The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis by Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo

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Sphingosine 1-Phosphate in Renal Diseases by Alexander Koch, Josef Pfeilschifter, Andrea Huwiler

Subjects: “…Sphingosine 1-phosphate…”
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Irisin Is Target of Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor-Mediated Signaling in Skeletal Muscle Cells by Federica Pierucci, Antony Chirco, Elisabetta Meacci

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Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2* by Hitoshi Ikeda, Naoko Watanabe, Isao Ishii, Tatsuo Shimosawa, Yukio Kume, Tomoaki Tomiya, Yukiko Inoue, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Satoko Iitsuka, Ryoto Fujita, Masao Omata, Jerold Chun, Yutaka Yatomi

“…Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells in the liver, and inhibits proliferation via S1P receptor 2 (S1P2) in hepatocytes in rats in vitro. …”
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Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1 by Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau

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Export of sphingosine-1-phosphate and cancer progression by Kazuaki Takabe, Sarah Spiegel

“…Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that promotes cell survival, proliferation, migration, angiogenesis, lymphangiogenesis, and immune response; all are critical processes of cancer progression. …”
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Plasma sphingosine-1-phosphate is elevated in obesity. by Greg M Kowalski, Andrew L Carey, Ahrathy Selathurai, Bronwyn A Kingwell, Clinton R Bruce

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Sphingosine-1-Phosphate: Boon and Bane for the Brain by Gerhild van Echten-Deckert, Nadine Hagen-Euteneuer, Ilker Karaca, Jochen Walter

Subjects: “…Sphingosine-1-phosphate…”
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Roles of sphingosine-1-phosphate signaling in cancer by Peng Wang, Yonghui Yuan, Wenda Lin, Hongshan Zhong, Ke Xu, Xun Qi

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Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases by Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen

Subjects: “…Sphingosine-1-phosphate…”
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Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase. by Timo Heckt, Laura J Brylka, Mona Neven, Michael Amling, Thorsten Schinke

“…We and others have previously identified sphingosine-1-phosphate (S1P) as a bone remodeling coupling factor, which is released by bone-resorbing osteoclasts to stimulate bone formation. …”
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Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells. by Kathinka W E M van Hooren, Léon J A Spijkers, Dorothee van Breevoort, Mar Fernandez-Borja, Ruben Bierings, Jaap D van Buul, Astrid E Alewijnse, Stephan L M Peters, Jan Voorberg

“…Sphingosine-1-phosphate (S1P) is an agonist for five distinct G-protein coupled receptors, that is released by platelets, mast cells, erythrocytes and endothelial cells. …”
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Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface by Kana Masuda-Kuroki, Anna Di Nardo

Subjects: “…sphingosine 1-phosphate…”
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Sources, metabolism, and regulation of circulating sphingosine-1-phosphate by Monika Książek, Marta Chacińska, Adrian Chabowski, Marcin Baranowski

“…Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts either as an intracellular messenger or as a ligand for its membrane receptors. …”
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Targeting Sphingosine-1-Phosphate Signaling in Breast Cancer by Masayuki Nagahashi, Yasuo Miyoshi

“…As such, the development of new therapies for refractory breast cancer that differ from conventional mechanisms of action is necessary. Sphingosine-1-phosphate (S1P) is a key molecule with a variety of bioactive activities, including involvement in cancer cell proliferation, invasion, and metastasis. …”
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Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate by Andreas V. Thuy, Christina-Maria Reimann, Nasr Y. A. Hemdan, Markus H. Gräler

“…Sphingosine 1-phosphate (S1P) is a lipid metabolite and a ligand of five G protein-coupled cell surface receptors S1PR1 to S1PR5. …”
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Divergent Role of Sphingosine 1-Phosphate on Insulin Resistance by Susann Fayyaz, Lukasz Japtok, Burkhard Kleuser

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Sphingosine 1-Phosphate Regulates Obesity and Glucose Homeostasis by Kazuo Kajita, Isao Ishii, Ichiro Mori, Motochika Asano, Masayuki Fuwa, Hiroyuki Morita

“…Several studies have shown that obesity and glucose homeostasis are influenced by sphingolipid mediators, including ceramide and sphingosine 1-phosphate (S1P). Cellular accumulation of ceramide impairs pancreatic β-cell survival, confers insulin resistance in the liver and the skeletal muscle, and deteriorates adipose tissue inflammation via unknown molecular mechanisms. …”
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The role of sphingosine-1-phosphate in bone remodeling and osteoporosis by Justus M. Grewe, Paul-Richard Knapstein, Antonia Donat, Shan Jiang, Daniel J. Smit, Weixin Xie, Johannes Keller

“…Abstract Osteoporosis is a systemic bone disease that affects more than 200 million people worldwide and is caused by the disruption of the equilibrium between osteoclastic bone resorption and osteoblastic bone formation. Sphingosine-1-phosphate (S1P) is a natural, bioactive sphingolipid that has been shown to play a major role in cardiovascular and immunological pathologies by regulating biological and cellular processes, including migration, differentiation, proliferation and survival. …”
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Sphingosine-1-phosphate expression in human epiretinal membranes. by Minho Kim, Soonil Kwon, Sohee Jeon, Byung Ju Jung, Kyu Seop Kim

“…However, there is only limited information about the molecular mechanism. Sphingosine-1-phosphate (S1P) is a mediator of the mechanosensitive response in several cell types that may have a role in the pathogenesis of ERM during abnormal PVD. …”
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