Contribution of humoral immunity to the therapeutic response in falciparum malaria. by Mayxay, M, Chotivanich, K, Pukrittayakamee, S, Newton, P, Looareesuwan, S, White, N

“…The proportion of IgM-positive cases at admission was also higher in the successfully treated group than in the group with failure (70% versus 30%) (P < 0.001). …”

Detection of CFTR transgene mRNA expression in respiratory epithelium isolated from the murine nasal cavity. by Holder, E, Stevenson, B, Farley, R, Hilliard, T, Wodehouse, T, Somerton, L, Larsen, M, O'Donoghue, J, Coles, R, Scheule, R, Cheng, S, Gill, DR, Hyde, S, Griesenbach, U, Alton, E, Porteous, D, Boyd, A

“…RESULTS: Laser microdissection successfully isolated RECs; however, time-consuming sample preparation made this technique unsuitable for high-throughput studies. …”

Testing for complex drivers of resource utilisation: a case-study of roost dynamics in bats by Culina, A, Linton, D, Macdonald, D

“…Understanding the utilization of this critical resource is a pre-requisite for any successful conservation management of (often declining) bat populations. …”

China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up. by Chen, Z, Chen, J, Collins, R, Guo, Y, Peto, R, Wu, F, Li, L

“…Blood collection was successful in 99.98% and the mean delay from sample collection to processing was 10.6 h. …”

Identities, Inequalities and Conflicts in Ghana. by Tsikata, D, Seini, W

“…These includes inter-ethnic conflicts, mostly centred on control over land and other resources and sovereignty issues; intra ethnic conflicts around land ownership, competing uses of land and the siting of institutions and services, but mostly about chieftaincy succession; and conflicts between state institutions, such as the police and communities, over policing and law and order issues arising from communal conflicts and inter-personal disputes. …”

Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing by Jansen, IE, Ye, H, Heetveld, S, Lechler, MC, Michels, H, Seinstra, RI, Lubbe, SJ, Drouet, V, Lesage, S, Majounie, E, Gibbs, JR, Nalls, MA, Ryten, M, Botia, JA, Vandrovcova, J, Simon-Sanchez, J, Castillo-Lizardo, M, Rizzu, P, Blauwendraat, C, Chouhan, AK, Li, Y, Yogi, P, Amin, N, Van Duijn, CM, Morris, HR, Brice, A, Singleton, AB, David, DC, Nollen, EA, Jain, S, Shulman, JM, Heutink, P

“…<br/><strong>Background: </strong>Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson’s disease (PD). …”

Using stable isotope analysis to answer fundamental questions in invasion ecology: Progress and prospects by McCue, MD, Javal, M, Clusella-Trullas, S, Le Roux, JJ, Jackson, MC, Ellis, AG, Richardson, DM, Valentine, AJ, Terblanche, JS

“…What makes some species successful invaders while others fail, and why some invaders have major impacts in invaded ecosystems are pivotal questions that are attracting major research effort. …”

Making and manipulating nanowires inside carbon nanotubes by So, K

“…Strips of these BPs were successfully prototyped as the moving component in a non-metallic electromechanical relay. …”

Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. by San Millan, A, Escudero, J, Gutierrez, B, Hidalgo, L, Garcia, N, Llagostera, M, Dominguez, L, Gonzalez-Zorn, B

“…All plasmids except pB1002 and pB1006 were successfully transformed into Escherichia coli. pB1000, also involved in beta-lactam resistance in Haemophilus parasuis (A. …”

Ensemble of deep convolutional neural networks with Monte Carlo dropout sampling for automated image segmentation quality control and robust deep learning using small datasets by Hann, E, Gonzales, RA, Popescu, IA, Zhang, Q, Ferreira, VM, Piechnik, SK

“…The proposed framework merges the advantages of both state-of-the-art deep ensembles and Bayesian approaches, to provide robust segmentation with inherent quality control. We successfully developed and tested this framework using just a small MRI dataset of 45 subjects. …”

Biophysical studies of oligonucleotides containing duplex stabilising modifications by Marafini, P

“…To enable easier access to this modification, a reductive amination labelling strategy was developed to produce pyrene-functionalised nucleobase analogues which allowed an easier synthesis of X-pyrene. Amino C6 dT was successfully functionalised with this methodology as well, obtaining the duplex stabilising mono- and di-labelled products. …”

