Structural resolution of ligand-receptor interactions in functional, membrane-embedded receptors and proteins using novel, non-perturbing solid-state NMR methods by Watts, A

“…Other examples for large integral proteins include the observation and kinetic description of solutes in the antimicrobial target sugar transporter proteins of bacteria, and the resolution of the chemistry of the binding site of acetylcholine when in the binding site of the nicotinic acetylcholine receptor. …”

Synthesis and studies on modified oligonucleotides for diagnostic and therapeutic applications by Bai, C

“…I show that the thermal stability of oligonucleotides containing the TL backbone bound to complementary RNA targets is improved when the triazole is combined with a locked nucleic acid sugar on the 3 ́-side of the triazole ring. TL-LNA nucleoside phosphoramidite dimers were synthesised to make the required oligonucleotide sequences. …”

Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae). by Asano, N, Yasuda, K, Kizu, H, Kato, A, Fan, J, Nash, R, Fleet, G, Molyneux, R

“…A thorough examination of the extract resulted in the discovery of 15 polyhydroxylated alkaloids, including the known alkaloids from seeds of this plant, 1,4-dideoxy-1,4-imino-D-arabinitol (DAB), 1-deoxymannojirimycin (DMJ) and 2,5-imino-1,2,5-trideoxy-D-mannitol (6-deoxy-DMDP). Among them, eight sugar-mimic alkaloids showed the potent inhibitory activity towards bovine epididymis alpha-L-fucosidase and their Ki values are as follows: 6-deoxy-DMDP (83 microM), 2,5-imino-1,2,5-trideoxy-L-glucitol (0.49 microM), 2,5-dideoxy-2,5-imino-D-fucitol (17 microM), 2,5-imino-1,2,5-trideoxy-D-altritol (3.7 microM), DMJ (4.7 microM), N-methyl-DMJ (30 microM), 6-O-alpha-L-rhamnopyranosyl-DMJ (Rha-DMJ, 0.06 microM), and beta-L-homofuconojirimycin (beta-HFJ, 0.0053 microM). …”

Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study by Zamora-Ros, R, Béraud, V, Franceschi, S, Cayssials, V, Tsilidis, K, Boutron-Ruault, M, Weiderpass, E, Overvad, K, Tjønneland, A, Eriksen, A, Bonnet, F, Affret, A, Katzke, V, Kühn, T, Boeing, H, Trichopoulou, A, Valanou, E, Karakatsani, A, Masala, G, Grioni, S, , d, Tumino, R, Ricceri, F, Skeie, G, Parr, C, Merino, S, Salamanca-Fernández, E, Chirlaque, M, Ardanaz, E, Amiano, P, Almquist, M, Drake, I, Hennings, J, Sandström, M, Bueno-de-Mesquita, H, Peeters, P, Khaw, K, Wareham, N, Schmidt, J, Perez-Cornago, A, Aune, D, Riboli, E, Slimani, N, Scalbert, A, Romieu, I, Agudo, A, Rinaldi, S

“…This study did not find any significant association between F&V; intakes and differentiated TC risk; however a positive trend with fruit juice intake was observed, possibly related to its high sugar content.…”

The optimal second-line therapy for older adults with type 2 diabetes mellitus: protocol for a systematic review and network meta-analysis using individual participant data (IPD) by Wang, J, Nirantharakumar, K, Sainsbury, C, Moore, DJ, Sinclair, A, Thomas, GN, Hanif, W, Singh, M, Tan, L, Wang, Z, Simms-Williams, N, Yao, M, Gunathilaka, MN, Singh, P, Toulis, K, Tsapas, A, Coomar, D, Price, MJ

“…When metformin alone does not control blood sugar, the choice of which second-line therapy to prescribe next is not clear from currently available evidence. …”

Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding. by Chong, M, Hodson, L, Bickerton, A, Roberts, R, Neville, M, Karpe, F, Frayn, K, Fielding, B

“…DESIGN: Eight subjects consumed isoenergetic 3-d HC (10% fat; 75% carbohydrates) or higher fat (HF; 40% fat; 45% carbohydrates) diets (sugar to starch ratio: 60:40 for both) in a crossover study. …”

New dimensions for hospital services and early detection of disease: a Review from the Lancet Commission into liver disease in the UK by Williams, R, Alessi, C, Alexander, G, Allison, M, Aspinall, R, Batterham, RL, Bhala, N, Day, N, Dhawan, A, Drummond, C, Ferguson, J, Foster, G, Gilmore, I, Goldacre, R, Gordon, H, Henn, C, Kelly, D, MacGilchrist, A, McCorry, R, McDougall, N, Mirza, Z, Moriarty, K, Newsome, P, Pinder, R, Roberts, S, Rutter, H, Ryder, S, Samyn, M, Severi, K, Sheron, N, Thorburn, D, Verne, J, Williams, J, Yeoman, A

“…These measures include the food sugar levy and the introduction of the minimum unit price policy to reduce alcohol consumption. …”

Maternal nutritional risk factors for pre-eclampsia incidence: findings from a narrative scoping review by Kinshella, M-LW, Omar, S, Scherbinsky, K, Vidler, M, Magee, LA, von Dadelszen, P, Moore, SE, Elango, R

“…Maternal nutritional risk factors for pre-eclampsia incidence with the strongest consistency, effect and biological plausibility include vitamin C and its potential relationship with iron status, vitamin D (both on its own and combined with calcium and magnesium), and healthy dietary patterns featuring high consumption of fruits, vegetables, whole grains, fish, seafood and monounsaturated vegetable oils. Foods high in added sugar, such as sugary drinks, were associated with increased risk of pre-eclampsia incidence.…”

