Development of genomic phenotype and immunophenotype of acute respiratory distress syndrome using autophagy and metabolism-related genes by Feiping Xia, Hui Chen, Hui Chen, Yigao Liu, Lili Huang, Shanshan Meng, Jingyuan Xu, Jianfeng Xie, Guozheng Wang, Fengmei Guo

“…The mean risk score was determined to be 2.231332, and based on this score, patients were classified into high-risk and low-risk groups. 371 differential genes in high- and low-risk groups were analyzed. ITGAM, TYROBP, ITGB2, SPI1, PLEK, FGR, MPO, S100A12, HCK, and MYC were identified as hub genes. …”
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Spatial Prediction of Landslide Susceptibility Using Logistic Regression (LR), Functional Trees (FTs), and Random Subspace Functional Trees (RSFTs) for Pengyang County, China by Hui Shang, Lixiang Su, Wei Chen, Paraskevas Tsangaratos, Ioanna Ilia, Sihang Liu, Shaobo Cui, Zhao Duan

“…Next, we extracted 15 landslide conditioning factors, including the slope angle, elevation, profile curvature, plan curvature, slope aspect, TWI (topographic wetness index), TPI (topographic position index), distance to roads and rivers, NDVI (normalized difference vegetation index), rainfall, land use, lithology, SPI (stream power index), and STI (sediment transport index), from the spatial database. …”
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Identification of RNA Transcript Makers Associated With Prognosis of Kidney Renal Clear Cell Carcinoma by a Competing Endogenous RNA Network Analysis by Qiwei Yang, Qiwei Yang, Weiwei Chu, Wei Yang, Yanqiong Cheng, Chuanmin Chu, Xiuwu Pan, Jianqing Ye, Jianwei Cao, Sishun Gan, Xingang Cui, Xingang Cui

“…Seven mRNA targets of miRNA-21 (FASLG, FGF1, TGFBI, ALX1, SLC30A10, ADCY2, and ABAT) and 12 mRNAs targets of miRNA-155 (STXBP5L, SCG2, SPI1, C12orf40, TYRP1, CTHRC1, TDO2, PTPRQ, TRPM8, ERMP1, CD36, and ST9SIA4) also acted as prognostic biomarkers for KIRC patients.ConclusionWe screened numerous novel prognosis-related RNA markers for KIRC patients by a ceRNA network analysis, providing deeper understandings of prognostic values of RNA transcripts for KIRC.…”
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Identification of QTLs Conferring Agronomic and Quality Traits in Hexaploid Wheat by Jun MA, Cai-ying ZHANG, Gui-jun YAN, Chun-ji LIU

“…Data of a multiple environmental test was employed to genetically dissect quantitative trait loci (QTL) for agronomic traits such as plant height (PH), spike length (SL), spikelet per spike (SPI), grain number per spike (GNS) and thousand grains weight (TGW) and for quality traits including grain protein content (GPC), gluten content (GC), grain hardness (GH), falling number (FN) and sedimentation value (SV). …”
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Degradation of epigallocatechin and epicatechin gallates by a novel tannase TanHcw from Herbaspirillum camelliae by Jia Lei, Yong Zhang, Xuechen Ni, Xuejing Yu, Xingguo Wang

“…TanHcw was a secretary enzyme with a Sec/SPI signal peptide of 48 amino acids at the N-terminus, and it catalyzed the degradation of tannin, methyl gallate (MG), epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG). …”
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Whole-genome sequencing of extensively drug-resistant Salmonella enterica serovar Typhi clinical isolates from the Peshawar region of Pakistan by Mah Noor Mumtaz, Muhammad Irfan, Sami Siraj, Aslam Khan, Hizbullah Khan, Muhammad Imran, Ishtiaq Ahmad Khan, Asifullah Khan

