Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and Disease by Chaeeun Hannah Lee, Charlotte Ellzabeth Murrell, Alexander Chu, Xiaoyue Pan

“…The clock genes govern the central clock in the suprachiasmatic nucleus (SCN) of the brain. One function of the circadian clock is regulating lipid metabolism. …”
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Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases by Srinivasan Chinnapaiyan, Rajib Kumar Dutta, Dinesh Devadoss, Hitendra S Chand, Irfan Rahman, Hoshang Jehangir Unwalla

“…The central circadian clock consists of a central pacemaker in the suprachiasmatic nucleus that is entrained by light dark cycles and this, in turn, synchronizes the peripheral clock inherent in other organs. …”
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Circadian rhythms in colonic function by Timothy J. Hibberd, Stewart Ramsay, Phaedra Spencer-Merris, Phil G. Dinning, Phil G. Dinning, Vladimir P. Zagorodnyuk, Nick J. Spencer

“…Peripheral clocks are subject to entrainment by a multitude of factors, many of which are directly or indirectly controlled by the light-entrainable clock located in the suprachiasmatic nucleus of the hypothalamus. Peripheral clocks occur in the gastrointestinal tract, notably the epithelia whose functions include regulation of absorption, permeability, and secretion of hormones; and in the myenteric plexus, which is the intrinsic neural network principally responsible for the coordination of muscular activity in the gut. …”
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Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway by Xinxing Wan, Linghao Wang, Md Asaduzzaman Khan, Lin Peng, Keke Zhang, Xiaoying Sun, Xuan Yi, Zhouqi Wang, Ke Chen

“…Early growth response 3 (EGR3) is a member of early growth response (EGR) family, which is involved in several cellular responses, had been reported as a circadian rhythm gene in suprachiasmatic nucleus. In this research, EGR3 was found to be widely expressed in the different tissue of human and mice, and downregulated in adipose tissue of obese subjects and high-fat diet mice. …”
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Mesoscopic Mapping of Visual Pathway in a Female 5XFAD Mouse Model of Alzheimer’s Disease by Yunkwon Nam, Sujin Kim, Jieun Kim, Hyang-Sook Hoe, Minho Moon

“…Retinal efferents to the suprachiasmatic nucleus and lateral geniculate nucleus were impaired in the early stage of AD. …”
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The Circadian Regulation of Nutrient Metabolism in Diet-Induced Obesity and Metabolic Disease by Lauren N. Woodie, Kaan T. Oral, Brianna M. Krusen, Mitchell A. Lazar

“…In mammals, daylight entrains the hypothalamic suprachiasmatic nucleus (SCN) to a ≈24 h cycle by initiating a transcription/translation feedback loop (TTFL) of molecular clock genes. …”
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A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal by Ian D Blum, Lei Zhu, Luc Moquin, Maia V Kokoeva, Alain Gratton, Bruno Giros, Kai-Florian Storch

“…Ultradian (∼4 hr) rhythms in locomotor activity that do not depend on the master circadian pacemaker in the suprachiasmatic nucleus have been observed across mammalian species, however, the underlying mechanisms driving these rhythms are unknown. …”
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Influences of desflurane on the central and hepatic circadian clock persist at 24 hours following anaesthesia in rats by Ilknur Hatice AKBUDAK, Ozgen KILIC-ERKEK, Melek BOR-KUCUKATAY

“…The effects of 6% desflurane on suprachiasmatic nucleus (SCN), liver, and pancreas PER2, CRY1, BMAL, and CLOCK circadian protein levels and serum concentrations of glucose, melatonin, cortisol 24 h following the administration of anaesthesia were determined in this study. 10–12-weekold Wistar albino male rats (n=12) were divided into two groups. …”
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Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation by Ewa Szczepanska-Sadowska, Agnieszka Wsol, Agnieszka Cudnoch-Jedrzejewska, Tymoteusz Żera

“…The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. …”
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Astrocytes actively support long-range molecular clock synchronization of segregated neuronal populations by Lidia Giantomasi, João F. Ribeiro, Olga Barca-Mayo, Mario Malerba, Ermanno Miele, Davide De Pietri Tonelli, Luca Berdondini

“…Abstract In mammals, the suprachiasmatic nucleus of the hypothalamus is the master circadian pacemaker that synchronizes the clocks in the central nervous system and periphery, thus orchestrating rhythms throughout the body. …”
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Current state of knowledge on the centrifugal visual system (including the pinealo-to-retinal connection) in mammals and its hypothesized role in circadian rhythms by Viktória Vereczki, Katalin Köves, Ágnes Csáki

