Regulation of Synaptic Development by Astrocyte Signaling Factors and Their Emerging Roles in Substance Abuse by Christopher D. Walker, W. Christopher Risher, Mary-Louise Risher

“…In this way, astrocytes engage in crosstalk with neurons to mediate a variety of CNS processes including the regulation of extracellular matrix protein signaling, formation and maintenance of the blood-brain barrier (BBB), axon growth and guidance, homeostasis of the synaptic microenvironment, synaptogenesis, and the promotion of synaptic diversity. …”
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Analysis of Neurocognitive Development of Moderate and Late Preterm Children in Early Childhood Using Bayley-III by N. I. Bakushkina, T. V. Rogacheva

“…Premature birth has a certain impact on the development of the infant’s brain, affecting the important processes of differentiation of neurons, myelination, synaptogenesis, etc. Neurocognitive functions were measured by the Bayley Scales behavioral technique, third edition (Bayley-III). …”
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A brief review of risk-factors for growth and developmental delay among preschool children in developing countries by Syed Sadat Ali

“…A child′s brain during the first 3 years of life is rapidly developing through generation of neurons, synaptogenesis, axonal, and dendric growth and synaptic pruning each of which build upon each other. …”
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Late Recruitment of Synapsin to Nascent Synapses Is Regulated by Cdk5 by Courtney Easley-Neal, Javier Fierro, Jr., JoAnn Buchanan, Philip Washbourne

“…These results point to additional layers of complexity in the established mechanisms of synaptogenesis.…”
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THE INFLUENCE OF PHYSICAL ACTIVITY ON THE IMPROVEMENT OF MOTOR FUNCTIONING IN PEOPLE WITH PARKINSON’S DISEASE by Anna Marszałek, Tadeusz Kasperczyk, Robert Walaszek

“…Studies carried out on humans and animal models of PD have shown that increased physical activity improves the patterns of motor behavior and enhances the process of angiogenesis, synaptogenesis, and neurogenesis in the brain. It also increases the level of neurotrophic factors. …”
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Premorbid effects of APOE on synaptic proteins in human temporal neocortex. by Love, S, Siew, L, Dawbarn, D, Wilcock, G, Ben-Shlomo, Y, Allen, S

“…Experimental studies suggest that APOE influences synaptogenesis. We measured the concentration of two presynaptic proteins, synaptophysin and syntaxin 1, and also postsynaptic density-95 (PSD95), in superior temporal cortex from 42 AD and 160 normal brains, and determined the APOE genotypes. …”

Placental DNA methylation profile as predicting marker for autism spectrum disorder (ASD) by Amin Ravaei, Marco Emanuele, Giovanni Nazzaro, Luciano Fadiga, Michele Rubini

“…Differentially methylated regions (DMRs) in ASD-developing placenta were found to be mainly enriched in ASD gene loci affecting synaptogenesis, microtubule dynamics, neurogenesis and neuritogenesis. …”
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Spatiotemporal molecular approach of in utero electroporation to functionally decipher endophenotypes in neurodevelopmental disorders by Sharon Margriet Kolk, Annetrude Johanne De Mooij - Van Malsen, Gerard Julianus Maria Martens

“…Brain area-specific genes expressed within a particular time window direct neurodevelopmental events such as proliferation, migration, axon guidance, dendritic arborization and synaptogenesis. These genes can pose as susceptibility factors in neurodevelopmental disorders eventually resulting in area-specific cognitive deficits. …”
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Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity? by Patrick Müller, Yves Duderstadt, Volkmar Lessmann, Notger G. Müller

“…One potential mediator of exercise effects is the neurotrophin BDNF, which enhances neuroplasticity via different pathways (e.g., synaptogenesis, neurogenesis, long-term potentiation). …”
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Complex protein interactions mediate Drosophila Lar function in muscle tissue. by Jessica Kawakami, David Brooks, Rana Zalmai, Steven D Hartson, Samuel Bouyain, Erika R Geisbrecht

