RESTRICTED FEEDING SCHEDULES MODULATE IN A DIFFERENT MANNER THE EXPRESSION OF CLOCK GENES IN RAT HYPOTHALAMIC NUCLEI. by Leonardo Domingues de Araujo, Silvia Ruiz Roa, Ana Carolina Bueno, Fernanda Borchers Coeli-Lacchini, Clarissa Silva Martins, Ernane Torres Uchoa, Jose Antunes-Rodrigues, Lucila Leico Kagohara Elias, Paula Conde Lamparelli Elias, Ayrton Custodio Moreira, Margaret de Castro

“…We hypothesized that different feeding restriction patterns could modulate the expression of clock genes in the suprachiasmatic nucleus (SCN) master clock and in extra-SCN oscillators such as the paraventricular (PVN) and arcuate (ARC) hypothalamic nuclei. …”
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Role of Dorsomedial Hypothalamus GABAergic Neurons in Sleep–Wake States in Response to Changes in Ambient Temperature in Mice by Lei Li, Meng-Qi Zhang, Xiao Sun, Wen-Ying Liu, Zhi-Li Huang, Yi-Qun Wang

“…It also receives projection from the preoptic area, which is an important region for sleep and energy homeostasis and the suprachiasmatic nucleus—a main control area of the clock rhythm. …”
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Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription by Tan, Jen Jen., Ong, Angeline Shufen., Chen, Ken-Shiung.

“…The Rasd1 protein is a dexamethasone induced monomeric Ras-like G protein that oscillates in the suprachiasmatic nucleus (SCN). Previous studies have shown that Rasd1 modulates multiple signaling cascades. …”
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Redox and Antioxidant Modulation of Circadian Rhythms: Effects of Nitroxyl, N-Acetylcysteine and Glutathione by Santiago Andrés Plano, Fernando Martín Baidanoff, Laura Lucía Trebucq, Sebastián Ángel Suarez, Fabio Doctorovich, Diego Andrés Golombek, Juan José Chiesa

“…The circadian clock at the hypothalamic suprachiasmatic nucleus (SCN) entrains output rhythms to 24-h light cycles. …”
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Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway by Qiaocheng Zhai, Yizhun Zeng, Yue Gu, Zhihao Li, Tao Zhang, Baoshi Yuan, Tao Wang, Jie Yan, Han Qin, Ling Yang, Xiaowei Chen, Antonio Vidal-Puig, Ying Xu

“…Summary: The suprachiasmatic nucleus (SCN) integrates light and systemic signals from peripheral tissues to coordinate physiology and behavior daily rhythms. …”
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Dex modulates the balance of water-electrolyte metabolism by depressing the expression of AVP in PVN by Wenzhi Yang, Hao Li, Hao Li, Zhongle Cheng, You Lu, Wuli Li, Jun Feng, Liecheng Wang, Juan Cheng, Juan Cheng

“…They are responsible for the secretion of AVP. The suprachiasmatic nucleus (SCN) is also one of the brain regions where AVP neurons are densely distributed in the hypothalamus. …”
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Circadian signatures of anterior hypothalamus in time-restricted feeding [version 1; peer review: 2 approved] by Haoran Xin, Xiaogen Ma, Jianghui Chen, Rongfeng Huang, Meiyu Zhou, Zhihui Zhang, Min-Dian Li, Lihua Li, Fang Deng

“…Background: Meal timing resets circadian clocks in peripheral tissues, such as the liver, in seven days without affecting the phase of the central clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Anterior hypothalamus plays an essential role in energy metabolism, circadian rhythm, and stress response. …”
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Sleep/Wake Disruption in a Mouse Model of BLOC-1 Deficiency by Frank Y. Lee, Huei-Bin Wang, Olivia N. Hitchcock, Dawn Hsiao Loh, Daniel S. Whittaker, Yoon-Sik Kim, Achilles Aiken, Collette Kokikian, Esteban C. Dell’Angelica, Christopher S. Colwell, Cristina A. Ghiani, Cristina A. Ghiani

“…At the level of the central circadian clock (the suprachiasmatic nucleus, SCN), loss of BLOC-1 caused subtle morphological changes including a larger SCN and increased expression of the relative levels of the clock gene Per2 product during the day but did not affect the neuronal activity rhythms. …”
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Differential Expression of Circadian Clock Genes in the Bovine Neuroendocrine Adrenal System by Audrey L. Earnhardt-San, Emilie C. Baker, David G. Riley, Noushin Ghaffari, Charles R. Long, Rodolfo C. Cardoso, Ronald D. Randel, Thomas H. Welsh

“…Knowledge of circadian rhythm clock gene expression outside the suprachiasmatic nucleus is increasing. The purpose of this study was to determine whether expression of circadian clock genes differed within or among the bovine stress axis tissues (e.g., amygdala, hypothalamus, pituitary, adrenal cortex, and adrenal medulla). …”
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Altered Clock Gene Expression in Female APP/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina by Laura Carrero, Desireé Antequera, Ignacio Alcalde, Diego Megias, Lara Ordoñez-Gutierrez, Cristina Gutierrez, Jesús Merayo-Lloves, Francisco Wandosell, Cristina Municio, Eva Carro

