Novel 1,4-Dihydropyridine Derivatives as Mineralocorticoid Receptor Antagonists by Felipe Luis Pérez-Gordillo, Natalia Serrano-Morillas, Luz Marina Acosta-García, María Teresa Aranda, Daniela Passeri, Roberto Pellicciari, María Jesús Pérez de Vega, Rosario González-Muñiz, Diego Alvarez de la Rosa, Mercedes Martín-Martínez

“…The mineralocorticoid receptor (MR) belongs to the steroid receptor subfamily of nuclear receptors. MR is a transcription factor key in regulating blood pressure and mineral homeostasis. …”
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Advancing breast cancer diagnosis with a near-infrared fluorescence imaging smart sensor for estrogen/progesterone receptor detection by Gong Zhang, Min Dong, Xiulei Yao, Yuke Xia, Han Yu, Yu zhou, Chao Lian, Yunlei Zhang, Yiyao Cui

“…Our findings suggest that the reporter system consisting of steroid receptor response elements and near-infrared proteins provides a practical system for identifying biomarkers and advancing cancer diagnosis and therapy.…”
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Sex, signalling, and steroids: regulation of nuclear size and intracellular trafficking in secondary cells in the D. melanogaster male accessory gland by Hellberg, J

“…Previous work has shown that BMP signalling regulates a D. melanogaster steroid receptor—the ecdysone receptor (EcR)—to form a BMP/EcR signalling axis that controls secondary cell nuclear growth.…”

Breast cancer development in rats under the influence of platelet factor-4 (PF4) and/or rapamycin by Yaman, Zaihassni Mat

“…In this study, ER and PR were selected as markers for steroid receptor determination due to the strong association between breast cancer development and the influence of steroid hormones as demonstrated in many studies. …”
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Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Coho... by Stallcup Michael R, Kolonel Laurence N, Henderson Brian E, Le Marchand Loic, Sheng Xin, Ha Helen, Xia Lucy, Hsu Chris, Garcia Rachel R, Haiman Christopher A, Greene Geoffrey L, Press Michael F

“…Given the established role of estrogens in breast cancer, we hypothesized that coding variation in steroid receptor coactivator and corepressor genes may alter inter-individual response to estrogen and serve as markers of breast cancer risk.…”
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Androgen receptor cofactors: A potential role in understanding prostate cancer by Xiang Li, Haojun Xiong, Xingzhu Mou, Cancan Huang, Elizabeth Rosalind Thomas, Wenjing Yu, Yu Jiang, Yan Chen

“…This review encapsulates the pivotal roles played by coactivators and corepressors of AR, notably androgen receptor-associated protein (ARA) and steroid receptor Coactivators (SRC) in PCa. Our data unveils how these cofactors intricately modulate histone modifications, cell cycling, SUMOylation, and apoptosis through their interactions with AR. …”
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Comprehensive mapping of post-translational modifications of progesterone receptor (PR) and functional analysis of novel methylation and acetylation of PR. by Chung, Hwa Hwa.

“…The study also suggests that the heightened ligand-induced activity of PRB-K464Q is mediated through increased functional interaction with transcription co-regulators NCoR-l(Nuclear receptor corepressor 1) and SRC-l (Steroid receptor coactivator 1). Contrastingly, a mutation of K464 to the bulkier arginine or phenylalanine, mimicking methylation effects, had no effect or inhibited PR activity which suggests K464 methylation inhibits PR activity. …”
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Effect of atrazine on testicular toxicity involves accommodative disorder of xenobiotic metabolizing enzymes system and testosterone synthesis in European quail (Coturnix coturnix) by Lei Qin, Ping-An Jian, Bao-Jin Yi, Xiang-Yu Ma, Wei-Hong Lu, Xue-Nan Li, Jin-Long Li