“…The type IIa family of receptor protein tyrosine phosphatases (RPTPs), including Lar, RPTPσ and RPTPδ, are well-studied in coordinating actin cytoskeletal rearrangements during axon guidance and synaptogenesis. To determine whether this regulation is conserved in other tissues, interdisciplinary approaches were utilized to study Lar-RPTPs in the Drosophila musculature. …”
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Chemical Treatments for Insect Cell Differentiation: The Effects of 20-Hydroxyecdysone and Veratridine on Cultured <i>Spodoptera frugiperda</i> (<i>Sf</i>21) Insect Cell Ultrastruc... by Lacey J. Jenson, James J. Becnel, Jeffrey R. Bloomquist

“…It is concluded that additional agents would be required to induce functional synaptogenesis in <i>Sf</i>21 cells.…”
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Glial cell contributions to auditory brainstem development by Karina S Cramer, Edwin W Rubel

“…Factors from late appearing astrocytes promote synaptogenesis and dendritic maturation, and astrocytes remain integral parts of specialized auditory synapses. …”
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Synapse development in health and disease by Melom, Jan Elizabeth, Littleton, J. Troy

“…Our understanding of the basic biology of synaptogenesis is therefore critical to unraveling the pathogenesis of neuropsychiatric disorders.…”
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Structural basis for integration of GluD receptors within synaptic organizer complexes by Elegheert, J, Kakegawa, W, Clay, J, Shanks, N, Behiels, E, Matsuda, K, Kohda, K, Miura, E, Rossmann, M, Mitakidis, N, Motohashi, J, Chang, V, Siebold, C, Greger, I, Nakagawa, T, Yuzaki, M, Aricescu, A

“…This arrangement promotes synaptogenesis and is essential for D: -serine-dependent GluD2 signaling in vivo, which underlies long-term depression of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses and motor coordination in developing mice. …”

Isoform-specific binding of the tyrosine phosphatase PTPsigma to a ligand in developing muscle. by Sajnani-Perez, G, Chilton, J, Aricescu, A, Haj, F, Stoker, A

“…Given that invertebrate relatives of PTPsigma can control motor axon guidance, target contact, and synaptogenesis, we have asked if extracellular ligands exist for cPTPsigma, the avian PTPsigma orthologue, in the neuromuscular system. …”

Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation by Yves Jossin

“…During embryonic development and adulthood, Reelin exerts several important functions in the brain including the regulation of neuronal migration, dendritic growth and branching, dendritic spine formation, synaptogenesis and synaptic plasticity. As a consequence, the Reelin signaling pathway has been associated with several human brain disorders such as lissencephaly, autism, schizophrenia, bipolar disorder, depression, mental retardation, Alzheimer’s disease and epilepsy. …”
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Optimized Mass Spectrometry Detection of Thyroid Hormones and Polar Metabolites in Rodent Cerebrospinal Fluid by Ryann M. Fame, Ilhan Ali, Maria K. Lehtinen, Naama Kanarek, Boryana Petrova

“…Tight TH level regulation in the central nervous system is essential for developmental gene expression, which governs neurogenesis, myelination, and synaptogenesis. This integrated function of TH highlights the importance of developing precise and reliable methods for assessing TH levels in CSF. …”
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Glycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration by Ariel Avila, Pía M. Vidal, T. Neil Dear, Robert J. Harvey, Jean-Michel Rigo, Laurent Nguyen

“…Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. …”
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Running wheel training does not change neurogenesis levels or alter working memory tasks in adult rats by Cesar A. Acevedo-Triana, Manuel J. Rojas, Fernando Cardenas P.

“…Background Exercise can change cellular structure and connectivity (neurogenesis or synaptogenesis), causing alterations in both behavior and working memory. …”
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The effects of physical activity on glutamate neurotransmission in neuropsychiatric disorders by Richard Baskerville, Thomas McGrath, Lindy Castell

“…Exercise improves mitochondrial function, angiogenesis and synaptogenesis. Within the glutamate hypothesis of depression, the mechanisms of stress and inflammation have been extensively researched, but PA as a mitigator is less understood. …”
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