Digitally augmented geographies by Graham, M

“…It passed from person to person, often changing because it was so difficult to attach it to stable containers. But then, a succession of technological advancements (like papyrus and the printing press) allowed for the invention of books, newspapers, maps, and other media. …”

Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune enceph... by Vandenbark, A, Rich, C, Mooney, J, Zamora, A, Wang, C, Huan, J, Fugger, L, Offner, H, Jones, R, Burrows, G

“…Some mice treated with lower doses of VG312 relapsed after cessation of daily treatment, but the mice could be successfully re-treated with a higher dose of VG312. …”

Targeting mitochondrial metabolism as a promising therapeutic strategy in cancer by Stoker, ML

“…</p> <p>In this study, NBS037 treatment caused a significant decrease in cell viability and mitochondrial respiration in susceptible cancer cell lines, without increasing production of reactive oxygen species. Successful target engagement of mitochondrial ribosomes was observed, suggesting the mechanism of action lies in inhibition of mitochondrial protein translation, as expected. …”

International assistance and cooperation in access to essential medicines: a study of the issues in governance and implementation by Mok, E

“…It was determined that the international order possesses an influential array of ‘socialization’ methods that have been successful in inducing states toward norm compliance (when backed by the support of international NGO networks and domestic pressure). …”

Opportunities and priorities for breast surgical research by Cutress, RI, McIntosh, SA, Potter, S, Goyal, A, Kirwan, CC, Harvey, J, Francis, A, Carmichael, AR, Vidya, R, Vaidya, JS, Fairbrother, P, Benson, JR, Reed, MWR, Association Of Breast Surgery Surgical Gap Analysis Working Group

“…Development of infrastructure and surgical research capacity, together with appropriate allocation of research funding, is needed to successfully address the key clinical and translational research gaps that are highlighted in this Review within the next two decades.…”

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies. by Roach, P, Clifton, I, Hensgens, C, Shibata, N, Long, A, Strange, R, Hasnain, S, Schofield, C, Baldwin, J, Hajdu, J

“…Isopenicillin N synthase (IPNS) was cocrystallised with ferrous sulphate and its substrate, delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine (Aad-Cys-Val). Vital to the successful procedure was the maintenance of a rigorously anaerobic environment. …”

DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition. by Butler, D, Malfait, A, Mason, L, Warden, P, Kollias, G, Maini, R, Feldmann, M, Brennan, F

“…We have backcrossed these mice onto the arthritis-susceptible DBA/1 background and found an acceleration of the onset of arthritis with successive generations of interbreeding. Bioactive TNF-alpha in primary synovial membrane cell cultures was significantly higher in the DBA/1 transgenic mice than in transgenic mice on the original background. …”

Rethinking representation and European integration by Prosser, C

“…</p> <p>However, as a result of institutional differences between national and European Parliament elections rather than the emergence of the EU as an electoral issue, the size of party systems at European Parliament elections has grown considerably over successive elections in many member-states, a change that has fed into national party systems. …”

Fine tuning gene expression levels in mammalian cells with engineered microRNA target sites by Michaels, Y

“…In addition to tuning a PD-1 transgene in Jurkat T-cells, we successfully introduced miSFITs into the endogenous PD-1 3’UTR in embryonic stem cells using the CRISPR/Cas9 system. …”

Translation of artemether-lumefantrine treatment policy into paediatric clinical practice: an early experience from Kenya. by Zurovac, D, Njogu, J, Akhwale, W, Hamer, D, Snow, R

“…CONCLUSIONS: Changes in clinical practices at the point of care might take longer than anticipated. Delivery of successful interventions and their scaling up to increase coverage are important during this process; however, this should be accompanied by rigorous research evaluations, corrective actions on existing interventions and testing cost-effectiveness of novel interventions capable of improving and maintaining health worker performance and health systems to deliver artemisinin-based combination therapy in Africa.…”

The legacy of muscular Judaism: Jewish-Israeli identity through sport by Hancock, SP

“…In the first ethnographic chapter (4), I show how community-based sport fits within the greater normalisation debate, viewing its successes and failures in response to the prevailing Jewish state. …”

Functional and oncological outcomes after limb-salvage surgery for primary sarcomas of the upper limb. by Wright, E, Gwilym, S, Gibbons, C, Critchley, P, Giele, H

“…All four low-grade recurrences were successfully re-excised, as were five of the high-grade recurrences. …”

Cosmological weak lensing with the HST GEMS survey by Heymans, C, Brown, M, Barden, M, Caldwell, J, Jahnke, K, Peng, C, Rix, H, Taylor, A, Beckwith, S, Bell, E, Borch, A, Haeussler, B, Jogee, S, McIntosh, D, Meisenheimer, K, Sanchez, S, Somerville, R, Wisotzki, L, Wolf, C

“…Our correction for the temporal and spatial variability of the PSF is shown to be successful through a series of diagnostic tests.…”

Opening the black box: the politics of allocating public resources for health in Barbados by Headley, J

“…In particular, I find that these actors are successful in generating priority when they are able to propagate powerful framing ideas and can effectively navigate the policy context by seizing windows of opportunity and managing negative constraints. …”

Robust control system design with application to high performance helicopters by Tombs, M

“…A controller designed for a 4-input, 6-output, 8-state linearized plant model was successfully implemented in a non-linear simulation with rotor dynamics. …”

The effects of parasite diversity on eco-evolutionary dynamics by Betts, A

“…Coevolution between hosts and parasite communities drove more successive increases in host resistance coupled with increasingly frequent selective sweeps at the genomic level. …”

Local genes for local bacteria: Evidence of allopatry in the genomes of transatlantic Campylobacter populations by Pascoe, B, Meric, G, Yahara, K, Wimalarathna, H, Murray, S, Hitchings, M, Sproston, E, Carrillo, C, Taboada, E, Cooper, K, Huynh, S, Cody, A, Jolley, K, Maiden, M, McCarthy, N, Didelot, X, Parker, C, Sheppard, S

“…In Campylobacter, analyses of genomic data and molecular typing have been successful in determining the reservoir host species, but not geographical origin. …”

A health and social legacy for East London: Narratives of 'problem' and 'solution' around London 2012 by Thompson, C, Lewis, D, Greenhalgh, P, Taylor, S, Cummins, S

“…The bid for the London 2012 Olympic and Paralympic Games was successful partly due to its promise to deliver a lasting health and social legacy by using the Games as a driver of regeneration in East London. …”

Purification and characterisation of extracellular vesicles released from pluripotent stem cells by Lee, Y

“…In initial experiments, we successfully purified EVs from mouse iPSCs using the differential ultracentrifugation (UC) method. …”

Matching patients to an intervention for back pain: classifying patients using a latent class approach. by Barons, M, Griffiths, F, Parsons, N, Alba, A, Thorogood, M, Medley, G, Lamb, S

“…For this cohort of patients, the STarT system was as successful, but not superior.…”