Tandem Substitutions in Somatic Hypermutation by Julieta H. Sepúlveda-Yáñez, Julieta H. Sepúlveda-Yáñez, Diego Alvarez Saravia, Bas Pilzecker, Bas Pilzecker, Pauline A. van Schouwenburg, Mirjam van den Burg, Hendrik Veelken, Marcelo A. Navarrete, Heinz Jacobs, Marvyn T. Koning

“…Upon antigen recognition, activation-induced cytosine deaminase initiates affinity maturation of the B-cell receptor by somatic hypermutation (SHM) through error-prone DNA repair pathways. …”
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Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation by Filip Senigl, Yaakov Maman, Ravi K. Dinesh, Jukka Alinikula, Rashu B. Seth, Lubomira Pecnova, Arina D. Omer, Suhas S.P. Rao, David Weisz, Jean-Marie Buerstedde, Erez Lieberman Aiden, Rafael Casellas, Jiri Hejnar, David G. Schatz

“…Summary: Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. …”
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AID function in somatic hypermutation and class switch recombination by Yu Kefei

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Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation by Ryan Costello, Jose F. Cantillo, Amy L. Kenter

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Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences. by Jean-Marie Buerstedde, Jukka Alinikula, Hiroshi Arakawa, Jessica J McDonald, David G Schatz

“…Somatic hypermutation (SH) generates point mutations within rearranged immunoglobulin (Ig) genes of activated B cells, providing genetic diversity for the affinity maturation of antibodies. …”
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Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation by Zizhang Sheng, Zizhang Sheng, Jude S. Bimela, Phinikoula S. Katsamba, Saurabh D. Patel, Yicheng Guo, Yicheng Guo, Haiqing Zhao, Youzhong Guo, Youzhong Guo, Peter D. Kwong, Peter D. Kwong, Lawrence Shapiro, Lawrence Shapiro, Lawrence Shapiro

“…Accumulation of somatic hypermutation (SHM) is the primary mechanism to enhance the binding affinity of antibodies to antigens in vivo. …”
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Antibody Dynamics Simulation—A Mathematical Exploration of Clonal Deletion and Somatic Hypermutation by Zhaobin Xu, Qingzhi Peng, Weidong Liu, Jacques Demongeot, Dongqing Wei

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Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory by Edward J. Steele

Subjects: “…somatic hypermutation…”
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Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design by Chaim A. Schramm, Daniel C. Douek

Subjects: “…somatic hypermutation…”
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Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity by Modi Safra, Modi Safra, Zvi Tamari, Zvi Tamari, Pazit Polak, Pazit Polak, Shachaf Shiber, Shachaf Shiber, Moshe Matan, Hani Karameh, Yigal Helviz, Adva Levy-Barda, Vered Yahalom, Avi Peretz, Avi Peretz, Eli Ben-Chetrit, Baruch Brenner, Baruch Brenner, Tamir Tuller, Meital Gal-Tanamy, Gur Yaari, Gur Yaari

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Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma. by Yanwen Jiang, T David Soong, Ling Wang, Ari M Melnick, Olivier Elemento

“…The processes of somatic hypermutation (SHM) and class switch recombination introduced by activation-induced cytosine deaminase (AICDA) at the Immunoglobulin (Ig) loci are key steps for creating a pool of diversified antibodies in germinal center B cells (GCBs). …”
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Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus by Jeannine A Ott, Caitlin D Castro, Thaddeus C Deiss, Yuko Ohta, Martin F Flajnik, Michael F Criscitiello

Subjects: “…somatic hypermutation…”
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A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation. by Likun Du, Deborah K Dunn-Walters, Krystyna H Chrzanowska, Tanja Stankovic, Ashwin Kotnis, Xin Li, Jiayi Lu, Gösta Eggertsen, Claire Brittain, Sergey W Popov, Andrew R Gennery, A Malcolm R Taylor, Qiang Pan-Hammarström

“…Activation-induced cytidine deaminase (AID) is believed to initiate somatic hypermutation (SHM) by deamination of deoxycytidines to deoxyuridines within the immunoglobulin variable regions genes. …”
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Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells. by Alan M Williams, Yaakov Maman, Jukka Alinikula, David G Schatz

“…The activation induced cytosine deaminase (AID) mediates diversification of B cell immunoglobulin genes by the three distinct yet related processes of somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion (GCV). …”
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Evaluation of Somatic Hypermutation Status in Chronic Lymphocytic Leukemia (CLL) in the Era of Next Generation Sequencing by Sanjeev Kumar Gupta, David S. Viswanatha, Keyur P. Patel

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B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S by Catherine Jacob-Dolan, Michelle Lifton, Olivia C. Powers, Jessica Miller, Nicole P. Hachmann, Mya Vu, Nehalee Surve, Camille R. Mazurek, Jana L. Fisher, Stefanie Rodrigues, Robert C. Patio, Trisha Anand, Mathieu Le Gars, Jerald Sadoff, Aaron G. Schmidt, Dan H. Barouch

“…Through 8 months post vaccination, serum NAb responses increased to variants, including B.1.351 (Beta) and B.1.617.2 (Delta), without additional boosting or infection. The level of somatic hypermutation, measured by nucleotide changes in the VDJ region of the heavy and light antibody chains, increased in Spike-specific B cells. …”
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Deep learning model of somatic hypermutation reveals importance of sequence context beyond hotspot targeting by Catherine Tang, Artem Krantsevich, Thomas MacCarthy

“…Summary: B cells undergo somatic hypermutation (SHM) of the Immunoglobulin (Ig) variable region to generate high-affinity antibodies. …”
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The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies by Sok, Devin, Laserson, Uri, Laserson, Jonathan, Liu, Yi, Vigneault, Francois, Julien, Jean-Philippe, Briney, Bryan, Ramos, Alejandra, Saye, Karen F., Le, Khoa, Mahan, Alison E., Wang, Shenshen, Kardar, Mehran, Yaari, Gur, Walker, Laura M., Simen, Birgitte B., St. John, Elizabeth P., Chan-Hui, Po-Ying, Swiderek, Kristine, Kleinstein, Stephen H., Alter, Galit, Seaman, Michael S., Koller, Daphne, Wilson, Ian A., Burton, Dennis R., Poignard, Pascal, Chakraborty, Arup K, Church, George M

“…We used 454 sequencing and designed a novel phylogenetic method to model lineage evolution of the bnAbs PGT121–134 and found a positive correlation between the level of somatic hypermutation (SHM) and the development of neutralization breadth and potency. …”
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Somatic hypermutations confer rheumatoid factor activity in hepatitis C virus-associated mixed cryoglobulinemia. by Charles, E, Orloff, M, Nishiuchi, E, Marukian, S, Rice, C, Dustin, L

“…We have proposed that IgG-HCV immune complexes stimulate B cell expansion and somatic hypermutation (SHM)-induced affinity maturation in part via engagement of an RF-like B cell receptor. …”

Correction: The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies. by Devin Sok, Uri Laserson, Jonathan Laserson, Yi Liu, Francois Vigneault, Jean-Philippe Julien, Bryan Briney, Alejandra Ramos, Karen F. Saye, Khoa Le, Alison Mahan, Shenshen Wang, Mehran Kardar, Gur Yaari, Laura M. Walker, Birgitte B. Simen, Elizabeth P. St. John, Po-Ying Chan-Hui, Kristine Swiderek, Stephen H. Kleinstein, Galit Alter, Michael S. Seaman, Arup K. Chakraborty, Daphne Koller, Ian A. Wilson, George M. Church, Dennis R. Burton, Pascal Poignard

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