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Clinical and pharmacological aspects of using hormone-like effects of micronutrients during menopause
Published 2016-12-01Subjects: Get full text
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62
Glucocorticoid receptor (NR3C1) genetic polymorphisms and the outcomes of sudden sensorineural hearing loss
Published 2023-02-01Subjects: Get full text
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63
Endometrial receptivity during hormonal therapy in women of reproductive age with abnormal uterine bleeding due to ovulatory disorders
Published 2022-09-01“…To study endometrial steroid receptor expression in women of reproductive age after an episode of abnormal uterine bleeding due to ovulatory dysfunction during micronized progesterone or combined oral contraceptive therapy with bioidentical estrogen and dienogest. …”
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64
AIB1/SRC-3/NCOA3 function in estrogen receptor alpha positive breast cancer
Published 2023-08-01“…The estrogen receptor alpha (ERα) is a steroid receptor that is pivotal in the initiation and progression of most breast cancers. …”
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65
Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra
Published 2012-08-01“…How midbrain dopamine neurons respond to sex steroids depends on the presence of sex steroid receptor(s) and the level of steroid conversion enzymes (aromatase and 5α-reductase). …”
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Spatial definition of the human progesterone receptor-B transcriptional complex
Published 2022-11-01“…Summary: We report the quaternary structure of core transcriptional complex for the full-length human progesterone receptor-B (PR-B) homodimer with primary coactivator steroid receptor coactivator-2 (SRC-2) and the secondary coactivator p300/CREB-binding protein (CBP). …”
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68
Protocadherin 19 Clustering Epilepsy and Neurosteroids: Opportunities for Intervention
Published 2021-09-01“…We recently reported that cell adhesion molecule protocadherin 19 (encoded by the <i>PCDH19</i> gene) is involved in the coregulation of steroid receptor activity on gene expression. <i>PCDH19</i> variants cause early-onset developmental epileptic encephalopathy clustering epilepsy (CE), with altered steroidogenesis and NHR-related gene expression being identified in these individuals. …”
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69
Heat Shock Proteins (HSPs): a Review
Published 2023-09-01“…The HSP90 family are important in the formation of the steroid receptor complex. The HSP70 family is necessary for protein synthesis, translocation, and folding. …”
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70
Steroid withdrawal or avoidance in renal transplant recipients
Published 2006“…Steroids bind to intracellular receptors and the resulting steroid-receptor complex alters the transcription of cytokines by binding to glucocorticoid response elements on DNA. …”
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71
TMEM65 is a mitochondrial inner-membrane protein
Published 2014-04-01“…It has been reported that the expression of TMEM65 is regulated by steroid receptor RNA activator (SRA). To date, however, the localization and function of TMEM65 remained unknown. …”
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72
Roles of estrogens, estrogen-like compounds, and endocrine disruptors in adipocytes
Published 2022-09-01“…Estrogens have several mechanisms of action, which mainly include the modification of specific receptors that belong to the steroid receptor superfamily. The alpha estrogen receptors (ERα) and the beta receptors (ERβ) have a fundamental role in the metabolic control of the individual, with a very characteristic corporal distribution that exerts an influence on the metabolism of lipids and glucose. …”
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73
Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity.
Published 2010-12-01“…We show that the non-coding RNA, Steroid receptor RNA Activator (SRA), associates with PPARγ and coactivates PPARγ-dependent reporter gene expression. …”
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74
Integrin α9 regulates smooth muscle cell phenotype switching and vascular remodeling
Published 2021-05-01“…Mechanistically, suppressed synthetic phenotype and reduced proliferation were associated with decreased focal adhesion kinase/steroid receptor coactivator signaling and downstream targets, including phosphorylated ERK, p38 MAPK, glycogen synthase kinase 3β, and nuclear β-catenin, with reduced transcriptional activation of β-catenin target genes. …”
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75
Luteotropic and Luteolytic Factors Modulate the Expression of Nuclear Receptor Coregulators in Bovine Luteal Cells Independently of Histone Acetyltransferase and Histone Deacetylas...
Published 2023-08-01“…The aims of this study were to examine the effect of luteotropic and luteolytic factors on the mRNA and protein expression of the coactivators HAT: histone acetyltransferase p300 (P300), cyclic adenosine monophosphate response element-binding protein (CREB), and steroid receptor coactivator-1 (SRC-1) and the corepressor: nuclear receptor corepressor-2 (NCOR-2) in bovine luteal cells on days 6–10 and 16–20. …”
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76
Physiological Action of Progesterone in the Nonhuman Primate Oviduct
Published 2022-05-01“…Specific receptors mediate these actions of progesterone, and synthetic progesterone receptor modulators (PRMs) disrupt the normal cyclic regulation of the tube, significantly altering steroid receptor expression, cilia abundance, cilia beat frequency, and the tubal secretory milieu. …”
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Loss of the nuclear receptor corepressor SLIRP compromises male fertility.
Published 2013-01-01“…SRA stem Loop Interacting RNA-binding Protein (SLIRP) is a Steroid receptor RNA Activator (SRA) RNA-binding protein that is a potent repressor of NR activity. …”
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Direct observation of frequency modulated transcription in single cells using light activation
Published 2013-09-01“…Here we utilize single-molecule observations of RNA in fixed and living cells to develop a single-cell model of steroid-receptor mediated gene activation. We determine that steroids drive mRNA synthesis by frequency modulation of transcription. …”
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79
Correlations between hypothalamus-pituitary-adrenal axis parameters depend on age and learning capacity.
Published 2005“…Hippocampal mineralocorticoid receptor and glucocorticoid receptor mRNAs differed modestly between groups, but steroid receptor coactivator and heat-shock-protein 90 mRNAs were not different. …”
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Importance of Micromilieu for Pathophysiologic Mineralocorticoid Receptor Activity—When the Mineralocorticoid Receptor Resides in the Wrong Neighborhood
Published 2022-10-01“…The mineralocorticoid receptor (MR) is a member of the steroid receptor family and acts as a ligand-dependent transcription factor. …”
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