Transient expression of the neuropeptide galanin modulates peripheral‑to‑central connectivity in the somatosensory thalamus during whisker development in mice by Zsofia Hevesi, Joanne Bakker, Evgenii O. Tretiakov, Csaba Adori, Anika Raabgrund, Swapnali S. Barde, Martino Caramia, Thomas Krausgruber, Sabrina Ladstätter, Christoph Bock, Tomas Hökfelt, Tibor Harkany

“…RNAi-mediated silencing of galanin expression disrupted glutamatergic synaptogenesis, which manifested as impaired whisker-dependent exploratory behaviors in infant mice, with behavioral abnormalities enduring into adulthood. …”
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Epilepsy and Thyroid Hormones by Sibel GÜLDİKEN

“…Thyroid hormones, in particular, bind to the nuclear receptors of neuronal and glial cells, which affects migration, myelination, and synaptogenesis, and contributes to the development and differentiation of the nervous system. …”
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HIPPOCAMPAL SYNAPTIC PLASTICITY: EFFECTS OF NEONATAL STRESS IN FREELY MOVING ADULT MALE RATS by M. Petrosino, J.D. Bronzino, G. P. Pizzuti

“…Since significant neuro- and synaptogenesis occurs postnatally within specific subfields of the hippocampal formation, the adaptative response to stress which occurs in this structure is of particular interest. …”
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Immune‐related interaction perturbation networks unravel biological peculiars and clinical significance of glioblastoma by Zaoqu Liu, Yudi Xu, Yuhui Wang, Siyuan Weng, Hui Xu, Yuqing Ren, Chunguang Guo, Long Liu, Zhenyu Zhang, Xinwei Han

“…In the four subtypes, C1 was an inflammatory subtype with high immune infiltration, low tumor purity, and potential response to immunotherapy; C2, an invasive subtype, was featured with dismal prognosis, telomerase reverse transcriptase promoter mutations, moderate levels of immunity, and stromal constituents, as well as sensitivity to receptor tyrosine kinase signaling inhibitors; C3 was a proliferative subtype with high tumor purity, immune‐desert microenvironment, sensitivity to phosphatidylinositol 3′‐kinase signaling inhibitor and DNA replication inhibitors, and potential resistance to immunotherapy; C4, a synaptogenesis subtype with the best prognosis, exhibited high synaptogenesis‐related gene expression, prevalent isocitrate dehydrogenase mutations, and potential sensitivity to radiotherapy and chemotherapy. …”
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Maternal Diabetes Deregulates the Expression of Mecp2 via miR-26b-5p in Mouse Embryonic Neural Stem Cells by Sukanya Shyamasundar, Seshadri Ramya, Deepika Kandilya, Dinesh Kumar Srinivasan, Boon Huat Bay, Suraiya Anjum Ansari, S Thameem Dheen

“…Overall, hyperglycemia dysregulates synaptogenesis that may manifest as neurodevelopmental disorders in offspring from diabetic pregnancy.…”
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New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization by Antoni Parcerisas, Alba Ortega-Gascó, Marc Hernaiz-Llorens, Maria Antonia Odena, Fausto Ulloa, Eliandre de Oliveira, Miquel Bosch, Lluís Pujadas, Eduardo Soriano

“…Our results expand the knowledge of NCAM2 interactome and confirm the key role of NCAM2 in cytoskeleton organization, neuronal morphogenesis and synaptogenesis. These findings are of interest in explaining the phenotypes observed in different pathologies with alterations in the NCAM2 gene.…”
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Physical Enrichment Triggers Brain Plasticity and Influences Blood Plasma Circulating miRNA in Rainbow Trout (<em>Oncorhynchus mykiss</em>) by Emilie Cardona, Valentin Brunet, Elodie Baranek, Léo Milhade, Sandrine Skiba-Cassy, Julien Bobe, Ludovic Calandreau, Jérôme Roy, Violaine Colson

“…These included markers of cerebral activity and plasticity, neurogenesis, synaptogenesis, or selected neurotransmitters pathways (dopamine, glutamate, GABA, and serotonin). …”
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Genetic background mutations drive neural circuit hyperconnectivity in a fragile X syndrome model by Tyler Kennedy, David Rinker, Kendal Broadie

“…This work identifies a number of genetic regions that contain mutations disrupting proper synaptogenesis within a particularly well-mapped neural circuit. …”
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Young Astrocytic Mitochondria Attenuate the Elevated Level of CCL11 in the Aged Mice, Contributing to Cognitive Function Improvement by Ryosuke Tashiro, Dan Ozaki, Jesus Bautista-Garrido, Guanghua Sun, Lidiya Obertas, Alexis S. Mobley, Gab Seok Kim, Jaroslaw Aronowski, Joo Eun Jung

