Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase. by Walport, L, Hopkinson, R, Vollmar, M, Madden, S, Gileadi, C, Oppermann, U, Schofield, C, Johansson, C

“…KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that catalyze demethylation of N(ϵ)-methylated histone 3 lysine 27 (H3K27), a mark important for transcriptional repression. …”

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4. by Lee, W, Lukacik, P, Guo, K, Ugochukwu, E, Kavanagh, K, Marsden, B, Oppermann, U

“…Based on the evidence gathered from our docking experiments and experimental structures, this tryptophan residue emerges as a major determinant governing substrate specificity of a subset of enzymes belonging to the AKR1 subfamily.…”

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. by McClenaghan, C, Schewe, M, Aryal, P, Carpenter, E, Baukrowitz, T, Tucker, S

“…The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. …”

A robust phylogenomic framework for the calamoid palms by Kuhnhäuser, BG, Bellot, S, Couvreur, TLP, Dransfield, J, Henderson, A, Schley, R, Chomicki, G, Eiserhardt, WL, Hiscock, SJ, Baker, WJ

“…Well-supported phylogenies are a prerequisite for the study of the evolution and diversity of life on earth. The subfamily Calamoideae accounts for more than one fifth of the palm family (Arecaceae), occurs in tropical rainforests across the world, and supports a billion-dollar industry in rattan products. …”

A complete dichotomy for complex-valued Holant^c by Backens, M

“…<p>Holant problems are a family of counting problems on graphs, parametrised by sets of complex-valued functions of Boolean inputs. Holant^c denotes a subfamily of those problems, where any function set considered must contain the two unary functions pinning inputs to values 0 or 1. …”

Structures of down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition by Soundararajan, M, Roos, A, Savitsky, P, Filippakopoulos, P, Eswaran, J, Knapp, S, Elkins, J, Kettenbach, A, Gerber, SA, Olsen, J

“…We present crystal structures of one representative member of each DYRK subfamily: DYRK1A with an ATP-mimetic inhibitor and consensus peptide, and DYRK2 including NAPA and DH (DYRK homology) box regions. …”

Small-molecule inhibition of BRDT for male contraception. by Matzuk, M, McKeown, MR, Filippakopoulos, P, Li, Q, Ma, L, Agno, J, Lemieux, M, Picaud, S, Yu, R, Qi, J, Knapp, S, Bradner, J

“…Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhibitor (JQ1) of the bromodomain and extraterminal (BET) subfamily of epigenetic reader proteins. Here, we report potent inhibition of the testis-specific member BRDT, which is essential for chromatin remodeling during spermatogenesis. …”

Differential effects of ethanol on electrical properties of various potassium channels expressed in oocytes. by Anantharam, V, Bayley, H, Wilson, A, Treistman, SN

“…The response to ethanol was not determined exclusively by membership in a genetic subfamily. In addition, the relative sensitivity among different channels could vary independently for different electrical parameters. …”

DNA-based characterisation and classification of forensically important flesh flies (Diptera: Sarcophagidae) in Malaysia by Tan, S.H., Rizman-Idid, M., Mohd-Aris, E., Kurahashi, H., Mohamed, Z.

“…These groups correspond with generic or subgeneric taxa of the subfamily Sarcophaginae: Boettcherisca, Parasarcophaga, Liosarcophaga, Sarcorohdendorfia-Lioproctia, Harpagophalla-Seniorwhitea and Liopygia. …”

Gonadal transcriptomes reveal sex-biased expression genes associated with sex determination and differentiation in red-tail catfish (Hemibagrus wyckioides) by Wen-Yu Wei, Yi Gong, Xin-Fen Guo, Min Liu, Yu-Lin Zhou, Zhi Li, Li Zhou, Zhong-Wei Wang, Jian-Fang Gui

“…Real-time quantitative PCR (RT-qPCR) further confirmed that anti-Mullerian hormone (amh), growth differentiation factor 6a (gdf6a), testis-specific gene antigen 10 (tsga10), and cytochrome P450 family 17 subfamily A (cyp17a) were highly expressed mainly in the male, while cytochrome P450 family 19 subfamily A polypeptide 1b (cyp19a1b), forkhead box L2 (foxl2), and hydroxysteroid 17-beta dehydrogenase 1 (hsd17b1) were highly expressed in the female. …”
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Kunitz-Type Peptide HCRG21 from the Sea Anemone Heteractis crispa Is a Full Antagonist of the TRPV1 Receptor by Margarita Monastyrnaya, Steve Peigneur, Elena Zelepuga, Oksana Sintsova, Irina Gladkikh, Elena Leychenko, Marina Isaeva, Jan Tytgat, Emma Kozlovskaya

“…The sequence of a new Kunitz-type peptide, HCRG21, belonging to the Heteractis crispa RG (HCRG) peptide subfamily was deduced on the basis of the gene sequence obtained from the Heteractis crispa cDNA. …”
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A novel lineage of candidate pheromone receptors for sex communication in moths by Lucie Bastin-Héline, Arthur de Fouchier, Song Cao, Fotini Koutroumpa, Gabriela Caballero-Vidal, Stefania Robakiewicz, Christelle Monsempes, Marie-Christine François, Tatiana Ribeyre, Annick Maria, Thomas Chertemps, Anne de Cian, William B Walker III, Guirong Wang, Emmanuelle Jacquin-Joly, Nicolas Montagné

“…In the highly diversified insect order Lepidoptera, male PRs tuned to female-emitted type I pheromones (which make up the vast majority of pheromones identified) form a dedicated subfamily of odorant receptors (ORs). Here, using a combination of heterologous expression and in vivo genome editing methods, we bring functional evidence that at least one moth PR does not belong to this subfamily but to a distantly related OR lineage. …”
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Trench Foot or Non-Freezing Cold Injury As a Painful Vaso-Neuropathy: Clinical and Skin Biopsy Assessments by Praveen Anand, Rosario Privitera, Yiangos Yiangou, Philippe Donatien, Rolfe Birch, Peter Misra

