Growth Hormone (GH) Enhances Endogenous Mechanisms of Neuroprotection and Neuroplasticity after Oxygen and Glucose Deprivation Injury (OGD) and Reoxygenation (OGD/R) in Chicken Hip... by Juan David Olivares-Hernández, Jerusa Elienai Balderas-Márquez, Martha Carranza, Maricela Luna, Carlos G. Martínez-Moreno, Carlos Arámburo

“…This hormone might also act as a neurotrophin, since GH is able to induce neuroprotection, neurite growth, and synaptogenesis during the repair process that occurs in response to neural injury. …”
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The impact of acupuncture on neuroplasticity after ischemic stroke: a literature review and perspectives by Siru Qin, Zichen Zhang, Yadan Zhao, Jingyi Liu, Jiwen Qiu, Jiwen Qiu, Jiwen Qiu, Yinan Gong, Yinan Gong, Wen Fan, Yongming Guo, Yongming Guo, Yongming Guo, Yi Guo, Yi Guo, Yi Guo, Zhifang Xu, Zhifang Xu, Zhifang Xu, Yang Guo, Yang Guo

“…These processes are possible thanks to neuroplasticity, which involves neurogenesis, synaptogenesis, and angiogenesis. However, the repair of ischemic damage is not complete, and neurological deficits develop eventually. …”
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A Mixture of Chemicals Found in Human Amniotic Fluid Disrupts Brain Gene Expression and Behavior in <i>Xenopus laevis</i> by Michelle Leemans, Petra Spirhanzlova, Stephan Couderq, Sébastien Le Mével, Alexis Grimaldi, Evelyne Duvernois-Berthet, Barbara Demeneix, Jean-Baptiste Fini

“…Thyroid hormones (TH) are essential for normal brain development, influencing neural cell differentiation, migration, and synaptogenesis. Multiple endocrine-disrupting chemicals (EDCs) are found in the environment, raising concern for their potential effects on TH signaling and the consequences on neurodevelopment and behavior. …”
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Identification of potential biomarkers related to mesenchymal stem cell response in patients with Alzheimer’s disease by Yejoo Choi, Sungho Shin, Hyo Jin Son, Na-Hee Lee, Su Hyeon Myeong, Cheolju Lee, Hyemin Jang, Soo Jin Choi, Hee Jin Kim, Duk L. Na

“…Additionally, functional analysis revealed that the increased CSF proteins after the third injection compared to the baseline in the typical GR were associated with synaptogenesis. Conclusions This study identified two proteins (RCN3 and FSTL3) that may be potential biomarkers for predicting MSC response and four proteins (SCRG1, NPDC1, ApoE, CysC) that may be potential biomarkers for monitoring MSC response in patients with AD. …”
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Long-acting dolutegravir formulations prevent neurodevelopmental impairments in a mouse model by Emma G. Foster, Brady Sillman, Yutong Liu, Micah Summerlin, Vikas Kumar, Balasrinivasa R. Sajja, Adam R. Cassidy, Benson Edagwa, Howard E. Gendelman, Howard E. Gendelman, Aditya N. Bade

“…Proteomic profiling of embryo brain tissues harvested at GD 17.5 demonstrated reductions in oxidative stress, mitochondrial impairments, and amelioration of impaired neurogenesis and synaptogenesis in NDTG-treated mice. Pharmacokinetic (PK) tests determined that both daily oral native DTG and parenteral NDTG achieved clinically equivalent therapeutic plasma DTG levels in dams (4,000–6,500 ng/mL). …”
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Effects of dietary edible bird’s nest supplementation on cognitive function of transgenerational mice by Mahaq, Obaidullah

“…In mammals, the highest absorption of sialic acid from EBN occurs in the brain where it participates as an integral part of ganglioside structure in synaptogenesis and neural transmission. Sialic acid in EBN is vital during rapid brain growth particularly for preterm infants. …”
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Sleep across the first year of life is prospectively associated with brain volume in 12-months old infants by Katharina Pittner, Jerod Rasmussen, Miranda M. Lim, John H. Gilmore, Martin Styner, Sonja Entringer, Pathik D. Wadhwa, Claudia Buss

“…The fact that sleep duration was not associated with gray matter volume is in line with preclinical studies suggesting that sleep may be crucial for the balance between synaptogenesis and synaptic pruning but not necessarily relate to a net increase in gray matter volume. …”
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Integrative analysis of long noncoding RNAs dysregulation and synapse-associated ceRNA regulatory axes in autism by Miaomiao Jiang, Ziqi Wang, Tianlan Lu, Xianjing Li, Kang Yang, Liyang Zhao, Dai Zhang, Jun Li, Lifang Wang

