T cell phenotype and function in Spondyloarthritis by Ridley, AL

“…<p>Th17 cells are implicated in a variety of inflammatory disorders including Spondyloarthritis (SpA). Ankylosing spondylitis (AS), the most common SpA, is genetically associated with HLA-B27 and IL-23R polymorphisms, although the link remains unexplained. …”

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27. by Chen, L, Fischer, R, Peng, Y, Reeves, E, McHugh, K, Ternette, N, Hanke, T, Dong, T, Elliott, T, Shastri, N, Kollnberger, S, James, E, Kessler, B, Bowness, P

“…OBJECTIVE: HLA-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are the two strongest genetic factors predisposing to ankylosing spondylitis (AS). A key aminopeptidase in class I major histocompatibility complex presentation, ERAP1 potentially contributes to the pathogenesis of AS by altering HLA-B27 peptide presentation. …”

Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease. by Orchard, T, Thiyagaraja, S, Welsh, K, Wordsworth, B, Hill Gaston, J, Jewell, D

“…The results were compared with those of a cohort of 30 patients with postenteric reactive arthritis (ReA) and 16 patients with IBD-associated ankylosing spondylitis (IBD-AS). RESULTS: Type 1 arthropathy was associated with HLA-DRB1*0103 (DR103; a rare subtype of DR1) in 33% (P &lt; 0.0001; relative risk [RR], 12.1), B*35 in 30% (P = 0.01; RR, 2.2), and B*27 in 26% (P = 0. 001; RR, 4.0). …”

Results of a global, patient-based survey assessing the impact of psoriatic arthritis discussed in the context of the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire by Coates, LC, Orbai, A-M, Azevedo, VF, Cappelleri, JC, Steinberg, K, Lippe, R, Lim, I, Eder, L, Richette, P, Weng, MY, Queiro Silva, R, Fallon, L

“…<p><strong>Background:</strong> Psoriatic arthritis (PsA) is a chronic immune-mediated inflammatory musculoskeletal disease, manifesting as peripheral arthritis, enthesitis, dactylitis, spondylitis, and skin and nail psoriasis. A core set of domains for measuring the impact of PsA has been developed, including pain, patient global assessment, physical function, health-related quality of life (HRQoL), and fatigue. …”

Endoplasmic reticulum aminopeptidase 1 (ERAP1) plays a critical role in determining the length and sequence of peptides bound and presented by HLA-B27 by Chen, L, Fischer, R, Peng, Y, Reeves, E, McHugh, K, Ternette, N, Hanke, T, Dong, T, Elliott, T, Shastri, N, Kollnberger, S, James, E, Bowness, P

“…</strong> HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondylitis (AS). A key aminopeptidase in MHC class I presentation, ERAP1 potentially contributes to AS pathogenesis through altering HLA-B27 peptide presentation. …”

Epidemiology of low back pain: frequency, risk factors, and patterns in South-South Nigeria by Airenakho Emorinken, Cyril Oshomah Erameh, Blessyn Omoye Akpasubi, Mercy Ofunami Dic-Ijiewere, Asuwemhe Johnson Ugheoke

“…Common etiologies were spondylosis (66.5%), spondylolisthesis (22.3%), disc prolapse (19.4%), spinal canal stenosis (15.4%), muscle spasm (12.2%), and tuberculous spondylitis (9.7%). Acute and chronic LBP constituted 12.2% and 79.9% of cases, respectively. …”
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ANTI-HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN B1 (ANTI-RA33) ANTIBODIES IN RHEUMATOID ARTHRITIS AND SYSTEMIC SCLEROSIS by P. A. Kuznetsova, A. L. Maslyansky, S. V. Lapin, O. Yu. Tkachenko, V. I. Mazurov

“…The authors studied the frequency of anti-RNP B1 AAbs in 300 patients with systemic ARDs, including those with rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and Sjö gren's syndrome (SS) and in 53 people without ARDs, who constituted a control group. …”
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Causal associations between common musculoskeletal disorders and dementia: a Mendelian randomization study by Jiachen Wang, Mingyi Yang, Ye Tian, Ruoyang Feng, Ke Xu, Menghao Teng, Junxiang Wang, Qi Wang, Peng Xu