“…Altogether, testicular coefficient decreased significantly in the high-dose group (1.22%) compared with the control group (3.03%) after 45 days of ATR exposure, and ATR is a potent CYP disruptor that acts through the NXRs and steroid receptor subfamily (APND, CAR, ERND and ERα) without a dose-dependent manner. …”
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Sex-Dependent Modulation of Acute Stress Reactivity After Early Life Stress in Mice: Relevance of Mineralocorticoid Receptor Expression by Valeria Bonapersona, Ruth Damsteegt, Mirjam L. Adams, Lisa T. C. M. van Weert, Onno C. Meijer, Marian Joëls, Marian Joëls, Ratna Angela Sarabdjitsingh

“…Additionally, we measured the effects of ELS on steroid receptor [MR and glucocorticoid receptor (GR)] levels in the dorsal hippocampus and medial prefrontal cortex (mPFC) with western blot. …”
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Long, Noncoding RNA SRA Induces Apoptosis of β-Cells by Promoting the IRAK1/LDHA/Lactate Pathway by Yu-Nan Huang, Shang-Lun Chiang, Yu-Jung Lin, Su-Ching Liu, Yen-Hsien Li, Yu-Chen Liao, Maw-Rong Lee, Pen-Hua Su, Fuu-Jen Tsai, Hui-Chih Hung, Chung-Hsing Wang

“…Long non-coding RNA steroid receptor RNA activators (LncRNA SRAs) are implicated in the β-cell destruction of Type 1 diabetes mellitus (T1D), but functional association remains poorly understood. …”
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Simulating androgen receptor selection in designer yeast by Haoran Zhang, Lu Zhang, Yipeng Xu, Shaoyong Chen, Zhenyi Ma, Mingdong Yao, Fangyin Li, Bo Li, Yingjin Yuan

“…Yeast HIS3 gene transactivation was associated with the ligand-induced recruitment of steroid receptor coactivator-1 (SRC-1) by AR mutants, where yeast growth in histidine-free medium was determined as the outcome. …”
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2325 by Evan Brady Lynch, Tatiana Goretsky, Emily Bradford, Tianyan Gao, Terrence Barrett

“…Decreases in TCF/LEF transcriptional activation (nuclear β-catenin’s DNA binding target) can be reversed with steroid receptor blockade with RU-486, suggesting that a receptor level interaction may be occurring. …”
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Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance by Vianet Argelia Tello-Flores, Fredy Omar Beltrán-Anaya, Marco Antonio Ramírez-Vargas, Brenda Ely Esteban-Casales, Napoleón Navarro-Tito, Luz del Carmen Alarcón-Romero, Carlos Aldair Luciano-Villa, Mónica Ramírez, Óscar del Moral-Hernández, Eugenia Flores-Alfaro

“…In recent years, several mechanisms have been reported to explain the key roles of lncRNAs in the development of IR, including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), imprinted maternal-ly expressed transcript (H19), maternally expressed gene 3 (MEG3), myocardial infarction-associated transcript (MIAT), and steroid receptor RNA activator (SRA), HOX transcript antisense RNA (HOTAIR), and downregulated Expression-Related Hexose/Glucose Transport Enhancer (DREH). …”
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Prognostic Role of Androgen Receptor Expression in HER2+ Breast Carcinoma Subtypes by Sandra Orrù, Emanuele Pascariello, Giovanni Sotgiu, Daniela Piras, Laura Saderi, Maria Rosaria Muroni, Ciriaco Carru, Caterina Arru, Cristina Mocci, Giampietro Pinna, Raffaele Barbara, Paolo Cossu-Rocca, Maria Rosaria De Miglio

“…A high prevalence of AR expression (91.5%) in BC HER+ was observed, with minimal differences between luminal and non-luminal tumor. According to steroid receptor expression, tumors were classified in four subgroups, including BC luminal and non-luminal HER2+ expressing or not AR. …”
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IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study. by Yunlei Li, Jessica G C A M Buijs-Gladdines, Kirsten Canté-Barrett, Andrew P Stubbs, Eric M Vroegindeweij, Willem K Smits, Ronald van Marion, Winand N M Dinjens, Martin Horstmann, Roland P Kuiper, Rogier C Buijsman, Guido J R Zaman, Peter J van der Spek, Rob Pieters, Jules P P Meijerink

