Using siRNA to define functional interactions between melanopsin and multiple G Protein partners. by Hughes, S, Jagannath, A, Hickey, D, Gatti, S, Wood, M, Peirson, S, Foster, R, Hankins, M

“…Furthermore, using RNAi based gene silencing we show that melanopsin can signal via Gnaq, Gna11 or Gna14 in vitro, and demonstrate that multiple members of the Gnaq/11 subfamily, including Gna14 and at least Gnaq or Gna11, can participate in melanopsin phototransduction in vivo and contribute to the pupillary light responses of mice lacking rod and cone photoreceptors. …”

Conformational stability and activity of p73 require a second helix in the tetramerization domain. by Coutandin, D, Löhr, F, Niesen, F, Ikeya, T, Weber, T, Schäfer, B, Zielonka, E, Bullock, A, Yang, A, Güntert, P, Knapp, S, McKeon, F, Ou, H, Dötsch, V

“…No heterooligomerization between p53 and the p73/p63 subfamily was observed, supporting the notion of functional orthogonality within the p53 family.…”

TASK-like potassium channels and oxygen sensing in the carotid body. by Buckler, K

“…The pharmacological and biophysical characteristics of these channels suggest that they are probably closely related to the TASK subfamily of tandem-P-domain K(+)-channels. Indeed they show greatest similarity to TASK-1 and -3. …”

Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues by Langley, G, Brinkø, A, Münzel, M, Walport, L, Schofield, C, Hopkinson, R

“…Demethylation of a trans-C-4/C-5 dehydrolysine substrate analogue was observed with representative KDM4 subfamily members KDM4A, KDM4B and KDM4E, and KDM7B, which are predicted, based on crystallographic analyses, to bind the N(ε)-methylated lysine residue in different conformations during catalysis. …”

Cell cycle regulation of central spindle assembly. by Mishima, M, Pavicic, V, Grüneberg, U, Nigg, E, Glotzer, M

“…The mitotic kinase Cdk1/cyclin B phosphorylates the motor domain of ZEN-4 on a conserved site within a basic amino-terminal extension characteristic of the MKLP1 subfamily. Phosphorylation by Cdk1 diminishes the motor activity of ZEN-4 by reducing its affinity for microtubules. …”

KOJAK encodes a cellulose synthase-like protein required for root hair cell morphogenesis in Arabidopsis. by Favery, B, Ryan, E, Foreman, J, Linstead, P, Boudonck, K, Steer, M, Shaw, P, Dolan, L

“…KOJAK/AtCSLD3 is the first member of this subfamily of proteins to be shown to have a function in cell growth. …”

The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels by Rinné, S, Kiper, A, Vowinkel, K, Ramírez, D, Schewe, M, Bedoya, M, Aser, D, Gensler, I, Netter, M, Stansfeld, P, Baukrowitz, T, Gonzalez, W, Decher, N

“…Here, we identified a novel binding site and allosteric inhibition mechanism, disrupting the recently proposed K⁺-flux gating mechanism of K_2P channels, which results in an unusual voltage-dependent block of leak channels belonging to the TASK subfamily. The new binding site and allosteric mechanism of inhibition provide structural and mechanistic insights into the gating of TASK channels and the basis for the drug design of a new class of potent blockers targeting specific types of K_2P channels.…”

Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66. by Türkmen, VA, Hintzen, JCJ, Tumber, A, Moesgaard, L, Salah, E, Kongsted, J, Schofield, CJ, Mecinović, J

“…We describe studies on the substrate selectivity and inhibition of the human ribosomal oxygenases (ROX) MINA53 and NO66, members of the JmjC 2OG oxygenase subfamily, which catalyse C-3 hydroxylation of histidine residues in Rpl27a and Rpl8, respectively. …”

Projection structure of a transcriptional regulator, HupR, determined by electron cryo-microscopy. by Vénien-Bryan, C, Schertler, G, Thouvenin, E, Courty, S

“…HupR is a response regulator of the NtrC subfamily; it activates the transcription of the structural genes hupSLC, of [NiFe]hydrogenase. …”

Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis. by Shang, L, Ranson, S, Tucker, S

“…The inwardly-rectifying potassium channel subunit Kir5.1 selectively co-assembles with members of the Kir4.0 subfamily to form novel pH-sensitive heteromeric channels with unique single channel properties. …”

Phenotypic characterisation of the C. elegans latrophilin homolog, lat-1 by Mestek, L

“…The results implicate a second evolutionary conserved subfamily of adhesion GPCRs in the control of tissue polarity and morphogenesis.…”

Structural and functional studies of the response regulator HupR. by Davies, K, Skamnaki, V, Johnson, L, Vénien-Bryan, C