“…Simultaneously, ankylosing spondylitis was an independent risk factor for dementia, dementia with Lewy bodies, and dementia in Alzheimer’s disease. …”
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Efficacy and safety of ixekizumab treatment in patients with axial spondyloarthritis: 2-year results from COAST by Maxime Dougados, Atul Deodhar, Jürgen Braun, Uta Kiltz, Chen-Yen Lin, Tetsuya Tomita, Rebecca Bolce, Jessica Walsh, David Sandoval

“…The proportion of patients achieving Ankylosing Spondylitis Disease Activity Score &lt;2.1 through week 116 was 57.0% and 52.9% for bDMARD-naïve patients with r-axSpA and nr-axSpA, respectively, and 33.6% for TNFi-experienced patients. …”
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Characteristic analysis of adverse reactions of five anti-TNFɑ agents: a descriptive analysis from WHO-VigiAccess by Mingming Li, Ruxu You, Yuyong Su, Hongbo Zhou, Shiwei Gong

“…Introduction: Tumor necrosis factor (TNF) inhibitors (adalimumab, infliximab, etanercept, golimumab, and certolizumab pegol) have revolutionized the treatment of severe immune-mediated inflammatory diseases, including rheumatoid arthritis, Crohn’s disease, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. This study assessed adverse drug reactions (ADRs) after the use of TNFα inhibitors in VigiAccess of the World Health Organization (WHO) and compared the adverse reaction characteristics of five inhibitors to select the drug with the least risk for individualized patient use.Methods: The study was a retrospective descriptive analysis method in design. …”
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Assessment of PD-1 gene variation in patients with multiple sclerosis by Shadmehri AA, Nicknam MH, Shokrgozar MA, Mahmoudi M, Sarial Sh, Ahmadi Shadmehri A, Moradi B, Farhadi E, Amirzargar AA

“…This study was performed to investigate the role of polymorphisms of the programmed cell death 1 (PD-1) gene on susceptibility to ankylosing spondylitis. This gene codes an immunoreceptor named PD-1, which has a cytoplasmic domain containing two tyrosine residues located within immunoreceptor tyrosine-based inhibitory and switch motifs (ITIM and ITSM), suggesting that PD-1 is predominantly inhibitory which responsible for the negative regulation in T cell activation and peripheral tolerance. …”
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Diagnostic Significance of the Level of Soluble Stimulating Growth Factor in Patients with Spondyloarthritis as an Early Marker of Cardiovascular Pathology by K. D. Dorogoykina, K. N. Safarova, E. A. Fedotov, A. P. Rebrov

“…A total of 46 patients aged 39.2 ± 10.2 years with SpA (including 40 (87 %) with ankylosing spondylitis, 6 (13 %) with psoriatic arthritis) were examined. …”
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Evaluation of 55 Cases with Spondylodiscitis Due to Brucellosis by Servet KÖLGELİER, Nazlım AKTUĞ DEMİR, Aykut AKPINAR, Serap ÖZÇİMEN, Lütfi Saltuk DEMİR, Adem YILDIRIM, Şua SÜMER

“…In spinal brucellosis, first the vertebra corpus is involved, then spread to the neighboring disc space and vertebra corpus is observed, and with disc involvement, spondylitis evolves into spondylodiscitis. Brucellosis should be considered in the differential diagnosis in the presence of fever and lower back symptoms, especially in patients living in endemic regions.…”
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Evaluation of active inflammation, chronic structural damage, and response to treatment of sacroiliitis in axial spondyloarthritis using the Spondyloarthritis research consortium o... by Yimeng Zhang, Zikang Guo, Ying Zhan, Jin Qu, Xinwei Lei

“…To investigate whether there are differences in inflammatory and chronic structural damages, as assessed by a semiquantitative MRI scoring method, between non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) patients with active inflammation at baseline, and to evaluate the treatment response in these patients after 3 months of tumor necrosis factor-alpha (TNF-α) inhibitor treatment. …”
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The Treatment with Interleukin 17 Inhibitors and Immune-Mediated Inflammatory Diseases by Laura Țiburcă, Marius Bembea, Dana Carmen Zaha, Alexandru Daniel Jurca, Cosmin Mihai Vesa, Ioana Adela Rațiu, Claudia Maria Jurca

