Acute and Chronic Pain from Facial Skin and Oral Mucosa: Unique Neurobiology and Challenging Treatment by Man-Kyo Chung, Sheng Wang, Se-Lim Oh, Yu Shin Kim

“…A lack of pain in chronic inflammation inside the oral cavity, such as chronic periodontitis, involves the specialized functioning of oral bacteria. A more detailed understanding of the unique neurobiology of pain from the orofacial skin and the oral mucosa should help us develop novel methods for better treating persistent orofacial pain.…”
Get full text

Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa by Stephanie Kullmann, Katrin E. Giel, Martin Teufel, Ansgar Thiel, Stephan Zipfel, Hubert Preissl

“…We were able to show that the bilateral inferior frontal gyrus (IFG) is a region of special functional importance within the whole-brain network, in AN patients, revealing reduced functional connectivity compared to both healthy control groups. …”
Get full text

Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas by Lili Li, Yichao Fan, Xin Huang, Jie Luo, Lan Zhong, Xing-sheng Shu, Li Lu, Tingxiu Xiang, Anthony T.C. Chan, Winnie Yeo, Ceshi Chen, Wai Yee Chan, Richard L. Huganir, Qian Tao

“…We identified a Ras GTPase-activating gene RASA5/SYNGAP1, at the common 6p21.3 deletion, methylated/downregulated in multiple carcinomas and different from other RASA family members (RASA1–RASA4), indicating its special functions in tumorigenesis. RASA5 mutations are rare, unlike other RASA members, whereas its promoter CpG methylation is frequent in multiple cancer cell lines and primary carcinomas and associated with patient’s poor survival. …”
Get full text

Polyphasic Characterization of Yeasts and Lactic Acid Bacteria Metabolic Contribution in Semi-Solid Fermentation of Chinese Baijiu (Traditional Fermented Alcoholic Drink): Towards... by Rufei Ma, Lu Sui, Jingsheng Zhang, Jinrong Hu, Ping Liu

“…This study attaches importance to the special functions of <i>S. fibuligera</i>, <i>S. cerevisiae</i>, and <i>P. acidilactici</i> in Chinese Baijiu making, and investigates their metabolic characteristics in the process of lab-scale semi-solid fermentation.…”
Get full text

Lie-Poisson neural networks (LPNets): data-based computing of Hamiltonian systems with symmetries by Eldred, Christopher, Gay-Balmaz, François, Huraka, Sofiia, Putkaradze, Vakhtang

“…Using this approach, we develop a network based on transformations that exactly preserve the Poisson bracket and the special functions of the Lie-Poisson systems (Casimirs) to machine precision. …”
Get full text

Regulation of Human Macrophage M1–M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1 by Federica Raggi, Simone Pelassa, Daniele Pierobon, Federica Penco, Marco Gattorno, Francesco Novelli, Alessandra Eva, Luigi Varesio, Mirella Giovarelli, Maria Carla Bosco

“…They can undergo diverse forms of activation in response to environmental factors, polarizing into specialized functional subsets. A common hallmark of the pathologic environment is represented by hypoxia. …”
Get full text

Organizational and Functional Reassignment of a Scientific Plague Control Institution of the Rospotrebnadzor under Conditions of Coronavirus Infection Pandemic by A. K. Noskov, V. D. Kruglikov, O. S. Chemisova, N. E. Gaevskaya, E. V. Kovalev, G. V. Karpushchenko, A. A. Lopatin, S. M. Ivanova, S. N. Tikhonov

“…It allowed an effective distribution of the forces and assets without damage for specialized functioning in the main areas of scientific and practical activities. …”
Get full text

The effects of general anesthetics on mitochondrial structure and function in the developing brain by Kaley Hogarth, Kaley Hogarth, Doorsa Tarazi, Doorsa Tarazi, Jason T. Maynes, Jason T. Maynes, Jason T. Maynes, Jason T. Maynes

“…In addition to meeting their immense energy demands, neurons are particularly dependent on the proper function and spatial organization of mitochondria to mediate specialized functions including neurotransmitter trafficking and release. …”
Get full text

Divergence and evolution of cotton bHLH proteins from diploid to allotetraploid by Bingliang Liu, Xueying Guan, Wenhua Liang, Jiedan Chen, Lei Fang, Yan Hu, Wangzhen Guo, Junkang Rong, Guohua Xu, Tianzhen Zhang

“…Both recent and old duplicated pairs (68.8%) showed a divergent expression profile, indicating specialized functions. The expression diversification of the duplicated genes suggested it might be a universal feature of the long-term evolution of cotton. …”
Get full text

Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation by J. Yuyang Lu, Wen Shao, Lei Chang, Yafei Yin, Tong Li, Hui Zhang, Yantao Hong, Michelle Percharde, Lerui Guo, Zhongyang Wu, Lichao Liu, Wei Liu, Pixi Yan, Miguel Ramalho-Santos, Yujie Sun, Xiaohua Shen