“…In conclusion, dysregulation of MIR600HG, a novel specific lncRNA associated with ASD, is responsible for the ASD-associated miRNA-mRNA axes, thereby potentially regulating synaptogenesis.…”
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Dissecting the Shared and Context-Dependent Pathways Mediated by the p140Cap Adaptor Protein in Cancer and in Neurons by Jennifer Chapelle, Oksana Sorokina, Colin McLean, Vincenzo Salemme, Annalisa Alfieri, Costanza Angelini, Alessandro Morellato, Annie Adrait, Elisabetta Menna, Elisabetta Menna, Michela Matteoli, Michela Matteoli, Yohann Couté, Ugo Ala, Emilia Turco, Paola Defilippi, J. Douglas Armstrong

“…In neurons, where p140Cap is key in regulating synaptogenesis, synaptic transmission and synaptic plasticity, it establishes an extensive interactome with proteins that cluster to sub complexes located in the postsynaptic density. p140Cap interactors converge on key synaptic processes, including synaptic transmission, actin cytoskeleton remodeling and cell-cell junction organization. …”
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Codonopsis pilosula Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice by Qing Zhang, Yiyuan Xia, Hongbin Luo, Sheng Huang, Yongjun Wang, Yangping Shentu, Yacoubou Abdoul Razak Mahaman, Fang Huang, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Jian-Zhi Wang, Bin Zhang, Xiaochuan Wang, Xiaochuan Wang

“…Together, our data suggest that CPPs might prevent AD-like tau hyperphosphorylation via activation of PP2A and attenuates AD-like cognitive impairments through restoring the synaptic plasticity and synaptogenesis. In conclusion, our findings suggest that CPPs might be a potential candidate compound for the treatment of tau related diseases.…”
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Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders by Nune Darbinian, Armine Darbinyan, John Sinard, Gabriel Tatevosian, Nana Merabova, Faith D’Amico, Tarek Khader, Ahsun Bajwa, Diana Martirosyan, Alina K. Gawlinski, Richa Pursnani, Huaqing Zhao, Shohreh Amini, Mary Morrison, Laura Goetzl, Michael E. Selzer

“…EtOH use by mothers, assessed by self-report, was associated with reduced fetal eye diameter, brain size, and markers of synaptogenesis. Brain caspase-3 activity was increased. …”
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Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component... by Florine Seidel, Florine Seidel, Kees Fluiter, Robert Kleemann, Nicole Worms, Anita van Nieuwkoop, Martien P. M. Caspers, Nikolaos Grigoriadis, Amanda J. Kiliaan, Frank Baas, Iliana Michailidou, Martine C. Morrison

“…In addition, NGS data of hippocampi from Ldlr-/-.Leiden mice showed that HFD feeding affected multiple molecular pathways relative to chow-fed controls: HFD notably inactivated synaptogenesis and activated neuroinflammation pathways. …”
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Cadherin-13 Deficiency Increases Dorsal Raphe 5-HT Neuron Density and Prefrontal Cortex Innervation in the Mouse Brain by Andrea Forero, Olga Rivero, Sina Wäldchen, Hsing-Ping Ku, Dominik P. Kiser, Yvonne Gärtner, Laura S. Pennington, Jonas Waider, Patricia Gaspar, Charline Jansch, Frank Edenhofer, Frank Edenhofer, Thérèse J. Resink, Robert Blum, Markus Sauer, Klaus-Peter Lesch, Klaus-Peter Lesch, Klaus-Peter Lesch

“…One of these molecules, cadherin-13 (Cdh13) has been shown to play a role in cell migration, axon pathfinding, and synaptogenesis. This study aimed to investigate the contribution of Cdh13 to the development of the murine brain 5-HT system.Methods: For detection of Cdh13 and components of the 5-HT system at different embryonic developmental stages of the mouse brain, we employed immunofluorescence protocols and imaging techniques, including epifluorescence, confocal and structured illumination microscopy. …”
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Time and age dependent regulation of neuroinflammation in a rat model of mesial temporal lobe epilepsy: Correlation with human data by Sinem Erisken, Sinem Erisken, George Nune, George Nune, Hyokwon Chung, Hyokwon Chung, Joon Won Kang, Joon Won Kang, Sookyong Koh, Sookyong Koh

