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Binding Sites of a Positron Emission Tomography Imaging Agent in Alzheimer’s β-Amyloid Fibrils Studied Using 19F Solid-State NMR
Published 2022“…Analytical high-performance liquid chromatography and 19F NMR spectra show that flutemetamol binds the current Aβ40 fibril polymorph with a stoichiometry of one ligand per four to five peptides. …”
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663
Calcium Binding to the Innate Immune Protein Human Calprotectin Revealed by Integrated Mass Spectrometry
Published 2022“…Integration of these methods allowed us to (i) observe the four regions of hCP that serve as Ca2+-binding sites, (ii) determine the binding stoichiometry to be four Ca2+ per CP heterodimer and eight Ca2+ per CP heterotetramer, (iii) establish the protein-to-Ca2+ molar ratio that causes the dimer-to-tetramer transition, and (iv) calculate the binding affinities associated with the four Ca2+-binding sites per heterodimer. …”
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664
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669
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Calcium Ion Gradients Modulate the Zinc Affinity and Antibacterial Activity of Human Calprotectin
Published 2013“…Zinc competition titrations employing chromophoric Zn(II) indicators provide a 2:1 Zn(II):CP stoichiometry, confirm that the His[subscript 3]Asp and His[subscript 4] sites of CP coordinate Zn(II), and reveal that the Zn(II) affinity of both sites is calcium-dependent. …”
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Thermal conductivity control by oxygen defect concentration modification in reducible oxides: The case of Pr0.1Ce0.9O2−δ thin films
Published 2015“…Corresponding changes in the oxygen non-stoichiometry (δ) are monitored by detecting the lattice parameters of the films with high-resolution X-ray diffraction, while the thermal properties are characterized by time-domain thermoreflectance measurements. …”
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675
Modeling CO[subscript 2] Chemical Effects on CO Formation in Oxy-Fuel Diffusion Flames Using Detailed, Quasi-Global, and Global Reaction Mechanisms
Published 2015“…Equilibrium calculation confirms higher CO concentration associated with fuel-rich stoichiometry in CO[subscript 2] diluted combustion environment. …”
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676
Limitations of Cs3Bi2I9 as lead-free photovoltaic absorber materials
Published 2020“…The efficiency of the Cs3Bi2I9 solar cell can be slightly improved by changing the stoichiometry of the precursor solutions, which is most probably due to the reduction in nonradiative defects as evident from our single-crystal photoluminescence spectroscopy. …”
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Journal Article -
677
Influence of microstructure topology on the mechanical properties of powder compacted materials
Published 2021“…Powder compaction is an important technique for fabricating engineering materials as it offers good resolution and is compatible with complex stoichiometry and geometries. It forms the basis of important manufacturing processes such as powder bed 3D printing, powder metallurgy and metal injection moulding. …”
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Journal Article -
678
Positive cooperativity in the activation of E. coli aquaporin Z by cardiolipin: potential for lipid-based aquaporin modulators
Published 2022“…However, although it has been predicted that eCDL binds at the monomer-monomer interfaces of the AqpZ tetramer [5,10], neither binding site, stoichiometry or precise mode of activation of AqpZ by eCDL are known. …”
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Journal Article -
679
Improvement of the ITC binding analysis methodology for the unspecific interaction between serum proteins and polymer brushes grafted to nanoparticles
Published 2023“…This work focuses on measuring affinity, stoichiometry, and thermodynamic parameters of the weak interaction between thermoresponsive polymer brushes densely grafted on small superparamagnetic iron oxide nanoparticles (SPIONs) and blood proteins with the rarely used isothermal titration calorimetry (ITC) method. …”
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Thesis-Doctor of Philosophy -
680
Characterization of protein-protein interactions underlying liquid-liquid phase separation in Rubisco biomolecular condensates
Published 2025“…The interplay between homotypic and heterotypic interactions, which varies with the stoichiometry of dense phase components, determines the liquid dynamics of heterotypic condensates. …”
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Thesis-Doctor of Philosophy