“…We then performed a functional study to examine the mechanisms underlying steroid resistance and found that, rather than changing the steroid receptor's ability to activate downstream targets, steroid resistance was associated with strong activation of MEK-ERK and AKT, downstream components of the IL7R signaling pathway, thereby inducing a robust antiapoptotic response by upregulating MCL1 and BCLXL expression. …”
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Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19 by Takahiro Kawasaki, Yoshito Takeda, Ryuya Edahiro, Yuya Shirai, Mari Nogami-Itoh, Takanori Matsuki, Hiroshi Kida, Takatoshi Enomoto, Reina Hara, Yoshimi Noda, Yuichi Adachi, Takayuki Niitsu, Saori Amiya, Yuta Yamaguchi, Teruaki Murakami, Yasuhiro Kato, Takayoshi Morita, Hanako Yoshimura, Makoto Yamamoto, Daisuke Nakatsubo, Kotaro Miyake, Takayuki Shiroyama, Haruhiko Hirata, Jun Adachi, Yukinori Okada, Atsushi Kumanogoh

“…Moreover, molecular network analysis showed that pathways such as “estrogen signaling pathway,” “p160 steroid receptor coactivator (SRC) signaling pathway,” and “transcriptional regulation by STAT” were enriched in the transcriptome of monocytes in the peripheral blood mononuclear cells and lungs, and they were also commonly enriched in extracellular vesicle proteomics. …”
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Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study by Yanju Li, Xu Yang, Feiqing Wang, Feiqing Wang, Jianing Zhao, Chike Zhang, Dan Wu, Bo Yang, Rui Gao, Peng Zhao, Yun Zan, Min Su, Zhixu He, Yang Liu, Yang Liu, Yang Liu, Jishi Wang, Dongxin Tang

“…Enrichment analyses showed that “steroid receptor activity” and the “PI3K/AKT signaling pathway” were the most enriched biological process and signaling pathway, respectively. …”
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Ulipristal acetate versus levonorgestrel-releasing intrauterine system for heavy menstrual bleeding: the UCON randomised controlled trial and mechanism of action study by Lucy HR Whitaker, Lee J Middleton, Lee Priest, Smita Odedra, Versha Cheed, Elaine P Nicholls, Alistair RW Williams, Neil Roberts, Clive E Stubbs, Konstantios Tryposkiadis, Hannah Bensoussane, Rohan Chodankar, Alison A Murray, Moira Nicol, Aleksandra O Tsolova, Kaiming Yin, Marcos Cruz, Hui Wei Leow, Lucy E Kershaw, Suzanne L McLenachan, Graham McKillop, Jane Walker, Scott I Semple, T Justin Clark, Mary Ann Lumsden, Dharani K Hapangama, Lucky Saraswat, Siladitya Bhattacharya, Paul Smith, Jane Daniels, Hilary OD Critchley

“…Analysis of selected markers of endometrial cellular function demonstrated UPA modulation of the progesterone receptor, resulting in molecular and cellular alteration in steroid receptors within the endometrium, consistent with the development of a local (endometrial) oestrogenic microenvironment. …”
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Modulation of Xenobiotic Receptors by Steroids by Delira Robbins, Monimoy Banerjee, Taosheng Chen

“…Therefore, steroids, their metabolism and metabolites, xenobiotic receptors, steroid receptors, and the respective signaling pathways they regulate have functional interactions. …”
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Developmental and adult stress: effects of steroids and neurosteroids by Isha R. Gore, Elizabeth Gould

“…Glucocorticoids and sex steroids are produced in endocrine glands and the brain from cholesterol; these molecules bind to nuclear and membrane-associated steroid receptors. Unlike other steroids that can also be made in the brain, neurosteroids bind specifically to neurotransmitter receptors, not steroid receptors. …”
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