“…The protein belongs to the NtrC subfamily of response regulators and is the second protein of a two-component system. …”

The Upper Cenomanian transgression in the High Moulouya and southern middle Atlas, Morocco by Charrière, A, Andreu, B, Ciszak, R, Kennedy, W, Rossi, A, Vila, J

“…In the Southern Middle Atlas of Morocco, the well-documented Marnes a gypse (Cenomanian) are overlain by the lower part of the Amghourzif Formation, dated as Upper but not uppermost Cenomanian on the basis of benthonic foraminifera of the subfamily Rhapidionininae. The upper part of the Amghourzif yields upper Upper Cenomanian Cauvini zone ammonites, and planctonic foraminifera of Whiteinella archaeocretacea biozone of uppermost Cenomanian-lowest Turonian date. …”

A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondii. by Anderson-White, B, Ivey, F, Cheng, K, Szatanek, T, Lorestani, A, Beckers, C, Ferguson, D, Sahoo, N, Gubbels, M

“…In order to elucidate the division process, we have characterized a 14-member subfamily of Toxoplasma IMC proteins that share a repeat motif found in proteins associated with the cortical alveoli in all alveolates. …”

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. by McClenaghan, C, Schewe, M, Aryal, P, Carpenter, E, Baukrowitz, T, Tucker, S

“…The TREK subfamily of two-pore domain (K2P) K+ channels exhibit polymodal gating by a wide range of physical and chemical stimuli. …”

Phylogenetic relationships of Clerodendrum s.l. (Lamiaceae) inferred from chloroplast DNA by Steane, D, Scotland, R, Mabberley, D, Wagstaff, S, Reeves, P, Olmstead, R

“…The ndhF sequence data suggest that Tetraclea belongs in Clade I of Clerodendrum and support the monophyly of the recently circumscribed subfamily Teucriodeae.…”

Checklist of ants of selected hill dipterocarp forests of peninsular Malaysia. by Nur Zati A.Mustafa, Lim , G.T, Idris , A.B

“…A Survey of ants (Hymenoptera;formicidae) in six hill dipterocarp forests in peninsular Malaysia recorded 187 species (=morphospecies from seven subfamilies and 50 genera. Gunung Angsi forest reseach yielded the higher species richness (87 species).while Ulu Gombak forest reserve, the lowest(60 species)tewnty five genera were recorded for the subfamily myrmicinae, while the subfamilies ponerinae, formininae and dolichoderinae had 12,7 and 3 genera, respectively, cerapa aenictinae and psedomyricinae recorded one genus each.Myrmicines were the most speciose and abundant among the ant subfamilies,comprising 50.8% of total ant species and 50.6% of all ants collected, followed by ponerinae (21.4% and 35.7%),formicinae (17.6 and 11.6%)dolichoderinae (5.4%and 5.8 %),Aenictinae(2.1%and 0.2%),cerapachyinae(1.6% and 0.2%),and pseudomyrmininae(1.1%and 0.1% respectively).Pheidole was the most speciose genera, comprising 12.8% of ant species found.Lophomyrmes bedoti,odontoponera transversa,odontomachus rixosus, Diacamma scupturatum gnamptogenys modiglianii and unidentified species of pheidole,pachycondyla pheidolegeton and psedolasius were common species present in all the forest reserves sampled. …”

Effects of Different Aged Logged-Over Forests on the Great Argus (Argusianus Argus) (Linnaeus) at Sungai Lalang Forest Reserve, Malaysia by Phirasack, Sengrath

“…It belongs to the family Phasianidae and subfamily Argusianinae. This subspecies of Great Argus is found in most lowland and hill Dipterocarp forests up to 818 m above sea level, but is absent from heavily disturbed and fragmented forest sites. …”
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Reproductive and Seed Germination Characteristics of Woody Borreria (Diodia Ocimifolia) in a Plantation Ecosystem by Lim, Fang Woei

“…Woody borreria belongs to the subfamily Rubioidene in the family Rubiacene. It is a brush weed 1 to 1.5 m high and reproduces through seeds. …”
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Complete mitochondrial genome sequence of the Indian pipistrelle Pipistrellus coromandra (Vespertilioninae) by Rahman, Md. Mafizur, Yoon, Kwang Bae, Kim, Ji Young, Hussin, Mohamed Zakaria, Park, Yung Chul

“…We characterized the complete mitogenome of Pipistrellus coromandra (Indian pipistrelle) for comparative analysis of mitogenomes and for resolving the phylogenetic relationship of four tribes in the subfamily Vespertilioninae. The mitogenome size of P. coromandra was 17,153 bp, with a control region and a typical set of 37 mitochondrial genes. …”
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