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101
Circadian rhythms – from genes to physiology and disease
Published 2014-07-01“…A central pacemaker in the suprachiasmatic nucleus (SCN), located in the ventral hypothalamus, coordinates all overt rhythms in our body through neuronal and humoral outputs. …”
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102
The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis
Published 2023-09-01“…The circadian rhythm is controlled by the central clock located in the suprachiasmatic nucleus and clock genes (molecular clock) located in all cells. …”
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103
Insights into the role of the habenular circadian clock in addiction
Published 2016-01-01“…Moreover, the LHb has circadian properties: LHb cellular activity (i.e., firing rate and clock genes expression) oscillates in a 24h range, and the nucleus is affected by photic stimulation and has anatomical connections with the main circadian pacemaker, the suprachiasmatic nucleus. Here, we describe the current insights on the role of the LHb as a circadian oscillator and its possible implications on the rhythmic regulation of the dopaminergic activity and drug intake. …”
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104
On the Evolution of Memory: A Time for Clocks
Published 2012-02-01“…Time-of-day dependent changes have been observed in long-term potentiation (LTP) within the mammalian suprachiasmatic nucleus and hippocampus, along with light-induced circadian phase resetting and fear conditioning behaviors. …”
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105
The role of Melatonin in reducing Obesity and its safety of use: A Review
Published 2023-06-01“…Melatonin is the chiefly hormone formed via the pineal gland, its endogenous synthesis occur during the dark phase and controlled by the Suprachiasmatic Nucleus SCN, melatonin is a long-established and widely distributed chemical in nature that exhibits a variety of modes of action and functions in almost every living thing regulating the circadian rhythms, sleep and wakefulness cycle, energy metabolism in addition to its ability to regulate the raleasing of many cytokines participate in weight plus appetite control . …”
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106
Insights into exercise timing to regulate circadian clocks and phenotypes
Published 2023-02-01“…Summary: Circadian clocks consist of the central clock in the suprachiasmatic nucleus (SCN) and the peripheral clocks in the peripheral tissues and provide endogenous control of physiological functions. …”
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107
Neuroendocrine effects of the duper mutation in Syrian hamsters: a role for Cryptochrome 1
Published 2024-02-01“…We note that GnRH fibers coursing through the suprachiasmatic nucleus (SCN) contact vasopressin- and VIP-immunoreactive cells, suggesting a possible locus of circadian control of the LH surge. …”
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108
Research Progress and Effects of Light on Poultry Circadian Rhythm Regulation Based on CiteSpace
Published 2023-03-01“…In summary, the current research frontiers of light and circadian rhythm are lighting, hepatocytes, the suprachiasmatic nucleus (SCN), blue light, and immune function. …”
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109
Circadian Rhythm and Health : Influence of Food Intake Timing and Regular Exercise
Published 2023-06-01“…It is mainly controlled by the central command through the suprachiasmatic nucleus, and modern society features can disturb the central CR, contributing to various diseases. …”
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110
Melatonin administration for sleep disorders in traumatic brain injury: A review of the literature
Published 2022-01-01“…Melatonin is a neurohormone that acts at the suprachiasmatic nucleus to diminish the wake-promoting signal of the circadian clock and induce sleepiness. …”
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111
Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina.
Published 2005“…Even at P0, the ipRGCs form functional connections with the suprachiasmatic nucleus, as assessed by light-induced Fos expression. …”
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112
Temporal transcriptomics suggest that twin-peaking genes reset the clock.
Published 2015“…The mammalian suprachiasmatic nucleus (SCN) drives daily rhythmic behavior and physiology, yet a detailed understanding of its coordinated transcriptional programmes is lacking. …”
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113
Daily methylphenidate and atomoxetine treatment impacts on clock gene protein expression in the mouse brain.
Published 2013“…We report drug, brain region and molecular specific effects of such treatments, including alterations in expression profiles in the suprachiasmatic nucleus, the master circadian pacemaker. These results indicate that drugs used in the clinical management of attention deficit hyperactivity disorder can alter molecular factors that are believed to underpin circadian timekeeping, and such effects may be of importance in both the therapeutic and side effect profiles of such drugs.…”
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114
Ultraviolet light provides a major input to non-image-forming light detection in mice.
Published 2012“…Here we examine the role of ultraviolet-sensitive (UVS) cones in the modulation of circadian behavior, sleep, and suprachiasmatic nucleus (SCN) electrical activity. UV light exposure leads to phase-shifting responses comparable to those of white light. …”
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115
Agomelatine in Depressive Disorders: Its Novel Mechanisms of Action
Published 2012“…Identification of high concentrations of MT1 and MT2 melatonergic receptors in the suprachiasmatic nucleus of the anterior hypothalamus, the structure concerned with regulation of circadian rhythms and sleep–wake cycles, has led to the development of melatonergic agonists with greater potency and longer durations of action. …”
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116
Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons.
Published 2011-01-01“…Neuropeptide signaling plays roles in coordinating cellular activities and maintaining robust oscillations within the mammalian suprachiasmatic nucleus (SCN). Prokineticin2 (PK2) is a signaling molecule from the SCN and involves in the generation of circadian locomotor activity. …”
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117
Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork.
Published 2012-01-01“…Two weeks of timed sleep restriction has moderate effects on diurnal activity patterns, feeding behavior, and clock gene regulation in the circadian pacemaker of the suprachiasmatic nucleus. In contrast, microarray analyses reveal global disruption of diurnal liver transcriptome rhythms, enriched for pathways involved in glucose and lipid metabolism and correlating with first indications of altered metabolism. …”
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118
Neuroprotective effects of melatonin in neurodegenerative and autoimmune central nervous system diseases
Published 2023-04-01“…The suprachiasmatic nucleus (SCN) in the anterior hypothalamus is the major circadian pacemaker in humans. …”
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119
Light sets the brain’s daily clock by regional quickening and slowing of the molecular clockworks at dawn and dusk
Published 2021-12-01“…How daily clocks in the brain are set by light to local environmental time and encode the seasons is not fully understood. The suprachiasmatic nucleus (SCN) is a central circadian clock in mammals that orchestrates physiology and behavior in tune with daily and seasonal light cycles. …”
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120
Light Pollution and Oxidative Stress: Effects on Retina and Human Health
Published 2024-03-01“…These cells relay information to the suprachiasmatic nucleus in the brain, playing a crucial role in modulating melatonin secretion, which in turn helps in synchronizing the body’s circadian rhythms and responses to seasonal changes. …”
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