“…Tough, clinical trials of IL-17i have described cases of exacerbation or even onset of inflammatory bowel disease (IBD), such as Crohn’s disease and ulcerative colitis, after administration of these drugs in patients previously diagnosed with psoriasis (PS), psoriatic arthritis (PsA), or ankylosing spondylitis (AS). The pathophysiological mechanism of action is not well understood at present. …”
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Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry by Marta Valero, Carlos Sánchez-Piedra, Mercedes Freire, María Colazo, Noemí Busquets, Erardo Meriño-Ibarra, Carlos Rodríguez-Lozano, Sara Manrique, Cristina Campos, Fernando Sánchez-Alonso, Isabel Castrejón

“…Methods An observational retrospective study from the BIOBADASER registry comprising adult patients diagnosed with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA) and receiving 1 or 2 biological disease-modifying drugs (bDMARDs) between October 1999 and April 2021. …”
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Clinical Features of Human Brucellosis and Risk Factors for Focal Complications: A Retrospective Analysis in a Tertiary-Care Hospital in Beijing, China by Zhang Z, Zhang X, Chen X, Cui X, Cai M, Yang L, Zhang Y

“…Of all the patients, 76 (38.6%) were reported with focal complications, including 16 (8.1%) peripheral arthritis, 36 (18.3%) spondylitis, 17 (8.6%) epididymoorchitis, 8 (4.1%) meningitis and 3 (1.3%) endocarditis. …”
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Prevalence of familial autoimmune diseases in juvenile idiopathic arthritis: results from the international Pharmachild registry by Joeri W. van Straalen, Sytze de Roock, Gabriella Giancane, Ekaterina Alexeeva, Elena Koskova, Pablo Mesa-del-Castillo Bermejo, Francesco Zulian, Adele Civino, Davide Montin, Nico M. Wulffraat, Nicolino Ruperto, Joost F. Swart, for the Paediatric Rheumatology International Trials Organisation (PRINTO)

“…Results Eight thousand six hundred seventy three patients were included and the most common familial ADs were psoriasis, autoimmune thyroid disease, rheumatoid arthritis and ankylosing spondylitis. The prevalence of several ADs was higher in parents of the included JIA patients than in the general population. …”
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Clinical Application of Personalized Digital Surgical Planning and Precise Execution for Severe and Complex Adult Spinal Deformity Correction Utilizing 3D Printing Techniques by Hongtao Ding, Yong Hai, Lijin Zhou, Yuzeng Liu, Yiqi Zhang, Chaofan Han, Yangpu Zhang

“…The perioperative, and radiological parameters and complications, including surgery duration, estimated blood loss, pre- and post-operative cobb angle, trunk balance, and precision of osteotomy operation with screw implantation were collected retrospectively and analyzed to evaluate the clinical efficacy and safety of this technique. (3) Results: Of the eight patients, the primary pathology of scoliosis included two adult idiopathic scoliosis (ADIS), four congenital scoliosis (CS), one ankylosing spondylitis (AS), and one tuberculosis (TB). Two patients had a previous history of spinal surgery. …”
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Multi‐omics integration reveals a core network involved in host defence and hyperkeratinization in psoriasis by Jingwen Deng, Emmerik Leijten, Michel Olde Nordkamp, Guangjuan Zheng, Juliëtte Pouw, Weiyang Tao, Sarita Hartgring, Deepak Balak, Rianne Rijken, Runyue Huang, Timothy Radstake, Chuanjian Lu, Aridaman Pandit

“…Methods We collected the skin tissue biopsies and swabs in both lesional and non‐lesional skin of 13 patients with psoriasis, 15 patients with psoriatic arthritis and healthy skin from 12 patients with ankylosing spondylitis. To study the similarities and differences in the molecular profiles between these three conditions, and the associations between the host defence and microbiota composition, we performed high‐throughput RNA‐sequencing to quantify the gene expression profile in tissues. …”
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