advantages like enhanced specificity and reduced side effects, and there has been tremendous growth in their innovation thanks to modern DNA technologies and AI-driven algorithms. …”
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From Transparency to Accountability and Back by Cen, Sarah, Alur, Rohan

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Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery by Connor, Christopher W

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Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys by Mockenhaupt, Stefan, Grosse, Stefanie, Rupp, Daniel, Bartenschlager, Ralf, Grimm, Dirk

“…However, in principle, the sense strand also possesses silencing capacity that may contribute to adverse RNAi side effects including off-target gene regulation. Here, we address this concern with a novel strategy that reduces sense strand activity of vector-encoded shRNAs via codelivery of inhibitory tough decoy (TuD) RNAs. …”
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The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…Combination csDMARDs have shown some superiority over single therapies but there are limited data and concerns about side effects. Early use of biologics has also been shown to be superior to methotrexate but these drugs are costly and not usually funded first line. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. Conclusion: Our study underscores the critical importance of community-based screening in detecting undiagnosed hypertension. …”

Anti-ageing properties of edible bird's nest ascertained by in vitro and in vivo studies in animal model by Hou, Zhiping

“…Hormone replacement therapy (HRT) has been used to restore postmenopausal hormonal levels in order to relieve menopausal problems, but its associated side effects including development of cancers and cardiovascular diseases have necessitated the search for other alternatives such as natural food supplementation. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Generally, Gram-negative bacterial pathogens have additional outer membranes mainly composed of highly conserved and unique lipopolysaccharide (LPS) molecules, which serve as permeability barriers to prevent the cell bodies from toxic antimicrobial molecules1-2 including many photosensitizers, which have been successfully used in photoinactivation of Gram-positive strains.3-4 Furthermore, LPS, a potent inducer to human innate immune systems, hence called endotoxin, is now primarily responsible for sepsis associated with the infections of Gram-negative pethogens.5-6 Therefore, the most promising strategy is use of LPS neutralizing peptide as the binding ligand to deliver antibacterial agents meanwhile minimize the side effects.7 The first objective of the research in part I is the design and synthesis of photosensitizer-peptide conjugates for multivalent targeted cellular imaging and photodynamic inactivation (PDI) against Gram-negative bacterial strains. …”
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Virtual reality as a countermeasure for astronaut motion sickness during simulated post-flight water landings by Lonner, T. L., Allred, A. R., Bonarrigo, L., Gopinath, A., Smith, K., Kravets, V., Groen, E. L., Oman, C., DiZio, P., Lawson, B. D., Clark, T. K.

“…Anticholinergic pharmaceuticals (e.g., Meclizine) are often taken prior to landing; however, they have operationally adverse side effects (e.g., drowsiness). There is a need to develop non-pharmaceutical countermeasures to EMS. …”
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