An Emerging Role of PRRT2 in Regulating Growth Cone Morphology by Elisa Savino, Fabrizia Claudia Guarnieri, Jin-Wu Tsai, Anna Corradi, Fabio Benfenati, Flavia Valtorta

“…Indeed, PRRT2 participates in the regulation of neurotransmitter release, as well as of actin cytoskeleton dynamics during synaptogenesis. Here, we show a role of the protein also during early stages of neuronal development. …”
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On the Potential Therapeutic Roles of Taurine in Autism Spectrum Disorder by Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky

“…It can also stimulate neurogenesis, synaptogenesis, and reprogramming of proinflammatory M1 macrophage polarization by decreasing mitophagy (mitochondrial autophagy) and raising the expression of the markers of the anti-inflammatory and pro-healing M2 macrophages, such as macrophage mannose receptor (MMR, CD206) and interleukin 10 (IL-10), while lowering the expression of the M1 inflammatory factor genes. …”
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Potential protective roles of phytochemicals on glutamate-induced neurotoxicity: A review by Amir R. Afshari, Sahar Fanoudi, Arezoo Rajabian, Hamid Reza Sadeghnia, Hamid Mollazadeh, Azar Hosseini

“…Glutamate, as an essential neurotransmitter, has been thought to have different roles in the central nervous system (CNS), including nerve regeneration, synaptogenesis, and neurogenesis. Excessive glutamate causes an up-regulation of the multiple signaling pathways, including phosphoinositide-3 kinase/protein kinase B (PI3K/Akt), Akt/mammalian target of rapamycin (mTOR) protein, mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)1/2, and autophagy that are involved in neurodegenerative diseases pathophysiology. …”
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Pleiotropic Effects of Exosomes as a Therapy for Stroke Recovery by Yuji Ueno, Kenichiro Hira, Nobukazu Miyamoto, Chikage Kijima, Toshiki Inaba, Nobutaka Hattori

“…Specific microRNAs and molecules were identified by mechanistic investigations, and their amplification was shown to further enhance therapeutic effects, including neurogenesis, angiogenesis, axonal outgrowth, and synaptogenesis. Overall, this review addresses the current advances in exosome therapy for stroke recovery in preclinical studies, which can hopefully be preparatory steps for the future development of clinical trials involving stroke survivors to improve functional outcomes.…”
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A classification of genes involved in normal and delayed male puberty by Maleeha Akram, Syed Shakeel Raza Rizvi, Mazhar Qayyum, David J Handelsman

“…These include (i) hypothalamic development during embryogenesis, (ii) synaptogenesis where gonadotropin releasing hormone (GnRH) neurons form neuronal connections with suprahypothalamic neurons, (iii) maintenance of neuron homeostasis, (iv) regulation of synthesis and secretion of GnRH, (v) appropriate receptors/proteins on neurons governing GnRH production and release, (vi) signaling molecules activated by the receptors, (vii) the synthesis and release of GnRH, (viii) the production and release of gonadotropins, (ix) testicular development, (x) synthesis and release of steroid hormones from testes, and (xi)the action of steroid hormones in downstream effector tissues. …”
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Enteric Neural Network Assembly Was Promoted by Basic Fibroblast Growth Factor and Vitamin A but Inhibited by Epidermal Growth Factor by Jeng-Chang Chen, Wendy Yang, Li-Yun Tseng, Hsueh-Ling Chang

“…Our results might help to better manipulate ENSC propagation and differentiation in vitro, and open a new avenue for the study of enteric neuronal neuritogenesis and synaptogenesis.…”
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Antidepressant mechanisms of ketamine: a review of actions with relevance to treatment-resistance and neuroprogression by August P. M. Lullau, Emily M. W. Haga, Eivind H. Ronold, Gerard E. Dwyer, Gerard E. Dwyer

“…Converging evidence suggests that ketamine works to increase stress resilience and reverse stress-induced dysfunction, modulate systemic inflammation and neuroinflammation, attenuate neurotoxic processes and glial dysfunction, and facilitate synaptogenesis rather than neurodegeneration. Still, much remains to be revealed about ketamine’s antidepressant mechanisms of action, and research is lacking on the durability of effect. …”
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Assembly of the outer retina in the absence of GABA synthesis in horizontal cells by Parker Edward, Huckfeldt Rachel M, Schubert Timm, Campbell John E, Wong Rachel OL

“…Horizontal cells, a subset of interneurons in the outer retina, are transiently GABAergic during the period of cone photoreceptor synaptogenesis. In rodents, both horizontal cells and cone axonal terminals express GABA_Areceptors. …”
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Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice by Luisa Strackeljan, Ewa Baczynska, Carla Cangalaya, David Baidoe-Ansah, Jakub Wlodarczyk, Rahul Kaushik, Alexander Dityatev

“…The extracellular matrix (ECM) plays a key role in synaptogenesis and the regulation of synaptic functions in the central nervous system. …”
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Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain by Terezija Miškić, Ivica Kostović, Mladen-Roko Rašin, Željka Krsnik