“…Prophage and Salmonella Pathogenicity Island (SPI) analysis identified intact prophages and eight SPIs involved in Salmonella's invasion and replication within host cells. …”
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Bioinformatics analysis of potential pathogenesis and risk genes of immunoinflammation-promoted renal injury in severe COVID-19 by Zhimin Chen, Zhimin Chen, Caiming Chen, Caiming Chen, Fengbin Chen, Ruilong Lan, Guo Lin, Yanfang Xu, Yanfang Xu, Yanfang Xu

“…A further protein-protein interaction (PPI) network analysis screened 15 PPI-hub genes: ALOX5, CD38, GSF3R, LGR, RPR1, HCK, ITGAX, LYN, MAPK3, NCF4, SELP, SPI1, WAS, TLR2 and TLR4. Single-cell sequencing analysis indicated that PPI-hub genes were mainly distributed in neutrophils, macrophages, and dendritic cells. …”
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Co-expression modules construction by WGCNA and identify potential hub genes and regulation pathways of postpartum depression by Zhifang Deng, Wei Cai, Jue Liu, Aiping Deng, Yuan Yang, Jie Tu, Cheng Yuan, Han Xiao, Wenqi Gao

“…Eight genes (HNRNPA2B1, IL10, RAD51, UBA52, NHP2, RPL13A, FBL, SPI1) were identified as “real” hub genes from cross-validation data of the three modules and DEGs, and possessed diagnostic value in PPD. …”
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Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study by Helene Walger, Linda A. Antonucci, Alessandro Pigoni, Alessandro Pigoni, Rachel Upthegrove, Raimo K. R. Salokangas, Rebekka Lencer, Katharine Chisholm, Katharine Chisholm, Anita Riecher-Rössler, Theresa Haidl, Eva Meisenzahl, Marlene Rosen, Stephan Ruhrmann, Joseph Kambeitz, Lana Kambeitz-Ilankovic, Peter Falkai, Anne Ruef, Jarmo Hietala, Christos Pantelis, Stephen J. Wood, Stephen J. Wood, Stephen J. Wood, Paolo Brambilla, Alessandro Bertolino, Stefan Borgwardt, Nikolaos Koutsouleris, Frauke Schultze-Lutter, Frauke Schultze-Lutter

“…BS and the BS criteria, “Cognitive Disturbances” (COGDIS) and “Cognitive-perceptive BS” (COPER), were assessed with the “Schizophrenia Proneness Instrument, Adult version” (SPI-A). Using logistic regressions, prevalence rates of perceptive and cognitive BS, and of COGDIS and COPER, as well as the impact of social and role functioning on the association between age and BS were studied in three age groups (15–18 years, 19–23 years, 24–40 years). …”
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Synthetic single domain antibodies for the conformational trapping of membrane proteins by Iwan Zimmermann, Pascal Egloff, Cedric AJ Hutter, Fabian M Arnold, Peter Stohler, Nicolas Bocquet, Melanie N Hug, Sylwia Huber, Martin Siegrist, Lisa Hetemann, Jennifer Gera, Samira Gmür, Peter Spies, Daniel Gygax, Eric R Geertsma, Roger JP Dawson, Markus A Seeger

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Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla by Petr Bednarik, Petr Bednarik, Benjamin Spurny, Leo R. Silberbauer, Alena Svatkova, Patricia A. Handschuh, Birgit Reiter, Melisande E. Konadu, Thomas Stimpfl, Marie Spies, Wolfgang Bogner, Wolfgang Bogner, Rupert Lanzenberger

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Predicting Ventral Striatal Activation During Reward Anticipation From Functional Connectivity at Rest by Asako Mori, Asako Mori, Asako Mori, Manfred Klöbl, Go Okada, Murray Bruce Reed, Masahiro Takamura, Paul Michenthaler, Koki Takagaki, Patricia Anna Handschuh, Satoshi Yokoyama, Matej Murgas, Naho Ichikawa, Gregor Gryglewski, Chiyo Shibasaki, Marie Spies, Atsuo Yoshino, Andreas Hahn, Yasumasa Okamoto, Rupert Lanzenberger, Shigeto Yamawaki, Siegfried Kasper

