Regulation of prokineticin 2 expression by light and the circadian clock by Hattar Samer, Bittman Eric L, Cheng Michelle Y, Zhou Qun-Yong

“…<p>Abstract</p> <p>Background</p> <p>The suprachiasmatic nucleus (SCN) contains the master circadian clock that regulates daily rhythms of many physiological and behavioural processes in mammals. …”
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Chronothyroidology: Chronobiological Aspects in Thyroid Function and Diseases by Giuseppe Bellastella, Maria Ida Maiorino, Lorenzo Scappaticcio, Annamaria De Bellis, Silvia Mercadante, Katherine Esposito, Antonio Bellastella

“…The first input to biological rhythms is given by a central clock located in the suprachiasmatic nucleus (SCN), which dictates the timing from its hypothalamic site to satellite clocks that contribute in a hierarchical way to regulate the physiological rhythmicity. …”
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Interplay between retinal light responses and the circadian clock, and their implications for retinal degenerative diseases by Palumaa, T

“…</p> <p>Finally, melanopsin signalling also regulates the central light responses in the suprachiasmatic nucleus (SCN), but several reports on its role in retinal light sensitivity are conflicting. …”

Cortical regulation of sleep by Krone, LB

“…The neurophysiology of the circadian clock, with the suprachiasmatic nucleus of the hypothalamus at its centre, has also been elucidated. …”

Light, photophobia and headache: an investigation of visually-induced migraine by Lau, C

“…My results provided the first neuroimaging evidence that the suprachiasmatic nucleus (SCN) of the NIF system displays a sustained response to blue light but not to other wavelengths. …”

Analysis of the Anticipatory Behavior Formation Mechanism Induced by Methamphetamine Using a Single Hair by Riku Sato, Megumi Kanai, Yukina Yoshida, Shiori Fukushima, Masahiro Nogami, Takeshi Yamaguchi, Norio Iijima, Kenneth Sutherland, Sanae Haga, Michitaka Ozaki, Kazuko Hamada, Toshiyuki Hamada

“…While the suprachiasmatic nucleus (SCN) coordinates many daily rhythms, some circadian patterns of expression are controlled by SCN-independent systems. …”
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Gut microbiota depletion minimally affects the daily voluntary wheel running activity and food anticipatory activity in female and male C57BL/6J mice by David E. Ehichioya, S. K. Tahajjul Taufique, Isabel Magaña, Sofia Farah, Yuuki Obata, Yuuki Obata, Yuuki Obata, Shin Yamazaki, Shin Yamazaki

“…This nocturnal wheel-running activity is driven by the primary circadian pacemaker located in the suprachiasmatic nucleus (SCN). Food anticipatory activity (FAA) is the increased bout of locomotor activity that precedes the scheduled short duration of a daily meal. …”
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Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes by Da Young Lee, Inha Jung, So Young Park, Ji Hee Yu, Ji A Seo, Kyeong Jin Kim, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Nan Hee Kim

“…The circadian clock governs genetic, metabolic, hormonal, and behavioral signals in anticipation of cyclic 24-hour events through interactions between a “central clock” in the suprachiasmatic nucleus and “peripheral clocks” in the whole body. …”
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Visualization Analysis of Global Advances and Hot Spots in Intermittent Fasting by GUO Xian, ZHOU Yanbing, LIU Jingying, MU Jinhao, CAO Hui

“…Burst keywords included time-restricted feeding, suprachiasmatic nucleus, mice, growth, and mortality. Conclusion The research hot spots of intermittent fasting are mainly focused on its relationship with biological rhythms/circadian rhythms, its effect on improving chronic diseases and other diseases, and sensitive genes and related mechanisms. …”
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Alcohol use disorder and sleep disturbances: Current perspectives by C. Afonso Romano, S. Neves Martins, J. Amaral

“…On the other hand, alcohol consumption also affects the normal sleep-wake cycle, due to a disruption in the underlying circadian rhythms, a mechanism compassed by the suprachiasmatic nucleus and by photic and non-photic cues. …”
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Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and Melatonin in Insomnia Rats by Ao Huang, Gefang Xiao, Yiliu Chen, Zuying Hu, Pin-Hsuan Lee, Yusen Huang, Zifeng Zhuang, Yuling Zhang, Peng Qing, Canghuan Zhao

“…The level of TNF (tumor necrosis factor)-α in the SCN (suprachiasmatic nucleus) area of the hypothalamus was detected in situ using the TUNEL fluorescence staining assay. …”
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The regulation of circadian entrainment in mice by the adenosine the A2A/A1 receptor antagonist CT1500 by Aarti Jagannath, Simona Di Pretoro, Farid Ebrahimjee, Suzanne Ftouni, Lewis Taylor, Russell G. Foster, Sridhar Vasudevan