“…Importantly, imaging and sequencing analysis show that L1 repeats sequester a large set of genes with specialized functions in nucleolus- and lamina-associated inactive domains that are depleted of SINE repeats. …”
Get full text

Comparative Characterization of <i>Plasmodium falciparum</i> Hsp70-1 Relative to <i>E. coli</i> DnaK Reveals the Functional Specificity of the Parasite Chaperone by Charity Mekgwa Lebepe, Pearl Rutendo Matambanadzo, Xolani Henry Makhoba, Ikechukwu Achilonu, Tawanda Zininga, Addmore Shonhai

“…How Hsp70 exhibits specialized functions across species remains to be understood. …”
Get full text

The Impact of lncRNAs and miRNAs in Regulation of Function of Cancer Stem Cells and Progression of Cancer by Soudeh Ghafouri-Fard, Mohammadreza Hajiesmaeili, Hamed Shoorei, Zahra Bahroudi, Mohammad Taheri, Guive Sharifi

“…Stem cells have two important features, namely the ability for self-renewal and the capacity to differentiate into some cell kinds with specialized functions. These two features are also present in cancer stem cells (CSCs). …”
Get full text

Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer by Po-Shuan Huang, Chia-Jung Liao, Ya-Hui Huang, Chau-Ting Yeh, Cheng-Yi Chen, Hui-Chi Tang, Cheng-Chih Chang, Kwang-Huei Lin

“…Therefore, researchers particularly value microRNAs that are specific to or have special functions in liver cancer. These include miR-122, which is specifically expressed in the liver, and miR-34, which is necessary for the replication of the hepatitis C virus in liver cancer. …”
Get full text

Methods for determining the botanical origin of honey by Leonora Adamchuk, Vladyslav Sukhenko, Oleksandra Akulonok, Tetiana Bilotserkivets, Volodymyr Vyshniak, Dina Lisohurska, Olha Lisohurska, Natalia Slobodyanyuk, Olga Shanina, Ivan Galyasnyj

“…The demand for monofloral, original, and special (functional) kinds of honey, or those with geographical indication, is forecast. …”
Get full text

Novel Modular Rhodopsins from Green Algae Hold Great Potential for Cellular Optogenetic Modulation Across the Biological Model Systems by Mayanka Awasthi, Kumari Sushmita, Manish Singh Kaushik, Peeyush Ranjan, Suneel Kateriya

“…Here, we had identified 50 novel modular rhodopsins with variant domains and their diverse cognate signaling cascades encoded in a single ORF, which are associated with specialized functions in the cells. These novel modular algal rhodopsins have been characterized based on their sequence and structural homology with previously reported rhodopsins. …”
Get full text

Applications of <i>q</i>-Hermite Polynomials to Subclasses of Analytic and Bi-Univalent Functions by Caihuan Zhang, Bilal Khan, Timilehin Gideon Shaba, Jong-Suk Ro, Serkan Araci, Muhammad Ghaffar Khan

“…In mathematics, physics, and engineering, orthogonal polynomials and special functions play a vital role in the development of numerical and analytical approaches. …”
Get full text

Fractional Hermite-Hadamard Integral Inequalities for a New Class of Convex Functions by Pshtiwan Othman Mohammed, Thabet Abdeljawad, Shengda Zeng, Artion Kashuri

“…Finally, application to certain special functions are pointed out.…”
Get full text

Bioinspired Design Rules from Highly Mineralized Natural Composites for Two-Dimensional Composite Design by Anamika Prasad, Vikas Varshney, Dhriti Nepal, Geoffrey J. Frank

“…Although multiple critical engineering applications demand that such composites balance specialized functions with mechanical demands, the current knowledge of the mechanical performance and optimized traits necessary for such composite design is severely limited. …”
Get full text

YODA Kinase Controls a Novel Immune Pathway of Tomato Conferring Enhanced Disease Resistance to the Bacterium Pseudomonas syringae by Julio Téllez, Julio Téllez, Antonio Muñoz-Barrios, Antonio Muñoz-Barrios, Sara Sopeña-Torres, Amanda F. Martín-Forero, Alfonso Ortega, Rosa Pérez, Yolanda Sanz, Marisé Borja, Alberto de Marcos, Michael Nicolas, Torben Jahrmann, Montaña Mena, Lucía Jordá, Lucía Jordá, Antonio Molina, Antonio Molina

“…These results indicate that tomato orthologs have specialized functions and support that YDA also regulates immune responses in tomato and may be a trait for breeding disease resistance.…”
Get full text

Bullen-Mercer type inequalities with applications in numerical analysis by Miguel Vivas–Cortez, Muhammad Zakria Javed, Muhammad Uzair Awan, Muhammad Aslam Noor, Silvestru Sever Dragomir

“…Also, we deliver some applications of outcomes to means, special functions, error bounds, and iterative methods to solve non-linear problems. …”
Get full text