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پهنه‌بندی حساسیت خطر سیل در حوضه آبخیز رودخانه کشکان با استفاده از دو مدل WOE و EBF by فهیمه آزادی, سید حسن صدوق, منیژه قهرودی, هیمن شهابی

“…هر دو مدل 14 فاکتور مؤثر در ایجاد سیل را مورد توجه قرار داده‌اند که عبارتند از: شیب، جهت شیب، زمین‌شناسی، جنس خاک، کاربری اراضی، شاخص رطوبت توپوگرافی (TWI)، توان آبراهه (SPI)، بارش، فاصله از رودخانه، فاصله از جاده، پوشش گیاهی (NDVI)، انحنای شیب (Curvatior)، تراکم آبراهه و مدل ارتفاعی رقومی منطقه. …”
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Skin-to-blood pH shift triggers metabolome and proteome global remodelling in Staphylococcus epidermidis by Luis Gafeira Gonçalves, Susana Santos, Laidson Paes Gomes, Jean Armengaud, Maria Miragaia, Ana Varela Coelho

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Identification of Potential Key Genes and Regulatory Markers in Essential Thrombocythemia Through Integrated Bioinformatics Analysis and Clinical Validation by Wang J, Wu Y, Uddin MN, Chen R, Hao JP

“…Besides, we identified 4 TFs (SPI1, IRF4, SRF, and AR) as master transcriptional regulators that were associated with regulating the DEGs in ET. …”
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Prognostic analysis and validation of diagnostic marker genes in patients with osteoporosis by Xing Wang, Zhiwei Pei, Ting Hao, Jirigala Ariben, Siqin Li, Wanxiong He, Xiangyu Kong, Jiale Chang, Zhenqun Zhao, Baoxin Zhang

“…The interaction network was constructed between the hub genes and miRNAs, transcription factors, RNA binding proteins, and drugs.ResultsA total of 40 DEGs, eight OP-related differential genes, six OP diagnostic marker genes, four OP key diagnostic marker genes, and ten hub genes (TNF, RARRES2, FLNA, STXBP2, EGR2, MAP4K2, NFKBIA, JUNB, SPI1, CTSD) were identified. RT-qPCR results revealed a total of eight genes had significant differential expression between osteoporosis patients and control samples. …”
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A Decade of Post-Intensive Care Syndrome: A Bibliometric Network Analysis by Nicolas Paul, Valentina Albrecht, Claudia Denke, Claudia D. Spies, Henning Krampe, Björn Weiss

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Standard operating procedure for curation and clinical interpretation of variants in cancer by Arpad M. Danos, Kilannin Krysiak, Erica K. Barnell, Adam C. Coffman, Joshua F. McMichael, Susanna Kiwala, Nicholas C. Spies, Lana M. Sheta, Shahil P. Pema, Lynzey Kujan, Kaitlin A. Clark, Amber Z. Wollam, Shruti Rao, Deborah I. Ritter, Dmitriy Sonkin, Gordana Raca, Wan-Hsin Lin, Cameron J. Grisdale, Raymond H. Kim, Alex H. Wagner, Subha Madhavan, Malachi Griffith, Obi L. Griffith

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Assessment of a Loop-Mediated Isothermal Amplification (LAMP) Assay for the Rapid Detection of Pathogenic Bacteria from Respiratory Samples in Patients with Hospital-Acquired Pneum... by Andrea Vergara, Hervé Boutal, Adrián Ceccato, Míriam López, Adrià Cruells, Leticia Bueno-Freire, Javier Moreno-Morales, Jorge Puig de la Bellacasa, Pedro Castro, Antoni Torres, Francesc Marco, Climent Casals-Pascual, Jordi Vila

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Improved rates of exclusive breastfeeding at 14 weeks of age in KwaZulu Natal, South Africa: what are the challenges now? by C. Horwood, L. Haskins, IM Engebretsen, S. Phakathi, C. Connolly, A. Coutsoudis, L. Spies

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