Social and professional influences on antimicrobial prescribing for doctors-in-training: a realist review by Papoutsi, C, Mattick, K, Pearson, M, Brennan, N, Briscoe, S, Wong, G

“…<strong>Conclusions:</strong> This review contributes to a better understanding of how antimicrobial prescribing interventions for doctors-in-training can be embedded more successfully in the hierarchical and inter-professional dynamics of different healthcare settings.…”

An Investigation of isotropic and anisotropic magnetic field effects in fluorescent systems by Ferguson, K

“…Finally, in chapter 6, AMELIA, an experiment which can directly measure the anisotropic magnetic field response of a system, is presented and applied successfully to systems to detect directly the anisotropic field response of a photoexcited anthracene crystal.…”

Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay by Morissette, P, Polak, S, Chain, A, Zhai, J, Imredy, JP, Wildey, MJ, Travis, J, Fitzgerald, K, Fanelli, P, Passini, E, Rodriguez, B, Sannajust, F, Regan, C

“…In silico results successfully predicted the QTc interval prolongation outcome observed in the CVGP with an accuracy/specificity of 85%/73% and 75%/77%, when using PX and HTS ion channel data, respectively. …”

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. by Landeira, D, Sauer, S, Poot, R, Dvorkina, M, Mazzarella, L, Jørgensen, H, Pereira, C, Leleu, M, Piccolo, F, Spivakov, M, Brookes, E, Pombo, A, Fisher, C, Skarnes, W, Snoek, T, Bezstarosti, K, Demmers, J, Klose, R, Casanova, M, Tavares, L, Brockdorff, N, Merkenschlager, M, Fisher, A

“…Instead, they show a severely compromised capacity for successful differentiation towards neural or mesodermal fates and failed to correctly initiate lineage-specific gene expression in vitro. …”

Blind outcome assessment: the development and use of procedures to maintain and describe blinding in a pragmatic physiotherapy rehabilitation trial. by Minns Lowe, C, Wilson, MS, Sackley, C, Barker, K

“…RESULTS: Blind outcome assessment was believed successful for n = 74 (81.32%) assessments at 3-month follow-up, and n = 83 (91.21%) at 12 months. …”

Sharing stories: complex intervention for diabetes education in minority ethnic groups who do not speak English. by Greenhalgh, T, Collard, A, Begum, N

“…Whereas some organisations welcomed, successfully implemented, and sustained the advocate led groups, others failed to do so. …”

Environmental control of short-term variation in the plankton community of inner Tokyo Bay, Japan by Nakane, T, Nakaka, K, Bouman, H, Platt, T

“…Several short-term peaks of plankton abundance (blooms) occurred as responses to temporal changes in water quality from June to November, with consequent species succession. Significant fluctuations in the densities of the diatom Skeletonema costatum and several species of ciliates corresponded to the daily changes in the physical and chemical characteristics of the coastal environment. …”

Assessing the transparency of informed consent in feasibility and pilot studies: a single-centre quality assurance study protocol by Khan, MI, Holek, M, Bdair, F, Mbuagbaw, L, Eldridge, SM, Chan, CL, Campbell, MJ, Bond, CM, Hopewell, S, Lancaster, GA, Thabane, L

“…A highly transparent consent practice entails the consent documents communicate: (1) the term ‘pilot’ or ‘feasibility’ in the title; (2) the definition of a pilot/feasibility study; (3) the primary objectives of the study are to assess feasibility; (4) the specific feasibility objectives; and (5) the criteria for the study to successfully lead to the main study. The secondary objectives are to assess whether there is a difference between submitted and revised versions of the consent documents (revisions are made to obtain research ethics approval), to determine factors associated with transparent consent practices and to assess the consistency with which pilot and feasibility studies assess feasibility outcomes as their primary objectives.…”

The beginning of melting of fertile and depleted peridotite at 1.5 GPa by Robinson, J, Wood, B, Blundy, J

“…These experimental results provide the first direct tests of fractional melting models which invoke the successive extraction of low-degree partial melts. No melting model currently available provides a good description of the compositions of low-degree melts from a fertile peridotite at 1.5 GPa. © 1998 Elsevier Science B.V.…”