“…Immunohistochemistry was used to assess intraepidermal (IENF) and subepidermal (SENF) nerve fibres with a range of markers, including the pan-neuronal marker protein gene product 9.5 (PGP 9.5), regenerating fibres with growth-associated protein 43 (GAP43), and nociceptor fibres with transient receptor potential cation channel subfamily V member 1 (TRPV1), sensory neuron-specific receptor (SNSR), and calcitonin gene-related peptide (CGRP). von Willebrand factor (vWF), endothelial nitric oxide synthase (eNOS), and vascular endothelial growth factor (VEGF) were used for assessing blood vessels, and transient receptor potential cation channel, subfamily A member 1 (TRPA1) and P2X purinoceptor 7 (P2X7) for keratinocytes, which regulate nociceptors via release of nerve growth factor.ResultsClinical examination showed pinprick sensation was abnormal in the feet of 20 patients (67%), and between 67 and 83% had abnormalities of thermal thresholds to the different modalities. 7 patients (23%) showed reduced sensory action potential amplitude of plantar nerves. 27 patients (90%) had decreased calf skin PGP 9.5 IENF (p &lt; 0.0001), the remaining 3 patients had decreased nerve markers in subepidermis or foot skin. …”
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Composição da comunidade de Formicidae (Insecta, Hymenoptera) em copas de Attalea phalerata Mart. (Arecaceae), no Pantanal de Poconé, Mato Grosso, Brasil Composition of Formicidae... by Leandro Dênis Battirola, Marinêz Isaac Marques, Joachim Adis, Jacques H. C. Delabie

“…Myrmicinae was the most representative subfamily, with 6 tribes and 14 species, with Solenopsidini (5 species) distinguishing. …”
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Whole genome sequencing reveals population diversity and variation in HIV-1 specific host genes by Prisca K. Thami, Wonderful T. Choga, Wonderful T. Choga, Collet Dandara, Collet Dandara, Collet Dandara, Stephen J. O’Brien, Stephen J. O’Brien, Myron Essex, Simani Gaseitsiwe, Simani Gaseitsiwe, Emile R. Chimusa, Emile R. Chimusa

“…The most deleterious variants were enriched in five genes: ACTRT2 (the Actin Related Protein T2), HOXD12 (homeobox D12), ABCB5 (ATP binding cassette subfamily B member 5), ATP8B4 (ATPase phospholipid transporting 8B4) and ABCC12 (ATP Binding Cassette Subfamily C Member 12). …”
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Unlocking the Complete Chloroplast Genome of a Native Tree Species from the Amazon Basin, Capirona (<i>Calycophyllum Spruceanum</i>, Rubiaceae), and Its Comparative Analysis with O... by Carla L. Saldaña, Pedro Rodriguez-Grados, Julio C. Chávez-Galarza, Shefferson Feijoo, Juan Carlos Guerrero-Abad, Héctor V. Vásquez, Jorge L. Maicelo, Jorge H. Jhoncon, Carlos I. Arbizu

“…Capirona (<i>Calycophyllum spruceanum</i> Benth.) belongs to subfamily Ixoroideae, one of the major lineages in the Rubiaceae family, and is an important timber tree. …”
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The HD-ZIP Gene Family in Watermelon: Genome-Wide Identification and Expression Analysis under Abiotic Stresses by Xing Yan, Zhen Yue, Xiaona Pan, Fengfei Si, Jiayue Li, Xiaoyao Chen, Xin Li, Feishi Luan, Jianqiang Yang, Xian Zhang, Chunhua Wei

“…HD-ZIP members in the same subfamily generally shared similar gene structures and conserved motifs. …”
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Coffee prevents fatty liver disease induced by a high-fat diet by modulating pathways of the gut–liver axis by Paola Vitaglione, Giovanna Mazzone, Vincenzo Lembo, Giuseppe D'Argenio, Antonella Rossi, Maria Guido, Marcella Savoia, Federico Salomone, Ilario Mennella, Francesca De Filippis, Danilo Ercolini, Nicola Caporaso, Filomena Morisco

“…Accordingly, liver PPAR- α (P < 0·05) and acyl-CoA oxidase-1 (P < 0·05) as well as duodenal ATP-binding cassette (ABC) subfamily A1 (ABCA1) and subfamily G1 (ABCG1) (P < 0·05) mRNA expressions increased with coffee consumption. …”
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Comparative genomics and phylogenomics of the genus Glycyrrhiza (Fabaceae) based on chloroplast genomes by Liwei Wu, Panhui Fan, Jiaying Cai, Chenxi Zang, Yulin Lin, Zhichao Xu, Zhengjun Wu, Wei Gao, Jingyuan Song, Jingyuan Song, Hui Yao, Hui Yao

“…The results of phylogenetic analysis indicated that species from the six subfamilies formed distinct clusters, consistent with the classification scheme of the six subfamilies. …”
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MYB Superfamily in <i>Brassica napus</i>: Evidence for Hormone-Mediated Expression Profiles, Large Expansion, and Functions in Root Hair Development by Pengfeng Li, Jing Wen, Ping Chen, Pengcheng Guo, Yunzhuo Ke, Mangmang Wang, Mingming Liu, Lam-Son Phan Tran, Jiana Li, Hai Du

“…Phylogenetic analysis classified the Bn2R-MYBs into 43 subfamilies, and the BnMYBRs into five subfamilies. …”
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