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    The bisphosponates: chemical characteristics, skeletal biological effects and extra-skeletal effects by F.P. Cantatore, A. Corrado

    Published 2011-09-01
    “…Nevertheless there are several experimental evidence that BP possess different extra-skeletal biological effects, ranging from analgesic properties, anti-inflammatory and pro-inflammatory effects and the capacity of modifying the biological activity of cells other than osteoblasts and osteoclasts, such as the immune system cells and other cells of mesenchymal origin. …”
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