Gegen Qinlian Decoction Coordinately Regulates PPARγ and PPARα to Improve Glucose and Lipid Homeostasis in Diabetic Rats and Insulin Resistance 3T3-L1 Adipocytes by Jun Tu, Jun Tu, Shuilan Zhu, Bingtao Li, Bingtao Li, Guoliang Xu, Guoliang Xu, Xinxin Luo, Li Jiang, Li Jiang, Xiaojun Yan, Ruiping Zhang, Chen Chen, Chen Chen

“…These results suggested that GQD improved diabetes by intervening a diverse array of PPARγ and PPARα upstream and downstream signaling transduction cascades, which jointly optimized the expression of target gene profiles to promote fatty acid oxidation and accelerate glucose uptake and utilization than PPARγ full agonist rosiglitazone without stimulating PPARα activity. …”
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ASR1 and ASR2, Two Closely Related ABA-Induced Serine-Rich Transcription Repressors, Function Redundantly to Regulate ABA Responses in Arabidopsis by Hadia Hussain, Yuxin Cheng, Yating Wang, Yuan Yuan, Adnan, Yingying Li, Hainan Tian, Saddam Hussain, Siyu Chen, Rao Lin, Tianya Wang, Shucai Wang

“…The plant hormone abscisic acid (ABA) is able to regulate the expression of ABA-responsive genes via signaling transduction, and thus plays an important role in regulating plant responses to abiotic stresses. …”
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Transcriptome profiling of microRNAs reveals potential mechanisms of manual therapy alleviating neuropathic pain through microRNA-547-3p-mediated Map4k4/NF-κb signaling pathway by Chongjie Yao, Jun Ren, Ruixin Huang, Cheng Tang, Yanbin Cheng, Zhizhen Lv, Lingjun Kong, Sitong Fang, Jiming Tao, Yangyang Fu, Qingguang Zhu, Min Fang

“…MicroRNAs (miRNAs) are important regulators of pain signaling transduction, but are rarely reported in the chronic compression of dorsal root ganglia (CCD) model, and further investigation is needed to decipher whether they mediate anti-inflammatory and analgesic effects of MT. …”
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Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor by Xiao Cheng, Vijaya Bhaskar Baki, Matthew Moran, Baolong Liu, Jiujiu Yu, Miaoyun Zhao, Qingsheng Li, Jean-Jack Riethoven, Channabasavaiah B. Gurumurth, Edward N. Harris, Xinghui Sun

“…As such, there is a critical need to improve our understanding of gene expression regulation and signaling transduction in MASLD to develop new therapies. …”
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Molecular basis of hepatitis C virus -associated hepatocarcinogenesis by Isabelle Chemin

“…The other pathway involves the modulation of cellular gene expressions and intracellular signal transductions, such as mitogen-activated protein kinase pathway, which results in the activation of transcription factors and cell cycle machineries. …”
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Metabolomics, phytohormone and transcriptomics strategies to reveal the mechanism of barley heading date regulation to responds different photoperiod by Zhuo Ga, Liyun Gao, Xiruo Quzong, Wang Mu, Pubu Zhuoma, Xiongnu Taba, Guocheng Jiao, Dawa Dondup, Lhundrup Namgyal, Zha Sang

“…Results The circadian rhythm plant, plant hormone signaling transduction, starch and sucrose metabolism, and photosynthesis-related pathways are significantly enriched in barley under SD and LD to influence heading time. …”
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Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway by Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi

“…PCR array analysis confirmed the up-regulation, and down-regulation of several genes related to various signaling transduction pathways associated with autophagy machinery and shared effectors between autophagy and apoptosis in 40 and 120 mM MTF groups compared to the non-treated control group (p < 0.05). …”
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Design, Synthesis, and Evaluation of in-house Covid-19 Real-time PCR Diagnostic Kit by MR Zare, Z Ebrahimifar, M Sobhani Lari, H Shokrollahnia Roshan, M Abdollahpour-Alitappeh

“…COVID-19: immunopathogenesis and Immunotherapeutics. Signal Transduct Target Ther 2020; 5(1): 128. 13.Magalhaes E, Stoner A, Palmer J, Schranze R, Grandy S, Amin S, et al. …”
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