Rapid ATP-dependent priming of secretory granules precedes Ca(2+)-induced exocytosis in mouse pancreatic B-cells. by Eliasson, L, Renström, E, Ding, W, Proks, P, Rorsman, P

“…In intact B-cells, using the perforated patch whole-cell technique, glucose (5 mM) increased exocytotic responses evoked by membrane depolarization 5-fold over that observed in the absence of the sugar. Increasing the glucose concentration to 20 mM produced a further doubling of exocytosis. …”

Dairy product intake and risk of type 2 diabetes in EPIC-InterAct: a mendelian randomization study. by Vissers, LET, Sluijs, I, Van Der Schouw, YT, Forouhi, NG, Imamura, F, Burgess, S, Barricarte, A, Boeing, H, Bonet, C, Chirlaque, M-D, Fagherazzi, G, Franks, PW, Freisling, H, Gunter, MJ, Quirós, JR, Ibsen, DB, Kaaks, R, Key, T, Khaw, KT, Kühn, T, Mokoroa, O, Nilsson, PM, Overvad, K, Pala, V, Palli, D, Panico, S, Sacerdote, C, Spijkerman, AMW, Tjonneland, A, Tumino, R, Rodríguez-Barranco, M, Rolandsson, O, Riboli, E, Sharp, SJ, Langenberg, C, Wareham, NJ

“…Participants were genotyped, and rs4988235 (LCT-12910C>T), a SNP for lactase persistence (LP) which enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. …”

Development of composite panels for short span bridge construction using indigenous agro - based resources: Fabrication and mechanical testing / Ahmad Hussein Abdul Hamid by Abdul Hamid, Ahmad Hussein

“…Oil palm empty fruit bunch (OPEFB) fiber, oil palm frond (OPF) fiber mat and sugar cane (SC) husk, which is rich in cellulose, relatively inexpensive and have fairly good possibilities in waste management due to their biodegradability has the potential for polymer-reinforced composite. …”
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The association of eating pattern and grocery shopping practices among adult consumers at supermarket Puncak Alam, Selangor / Maziana Mat Zin by Mat Zin, Maziana

“…The eating pattern changes among consumers had been associated with the grocery shopping practices. High consumption of sugar, saturated fat and salt led to poor diet due to the availability of major products in the market in which high in calories, refined carbohydrates, fat and sodium. …”
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Clinical study of headache with special reference to ophthalmic cause by Shashi Jain, Shivcharan Lal Chandravanshi1, Laxmi Dukariya, Eva Rani Tirkey, Sheel Chandra Jain

“…Besides ocular examination, medical, ENT, dental, and neurological checkup along with investigations such as hemoglobin, blood sugar, X-ray of skull and paranasal sinuses, and CT scan of sinuses and brain were carried out whenever needed and treatment was advised accordingly. …”
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A comparative study of oil palm and Japanese beech on their fractionation and characterization as treated by supercritical water by Varman, M., Saka, S.

“…As a result, the water-soluble portion was determined to be composed of carbohydrate-derived products such as organic acids, sugar decomposed products and lignin- derived products, etc. for both species. …”
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Investigation of self-assembly properties and the effect of tween series co-surfactants on the stability of nonionic branched-chain glycolipid hexosomes by Sazalee, S.A., Ahmad, Noraini, Hashim, Rauzah

“…Sugar-based surfactants have recently drawn much attention due to their nonionic and bio-friendly properties. …”

Metabolic Syndrome in First Episode Schizophrenia, Based on the National Mental Health Registry of Schizophrenia (NMHR) in a General Hospital in Malaysia: A 10-Year Retrospective C... by Lee, Albert Muh Haur, Ng, Chong Guan, Koh, Ong Hui, Gill, Jesjeet Singh, Aziz, Salina Abdul

“…The diagnosis of metabolic syndrome was made using the National Cholesterol Education Program—Third Adult Treatment Panel (NCEP ATP III). (3) Results: All patients’ weight, body mass index, fasting blood sugar, and blood pressure are significantly increased. …”

The Association of Breakfast Frequency and Cardiovascular Disease (CVD) Risk Factors among Adolescents in Malaysia by Mustafa, Norashikin, Majid, Hazreen Abdul, Toumpakari, Zoi, Carroll, Harriet Amy, Jalaludin, Muhammad Yazid, Al Sadat, Nabilla, Johnson, Laura

“…Commonly consumed breakfast foods were cereal-based dishes (primarily rice), confectionery (primarily sugar), hot/powdered drinks (primarily Milo), and high-fat milk (primarily sweetened condensed milk). …”

Lipase-catalyzed synthesis of 6-o-d-glucosyldecanoate in tert-butanol: reaction optimization and effect of mixing power input by Han, J., Annuar, M.S.M., Ariffin, M.F.K., Gumel, A.M., Ibrahim, S., Heidelberg, T., Bakar, B., Hossain, A.B.M.S., Sharifuddin, Y.

“…The reaction product composed solely of monoester with sugar acylation occurring at 6-OH primary group of D-glucose where 60 (mole) of the product was 6-O-β-D-glucosyldecanoate and 40 (mole) 6-O-α-D-glucosyldecanoate.…”

The effect of Hydrocooung time calculated at different fruit layer and storage duration to postharvest quality of Saba Banana (Musa Balbisiana) by Nik Nur Akliu Nik Yaacob

“…Advantage of precooling application are delay conversion of starch to sugar resulting of lower soluble solid and higher firmness reading and lowers weight loss during storage. …”
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Effect of organic fertilisers on the yield and quality of Cocoa ( Theobroma Cacao L.) grown on a vertisol by Boney Muda

“…The parameters were studied in three stages; pre-harvest (pod and bean analyses, production of cocoa, and soil and leaf sampling for chemical analyses), post­harvest processing (sugar and fat content, pH and titratable acidity analyses) and chocolate production. …”
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