“…Moreover, the inhibition of CCL11-specific receptor C-C chemokine receptor 3 (CCR3) boosted the expression of synaptogenesis-related genes in the cultured hippocampal neurons and restored the neurite outgrowth. …”
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Regulation of Extrasynaptic Glutamatergic Signaling by Polysialylated NCAM in Health and Disease by Alexander Dityatev

“…During brain development, NCAM and the associated glycan, polysialic acid (polySia), play important roles in cell migration proliferation, neurite outgrowth and fasciculation, and synaptogenesis. In the adult rodent brain, NCAM regulates synaptic plasticity, learning, and memory. …”
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Protocol for the culturing of primary hippocampal mouse neurons for functional in vitro studies by Teresa M.L. Cramer, Shiva K. Tyagarajan

“…Summary: Primary hippocampal cultures grown from genetically modified mice provide a simplified context to study molecular mechanisms underlying neuronal development, synaptogenesis, and synapse plasticity in vitro. Here, we describe a simple protocol for culturing hippocampal neurons from P0 to P2 mice and a strategy for inducing alterations in synaptic strength at inhibitory and excitatory synapses in vitro. …”
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Neurotrophic Effect of Fish-Lecithin Based Nanoliposomes on Cortical Neurons by Catherine Malaplate, Aurelia Poerio, Marion Huguet, Claire Soligot, Elodie Passeri, Cyril J. F. Kahn, Michel Linder, Elmira Arab-Tehrany, Frances T. Yen

“…The high content of n-3 PUFA (46.3% of total fatty acid content) and docosahexanoic acid (26%) in these NL represented a means for enrichment of neuronal membranes that are potentially beneficial for neuronal growth and synaptogenesis. To test this, the primary cultures of rat embryo cortical neurons were incubated with NL on day 3 post-culture for 24 h, followed by immunoblots or immunofluorescence to evaluate the NL effects on synaptogenesis, axonal growth, and dendrite formation. …”
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Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway by Weisheng Li, Likui Lu, Dan Zhu, Jingliu Liu, Yajun Shi, Hongtao Zeng, Xi Yu, Jun Guo, Bin Wei, Yongle Cai, Miao Sun

“…The goal of this study was to investigate how fluoride impacts synaptogenesis, with a focus on the phosphorylation of Creb1 (p-Creb1)-brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB) pathway. …”
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A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT_2A Receptor Density in the Pig Brain by Nakul Ravi Raval, Annette Johansen, Lene Lundgaard Donovan, Nídia Fernandez Ros, Brice Ozenne, Hanne Demant Hansen, Gitte Moos Knudsen

“…The mechanism behind its antidepressive action is unknown but could be linked to increased synaptogenesis and down-regulation of cerebral 5-HT_2AR. …”
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New players tip the scales in the balance between excitatory and inhibitory synapses by El-Husseini Alaa, Levinson Joshua N

“…<p>Abstract</p> <p>Synaptogenesis is a highly controlled process, involving a vast array of players which include cell adhesion molecules, scaffolding and signaling proteins, neurotransmitter receptors and proteins associated with the synaptic vesicle machinery. …”
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Microglial Function and Regulation during Development, Homeostasis and Alzheimer’s Disease by Brad T. Casali, Erin G. Reed-Geaghan

“…During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic plasticity, in addition to their primary role as immune sentinels. …”
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A Review on Brain Evolution and Development by Fatemeh Tahmasebi, Homa Rasoolijazi, Shirin Barati

“…It is suggested that neurodevelopment involves some genetic bases in the neural stem cells proliferation, cortical neurons migration, cerebral cortex folding, synaptogenesis, gliogenesis, and myelination of neural fibers.…”
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An Interesting Molecule: γ-Aminobutyric Acid. What Can We Learn from Hydra Polyps? by Paola Pierobon

“…Besides its recognized neurotransmitter functions, GABA also plays a fundamental role in neurogenesis and synaptogenesis during embryonic development. In addition, GABAergic mechanisms are also involved in disorders of various peripheral tissues, ranging from diabetes to hypothyroidism to inflammatory responses. …”
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The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders by Orly Weissberg, Evan Elliott

“…The CHD8 protein is a transcriptional regulator that is expressed in nearly all cell types and has been implicated in multiple cellular processes, including cell cycle, cell adhesion, neuronal development, myelination, and synaptogenesis. Considering the central role of CHD8 in the genetics of autism, a deeper understanding of the physiological functions of CHD8 is important to understand the development of the autism phenotype and potential therapeutic targets. …”
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Iron and Neurodevelopment in Preterm Infants: A Narrative Review by Kendell R. German, Sandra E. Juul

“…Iron is critical for brain development, playing key roles in synaptogenesis, myelination, energy metabolism and neurotransmitter production. …”
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