“…The regulation of circadian rhythm depends on the light information that is projected from the retina to the suprachiasmatic nucleus in the hypothalamus. Studies of AD patients and AD transgenic mice have revealed AD retinal pathology, including amyloid-β (Aβ) accumulation that can directly interfere with the regulation of the circadian cycle. …”
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Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action by Mark J. Millan

“…Recruitment of MT receptors in the suprachiasmatic nucleus, thalamic reticular nucleus, and hippocampus appears to fulfil a complimentary role. …”
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A Free-Choice High-Fat High-Sugar Diet Alters Day–Night Per2 Gene Expression in Reward-Related Brain Areas in Rats by Aurea Susana Blancas-Velazquez, Aurea Susana Blancas-Velazquez, Aurea Susana Blancas-Velazquez, Aurea Susana Blancas-Velazquez, Unga A. Unmehopa, Unga A. Unmehopa, Leslie Eggels, Leslie Eggels, Laura Koekkoek, Laura Koekkoek, Andries Kalsbeek, Andries Kalsbeek, Andries Kalsbeek, Jorge Mendoza, Susanne E. la Fleur, Susanne E. la Fleur, Susanne E. la Fleur

“…Consuming a fcHFHS diet for 6 weeks disrupted day–night differences in Per2 mRNA expression in the nucleus accumbens (NAc) and lateral hypothalamus but not in the suprachiasmatic nucleus, habenula, and ventral tegmental area. …”
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Timed restricted feeding cycles drive daily rhythms in female rats maintained in constant light but only partially restore the estrous cycle by Natalí N. Guerrero-Vargas, Estefania Espitia-Bautista, Rene Escalona, Haydée Lugo-Martínez, Mariana Gutiérrez-Pérez, Raful Navarro-Espíndola, Raful Navarro-Espíndola, María Fernanda Setién, Sebastián Boy-Waxman, Elizabeth Angélica Retana-Flores, Berenice Ortega, Ruud M. Buijs, Carolina Escobar

“…In female rats, constant light (LL) eliminates the estrous cycle leading to a state of persistent estrus. The suprachiasmatic nucleus (SCN) drives circadian rhythms, and it interacts with the neuroendocrine network necessary for reproductive function. …”
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Long wavelength light reduces the negative consequences of dim light at night by Huei-Bin Wang, David Zhou, Shu Hon Christopher Luk, Hye In Cha, Amanda Mac, Rim Chae, Anna Matynia, Ben Harrison, Sina Afshari, Gene D. Block, Cristina A. Ghiani, Christopher S. Colwell

“…First, we confirmed that the short-wavelength enriched lighting produced strong acute suppression of locomotor activity (masking), robust light-induced phase shifts, and cFos expression in the suprachiasmatic nucleus in wild-type (WT) mice, while the long-wavelength enriched lighting evoked much weaker responses. …”
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Sex-dependent circadian alterations of both central and peripheral clock genes expression and gut–microbiota composition during activity-based anorexia in mice by Colin Salaün, Marine Courvalet, Léna Rousseau, Kévin Cailleux, Jonathan Breton, Christine Bôle-Feysot, Charlène Guérin, Marion Huré, Alexis Goichon, Jean-Claude do Rego, Pierre Déchelotte, David Ribet, Najate Achamrah, Moïse Coëffier

“…Circadian clock genes expression was assessed by RT-qPCR on peripheral (liver, colon and ileum) and central (hypothalamic suprachiasmatic nucleus or SCN) tissues. Cecal bacterial taxa abundances were evaluated by qPCR. …”
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Genetic and environmental circadian disruption induce weight gain through changes in the gut microbiome by Baraa Altaha, Marjolein Heddes, Violetta Pilorz, Yunhui Niu, Elizaveta Gorbunova, Michael Gigl, Karin Kleigrewe, Henrik Oster, Dirk Haller, Silke Kiessling

“…Methods: Core and accessory clock gene expression in different gastrointestinal (GI) tissues were determined by qPCR in two different models of circadian disruption - mice with Bmal1 deficiency in the circadian pacemaker, the suprachiasmatic nucleus (Bmal1SCNfl/-), and wild-type mice exposed to simulated shift work (SSW). …”
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A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior by Fang Gao, Jun Ma, Yao-Qing Yu, Xiao-Fei Gao, Yang Bai, Yi Sun, Juan Liu, Xianyu Liu, Devin M. Barry, Steven Wilhelm, Tyler Piccinni-Ash, Na Wang, Dongyang Liu, Rachel A. Ross, Yan Hao, Xu Huang, Jin-Jing Jia, Qianyi Yang, Hao Zheng, Johan van Nispen, Jun Chen, Hui Li, Jiayi Zhang, Yun-Qing Li, Zhou-Feng Chen

“…Gastrin-releasing peptide (GRP) and its receptor (GRPR) in the suprachiasmatic nucleus (SCN) of the hypothalamus mediates contagious itch behavior in mice. …”
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