Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay by Morissette, P, Polak, S, Chain, A, Zhai, J, Imredy, JP, Wildey, MJ, Travis, J, Fitzgerald, K, Fanelli, P, Passini, E, Rodriguez, B, Sannajust, F, Regan, C

“…In silico results successfully predicted the QTc interval prolongation outcome observed in the CVGP with an accuracy/specificity of 85%/73% and 75%/77%, when using PX and HTS ion channel data, respectively. …”

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. by Landeira, D, Sauer, S, Poot, R, Dvorkina, M, Mazzarella, L, Jørgensen, H, Pereira, C, Leleu, M, Piccolo, F, Spivakov, M, Brookes, E, Pombo, A, Fisher, C, Skarnes, W, Snoek, T, Bezstarosti, K, Demmers, J, Klose, R, Casanova, M, Tavares, L, Brockdorff, N, Merkenschlager, M, Fisher, A

“…Instead, they show a severely compromised capacity for successful differentiation towards neural or mesodermal fates and failed to correctly initiate lineage-specific gene expression in vitro. …”

Blind outcome assessment: the development and use of procedures to maintain and describe blinding in a pragmatic physiotherapy rehabilitation trial. by Minns Lowe, C, Wilson, MS, Sackley, C, Barker, K

“…RESULTS: Blind outcome assessment was believed successful for n = 74 (81.32%) assessments at 3-month follow-up, and n = 83 (91.21%) at 12 months. …”

Sharing stories: complex intervention for diabetes education in minority ethnic groups who do not speak English. by Greenhalgh, T, Collard, A, Begum, N

“…Whereas some organisations welcomed, successfully implemented, and sustained the advocate led groups, others failed to do so. …”

Environmental control of short-term variation in the plankton community of inner Tokyo Bay, Japan by Nakane, T, Nakaka, K, Bouman, H, Platt, T

“…Several short-term peaks of plankton abundance (blooms) occurred as responses to temporal changes in water quality from June to November, with consequent species succession. Significant fluctuations in the densities of the diatom Skeletonema costatum and several species of ciliates corresponded to the daily changes in the physical and chemical characteristics of the coastal environment. …”

Assessing the transparency of informed consent in feasibility and pilot studies: a single-centre quality assurance study protocol by Khan, MI, Holek, M, Bdair, F, Mbuagbaw, L, Eldridge, SM, Chan, CL, Campbell, MJ, Bond, CM, Hopewell, S, Lancaster, GA, Thabane, L

“…A highly transparent consent practice entails the consent documents communicate: (1) the term ‘pilot’ or ‘feasibility’ in the title; (2) the definition of a pilot/feasibility study; (3) the primary objectives of the study are to assess feasibility; (4) the specific feasibility objectives; and (5) the criteria for the study to successfully lead to the main study. The secondary objectives are to assess whether there is a difference between submitted and revised versions of the consent documents (revisions are made to obtain research ethics approval), to determine factors associated with transparent consent practices and to assess the consistency with which pilot and feasibility studies assess feasibility outcomes as their primary objectives.…”

The beginning of melting of fertile and depleted peridotite at 1.5 GPa by Robinson, J, Wood, B, Blundy, J

“…These experimental results provide the first direct tests of fractional melting models which invoke the successive extraction of low-degree partial melts. No melting model currently available provides a good description of the compositions of low-degree melts from a fertile peridotite at 1.5 GPa. © 1998 Elsevier Science B.V.…”

Respectable banking: the search for stability in London’s money and credit markets since the great currency crisis of 1695 by Hotson, A

“…<p>The history of London’s money and credit markets is one of intermittent crises interspersed with successive attempts to find ways and means of stabilizing the system. …”

Factors influencing the uptake of public health interventions delivery by community pharmacists: A systematic review of global evidence by Mumbi, A, Mugo, P, Barasa, E, Abiiro, GA, Nzinga, J

“…Incorporating these factors into the design of policies and public health programs is critical for the successful integration of community pharmacists in the delivery of broader public health to meet the rising demand for health care across health systems.…”

Developing combination therapy to improve viral vector cancer vaccine efficacy by Noblecourt, L

“…Undeniably, it is necessary to develop treatment combination strategies to overcome the multitude of mechanisms that cancer cells use to escape the immune system. However, to successfully combine therapies and generate synergy, research is needed to comprehend their respective therapeutic mechanisms, and determine the optimal sequence of treatment administration. …”