“…Given the Cux2 functions reported in animal models, our data further suggest that the expression of CUX2 in postmigratory SP and MZ neurons is associated with their unique dendritic and synaptogenesis characteristics.…”
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A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction by Smyth Neil, Ho Matthew SP, Fox Michael A, Sanes Joshua R

“…<p>Abstract</p> <p>Background</p> <p>The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by the synaptic portion of a basal lamina that completely ensheaths each muscle fiber. …”
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Metamorphic gene regulation programs in Xenopus tropicalis tadpole brain. by Samhitha Raj, Christopher J Sifuentes, Yasuhiro Kyono, Robert J Denver

“…Genes involved with neural cell differentiation, cell physiology, synaptogenesis and cell-cell signaling were upregulated, while genes involved with cell cycle, protein synthesis, and neural stem/progenitor cell homeostasis were downregulated. …”
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Mouse embryonic stem cell‐derived motor neurons are susceptible to ferroptosis by Alejandra M. Martinez, Ahryun Kim, Cristina Aguilar Flores, Daoud F. Rahman, Wan Seok Yang

“…Subsequent bioinformatic analysis revealed alterations in several biological pathways during ferroptosis, including synaptogenesis and calcium signaling. Finally, we found that edaravone, an FDA‐approved drug for treating amyotrophic lateral sclerosis (ALS) disease, rescued motor neurons from RSL3‐induced ferroptosis. …”
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MicroRNA Regulation of the Environmental Impact on Adolescent Neurobehavioral Development: A Systematic Review by Ana Vázquez-Ágredos, Fernando Gámiz, Milagros Gallo

“…During adolescence, this modifies the expression of a variety of genes involved in neurodevelopmental processes such as proliferation, differentiation, synaptogenesis, neural plasticity, and apoptosis. Hence, the effect of miRNAs dysregulation during adolescence might contribute to a long-term impact on brain function. …”
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Sodium-glucose cotransporter 2 inhibitors and neurological disorders: a scoping review by Thahesh Tharmaraja, Jamie S.Y. Ho, Ching-Hui Sia, Nicole-Ann Lim, Yao Feng Chong, Amanda Y.L. Lim, Rahul R. Rathakrishnan, Leonard L.L. Yeo, Vijay K. Sharma, Benjamin Y.Q. Tan

“…Most animal studies demonstrated significant improvements in behavioural and neurological deficits, which were reflected in beneficial changes in neurovascular units, synaptogenesis, neurotransmitter levels and target receptors’ docking energies. …”
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mRNAs encoding neurodevelopmental regulators have equal N6-methyladenosine stoichiometry in Drosophila neuroblasts and neurons by Josephine D. Sami, Robert C. Spitale, Michael D. Cleary

“…We identified 867 m6A targets; 233 of these are novel and preferentially encode regulators of neuroblast proliferation, cell fate-specification and synaptogenesis. Comparison of the neuroblast and neuron m6A transcriptomes revealed that m6A stoichiometry is largely uniform; we did not find evidence of neuroblast-specific or neuron-specific m6A modification. …”
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ECM-Mimetic Nylon Nanofiber Scaffolds for Neurite Growth Guidance by Olga Y. Antonova, Olga Y. Kochetkova, Yuri M. Shlyapnikov

“…Both types of scaffolds also improved synaptogenesis and the formation of connections between hippocampal neurons; however, the mechanisms of interaction of neurites with the scaffolds were substantially different. …”
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Broad epigenetic signature of maternal care in the brain of adult rats. by Patrick O McGowan, Matthew Suderman, Aya Sasaki, Tony C T Huang, Michael Hallett, Michael J Meaney, Moshe Szyf

“…Interestingly, the chromosomal region containing the protocadherin-α, -β, and -γ (Pcdh) gene families implicated in synaptogenesis show the highest differential response to maternal care.The results suggest for the first time that the epigenetic response to maternal care is coordinated in clusters across broad genomic areas. …”
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Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury by Heungsun Kwon, Karl Kevala, Hu Xin, Samarjit Patnaik, Juan Marugan, Hee-Yong Kim

“…<i>N</i>-docosahexaenoylethanolamine (synaptamide), an endogenous ligand of GPR110 that promotes neurite outgrowth and synaptogenesis in developing neurons, and a synthetic GPR110 ligand stimulated neurite growth in axotomized cortical neurons and in retinal explant cultures. …”
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Role of DSCAM in the Development of Neural Control of Movement and Locomotion by Maxime Lemieux, Louise Thiry, Olivier D. Laflamme, Frédéric Bretzner

“…DSCAM is known to be involved in lamination and delamination, synaptic targeting, axonal guidance, dendritic and cell tiling, axonal fasciculation and branching, programmed cell death, and synaptogenesis, all of which can impact the establishment of motor circuits during development, but also their maintenance through adulthood. …”
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