“…We propose that persistent changes in inflammatory gene expression after SE leads not only to structural damage but also to aberrant synaptogenesis that may lead to epileptogenesis. Furthermore, the sustained pattern of inflammatory genes upregulated in the epileptic mature brain was distinct from that of the immature brain that show transient changes and are resistant to cell death and neuropathologic changes. …”
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Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in hum... by Manfei Zhou, Yichun Fan, Liuting Xu, Zheng Yu, Sizhe Wang, Huaisha Xu, Jiuping Zhang, Linwei Zhang, Wenwei Liu, Linlin Wu, Jing Yu, Honghong Yao, Jun Wang, Rong Gao

“…Conclusions This study is the first to delineate the beneficial effects of Ri. on adolescent depression by balancing Trp-derived neurotransmitter metabolism and improving synaptogenesis and glial maintenance, which may yield novel insights into the microbial markers and therapeutic strategies of GBA in adolescent depression. …”
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Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons by Fabiola Rojas, Rodrigo Aguilar, Sandra Almeida, Elsa Fritz, Daniela Corvalán, Estibaliz Ampuero, Sebastián Abarzúa, Polett Garcés, Armando Amaro, Iván Diaz, Cristian Arredondo, Nicole Cortes, Mario Sanchez, Constanza Mercado, Lorena Varela-Nallar, Fen-Biao Gao, Martin Montecino, Martin Montecino, Brigitte van Zundert, Brigitte van Zundert

“…Additionally, mutant TDP43 astrocytes displayed a mild reactive signature and an aberrant function as they were unable to promote synaptogenesis of hippocampal neurons. The polyP-dependent neurotoxic nature of the TDP43A90V mutation was further confirmed as neutralization of polyP in ACM derived from mutant TDP43 astrocytes prevented MN death. …”
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Heritable Risk and Protective Genetic Components of Glaucoma Medication Non-Adherence by Julie L. Barr, Michael Feehan, Casey Tak, Leah A. Owen, Robert C. Finley, Parker A. Cromwell, John H. Lillvis, Patrice M. Hicks, Elizabeth Au, Michael H. Farkas, Asher Weiner, Andrew L. Reynolds, Sandra F. Sieminski, Richard M. Sherva, Mark A. Munger, Murray H. Brilliant, Margaret M. DeAngelis

“…IPA demonstrated significant overlap, utilizing, both standard measures including opioid signaling, drug metabolism, and synaptogenesis signaling. CREB signaling in neurons (which is associated with enhancing the baseline firing rate for the formation of long-term potentiation in nerve fibers) was shown to have <i>protective</i> associations. …”
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The different clinical facets of SYN1-related neurodevelopmental disorders by Ilaria Parenti, Elsa Leitão, Alma Kuechler, Laurent Villard, Laurent Villard, Cyril Goizet, Cyril Goizet, Cyril Goizet, Cécile Courdier, Cécile Courdier, Cécile Courdier, Allan Bayat, Allan Bayat, Allan Bayat, Alessandra Rossi, Alessandra Rossi, Sophie Julia, Ange-Line Bruel, Ange-Line Bruel, Frédéric Tran Mau-Them, Frédéric Tran Mau-Them, Sophie Nambot, Daphné Lehalle, Daphné Lehalle, Marjolaine Willems, Marjolaine Willems, James Lespinasse, Jamal Ghoumid, Jamal Ghoumid, Roseline Caumes, Roseline Caumes, Thomas Smol, Thomas Smol, Salima El Chehadeh, Elise Schaefer, Marie-Thérèse Abi-Warde, Boris Keren, Alexandra Afenjar, Anne-Claude Tabet, Jonathan Levy, Anna Maruani, Ángel Aledo-Serrano, Waltraud Garming, Clara Milleret-Pignot, Anna Chassevent, Marije Koopmans, Nienke E. Verbeek, Richard Person, Rebecca Belles, Gary Bellus, Bonnie A. Salbert, Frank J. Kaiser, Frank J. Kaiser, Laure Mazzola, Laure Mazzola, Philippe Convers, Philippe Convers, Laurine Perrin, Amélie Piton, Amélie Piton, Amélie Piton, Amélie Piton, Gert Wiegand, Gert Wiegand, Andrea Accogli, Andrea Accogli, Francesco Brancati, Francesco Brancati, Fabio Benfenati, Fabio Benfenati, Nicolas Chatron, Nicolas Chatron, David Lewis-Smith, David Lewis-Smith, Rhys H. Thomas, Rhys H. Thomas, Federico Zara, Federico Zara, Pasquale Striano, Pasquale Striano, Gaetan Lesca, Gaetan Lesca, Christel Depienne

“…Synapsin-I (SYN1) is a presynaptic phosphoprotein crucial for synaptogenesis and synaptic plasticity. Pathogenic SYN1 variants are associated with variable X-linked neurodevelopmental disorders mainly affecting males. …”
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