INVESTIGATING THE ROLE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE-1 (ERAP1) IN ANKYLOSING SPONDYLITIS by Chen, L, Fischer, R, Harvey, D, Kollnberger, S, Wordsworth, B, Oppermann, U, Kessler, B, Bowness, P

INVESTIGATING THE ROLE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE-1 (ERAP1) IN ANKYLOSING SPONDYLITIS by Chen, L, Fischer, R, Harvey, D, Kollnberger, S, Wordsworth, B, Oppermann, U, Kessler, B, Bowness, P

Axial spondyloarthritis: a new disease entity, not necessarily early ankylosing spondylitis. by Robinson, P, Wordsworth, B, Reveille, J, Brown, M

“…In the meantime the modified New York criteria for ankylosing spondylitis remain a very useful classification criteria set, defining a relatively homogenous group of cases for clinical use and research studies.…”

Axial spondyloarthritis: A new disease entity, not necessarily early ankylosing spondylitis by Robinson, P, Wordsworth, B, Reveille, J, Brown, M

“…In the meantime the modified New York criteria for ankylosing spondylitis remain a very useful classification criteria set, defining a relatively homogenous group of cases for clinical use and research studies.…”

Collagen-specific cytotoxic T lymphocyte responses in patients with ankylosing spondylitis and reactive arthritis. by Gao, X, Wordsworth, P, McMichael, A

“…Both ankylosing spondylitis (AS) and reactive arthritis (ReA) are strongly associated with HLA-B27 although the mechanism for this association is still unknown. …”

IMPACT OF ANKLOSING SPONDYLITIS-ASSOCIATED ERAP1 VARIANTS ON ITS AMINOPEPTIDASE ACTIVITY by Harvey, D, Kochan, G, Pointon, J, Opermann, U, Wordsworth, B

Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. by Davidson, S, Liu, Y, Danoy, P, Wu, X, Thomas, G, Jiang, L, Sun, L, Wang, N, Han, J, Han, H, Visscher, P, Brown, M, Xu, H

“… OBJECTIVES: Recent association studies by the Australo-Anglo-American Spondyloarthritis Consortium (TASC) in Caucasian European populations from Australia, North America and the UK have identified a number of genes as being associated with ankylosing spondylitis (AS). A candidate gene study in a Han Chinese population was performed based on these findings to identify associated genes in this population. …”

The effect of transforming growth factor beta1 gene polymorphisms in ankylosing spondylitis. by Jaakkola, E, Crane, A, Laiho, K, Herzberg, I, Sims, A, Bradbury, L, Calin, A, Brophy, S, Kauppi, M, Kaarela, K, Wordsworth, B, Tuomilehto, J, Brown, M

“…A structured questionnaire was used to assess the age of symptom onset, disease duration and disease severity scores, including the BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) and BASFI (Bath Ankylosing Spondylitis Functional Index). …”

A double-blind cross-over trial of fenoprofen and phenylbutazone in ankylosing spondylitis. by Wordsworth, B, Ebringer, R, Coggins, E, Smith, S

“…Fenoprofen, 600 mg, three times daily, was compared with phenylbutazone, 100 mg, three times daily, in 30 patients suffering from ankylosing spondylitis in a double-blind cross-over study. Assessments were made after an initial washout period and after each month-long treatment period. …”

Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism by Vecellio, M, Cortes, A, Roberts, A, Ellis, J, Cohen, C, Knight, J, Brown, M, Bowness, P, Wordsworth, B

“…To explore the functions of RUNX3 single nucleotide polymorphisms (SNPs) associated with ankylosing spondylitis (AS).Individual SNP associations were evaluated in 4230 UK cases. …”

Diagnostic capacity of genetic tests in Ankylosing spondylitis can exceed MRI scanning by Evans, D, Reveille, J, Weisman, M, Stone, M, Ward, M, Savage, L, Zhou, X, Wordsworth, B, Brown, M

A proteomic approach to the identification of marker proteins for ankylosing spondylitis and rheumatoid arthritis by Wright, C, Kessler, B, Bowness, P

IMPACT OF ANKYLOSING SPONDYLITIS-ASSOCIATED ERAP1 VARIANTS ON ITS AMINOPEPTIDASE ACTIVITY by Harvey, D, Kochan, G, Pointon, J, Oppermann, U, Wordsworth, B

Disease severity in Ankylosing Spondylitis: The influence of associated inflammatory bowel disease and psoriasis by Bradbury, L, Lewington, M, Warner, J, Farrar, C, Wordsworth, B, Brown, M

Functional genomic analysis of a RUNX3 polymorphism associated with ankylosing spondylitis by Vecellio, M, Chen, L, Cohen, CJ, Cortes, A, Li, Y, Bonham, S, Selmi, C, Brown, MA, Fischer, R, Knight, JC, Wordsworth, BP

“…Objective To investigate the functional consequences of the single-nucleotide polymorphism rs4648889 in a putative enhancer upstream of the RUNX3 promoter associated with susceptibility to ankylosing spondylitis (AS). Methods Using nuclear extracts from Jurkat cells and primary human CD8+ T cells, the effects of rs4648889 on allele-specific transcription factor (TF) binding were investigated by DNA pull-down assay and quantitative mass spectrometry (qMS), with validation by electrophoretic mobility shift assay (EMSA), Western blotting of the pulled-down eluates, and chromatin immunoprecipitation (ChIP)–quantitative polymerase chain reaction (qPCR) analysis. …”

EVALUATION OF EFFICACY AND SAFETY OF SECUKINUMAB IN THE TREATMENT OF PATIENTS WITH MODERATE-TO-SEVERE ANKYLOSING SPONDYLITIS by Emery, P, Baeten, D, Sieper, J, Braun, J, van der Heijde, D, McInnes, I, Van Laar, J, Landewe, R, Wordsworth, B, Wollenhaupt, J, Kellner, H, Paramarta, I, Bertolino, A, Wright, A, Hueber, W

Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis. by Brown, M, Edwards, S, Hoyle, E, Campbell, S, Laval, S, Daly, A, Pile, K, Calin, A, Ebringer, A, Weeks, D, Wordsworth, B

“…Ankylosing spondylitis (AS) is a common and highly familial rheumatic disorder. …”

Axial spondyloarthritis: A new disease entity, not necessarily early ankylosing spondylitis by Robinson, P, Wordsworth, B, Reveille, J, Brown, M

Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene (ANTXR2). by Karaderi, T, Keidel, S, Pointon, J, Appleton, L, Brown, M, Evans, D, Wordsworth, B

“…OBJECTIVES: ANTXR2 variants have been associated with ankylosing spondylitis (AS) in two previous genome-wide association studies (GWAS) (p∼9×10(-8)). …”

HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom. by Brown, M, Pile, K, Kennedy, L, Calin, A, Darke, C, Bell, J, Wordsworth, B, Cornélis, F

“…OBJECTIVE: To investigate the HLA class I associations of ankylosing spondylitis (AS) in the white population, with particular reference to HLA-B27 subtypes. …”