“…This main biological clock is located in the suprachiasmatic nucleus of the hypothalamus. This nucleus is connected with the retina by the retinohypothalamic tract. …”
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Emotionally clocked out: cell-type specific regulation of mood and anxiety by the circadian clock system in the brain by T. Chase Francis, Alessandra Porcu

“…Despite our understanding of central clock structure and function, the effect of circadian dysregulation in different neuronal subtypes in the suprachiasmatic nucleus (SCN), the master pacemaker region, as well as other brain systems regulating mood, including mesolimbic and limbic circuits, is just beginning to be elucidated. …”
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Oxyntomodulin regulates resetting of the liver circadian clock by food by Dominic Landgraf, Anthony H Tsang, Alexei Leliavski, Christiane E Koch, Johanna L Barclay, Daniel J Drucker, Henrik Oster

“…In mammals, a master clock residing in the suprachiasmatic nucleus (SCN) is reset by the light–dark cycle, while timed food intake is a potent synchronizer of peripheral clocks such as the liver. …”
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SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging by Chang, Hung-Chun, Guarente, Leonard Pershing

“…In aged wild-type mice, SIRT1 levels in the suprachiasmatic nucleus are decreased, as are those of BMAL1 and PER2, giving rise to a longer intrinsic period, a more disrupted activity pattern, and an inability to adapt to changes in the light entrainment schedule. …”
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Investigating circadian disruption in mouse models of neurological and metabolic disorders by Livieratos, A

“…Despite identification of phase advanced expression of signalling neuropeptides (e.g. arginine vasopressin) in the <em>Bdr</em> suprachiasmatic nucleus (SCN), the underlying mechanisms regulating circadian disruption in this model remain elusive; therefore, label-free shotgun proteomics was carried out over 24 hours to elucidate potential post-transcriptional pathways. …”

The neuroendocrine control of gonadotrophin secretion in the female rat with special emphasis on the effects of continuous exposure to light by Watts, A

“…Analysis of tissue using HPLC suggests that in the suprachiasmatic nucleus alterations in the release and reuptake mechanisms of 5-HT may contribute to the loss of diurnal LH release. …”

Cerebral oxidative metabolism mapping in four genetic mouse models of anxiety and mood disorders by Matrov, D, Kaart, T, Lanfumey, L, Maldonado, R, Sharp, T, Tordera, R, Kelly, P, Deakin, B, Harro, J

“…Overall, the top brain regions having the largest contribution to classification into depression model were the lateroanterior hypothalamic nucleus, the anterior part of the basomedial amygdaloid nucleus, claustrum, the suprachiasmatic nucleus, the ventromedial hypothalamic nucleus, and the anterior hypothalamic area. …”

Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator. by Nan Yang, Nicola J Smyllie, Honor Morris, Cátia F Gonçalves, Michal Dudek, Dharshika R J Pathiranage, Johanna E Chesham, Antony Adamson, David G Spiller, Egor Zindy, James Bagnall, Neil Humphreys, Judith Hoyland, Andrew S I Loudon, Michael H Hastings, Qing-Jun Meng

“…In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the principal co-ordinator of the cell-autonomous clocks distributed across all major tissues. …”
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Development of the Ontogenetic Self-Regulation Clock by Sari Goldstein Ferber, Aron Weller, Michal Ben-Shachar, Gil Klinger, Ronny Geva

“…The paper also describes the developing indirect signaling between the suprachiasmatic nucleus and the corticospinal tract. Finally, the paper proposes novel hypotheses for molecular, structural and functional investigation of the “clock” circuitry, including its associations with other biological clocks. …”
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LIGHT / DARK PREFERENCE IN <i>Danio rerio</i>: EFFECTS OF LIGHT EXPOSURE DURATION AND DAY PERIOD by Claudio Alberto Gellis de Mattos Dias, Bruno Rodrigues dos Santos, Bruno de Matos Mansur, Marcelo de Sena Pinheiro, Amanda Alves Fecury, Julio Cesar Sá-Oliveira, Paulo Henrique Matayoshi-Calixto, Euzébio de Oliveira, Amauri Gouveia Jr

“…In fish, the pineal gland cells contain photoreceptors and the suprachiasmatic nucleus seems to be involved in biological rhythm just like in other vertebrates. …”
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