Optimization in osmolality and range of density of a continuous ficoll-sodium-diatrizoate gradient for isopycnic purification of isolated human islets. by Eckhard, M, Brandhorst, D, Brandhorst, H, Brendel, MD, Bretzel, R

“…Using the DO-FSD may improve human islet purification allowing successful clinical islet transplantation.…”

Cross-cultural adaptation and psychometric validation of the Chichewa (Malawi) PedsQL ™ 4.0 Generic Core Scales child self-report and PedsQL ™ 4.0 GCS teen self-report by Ngwira, LG, Maheswaran, H, Petrou, S, Niessen, LW, Smith, SC

“…Conclusion: We have successfully adapted the PedsQL™ 4.0 GCS child self-report and teen self-report into Chichewa for use in Malawi. …”

Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury. by Li, H, Buchan, A

“…Delaying the initiation of treatment to 24 h was not successful, resulting in 50 +/- 28% injury (NS). In Experiment 3, saline-treated rats lost 81 +/- 19% of CA1 cells, while those given GYKI 52466 10 mg/kg i.p. x5 starting immediately following RP lost 80 +/- 14%.…”

On the onset of Central Atlantic Magmatic Province (CAMP) volcanism and environmental and carbon-cycle change at the Triassic–Jurassic transition (Neuquén Basin, Argentina) by Ruhl, M, Hesselbo, SP, Al-Suwaidi, A, Jenkyns, HC, Damborenea, SE, Manceñido, MO, Storm, M, Mather, TA, Riccardi, AC

“…Here, we present new data (total organic carbon, pyrolysis analysis, carbon-isotopes from bulk organic matter, elemental mercury, and other elemental contents) from a southern-hemisphere Triassic–Jurassic boundary succession in the Neuquén Basin, Argentina. The end-Triassic mass extinction there coincides with a relatively small (2–3‰) negative CIE in bulk organic matter, and we present a model that suggests that extreme aridity across the western Pangaean landmass may have resulted in rather limited terrestrial organic-matter flux to the sedimentary realm in eastern Panthalassic marine basins, hypothetically reducing the magnitude of the observed negative CIE in δ13CTOC. …”

Generic and disease-specific estimates of quality of life in macular degeneration: mapping the MacDQoL onto the EQ-5D-3L by Dixon, P, Dakin, H, Wordsworth, S

“…The selected models were successful at predicting means and standard deviations of target populations, but prediction is weaker at the upper and lower extremes of the EQ-5D-3L distribution. …”

A prospective evaluation of postural stimulation testing, computed tomography and adrenal vein sampling in the differential diagnosis of primary aldosteronism. by Lau, J, Sze, W, Reznek, R, Matson, M, Sahdev, A, Carpenter, R, Berney, D, Akker, SA, Chew, S, Grossman, AB, Monson, J, Drake, WM

“…For other patients, results from successful adrenal vein sampling were the diagnostic evidence against which CT and PST were assessed. …”

Knowledge of, and attitudes to giving expressed breastmilk to infants in rural coastal Kenya; focus group discussions of first time mothers and their advisers by Talbert, A, Tsofa, B, Mumbo, E, Berkley, J, Mwangome, M

“… <h4>Background</h4> <p>The World Health Organization (WHO)/UNICEF Baby-Friendly Hospital Initiative step number five of the “Ten steps to successful breastfeeding” states “Show mothers how to breastfeed and how to maintain lactation even if they should be separated from their infants.” …”

The management of head-and-neck paragangliomas. by Capatina, C, Ntali, G, Karavitaki, N, Grossman, AB

“…Further progress in the understanding of their pathogenesis will lead to more effective screening and earlier diagnosis, both critical to successful treatment.…”

An integrated genomic approach for the identification and analysis of single nucleotide polymorphisms that affect cancer in humans by Repapi, E

“…However, identifying the causal SNPs responsible for the associations has proven challenging, and GWAS have not been successful for time-to-event phenotypes such as cancer progression, due to the insurmountable obstacle of the large sample size needed. …”

Alexandre Brongniart (1770-1847): Kinship, natural history, and the invention of ceramic science by Carr-Trebelhorn, J

“…My discussion traces Brongniart’s successful and unsuccessful contributions to expanding scientific disciplines and to scientific language, including words such as Jurassic, Jovienne, Saturnienne, and, perhaps most importantly, "la céramique".…”