“…Circadian entrainment in mice relies primarily on photic cues that trigger the transcription of the core clock genes Period1/2 in the suprachiasmatic nucleus (SCN), thus aligning the phase of the clock with the dawn/dusk cycle. …”
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Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice by Kun Fang, Dong Liu, Salil S. Pathak, Bowen Yang, Jin Li, Ramanujam Karthikeyan, Owen Y. Chao, Yi-Mei Yang, Victor X. Jin, Ruifeng Cao

“…Adult SD mice fully entrained to the 8 h/8 h LD cycle, and the circadian oscillations of the clock proteins, PERIOD1 and PERIOD2, were disrupted in the suprachiasmatic nucleus and the hippocampus of these mice. …”
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Brain Dopamine–Clock Interactions Regulate Cardiometabolic Physiology: Mechanisms of the Observed Cardioprotective Effects of Circadian-Timed Bromocriptine-QR Therapy in Type 2 Dia... by Anthony H. Cincotta

“…A major component of this natural or Western lifestyle stressor-induced CNS clock neurophysiological shift potentiating the obese, insulin-resistant state is a diminution of the circadian peak of dopaminergic input activity to the pacemaker clock center, suprachiasmatic nucleus. Pharmacologically preventing this loss of circadian peak dopaminergic activity both prevents and reverses existing metabolic syndrome in a wide variety of animal models of the disorder, including high fat-fed animals. …”
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Functional characterization of the teleost multiple tissue (tmt) opsin family and their role in light detection. by Fu, JKY

“…<p>In addition to a central circadian clock in the suprachiasmatic nucleus (SCN), zebrafish (Danio rerio) have local clock systems in their peripheral tissues. …”

The protective effects of Ramelteon against 6‐OHDA‐induced cellular senescence in human SH‐SY5Y neuronal cells by Dan Liu, Xinyi Gu, Fang Han, Ming Cai, Weijie Liu, Li Han, Qiang Ma

“…Ramelteon is an oral hypnotic agent that specifically targets the receptors of the suprachiasmatic nucleus in the human hypothalamus. Here, an investigation is made to see whether Ramelteon possesses a beneficial effect against 6‐OHDA‐induced cellular senescence in human SH‐SY5Y neuronal cells. …”
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Neural function of Bmal1: an overview by Yuanjia Zheng, Lingyun Pan, Feixue Wang, Jinglan Yan, Taiyi Wang, Yucen Xia, Lin Yao, Kelin Deng, Yuqi Zheng, Xiaoye Xia, Zhikai Su, Hongjie Chen, Jie Lin, Zhenwei Ding, Kaitong Zhang, Meng Zhang, Yongjun Chen

“…This review also discusses oscillation and rhythmicity, especially in the suprachiasmatic nucleus, and provides perspective on future progress in Bmal1 research.…”
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Sleep patterns in patients treated for non-secreting intra- and parasellar tumors: A self-report case-control study by Carl Mathis Wild, Mareike Stieg, Günter K. Stalla, Günter K. Stalla, Caroline Jung-Sievers, Matthias K. Auer, Anastasia P. Athanasoulia-Kaspar, Anastasia P. Athanasoulia-Kaspar

“…Additionally, when treating patients surgically, especially by transcranial approach, damaging the suprachiasmatic nucleus should be avoided. Furthermore, circadian hydrocortisone replacement therapy ideally with dual-release hydrocortisone - if possible, in a dose not more than 20mg daily - that resembles physiological cortisol levels more closely may be beneficial and could improve sleep patterns and sleep-related quality of life.…”
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Targeted Disruption of the <i>Inhibitor of DNA Binding 4</i> (<i>Id4</i>) Gene Alters Photic Entrainment of the Circadian Clock by Giles E. Duffield, Maricela Robles-Murguia, Tim Y. Hou, Kathleen A. McDonald

“…To understand the basis for these properties, suprachiasmatic nucleus (SCN) and retinal structures were examined. …”
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A real-time measurement system for gene expression rhythms from deep tissues of freely moving mice under light-dark conditions by Mizuki Nakaya, Miho Wakamatsu, Hinaki Motegi, Ami Tanaka, Kenneth Sutherland, Masayori Ishikawa, Michitaka Ozaki, Hiroki Shirato, Kazuko Hamada, Toshiyuki Hamada

“…Clock gene expression in most organs of the living body exhibits a diurnal rhythm synchronized with the external 24 h light-dark (LD) cycle via circadian pacemaker suprachiasmatic nucleus (SCN). Disturbances in clock gene expression due to desynchronization of clock gene expression of the external LD cycle are risk factors for developing various diseases. …”
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